Clinical trials: First-episode Psychosis
Schizophrenia
Modulation of Repetitive Transcranial Magnetic Stimulation on Hippocampal Neurogenesis and Functional Network in Patients With Schizophrenia
Based on the hypothesis that high-frequency repetitive transcranial magnetic stimulation(rTMS) on the right dorsolateral prefrontal cortex(DLPFC) and left parietal cortex(LPC) could normalise cognitive abnormalities by promoting…
- Trial name
- NCT03608462
- Testing
- repetitive transcranial magnetic stimulation(DLPFC), repetitive transcranial magnetic stimulation(LPC)
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Schizophrenia
Pharmacogenomic and Pharmacoepigenomic Studies of Antipsychotic Drugs in First-Episode Schizophrenia
This study aims to explore the objective markers concerning schizophrenia risk and functional outcome from multiple dimensions such as multi-omics including genomics, proteomics, metabolomics, electrophysiology, imaging…
- Trial name
- NCT07102069
- Where
- China
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Tianjin Anding Hospital
Schizophrenia, Psychosis
Multi-site Communication Deficits in Schizophrenia
Multi-site Communication Deficits Underlying Cognitive Dysfunction in the Prodromal Phase and First Episode of Schizophrenia
- Trial name
- NCT01317121
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
First Episode Psychosis
Disengagement in CSC: Identifying Those at Risk and Addressing Their Needs
Maintaining treatment engagement is critical for first episode psychosis patients to experience gains possible with coordinated specialty care (CSC).
- Trial name
- NCT04005378
- Testing
- CSC Step-down intervention, Usual Care
- Where
- 3 sites in United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Early Psychosis
Decision-making and Decision Support Among Emerging Adults With First Episode Psychosis
The purpose of this study is to evaluate the impact of an antipsychotic medication decision aid and interpersonal and cognitive factors, such as attachment style and motivation, on emerging adults' ability to engage in shared…
- Trial name
- NCT04373590
- Testing
- Decision aid
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Temple University
Schizophrenia
Repetitive Transcranial Magnetic Stimulation for First-episode Schizophrenia Patients
The aim of the study is to evaluate the effects of repetitive transcranial magnetic stimulation(rTMS)in the first-episode Schizophrenic patients: the clinical and MRI findings
- Trial name
- rTMSfMRI (NCT01370291)
- Testing
- active Risperidone and active rTMS
- Where
- 2 sites in China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Schizophrenia, Psychotic Disorders
Effectiveness of Second Generation Antipsychotics in First Episode Psychosis Patients: 1-year Follow-up
This study compares the efficacy and effectiveness of two of the second-generation antipsychotics (SGAs) most used in our society in the treatment of schizophrenia (Aripiprazole and Risperidone) and the investigators do within an…
- Trial name
- PAFIP3_1Y (NCT02532491)
- Testing
- Aripiprazole, Risperidone
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fundación Marques de Valdecilla
First Episode Psychosis (FEP)
Dopamine and Insulin in Psychosis
Patients with schizophrenia have a high risk of developing metabolic disorders and current evidence points to an overlap in mechanisms underlying psychiatric symptoms and metabolic disturbances.
- Trial name
- DIPS (NCT07252752)
- Testing
- Intranasal Insulin, Low dose insulin infusion, [11C] (+)-4-propyl-(+)-4-propyl-9-hydroxynaphthoxazine (PHNO)
- Where
- Austria
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Schizophrenia
Dopaminergic, Functional, Structural, and Cognitive Disturbances in First-episode Schizophrenia
We wanted to compare dopamine D2 receptor activity, brain structure, brain function, sensory gating and cognition in neuroleptic-naive schizophrenic patients and matched healthy controls.
- Trial name
- NCT00206960
- Testing
- zuclopenthixol, risperidone
- Where
- 6 sites in Denmark
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Birte Glenthoj
First Episode Psychosis (FEP)
Self-administered COgnitive Personalized Training in Early Psychosis
The overall objective of SCOPe is to improve early intervention in psychosis by providing an innovative eHealth tool that will enable personalized cognitive training, adapted to the individual's cognitive abilities.
- Trial name
- SCOPe (NCT06634446)
- Testing
- a mobile application for cognitive training, video games
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Schizophrenia
Oral Versus Injectable Risperidone for Treating First-Episode Schizophrenia
This study will determine the effectiveness of oral risperidone versus long-acting injectable risperidone in treating people with first-episode schizophrenia.
