Clinical trials: First Trimester Pregnancy
Early Pregnancy Loss, Delayed Pregnancy Loss
CCT-102 or Expectant Management in Delayed Pregnancy Loss
A Phase 3, multi-center clinical trial of a CCT-102 regimen or expectant management to promote uterine evacuation in first trimester non-progressing Delayed Pregnancy Loss (DPL).
- Trial name
- MERMAID (NCT06121063)
- Testing
- CCT-102 A and CCT-102 B
- Where
- 15 sites in United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Conceptra Biosciences, LLC
Effect of Drug
Analgesia From Conscious Sedation Versus Paracervical Block for Manual Vacuum Aspiration
Miscarriage is one of the major causes of early pregnancy losses. Incomplete miscarriage is a major cause of maternal morbidity and mortality.
- Trial name
- NCT06539143
- Testing
- Lidocaine
- Where
- Nigeria
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Darlington-Peter Chibuzor Ugoji
Fetus Disorder
AutoFUSE or First-Trimester Ultrasound Scan
The goal of this clinical trial is to validate the clinical application capabilities of AutoFUSE. The main questions it aims to answer are: Does AutoFUSE reduce the time required to obtain standard planes in first-trimester…
- Trial name
- NCT07601191
- Testing
- AutoFUSE system, Traditional ultrasound scan
- Where
- 3 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Pregnancy Complications, Perinatal Problems
The Relation Between Placental Volume at the 1st Trimester and Perinatal Prognosis
It has been known for years that placental transport and endocrine and metabolic functions of the placenta are the main determinants of fetal nutrition and homeostasis.
- Conditions
- Pregnancy Complications, Perinatal Problems, Maternal-Fetal Relations
- Trial name
- NCT05429242
- Testing
- Ultrasonographic examination
- Where
- Turkey (Türkiye)
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Siirt University
Pain Acute, Acupuncture
Acupuncture for Pain Management During Uterine Aspiration
The proposed study will be a randomized, double blinded, placebo-controlled trial to evaluate the efficacy of auricular acupuncture as adjunct for pain management during abortion.
- Trial name
- NCT03391986
- Testing
- SEIRIN® Pyonex™ Acupuncture Needles, 12 mm Plasters
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Columbia University
Pelvic Floor Disorders, Stress Urinary Incontinence
Educating Women About Pelvic Floor Disorders During Pregnancy
The purpose of this study is to assess the increase in knowledge of pregnant patients regarding pelvic floor disorders when comparing two educational interventions: written handouts vs interactive workshops.
- Conditions
- Pelvic Floor Disorders, Stress Urinary Incontinence, Pelvic Organ Prolapse
- Trial name
- NCT05440539
- Testing
- Written Handouts, Interactive Workshop
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
Prediabetes, Gestational Diabetes
Treating Prediabetes in the First Trimester
The investigators plan to study a sample of women with prediabetes (diagnosed by Hemoglobin A1c (HbA1c) 5.7-6.4% or fasting plasma glucose (FPG) 92-125 mg/dL) in the first trimester of pregnancy, and patients will be randomized…
- Trial name
- NCT01926457
- Testing
- Treatment of Prediabetes
- Where
- United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Pain
Lidocaine and Pain Management in First Trimester Abortions
The purpose of this study is to examine the effect of lidocaine (a numbing medication) inside the uterus on patient pain during an early abortion, compared to the paracervical block (lidocaine injected on either side of the…
- Trial name
- NCT00613821
- Testing
- Lidocaine
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Pregnancy Trimester, First, Anxiety
Addressing Pregnant Women's First Trimester Worries and Information Needs With mHealth Solutions
The first 12 weeks of pregnancy, known as the first trimester, can be one of the most worrying times for women. (Where this lay summary refers to women, it should be taken to include people who do not identify as women but who…
- Conditions
- Pregnancy Trimester, First, Anxiety, Worries, Health Knowledge, Attitudes, Practice
- Trial name
- NCT07114471
- Where
- United Kingdom
- Volunteers
- 1,450 people, healthy volunteers welcome
- Sponsor
- Bournemouth University
Aneuploidy
A Pilot Study for Implementation of First Trimester Screening of Aneuploidies in Campania Region
The study aims to compare two different protocols for first trimester screening of aneuploidies, one based on nuchal translucency and NIPT and another one based on the integration between combined test and NIPT, in order to…
- Trial name
- PISTA (NCT05798858)
- Testing
- NIPT
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Federico II University
Hyperemesis Gravidarum - Severe, Resistin
First Trimester Resistin Levels in HG
This cross-sectional case-control study was conducted in Tuzla State Hospital Obstetrics Clinic in Turkey. The study evaluated 400 pregnant women during their first trimester of pregnancy.
