Clinical trials: Fever of Unknown Origin
Pyrexia
Comparison of FDG-PET/CT and CECT-CAP as Upfront Imaging Modality for the Diagnosis of Pyrexia of Unknown Origin
Pyrexia of unknown origin (PUO) remains one of the most challenging diagnostic problems in modern medicine. Despite advances in laboratory diagnostics, microbiological techniques, imaging modalities, and molecular testing, a…
- Trial name
- CET-PET-PUO (NCT07816783)
- Testing
- FDG-PET, CECT, Standard care of therapy
- Where
- India
- Volunteers
- 132 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Fever of Unknown Origin
Fever of Unknown Origin (FUO) in Elderly Patients
Objective: Fever of unknown (FUO) origin remains challenging in geriatric patients. Geriatric patients have a blunted immune response responsible for altered fever mechanisms and immune cells responses.
- Trial name
- FUO (NCT04810351)
- Testing
- observational study
- Where
- Belgium
- Sponsor
- Universitair Ziekenhuis Brussel
Fever of Unknown Origin, IgG4 Related Disease
The Investigators Will Evaluate the Diagnostic Performance of [18F]-AlF-FAPI-74 PET/CT in Inflammatory Disorders and Compare it With the Current Gold Standard for Inflammation, FDG PET/CT, in Three Patient Cohort: Patients Presenting With Fever of Unknown Origin, IgG4-RD and AxSpA.
The aim of the study to evaluate the performance of new [18F]-AlF-FAPI-74 PET/CT in three inflammatory disorders (fever of unknown origin, IgG4-related disease and axial spondyloarthritis) and compare with the current…
- Conditions
- Fever of Unknown Origin, IgG4 Related Disease, Axial Spondylarthritis (axSpA), Inflammation of Unknown Origin
- Trial name
- NCT07535554
- Testing
- [18F]AlF-FAPI-74 PET/CT
- Where
- Belgium
- Volunteers
- 140 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Fever of Unknown Origin, Inflammation of Unknown Origin
Utility of 18F-FDG PET/CT for Suspected Infection in the Inpatient Setting: a Single Centre Retrospective Cohort Study
Retrospective cohort study of inpatients at a South Australian tertiary hospital who underwent 18F FDG-PET/CT for investigation of undifferentiated fever or inflammatory syndrome.
- Conditions
- Fever of Unknown Origin, Inflammation of Unknown Origin, Fever, Inflammation
- Trial name
- NCT07430475
- Testing
- 18F-FDG PET/CT
- Where
- Australia
- Volunteers
- 266 people
- Sponsor
- University of Adelaide
Fever
Impact of the PET in the Diagnosis Strategy of FUO or Inflammatory Syndrome in Immunocompetent Patients FUO-TEP
Fever of unknown origin (FUO) and chronic inflammatory syndrome could be seen in many affections. The diagnostic process is still a challenge and could not be specified yet after several clinical studies performed by trained…
- Trial name
- FUO-TEP (NCT01200771)
- Testing
- TEP
- Where
- 19 sites in France
- Volunteers
- 116 people
- Sponsor
- University Hospital, Limoges
Heart Failure, Chronic Obstructive Pulmonary Disease
Primary Care-Hospital Embedding: a Prospective, Multicentric, Observational Study
This is a multicentric, prospective, observational study with two cohorts and adjunctive procedure. It aims at collecting and analyzing data about the function of an innovative hospital-territory integration health service for…
- Conditions
- Heart Failure, Chronic Obstructive Pulmonary Disease, Diabetes Mellitus, Pneumonia
- Trial name
- PRIME (NCT05723185)
- Testing
- Outpatient visit
- Where
- Italy
- Volunteers
- 246 people
- Sponsor
- Rovere Querini Patrizia
Fever of Unknown Origin
68Ga Citrate PET/MRI for Evaluation of Fever of Unknown Origin (FUO)
This is a Phase III study to evaluate 68Ga Citrate PET/MRI for detection of origin of fever of unknown origin.
- Trial name
- NCT04139395
- Testing
- 68Ga-Citrate PET/MRI, 67Ga-Citrate SPECT, Positron Emission Tomography
- Where
- United States
- Sponsor
- Carina Mari Aparici
Lyme Disease, Lyme Neuroborreliosis
PEMF Therapy to Treat Lingering Symptoms of Lyme Disease After Treatment With Antibiotics
Overview PEMF Therapy for relief or reduction of lingering symptoms after antibiotic treatment of Lyme disease of participants in the UK.
- Conditions
- Lyme Disease, Lyme Neuroborreliosis, Lyme Arthritis, Unknown Origin Fever
- Trial name
- PEMF (NCT04577053)
- Testing
- Scientific Consciousness Interface Operations (SCIO) Class II FDA approved medical device
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kasey Phifer
Fever of Unknown Origin
Fever of Unknown Orgin Registry in Internal Medicine Unit and Infectious Disease Units
This registry has the aim to collect epidemiological and clinical data of classical FUO cases in Italian Internal medicine Dept. and in Italian Infection diseases Dept.