- Trial name
- NCT00330551
- Testing
- Oral Risperidone, Risperidone in Long-Acting Injectable Form (Consta)
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Schizophrenia
Study on the Role and Mechanism of Plasma Exosome microRNAs in Cognitive Impairment in First-episode Schizophrenia
Schizophrenia is a severe mental illness characterised by positive symptoms, negative symptoms, and cognitive symptoms. In recent years, an increasing number of doctors and scholars have focused on cognitive symptoms; however…
- Trial name
- NCT07139171
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tianjin Anding Hospital
Schizophrenia
Ginkgo Biloba Extract for Schizophrenia
A double-blind, randomized, placebo-controlled trial of ginkgo biloba extract (Egb-761) as an add-on therapy to risperidone compared to risperidone plus placebo in the treatment of 200 treatment-naive first-episode patients with…
- Trial name
- NCT01524380
- Testing
- Ginkgo biloba extract
- Where
- China
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Beijing HuiLongGuan Hospital
Schizophrenia
Neurobiological and Neurocognitive Disturbances in First-episode Schizophrenia
We want to relate disturbances in first-episode schizophrenic patients in serotonin 5-HT2A receptors, brain structure, brain function, and information processing to each other and to psychopathology.
- Trial name
- NCT00207064
- Testing
- quetiapine
- Where
- 3 sites in Denmark
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Birte Glenthoj
Psychosis, Schizoaffective Disorder
OnTrack>An Online Role-Playing Game for Young People With First Episode Psychosis
The research team will develop and test a prototype version of OnTrack>An Online Role-Playing Game (OnTrack>The Game or OTG), an online role-playing game designed for youth and young adults experiencing First Episode Psychosis…
- Conditions
- Psychosis, Schizoaffective Disorder, Schizophrenia
- Trial name
- NCT03390491
- Testing
- OnTrack>TheGame (OTG), Recovery Videos (RV)
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Center for Social Innovation, Massachusetts
Schizophrenia, Psychotic Disorders
Neurocognitive Effectiveness in Treatment of First-episode Non-affective Psychosis: 3-years Follow-up
Cognitive enhancement is a primary goal in treating individuals with schizophrenia. Cognitive deficits are already present at the first break of the illness, seem to remain stable during early phases and noticeably influence…
- Conditions
- Schizophrenia, Psychotic Disorders, Psychosis
- Trial name
- PAFIP3_nc3Y (NCT03883204)
- Testing
- Aripiprazole, Risperidone
- Where
- Spain
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Fundación Marques de Valdecilla
First Episode Psychosis
Early Intervention Psychosis Communication and Engagement Trial
This study will examine whether or not the use of digital communication methods (text messages and emails) improves patient engagement with Early Intervention Psychosis (EIP) Services, compared to standard communication methods…
- Trial name
- NCT03196128
- Testing
- Digital communication, Non digital
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- South London and Maudsley NHS Foundation Trust
Schizophrenia
A Double-blind and Randomized Trial of Celecoxib Added to Risperidone in Treatment-naive First-episode Schizophrenia
A double-blind, randomized, placebo-controlled trial of celecoxib as an add-on therapy to risperidone compared to risperidone plus placebo in the treatment of 200 treatment-naive first-episode patients with schizophrenia.
- Trial name
- NCT00686140
- Testing
- celecoxib
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Beijing HuiLongGuan Hospital
First-episode Psychosis
HIIT in Patients With a First-episode Psychosis
This study aims to estimate the effect of a 3-month High Intensity Interval Training on antipsychotic-induced weight gain in patients with a first episode of psychosis, as well as to determine whether these effects are maintained…
- Trial name
- NCT04792476
- Testing
- High Intensity Interval Training
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Intervención Temprana en Psicosis de Cantabria (ITPCan)
Psychosis
Cognitive Behavior Therapy (CBT) Informed Mobile-Application for First Episode Psychosis
Onset of First Episode Psychosis (FEP) is at a young age and is a critical period influencing the long-term course of the disorder.
- Trial name
- TechCare (NCT05567575)
- Testing
- Cognitive Behavioral Therapy,
- Where
- 2 sites in Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Living and Learning