- Conditions
- Hyperemesis Gravidarum - Severe, Resistin, Gestational Diabetes Mellitus (GDM)
- Trial name
- NCT06757374
- Testing
- Resistin
- Where
- Turkey (Türkiye)
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Homozygous αº-thalassemia, Hb Bart's Disease
Use of 3D/4D Ultrasound in the Evaluation of Fetal Anomalies
Volumetry measurements can be a potential clinical use as non-invasive tools in prenatal diagnosis and screening and helps to reduce the risk and complications of invasive procedures.
- Trial name
- NCT00826917
- Where
- China
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Pregnancy, Gestational Diabetes Mellitus
Predictability of Gestational Diabetes Mellitus in First and Second Trimester
The objective of the study is, if an early oral glucose tolerance test combined with maternal history, condition and multiple biomarker analysis can be used to detect gestational diabetes mellitus in the first trimester (12-14…
- Trial name
- GDMPredict (NCT02035059)
- Where
- Switzerland
- Volunteers
- 820 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Excessive Weight Gain in Pregnancy, First Trimester, Excessive Weight Gain in Pregnancy With Baby Delivered
Early Prevention of Excessive Gestational Weight Gain Using Lifestyle Change
Nutrition and exercise behaviour change programs can prevent excessive gestational weight gain (EGWG). The Nutrition and Exercise Lifestyle Intervention Program (NELIP) is a previously published two-behaviour change program which…
- Conditions
- Excessive Weight Gain in Pregnancy, First Trimester, Excessive Weight Gain in Pregnancy With Baby Delivered, Birth Weight
- Trial name
- NELIP (NCT02804061)
- Testing
- NELIP
- Where
- Canada
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Abortion in First Trimester
Pharmacist Provision of Medication Abortion
This will be a pilot study among two pharmacists providing start to finish medication abortions to 10 patients utilizing a previously created toolkit.
- Trial name
- NCT04956731
- Testing
- Pharmacist Provision of Medication Abortion
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Gestational Diabetes
First Trimester Glycosylated Haemoglobin Und Plasma Glucose in Women at High Risk for Gestational Diabetes
Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance with onset or first recognition during pregnancy. If insulin resistance and hyperglycemia are recognized before pregnancy, the term pregestational…
- Trial name
- GDM HbA1c (NCT02139254)
- Where
- Switzerland
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pregnancy, Bacterial Vaginosis
Bacterial Vaginosis in Pregnancy: Detection by Weekly Vaginal pH Testing
Interventional study to assess the effect of early detection and treatment of bacterial vaginosis in pregnancy on preterm delivery rate.
- Conditions
- Pregnancy, Bacterial Vaginosis, Preterm Delivery
- Trial name
- NCT00799500
- Testing
- Screening
- Where
- Spain
- Volunteers
- 1,049 people, healthy volunteers welcome
- Sponsor
- Montse Palacio
Abortion Early, Abortion in First Trimester
Delivery of Audiovisual Information on Early Medical Abortion
The majority of abortions in the United Kingdom (UK) are performed before 9 weeks (63 days) gestation using a method known as Early Medical Abortion (EMA).
- Trial name
- EMAVID (NCT03417362)
- Testing
- Animation
- Where
- 3 sites in France, Sweden and 1 more
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- NHS Lothian