Clinical trials: First Trimester Pregnancy
Preeclampsia
Molecular Study of the Maternal-fetal Interface in Preeclampsia.
Preeclampsia (PE) is a major obstetric complication with short- and long-term consequences for the mother and the fetus. Early screening tools to reduce its mortality and morbidity, as well as to prevent the life-threatening…
- Trial name
- PREMAFE (NCT06232668)
- Testing
- Maternal-fetal interface biopsy and peripheral blood collection in cases group, Maternal-fetal interface biopsy and peripheral blood collection in control group
- Where
- 4 sites in Spain
- Volunteers
- 2,084 people
- Sponsor
- Carlos Simon Foundation
Gestational Diabetes Mellitus in Pregnancy
Afamin in Gestational Diabetes Mellitus
This study includes pregnancies in 11 to 14 th gestational weeks. Investigators will sample maternal plasma in the first trimester and analyze maternal plasma afamin values. All these women will then be screened by two step OGTT.
- Trial name
- NCT04054843
- Testing
- Afamin
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Etlik Zubeyde Hanım Women's Health Care, Training and Research Hospital
Large for Gestational Age Baby, Macrosomia, Fetal
A First Trimester Prediction Model for Large for Gestational Age Infants: a Preliminary Study
Large for gestational age infants (LGA) have increased risks of adverse short-term perinatal outcomes. This study aims to develop a multivariable prediction model for the risk of giving birth to a LGA baby, by using biochemical…
- Trial name
- PreMoLGA (NCT04838431)
- Testing
- Blood sample and ultrasound at first trimester
- Where
- Italy
- Volunteers
- 503 people, healthy volunteers welcome
- Sponsor
- University of Modena and Reggio Emilia
Preeclampsia, Gestational Hypertension
Serum Vasohibin, Cardiotrophin, Endocan & Perinatal Outcomes
Investigation of the relationship between maternal serum vasohibin-1, vasohibin-2, cardiotrophin -1 and endocan concentrations at the 11th and 14th weeks of gestation and adverse perinatal outcomes.
- Conditions
- Preeclampsia, Gestational Hypertension, Gestational Diabetes, Preterm Birth
- Trial name
- NCT06416995
- Testing
- first trimester serum diagnostic test
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Umraniye Education and Research Hospital
Missed Abortion
Oxytocin Effectiveness in First Trimester Dilatation and Curettage
The aim of this study is to investigate the impact of oxytocin on perioperative blood loss during the D\&C procedure, as well as to assess early and late complications associated with it's use.
- Trial name
- NCT06469203
- Testing
- Oxytocin, Sodium Chloride 0.9% Inj
- Volunteers
- 160 people
- Sponsor
- Assuta Ashdod Hospital
Maternal Behavior, Self Efficacy
This Study Aimed to Examine the Effects of Individualized Care and Counseling Given to Mothers in the First Trimester of Pregnancy on Maternal Attachment, Maternal Self-efficacy and Maternal Function.
Purpose of the research: This study aimed to examine the effects of individualized care and counseling given to mothers in the first trimester after birth on maternal attachment, maternal self-efficacy and maternal function.
- Conditions
- Maternal Behavior, Self Efficacy, Maternal Care Patterns
- Trial name
- NCT06537973
- Testing
- İndividualized care education
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Pregnancy Complications, Perinatal Problems
The Relation Between Placental Volume at the 1st Trimester and Perinatal Prognosis
It has been known for years that placental transport and endocrine and metabolic functions of the placenta are the main determinants of fetal nutrition and homeostasis.
- Conditions
- Pregnancy Complications, Perinatal Problems, Maternal-Fetal Relations
- Trial name
- NCT05429242
- Testing
- Ultrasonographic examination
- Where
- Turkey (Türkiye)
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Siirt University
Abortion in First Trimester
Dextromethorphan as a Novel Non-opioid Adjunctive Agent for Pain Control in Medication Abortion
This study evaluates dextromethorphan as a non-opioid adjunctive medication for pain control during medication abortion. This is double-blinded, four-arm randomized controlled trial enrolling 156 women over a period of 9-12…
- Trial name
- DexMab (NCT03480009)
- Testing
- Dextromethorphan Hydrobromide, Avicel PH101 (Microcrystalline Cellulose NF) for Compounding, Oxycodone
- Where
- 2 sites in United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Study Investigator-Sponsor
Vitamin D Intake in First Trimester and Incidence of Gestational Diabetes Recurrence
Effect of Vitamin D Intake in Pregnancy to Prevent Recurrence of Gestational Diabetes
primary outcome is vitamin D intake in first trimester for pregnant women with history of gestational diabetes in previous pregnancies and incidence of gestational diabetes recurrence secondary outcome is effect of vitamin D…
- Trial name
- NCT03701087
- Testing
- Vitamin D
- Where
- Egypt
- Volunteers
- 430 people
- Sponsor
- Kasr El Aini Hospital
Abortion in First Trimester, Pain
Transcutaneous Electrical Nerve Stimulation for Pain Control During First-trimester Abortion
First-trimester abortion aspiration procedures are painful and sedation is typically provided. It is unsafe to drive after sedation due to the prolonged motor delay from some anesthetic agents.