- Trial name
- FUO (NCT05254522)
- Testing
- not aplicable since it is a Registry
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fadoi Foundation, Italy
Fever of Unknown Origin
PLACE OF THE 18F-FDG-PET/CT IN THE DIAGNOSTIC WORKUP IN PATIENTS WITH CLASSICAL FEVER OF UNKNOWN ORIGIN (FUO)
Objective : To explore the diagnostic contribution of the 18F-FDG-PET/CT in a population of patients with classical fever of unknown origin (FUO), to precise its place in the diagnostic decision tree in a real-life setting and to…
- Trial name
- NCT04851379
- Where
- France
- Volunteers
- 44 people
- Sponsor
- University Hospital, Montpellier
Cardiac Disease, Dementia
PET-MRI in Diagnosing Patients With Cancer, Cardiac Diseases, or Neurologic Diseases
This randomized pilot clinical trial studies how well positron emission tomography (PET)-magnetic resonance imaging (MRI) works compared to standard-of-care PET-computed tomography (CT) in diagnosing patients with cancer, cardiac…
- Conditions
- Cardiac Disease, Dementia, Inflammatory Disease, Fever of Unknown Origin
- Trial name
- NCT02084147
- Testing
- positron emission tomography, computed tomography, magnetic resonance imaging
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Case Comprehensive Cancer Center
Fever of Unknown Origin
Causes of FUO in Infants and Children
Definition: fever < 38˚c for which the cause could not be identified, documented by a health care provider after 3w.evaluation as an outpatient [or after 1w. evaluation in the hospital].
- Trial name
- NCT04073108
- Testing
- tuberculin test
- Volunteers
- 50 people
- Sponsor
- Assiut University
Fever of Unknown Origin
Evaluation of Diagnosis of Fever and Biologic Inflammatory Syndrome of Unknown Origin
Fever of unknown origin (FUO) and biologic inflammatory syndrome of unknown origin (SII) are two frequent causes of hospitalization or consultation in infectious disease unit and internal medicine.
- Trial name
- FUO (NCT02786693)
- Where
- 2 sites in France
- Volunteers
- 39 people
- Sponsor
- University Hospital, Grenoble
Fever of Unknown Origin
A Two-step Method Apparently Improved the Physicians' Level of Diagnosis Decision-making for Adult Patients With FUO
The purpose of this study is to determine whether two-step method of diagnostic strategy is effective in the diagnosis and treatment of fever of unknown origin (FUO).
- Trial name
- NCT02035670
- Testing
- Two-step diagnostic strategy
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Tongji Hospital
Fever of Unknown Origin, Tick-borne Diseases
Clinical Research for the Diagnosis of Tick-borne Diseases in Patients With Unexplained Acute Fever
The study will use several laboratory diagnoses in the diagnosis of patients with fever，to find out which will be more helpful for making an accurate diagnosis in the early period of Tickborne Diseases.
- Trial name
- NCT02618655
- Testing
- diagnostic methods
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Friendship Hospital
Fever of Unknown Origin
Influence of Compound Qingre Granule on the Inflammatory Markers in Patient of FUO With Excess-heat Syndrome
The purpose of this study is to observe inflammatory markers like TNF (tumor necrosis factor), IL-1 (interleukin-1), IL-6 (interleukin-6),TREM-1 (triggering receptor expressed on myeloid cells-1), etc, in patient of FUO with…
- Trial name
- NCT02695914
- Testing
- Compound Qingre Granule
- Volunteers
- 80 people
- Sponsor
- Beijing Friendship Hospital
Respiratory Virus Infection, Fever of Unknown Origin
Rapid Viral Diagnostics in Adults to Reduce Antimicrobial Consumption and Duration of Hospitalization
Viral respiratory infections are common and often require use of health care resources. Patients receive inappropriate bacterial antibiotics, which has many problems including side-effects, development of resistance and costs.
- Conditions
- Respiratory Virus Infection, Fever of Unknown Origin, Dyspnea, Chest Pain
- Trial name
- NCT02538770
- Testing
- Rapid diagnostics using Anyplex TMII RV16 Detection, Delayed diagnostics Anyplex TMII RV16 Detection
- Where
- 2 sites in Finland
- Volunteers
- 900 people
- Sponsor
- University of Oulu
Neutropenia, Fever
Granulocyte Transfusions in Hematological Patients With Febrile Neutropenia
The investigators retrospectively evaluated the efficacy of granulocyte transfusions as adjunctive treatment for severe infections in neutropenic fever unresponsive to antimicrobial therapy in hematological patients.
- Conditions
- Neutropenia, Fever, Bacterial Infection, Fungal Infection
- Trial name
- NCT02544230
- Where
- Italy
- Volunteers
- 101 people
- Sponsor
- Sorveglianza Epidemiologica Infezioni Fungine Emopatie Maligne
Complications, Infective Endocarditis
PET CT in Suspected CIED Infection, a Pilot Study - PET Guidance I
The aim of this single-center randomized controlled trial is to assess clinical usefulness of positron emission tomography combined with computed tomography (PET CT) in the diagnostic process of suspected cardiovascular…
- Conditions
- Complications, Infective Endocarditis, Implant Site Pocket Infection, Fever of Unknown Origin
- Trial name
- PET Guidance I (NCT02196753)
- Testing
- PET CT
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Possible Fungal Infection
Immediate vs. Deferred Empirical Antifungal Treatment With Voriconazole In Neutropenic Patients
A well-known side-effect of cytostatics (drugs against malignancies) is a decrease in the number of white blood cells, especially of the so-called neutrophil granulocytes, which are very important for the defense against…
- Trial name
- IDEA (NCT00150345)
- Testing
- voriconazole (Vfend)
- Where
- 28 sites in Germany
- Volunteers
- 147 people
- Sponsor
- Pfizer