Clinical trials: Fistula in Ano
Anal Fistula
Randomized Control Trial of Micronized Purified Flavonoid Fraction for Post Operative Treatment in Anal Fistula Surgery
The aim of this study is to evaluate the effect of micronized purified flavonoid fraction on postoperative symptoms after surgery of anorectal fistulas.
- Trial name
- NCT06184438
- Testing
- Micronized purified flavonoid fraction(Daflon 1000mg)
- Where
- Taiwan
- Volunteers
- 106 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Anal Fistula
Ligation of the Intersphincteric Fistula Tract (LIFT) + Biodesign for Anal Fistula
The LIFT+Biodesign® study is a post-market observational study to evaluate the rate of fistula closure in patients with persistent trans-sphincteric anal fistula who receive the Biodesign® Tissue graft as part of their LIFT…
- Trial name
- LIFT+Graft (NCT01602081)
- Testing
- reinforce soft tissue
- Where
- 8 sites in United States
- Volunteers
- 28 people
- Sponsor
- Cook Group Incorporated
Fistula-in-ano, Rectal Polyp
Trial on Use of Coloshield in Transanal and Anal Surgery
In various transanal and anal procedures it is desirable to clean the operating field from stool contamination. Thus mechanical bowel preparation is not well tolerated by patients. Enema does not provide sufficient effect.
- Conditions
- Fistula-in-ano, Rectal Polyp, Rectal Adenoma, Hemorrhoids
- Trial name
- NCT02579330
- Testing
- Coloshield, Control
- Where
- Switzerland
- Volunteers
- 22 people
- Sponsor
- Daniel Steinemann, MD
Anal Fistula, Crohn's Disease
Long-term Follow-up of Anal Fistulae in Crohn's Disease Treated With Anti-TNFalpha and Interest of New MRI Sequences
Main purposes of this study are : Analysis of relapse risk of anal fistulae with prospective follow-up of patients undergoing pelvic MRI every 6 months for one year.
- Trial name
- FISTULE (NCT02883296)
- Testing
- Pelvis Magnetic resonance imaging
- Volunteers
- 15 people
- Sponsor
- Central Hospital, Nancy, France
Fistula in Ano, Transsphincteric Anal Fistula
Treatment of Fistula in Ano With Autologous Fatty Tissue Cells Transplantation
This is a prospective interventional study on the treatment of transsphincteric fistula in ano. After abdominal or thigh liposuction, fat was injected around the fistula tract that was then transected percutaneously with a sharp…
- Trial name
- NCT04660903
- Testing
- Autologous fat cell transplantation
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Konstantinos Tsimogiannis
Anal Fistula, LIFT-plug
LIFT-plug vs LIFT, a RCT Trial
To validate the effect of Ligation of Intersphincteric Fistula Tract (LIFT) Versus LIFT-plug procedure for Anal Fistula Repair in 7 medical centers
- Conditions
- Anal Fistula, LIFT-plug, Healing Rate, Anal Function
- Trial name
- LIFT 02 (NCT04310800)
- Testing
- LIFT-plug technique
- Where
- 7 sites in China
- Volunteers
- 384 people
- Sponsor
- Zhen Jun Wang
Crohn's Disease With Perianal Fistulas
Clinical Study on the Integration of Traditional Chinese Medicine Virtual Hanging Therapy With Mesenchymal Stem Cells for the Treatment of Crohn's Disease-Associated Anal Fistula.
To evaluate the efficacy and safety of TCM virtual hanging therapy combined with mesenchymal stem cellsin the treatment of CD anal fistula.
- Trial name
- VH-MSC-CDAF (NCT07113795)
- Testing
- TCM dummy therapy combined with mesenchymal stem cell injection therapy, Dummy Line Therapy Group, MSC Group
- Where
- China
- Volunteers
- 90 people
- Sponsor
- The Anorectal Center of Nanjing Hospital of Traditional Chinese Medicine
Anal Fistula
Treatment of Complex Anal Fistula With Draining Seton With or Without Rerouting of Track
This randomized trial aimed to compare conventional draining seton with or without rerouting of the fistula track in treatment of complex anal fistula
- Trial name
- NCT03636997
- Testing
- Draining seton, Rerouting of track
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Wound Healing, Anal Fistula
Platelet- Rich Plasma Injection
This randomized controlled study aims to investigate the effect of injection of platelet rich plasma on the postoperative outcome of perianal wound after anal fistula surgery in terms of healing time, reduction in wound size…
- Trial name
- prp (NCT06887166)
- Testing
- Platelet Rich Plasma
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Anal Fistula
3D Endoanal Ultrasound and Anal Fistula
The study aims to evaluate the use of 3D endoanal ultrasound in preoperative management of anal fistula disease.
- Trial name
- UFU (NCT03937752)
- Testing
- 3D endodanal ultrasound
- Where
- Sweden
- Volunteers
- 95 people
- Sponsor
- Region Skane
Hemorrhoids, Anal Fissure
Topical vs Oral Metronidazole After Benign Anorectal Surgery
While some investigators found oral metronidazole to be effective in reducing pain after hemorrhoidectomy, other researchers did not find a significant analgesic effect of systemic metronidazole.
- Conditions
- Hemorrhoids, Anal Fissure, Anal Fistula
- Trial name
- NCT05038605
- Testing
- Topical metronidazole, oral metronidazole
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Mansoura University
Crohn Disease, Perianal Fistula
Micro-fragmented Adipose Tissue and Complex Crohns' Anal Fistulas
The study aims to evaluate safety, feasibility and effectiveness of local injections of autologous and micro-fragmented adipose tissue obtained with the Lipogems® system in patients with refractory complex fistulizing perianal…
- Trial name
- NCT03555773
- Testing
- Lipogems
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Anal Fistula
Study on Repeat Liposomal Bupivacaine for Post-Surgery Pain in Anal Fistula Patients.
Anal Fistula refers to an abnormal infectious fistula tract between the anorectum and the perianal skin. The prevalence of anal fistula is approximately 8.6 cases per 100,000 individuals.
- Trial name
- NCT07081373
- Testing
- A single dose of liposomal bupivacaine is administered at the conclusion of surgery without adjunctive analgesics, followed by a supplemental dose 72 hours postoperatively.
- Where
- China
- Volunteers
- 408 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Anal Fistula Surgery, High Anal Fistula
IFOC Compared With LIFT in High Anal Fistula
Patients presenting to the outpatient clinic at Kasr Al-Ainy Hospitals with high anal fistula will be assessed according to the inclusion and exclusion criteria.
- Trial name
- NCT07520500
- Testing
- Intra-anal Fistulotomy With Fistula Opening Closure (IFOC), Ligation of the Intersphincteric Fistula Tract (LIFT)
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Cairo University
Kegel Exercises
Effect of Anal Lift Exercise on Rehabilitation After Anal Fistula Surgery
This prospective randomized controlled study aims to include patients who have undergone anal fistula surgery, to observe the impact of early postoperative pelvic floor muscle training combined with dietary intervention on…
- Trial name
- NCT07250711
- Testing
- Kegel exercises
- Where
- China
- Volunteers
- 124 people
- Sponsor
- The Affiliated Hospital of Putian University
Perianal Fistula, Fistula-in-Ano
Open Fistulectomy vs. Laser Closure for Low Perianal Fistula
Perianal fistula is an abnormal tunnel connecting the anal canal to the perianal skin, frequently causing chronic pain, discharge, and impaired quality of life.
- Conditions
- Perianal Fistula, Fistula-in-Ano, Low Perianal Fistula
- Trial name
- NCT07797842
- Testing
- Fistula-tract Laser Closure (FiLaC), Open Fistulectomy
- Volunteers
- 40 people
- Sponsor
- Assiut University
Anal Fistula
Long-term Follow-up of Anal Fistula Plug
Aim of the study is to evaluate long-term success rate of Biodesign® anal fistula plug for treatment of complex trans-sphincteric anal fistulas.
- Trial name
- NCT03961984
- Testing
- Biodesign® anal fistula plug
- Where
- Sweden
- Volunteers
- 95 people
- Sponsor
- Region Skane
Wound Healing, Fistulectomy
Comparison of Wound Healing in Fistulectomy and Fistulectomy With Marsupialization
The study was done at Central Park Medical College Lahore during January to September, 2024. Low fistula-in-ano patients were randomized into 2 groups i.e. Group A (SUR 1 fistulectomy) and Group B (170 patients in each group).
- Conditions
- Wound Healing, Fistulectomy, Fistulectomy With Marsupialization, Fistula in Ano
- Trial name
- NCT07080424
- Testing
- Fistulectomy with Marsupialization, Fistulectomy
- Where
- Pakistan
- Volunteers
- 340 people
- Sponsor
- Central Park Medical College
Anal Fistula
Clinical Trial to Evaluate the Efficacy and Safety of Stem Cells
Efficacy of treatment of perianal fistula with mesenchymal stem cells and surgery
- Trial name
- FISPAC (NCT01803347)
- Testing
- ◦Drug: ASCs. + fibrin glue, fibrin glue
- Where
- 5 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Anal Fistula, Rectal Fistula
A Prospective Evaluation of the Strattice-LIFT to Treat Anal Fistula
This clinical trial will evaluate the safety and efficacy of the Strattice-LIFT procedure to treat anal fistulas.
- Conditions
- Anal Fistula, Rectal Fistula, Fistula in Ano, Transsphincteric Fistula
- Trial name
- NCT02423330
- Testing
- Strattice-LIFT
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Rush University Medical Center