Clinical trials: Fibroids, Uterine
Uterine Fibroid
Epidemiology and Risk Factors of Uterine Fibroids in China
Uterine fibroids are the most common form of benign uterine tumors in the uterine muscle layer, which had a certain rate of malignancy, but it is rare.
- Trial name
- NCT05840042
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Wenwen Wang
Female Infertility, Uterine Fibroid
The Effects of Uterine Fibroids on Pregnancy in Women
Female fertility may be affected by uterine fibroids, although this association has not been elucidated. This retrospective cohort study aims to evaluate the impact of fibroids on women fertility.
- Trial name
- NCT06020924
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,658 people, healthy volunteers welcome
- Sponsor
- Wenwen Wang
Uterine Fibroid, Uterine Sarcoma
Radiomics-Based Non-Invasive MRI Differentiation of Uterine Sarcomas and Fibroids
This retrospective case-control study aims to develop and validate a diagnostic model based on multimodal big data and artificial intelligence to differentiate uterine leiomyoma from uterine sarcoma.
- Conditions
- Uterine Fibroid, Uterine Sarcoma, Diagnose Disease, AI (Artificial Intelligence)
- Trial name
- NCT07129005
- Testing
- No intervention (observational study)
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Tongji Hospital
Uterine Fibroid, Uterine Sarcoma
A Prospective Validation Study of Radiomics in the Differential Diagnosis of Uterine Leiomyoma and Uterine Sarcoma
In our previous study, based on the multi-center clinical big data collected from January 2012 to January 2025, we have completed the construction of a multimodal early warning model for the malignant transformation of uterine…
- Conditions
- Uterine Fibroid, Uterine Sarcoma, AI (Artificial Intelligence), Radiomic
- Trial name
- NCT07269535
- Testing
- No intervention (observational study)
- Volunteers
- 500 people
- Sponsor
- Tongji Hospital
Leiomyoma (Uterine Fibroids), Myomectomy
Investigation of the Impact of Myomectomy on Uterine Artery Doppler Velocimetry Findings
Objective: This scientific study aims to investigate whether myomectomy induces significant changes in uterine artery blood flow patterns.
- Conditions
- Leiomyoma (Uterine Fibroids), Myomectomy, Doppler Ultrasound
- Trial name
- MYO-DOP (NCT07343765)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Uterine Fibroid
Bearing nsPVA Embolization for Uterine Artery Embolization (BETTER-UAE)
This is a prospective, multicenter, observational, post-market clinical follow-up study in subjects treated with Bearing nsPVA Embolization Particles for uterine fibroid embolization.
- Trial name
- BETTER-UAE (NCT06153667)
- Testing
- Bearing nsPVA
- Where
- 4 sites in United States, Australia and 1 more
- Volunteers
- 100 people
- Sponsor
- Merit Medical Systems, Inc.
Leiomyoma, Uterine, Leiomyoma
Prescription of Letrozole for Uterine Myoma
The PLUM Study is a randomized, double-blinded, 2-arm, parallel-group, placebo-controlled trial is designed to compare the efficacy of letrozole versus placebo on leiomyoma-related symptoms and quality of life as well as…
- Conditions
- Leiomyoma, Uterine, Leiomyoma, Fibroid, Fibroid Uterus
- Trial name
- PLUM (NCT06143631)
- Testing
- Letrozole 2.5mg
- Where
- 5 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Uterine Fibroids (Leiomyoma), Adenomyosis of Uterus
Stellate Ganglion Block and Dexmedetomidine for Postoperative Sleep in Women Undergoing Laparoscopic Gynecologic Surgery
Study Objectives This study aims to investigate the effects of preoperative stellate ganglion block and intraoperative intravenous dexmedetomidine on postoperative sleep disturbance in patients undergoing laparoscopic gynecologic…
- Conditions
- Uterine Fibroids (Leiomyoma), Adenomyosis of Uterus, Endometriosis, Endometrial Cancer
- Trial name
- NCT07860203
- Testing
- DEX 0.2 μg/kg/h., SGB
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Catherin Zhang
Dysmenorrhea, Menstrual Pain
Vaginal Sildenafil for Primary Dysmenorrhea
This open-label, non-randomized mechanistic study will evaluate whether a single 100 mg vaginal sildenafil citrate suppository reduces uterine hypercontractility during menstruation in adults with moderate-to-severe dysmenorrhea.
- Conditions
- Dysmenorrhea, Menstrual Pain, Endometriosis, Uterine Fibroid
- Trial name
- SILDYS (NCT07508358)
- Testing
- Sildenafil citrate vaginal suppository
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Kevin Hellman
Dysmenorrhea (Disorder), Dysmenorrhea Primary
Mechanistic Characterization of Uterine Pain
There are limited treatment options for management of dysmenorrhea, and the physiological processes they affect are not completely understood.
- Conditions
- Dysmenorrhea (Disorder), Dysmenorrhea Primary, Dysmenorrhea Secondary, Endometrial Diseases
- Trial name
- MCUP (NCT04145518)
- Testing
- Naproxen Sodium
- Where
- United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Endometriosis, Adenomyosis of Uterus
Artificial Intelligence Into Ultrasound Diagnostics in Reproductive Medicine
The goal of this observational study is to develop and validate artificial intelligence (AI)-based algorithms that support ultrasound diagnosis of endometriosis, adenomyosis, myometrial masses, uterine malformations, and impaired…
- Conditions
- Endometriosis, Adenomyosis of Uterus, Leiomyoma (Uterine Fibroids), Uterine Neoplasms
- Trial name
- AUDRIE (NCT07810920)
- Where
- Hungary
- Volunteers
- 1,600 people
- Sponsor
- Semmelweis University
Uterine Fibroids (Leiomyoma)
Microwave Ablation of Uterine Fibroids
This prospective observational study aims to evaluate the effectiveness and acceptability of percutaneous or vaginal ultrasound guided microwave ablation for the treatment or symptomatic uterine fibroids.
- Trial name
- MyoMwa (NCT07780019)
- Testing
- microwave ablation
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Turku University Hospital
Benign Gynecological Disease, Uterine Fibroids
Prospective Perioperative Clinical Registry for Women Undergoing Benign Gynecological Surgery
This prospective observational registry aims to systematically collect preoperative, intraoperative, and postoperative clinical data from patients undergoing surgery for benign gynecological conditions.
- Conditions
- Benign Gynecological Disease, Uterine Fibroids, Endometriosis, Adenomyosis
- Trial name
- OPGYNBEN (NCT07772076)
- Testing
- Standard Surgical Procedures for Benign Gynecological Conditions
- Where
- Italy
- Volunteers
- 6,000 people
- Sponsor
- IRCCS San Raffaele
Uterine Fibroids (UF), Microwave Ablation
Safety and Efficacy of Microwave Ablation Alone Versus Microwave Ablation Combined With Chemical Ablation in the Treatment of Uterine Fibroids: A Prospective, Multicenter Study
Uterine fibroids are the most common benign tumors in women of reproductive age, with a prevalence of 20%-50%, often causing menorrhagia, anemia, pelvic pain, and pressure symptoms that markedly impair quality of life.
- Conditions
- Uterine Fibroids (UF), Microwave Ablation, Ultrasound
- Trial name
- NCT07754877
- Testing
- Microwave ablation combined with chemical ablation, Microwave ablation
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Peking University Aerospace Center Hospital
Uterine Fibroids (Leiomyoma), Uterine Myoma
Terlipressin vs Placebo to Reduce Bleeding in Fibroid Surgery
A myomectomy is a surgery to remove noncancerous growths (fibroids) from the uterus while keeping the uterus in place. This surgery can cause significant blood loss.
- Conditions
- Uterine Fibroids (Leiomyoma), Uterine Myoma, Leiomyoma
- Trial name
- NCT07746349
- Testing
- terlipressin (vasoconstrictor)
- Volunteers
- 80 people
- Sponsor
- Sevil Cankaya
Endometriosis, Fibroids
Impact of Educational Videos on Pre-operative Anxiety
The goal of this clinical trial is to learn if educational videos can reduce pre-operative anxiety in patients undergoing minimally invasive gynecologic surgery.
- Conditions
- Endometriosis, Fibroids, Adenomyosis, Pelvic Pain
- Trial name
- NCT07740759
- Testing
- educational video
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- UConn Health
Fibroid Uterus, Fibroid Tumor
Effects of Simvastatin on Uterine Leiomyoma Size
The study aims to study the effect of simvastatin on the size of uterine fibroids.
- Conditions
- Fibroid Uterus, Fibroid Tumor, Leiomyoma, Fibromyoma
- Trial name
- NCT03400826
- Testing
- Simvastatin 40mg
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Uterine Fibroids (Leiomyoma), Myomectomy
Bilateral Uterine Artery Occlusion During Laparoscopic Myomectomy
The current study is a multiple-arm, single blinded, and controlled randomized trial. It will be conducted in two gynecological endoscopy centers: • ElShatby University Hospital, a tertiary level hospital in Alexandria, Egypt.
- Conditions
- Uterine Fibroids (Leiomyoma), Myomectomy, Myomectomy; Surgical Blood Loss
- Trial name
- NCT07352761
- Testing
- Temporary clipping of uterine artery, Temporary occlusive suturing of uterine artery, Bipolar coagulation of uterine arteries
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Minimally Invasive Surgical Procedures, Abnormal Uterine Bleeding, Unspecified
Cyclobenzaprine for Postoperative Pain in Minimally Invasive Hysterectomy
Typical postoperative pain control after minimally invasive hysterectomy includes ibuprofen, acetaminophen, and a short course of narcotics.
- Conditions
- Minimally Invasive Surgical Procedures, Abnormal Uterine Bleeding, Unspecified, Adenomyosis of Uterus, Fibroid Uterus
- Trial name
- NCT07664956
- Testing
- Cyclobenzaprine
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Christiana Care Health Services
Uterine Fibroids (Leiomyoma)
FATIMA Trial: EGCG and Vitamin D3 for Prevention of Fibroid Recurrence
The aim of this randomized controlled clinical trial is to evaluate the efficacy of green tea (EGCG) and vitamin D3 supplementation in preventing uterine fibroid recurrence following fibroid removal.
- Trial name
- FATIMA (NCT07647198)
- Testing
- Vitamin D and Green Tea
- Where
- United Arab Emirates
- Volunteers
- 240 people
- Sponsor
- Sheikh Shakhbout Medical City