- Trial name
- TENS 2 0 (NCT05320432)
- Testing
- Transcutaneous electrical nerve stimulation (TENS)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Stanford University
Recurrent Miscarriage, First Trimester Abortion
Hydroxychloroquine for Prevention of Recurrent Miscarriage.
Recurrent miscarriage (RM) defined by >=3 consecutive losses affects 1% of fertile couples. Most women have recurrent early loss with a failure of development before 10 weeks' gestation.
- Trial name
- BBQ (NCT03165136)
- Testing
- Hydroxychloroquine
- Where
- 18 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Brest
Induced Abortion, First Trimester Abortion
Study of Clinic-based vs. Self-use of a Misoprostol-only Regimen for Induced Abortion
The goal of the study is to determine whether important clinical outcomes differ among women who access a misoprostol-only medication abortion regimen from a patent medicine vendor when compared with those who access it from a…
- Trial name
- NCT04242212
- Testing
- Misoprostol sourced from clinics, Misoprostol sourced from PMVs
- Where
- 3 sites in Nigeria
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Ipas
Miscarriage in First Trimester
Non-invasive Monitoring of Miscarriage
cfDNA is extremely useful to ascertain chromosomal causes of miscarriages at the point of miscarriage diagnosis by a simple blood test.
- Trial name
- NCT06581692
- Testing
- This is a routine procedure, no intervention will be provided.
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- Chinese University of Hong Kong
Pre-Eclampsia
Detection of False Positives From First-trimester Preeclampsia Screening (StopPRE) at the Second-trimester of Pregnancy
Pregnant women at a higher risk for pre-eclampsia (PE) should be offered preventive daily treatment with acetylsalicylic acid (ASA) started before 16 weeks of gestation.
- Trial name
- StopPRE (NCT03741179)
- Testing
- ASA-withdrawn group
- Where
- Spain
- Volunteers
- 974 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Vitamin D Deficiency Defined as Serum 25OHD < 75 Nmol/l or 30ng/ml, Preeclampsia
Vitamin D and Preeclampsia
Hypothesis : Vitamin D serum concentration is decreased in the first trimester in pregnant women who will develop preeclampsia in the second or third trimester compare to a control group Primary purpose : To determine the vitamin…
- Conditions
- Vitamin D Deficiency Defined as Serum 25OHD < 75 Nmol/l or 30ng/ml, Preeclampsia, Neonatal Hypercalcemia, Pregnancy
- Trial name
- FEPED (NCT01648842)
- Where
- France
- Volunteers
- 3,173 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pregnancy Termination, Pain Management
Non-Pharmacologic Patient Centered Pain Control Adjuncts During First Trimester Abortion
This study will examine the use of non-pharmacologic pain control techniques and pain-management counseling as an additional tool for reducing pain during first trimester aspiration abortion.
- Trial name
- NCT02590146
- Testing
- Non-pharmacologic pain control adjuncts
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Hawaii
First Trimester Abortion, Surgical Abortion
New Cross-linked Hyaluronan Gel to Prevent Adhesion After USG-MVA: RCT
The objective of this prospective, randomized controlled study was to evaluate the effectiveness of this NCH gel in the prevention of IUA development as assessed by hysteroscopy after USG-MVA, in the treatment for first-trimester…
- Conditions
- First Trimester Abortion, Surgical Abortion, Miscarriage With Afibrinogenemia
- Trial name
- NCT05360186
- Testing
- MateRegen® gel (BioRegen)
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- Chinese University of Hong Kong
Echocardiography, Pregnancy Related Conditions, Unspecified, First Trimester
Echocardiographic Assessment of Ventricular Strain During a Healthy Pregnancy in the First, Second, and Third Trimester.
Pregnancy is a physiological situation that produces transient preload and afterload changes. The heart is subjected to reversible morphological remodelings and hemodynamic and functional adaptations.
- Conditions
- Echocardiography, Pregnancy Related Conditions, Unspecified, First Trimester, Pregnancy Related Conditions, Unspecified, Second Trimester, Pregnancy Related Conditions, Unspecified, Third Trimester
- Trial name
- VStrain123P (NCT04395014)
- Testing
- 2D Echocardiography
- Where
- Mexico
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Miguel Ayala León
Miscarriage in First Trimester, Missed Miscarriage
Letrozole Plus Misoprostol Versus Misoprostol Alone for Treating Women With Missed Miscarriage
The goal of this clinical trial is to learn whether adding the medicine letrozole to Misoprostol helps women have a complete abortion more often than using Misoprostol alone for the treatment of missed miscarriage (when a…
- Trial name
- NCT07160855
- Testing
- Misoprostol (given vaginally), Letrozole 5 mg
- Where
- Pakistan
- Volunteers
- 92 people
- Sponsor
- Nishtar Medical University
Contraception
Study of Immediate Start of Progestin Contraceptives in Medical Abortion
This study will compare immediate to post-abortion start of two progestin-based contraceptives (DMPA and etonorgestrel implants) among women having first trimester medical abortion who wish to use that method for post-abortion…
- Trial name
- Quickstart (NCT01902485)
- Testing
- Timing of Contraceptive Initiation in Medical Abortion
- Where
- 8 sites in United States, Mexico
- Volunteers
- 937 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects