Clinical trials: First Nations
Healthy Children, Elementary School Age
Healthy Buddies Manitoba
School-based interventions are generally ineffective for preventing weight gain in children. In 2007, a group from the University of British Columbia, developed a program called Healthy Buddies, that relied on peer mentors to…
- Conditions
- Healthy Children, Elementary School Age, Rural and Urban, First Nations
- Trial name
- NCT01979978
- Testing
- Healthy Buddies Curriculum
- Where
- Canada
- Volunteers
- 647 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Smokeless Tobacco Cessation
Testing ANSOS for Efficacy in Multi-Tribal Urban Communities
This is a wait-list control trial to test for efficacy of the All Nations Snuff Out Smokeless (ANSOS) recreational tobacco cessation program in multi-tribal American Indian (AI) communities.
- Trial name
- NCT06566703
- Testing
- All Nations Snuff Out Smokeless, Healthy Living
- Where
- United States
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Lehigh University
Obesity Prevention, School Wellness Policy
Primary Prevention of Obesity in American Indian Youth in Rural Tribal Schools
The goal of this study is to learn if a culturally relevant health promotion curricula prevents obesity among 4th graders in rural tribal schools.
- Trial name
- NCT06864468
- Testing
- Health promotion curricula
- Where
- 3 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University
Obesity
Engaging Tribal Policy Makers to Improve the Food and Physical Activity Environments in American Indian Communities
The overall objective of the study is to reduce adult obesity in participating American Indian (AI) communities and to improve understanding of the behavioral and environmental factors affecting obesity in these settings.
- Trial name
- OPREVENT2 (NCT02803853)
- Testing
- Intervention
- Where
- United States
- Volunteers
- 876 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Cardiovascular Diseases, Heart Diseases
Preventing American Indian Children From Becoming Overweight
The purpose of this study is to establish an intervention to keep American Indian/Alaskan Native (AI/AN) children from becoming overweight.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity
- Trial name
- NCT00245180
- Testing
- Diet, Exercise
- Volunteers
- 577 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Advance Care Planning
Culturally-Adapting a Communication Intervention to Improve Palliative Care Literacy on Two Native American Reservations
This study will evaluate the feasibility, acceptability, and perceived effectiveness of the culturally-adapted COMFORT Communication Curriculum in two Native American reservation communities.
- Trial name
- NCT03569150
- Testing
- Cultural adaptation/implementation COMFORT CC
- Volunteers
- healthy volunteers welcome
- Sponsor
- South Dakota State University
Mental Health Wellness 1, Behavior, Health
Talking Circle for Native American Youth
Native American youth have higher rates of depression and lifetime major depressive episodes, and, by age 11, are more likely to have initiated alcohol and substance use than any other racial/ethnic group.
- Conditions
- Mental Health Wellness 1, Behavior, Health, Emotional Stress
- Trial name
- AYoLi (NCT06781736)
- Testing
- Talking Circle intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Substance Use
Culturally Grounded Early Substance Use Prevention for American Indian Families
This study involves adaptation, implementation, and rigorous evaluation of a family-based program designed to prevent early initiation of substance use on a Northern Plains Indian reservation.
- Trial name
- NCT02383225
- Testing
- Lakota Language enhancement, Facebook Supplement, Substance Use Resistance Skills
- Where
- United States
- Volunteers
- 449 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Applied Suicide Intervention Skills Training
The Safety and Effectiveness of Gatekeeper Training in First Nations Communities
Gatekeeper training is where people in the community are trained to recognize and identify those who are at risk for suicide and assist them in getting care. Gatekeeper training has been widely implemented around the world.
- Trial name
- NCT02118116
- Testing
- Applied Suicide Intervention Skills Training
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Manitoba
Haemophilus Influenzae Type B, Carrier State
Study to Eliminate Hib Carriage in Rural Alaska Native Villages
Hib disease rates in rural Alaska before introduction of HIb conjugate vaccine were among the highest in the world. Since vaccine introduction, rates have fallen by 90% but the disease has not been eliminated.
- Trial name
- NCT00153556
- Testing
- Hib conjugate vaccine (HbOC, Wyeth Vaccines)
- Where
- United States
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Stroke, Atherosclerosis
Stroke Prevention in the Wisconsin Native American Population
This project will develop a "Stroke Awareness Team" including training of Oneida Health Service Coaches working in partnership with the UW team for a population-based health awareness program.
- Trial name
- NCT04382963
- Testing
- High Risk - intensive coaching, High Risk - standard care, Low Risk - control
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Violence, Domestic, Violence-Related Symptom
The weWomen and ourCircle Intervention for Immigrant, Refugee and Indigenous Women
This study evaluates the impact of administering culturally-specific versions of the Danger Assessment (DA) tool followed by the tailored safety planning/referral via use of internet/smartphone-based safety decision aid (SDA) on…
- Trial name
- NCT03265847
- Testing
- Culturally-tailored Safety Planning
- Where
- United States
- Volunteers
- 688 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
HIV/AIDS
Adapting and Evaluating an EBI to Prevent HIV/AIDS Risk Among Apache Youth
The investigators seek to adapt, implement and evaluate a randomized controlled trial of an evidence based intervention delivered by Apache interventionists to reduce HIV/AIDS risk, targeting Apache adolescents.
- Trial name
- NCT01910714
- Testing
- Focus On Youth, Health Education Control Condition
- Where
- United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Anxiety Disorder, Depressive Disorder
Feasibility of a Culturally Adapted Emotional-Behavioral Prevention Program for American Indian Children
American Indians (AI) are at greater risk for anxiety and depression early in life. This is concerning given the potential negative effects of these conditions across the lifespan (substance use, suicide).
- Trial name
- NCT05371665
- Testing
- Culturally Adapted Cognitive-Behavioral Prevention and Early Intervention (PEI) Program
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Montana State University
Suicide, Trauma, Psychological
Wakȟáŋyeža (Little Holy One)
The overall goal of this study is to develop, adapt and evaluate an intergenerational prevention intervention, named "Wakȟáŋyeža (Little Holy One)," with Native American caregivers on a Northern Plains reservation and the…
- Conditions
- Suicide, Trauma, Psychological, Parenting
- Trial name
- NCT04201184
- Testing
- Newly created cultural components, adapted Family Spirit lessons, adapted CETA modules, Active nutrition control
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Smoking Cessation
American Indian Smokefree Native RCT
The aim of this clinical trial is to test the efficacy of a culturally aligned digital smoking cessation resource for American Indian persons who smoke, via a remotely conducted randomized controlled trial.
- Trial name
- NCT06544811
- Testing
- Smoking Cessation Program, Cultural Smoking Cessation Program
- Where
- United States
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Pulmonary Disease, Chronic Obstructive
Bayis Ilh Tus - A Strong Breath: Prevalence and Contributors to COPD in First Nations Communities in British Columbia
Background. First Nations peoples in Canada carry an increased respiratory health burden compared to non-First Nations. However, there is little accurate information of how many First Nations people have COPD, especially in…
- Trial name
- ASB (NCT04105088)
- Where
- Canada
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Periodontal Disease, Atherosclerosis
Assess the Effect of Treating Periodontal Disease on Cardiovascular Function in Young Adults
We propose to examine a population of Native Americans who have had little or no dental care, and to determine if periodontal disease is associated with early signs of vascular dysfunction or systemic inflammation.
- Trial name
- NCT01376791
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Diabetes
Strong Men, Strong Communities Diabetes Risk Reduction in American Indian Men
SMSC will inform the design and implementation of culturally informed, community-based lifestyle interventions for diabetes prevention in AI men in our partner communities and elsewhere, as well as in men of other minority groups…
- Trial name
- SMSC (NCT02953977)
- Testing
- Diabetes Prevention Program
- Where
- United States
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Washington State University
Alzheimer Disease
Alzheimer's Disease and Precision Medicine Research Among Native People
This project intends to address the gaps in Alzheimer's disease (AD) and precision medicine (PM) research in American Indian and Alaska Native (AI/AN) populations by comparing written and video-based materials for recruitment…
- Trial name
- NCT03448601
- Testing
- Culturally tailored brochure intervention group, Culturally tailored video intervention group
- Where
- United States
- Volunteers
- 523 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver