Clinical trials: Fluid Deficit
Temperature Change, Body, Hypovolemia
Hemodynamic Effects of Cold Versus Warm Fluid Bolus
Fluid boluses are often administered with the aim of improving tissue perfusion in critically ill patients. It is unclear whether the temperature of the fluid has an impact on the hemodynamic response.
- Trial name
- NCT03209271
- Testing
- Ringer's Acetate (warm), Ringer's Acetate (cold)
- Where
- Sweden
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Anesthesia, ERAS
Goal-Directed Fluid Therapy in Patients Undergoing Lower Limb Surgeries
Controlling the amount of fluids given to patients in perioperative setting can significantly influence their outcomes.
- Conditions
- Anesthesia, ERAS, Fluid Overload, Hypovolemia; Surgical Shock
- Trial name
- NCT06133257
- Testing
- Goal-Directed Fluid Therapy guided by Inferior Vena Cava Collapsibility Index, standard fluid management
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Hypovolemia, Surgery
Focused Assessed Echocardiography to Predict Fluid Responsiveness
The aims of the study are: 1. To evaluate the feasibility of echocardiography monitoring in postoperative unit; 2. To assess diagnostic value of different focussed echocardiography parameters to define fluid responsiveness for…
- Conditions
- Hypovolemia, Surgery, Hypotension
- Trial name
- fluidres (NCT03044405)
- Testing
- Fluid challenge, Focused transthoracic echocardiography
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Hypovolemia
Study on Prediction of Fluid Responsiveness Using an Abdominal Compression-induced Change of Blood Pressure in Children
The purpose of this study is to evaluate predictability of an abdominal compression-induced change of blood pressure for fluid responsiveness in children.
- Trial name
- NCT02471534
- Testing
- abdominal compression
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Hypovolemia, Hyperoxia
Supplemental Oxygen in Hypovolemia
Supplemental oxygen is frequently administered in acutely and critically ill patients, specifically, it is often administered in trauma patients to avoid arterial hypoxemia and tissue hypoxia.
- Trial name
- NCT05150418
- Testing
- Oxygen gas, Air
- Where
- Norway
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Acute Pain, Trauma
Determination of Analgesic Equipotent Doses of Inhaled Metoxyflurane vs. Intravenous Fentanyl
The aim of this study is to determinate the equipotent doses of inhaled metoxyflurane vs. intravenous fentanyl.
- Conditions
- Acute Pain, Trauma, Hypovolemia
- Trial name
- NCT03894800
- Testing
- Methoxyflurane (M), Fentanyl (F1), Fentanyl (F2)
- Where
- Norway
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Hypovolemia
Photoplethysmography for Diagnose Incipient Hypovolemia
Hypovolemia caused by acute bleeding increased morbi-mortality in emergency and operatin rooms. Precise real-time diagnosis of incipient acute hypovolemia is lacking at the bedside.
- Trial name
- NCT05512611
- Testing
- Finger photoplethysmography
- Where
- Argentina
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital Privado de Comunidad de Mar del Plata
Shock, Cardiogenic, Cardiac Tamponade
Validation of Epworth Richmond's Echocardiography Education Focused Year
The use of echocardiography in intensive care is a developing field. In expert hands echocardiography has proven its utility in diagnosing cardiac pathology, differentiating shock states and in haemodynamic monitoring.
- Conditions
- Shock, Cardiogenic, Cardiac Tamponade, Pulmonary Embolism, Hypovolemia
- Trial name
- VEREEFY (NCT02961439)
- Testing
- Epworth Richmond's Echocardiography Focused Year
- Where
- Australia
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Epworth Healthcare
Infection, Hypervolemia
Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emergency Department Patients
The overall goal of this multicenter project is to characterize the expected normal range of Peripheral IntraVenous Volume Analysis (PIVA) values during a euvolemic state, and how those ranges may be altered by comorbidities; the…
- Conditions
- Infection, Hypervolemia, Hypovolemia, Septic Shock
- Trial name
- PIVA (NCT03736421)
- Testing
- Peripheral Intravenous Analysis (PIVA), Non-invasive fluid response measure, Passive leg raise (PLR)
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Hypovolemia
Detecting a Volume Deficit During Spontaneous Breathing
13 healthy volunteers (4 females) were tilted 45° head-up while breathing through a facemask fitted with an inspiratory and expiratory resistor.
- Trial name
- NCT02549482
- Testing
- Respiratory resistor
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Hypovolemia
Effect of Preoperative Fluid Therapy on Post-induction Hypotension
Although preoperative dehydration is a known risk factor for post-induction hypotension, evidence regarding preemptive weight-based fluid therapy remains limited.
- Trial name
- NCT06231472
- Testing
- weight-based fluid therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Mustafa Burgac
Hypovolemia, Surgery
Volume Deficit Prior to Surgery
It is the purpose of the researchers to identify the variation in intravascular deficits which can have relevance in high risk patients for minor and medium sized surgery.
- Trial name
- NCT00380107
- Where
- Denmark
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hypovolemia
Detection of Hypovolemia Using Pleth Variability Index (PVI)
The purpose with the planned study is to study Pleth Variability Index (PVI) as a non invasive indicator for mild hypovolemia during spontaneous breathing in healthy subjects.
- Trial name
- NCT01456559
- Testing
- Lower body negative pressure (LBNP)
- Where
- 2 sites in Sweden
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping
Anesthesia Complication, Hypotension on Induction
Ultrasound Assessment of the Subclavian Vein for Predicting Hypotension in Children After Anaesthesia Induction
Intra operative hypotension is a risk factor in pediatric anesthesia (McCann ME et al.Pediatr Anesth 2014; 24: 68-73). In summary, the study aims at examine if ultrasound assessment of the diameter and collapsibility index of the…
- Conditions
- Anesthesia Complication, Hypotension on Induction, Hypovolemia
- Trial name
- NCT04573842
- Testing
- Ultrasound assessment of SCV
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Hypovolemia, Cardiac Output, Low
Methoxyflurane and Fentanyl in LBNP
The study is a single-centre, placebo-controlled, crossover study on healthy volunteers aiming to explore non-inferiority of methoxyflurane and fentanyl compared to placebo on the tolerance to hypovolemia.
- Conditions
- Hypovolemia, Cardiac Output, Low, Analgesia
- Trial name
- NCT04641949
- Testing
- Lower body negative pressure (LBNP)
- Where
- Norway
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Surgery
Solution Temperature and Fluid Deficit During Hysteroscopy
Hysteroscopic surgery is widely used for the treatment of gynecological diseases, such as septum, synechiae, polyp and intrauterine fibroids.
- Trial name
- STOFD (NCT05622097)
- Testing
- 0.9% Saline warmed to 37 degrees Celsius, 0.9% Saline warmed to 24 degrees Celsius
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Hypovolemia, Hypervolemia
Pilot Validation of a Hemodilution Technique to Estimate Blood Volume in Vivo
The objective of this study is to determine the accuracy of estimating patient blood volume using field-expedient point-of-care measurement of hematocrit before and after hemodilution with a standardized volume of intravenous…
- Trial name
- NCT03031600
- Testing
- Radiodilution via Daxor BVA-100, Hemodilution via hematocrit measurement
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Heat Stroke, Acute Kidney Injury
Use of Sodium Bicarbonate as Prophylaxis for Kidney Damage in Patients With Heatstroke
This study protocol aims to prevent the need for renal replacement therapy in patients with rhabdomyolysis secondary to heatstroke.
- Conditions
- Heat Stroke, Acute Kidney Injury, Acute Kidney Injury Due to Hypovolaemia
- Trial name
- NCT06622525
- Testing
- Sodium bicarbonate, No intervention
- Where
- Mexico
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Hospital General de Mexicali
Hypovolemia, Fluid Loss
Acetated Ringer´s Solution in Experimental Hypovolemia
Intravenous fluids are often given to increase stroke volume and thereby improve global oxygen delivery. The effect is however often transient, but the effect of a fluid bolus on stroke volume and other hemodynamic variables over…
- Conditions
- Hypovolemia, Fluid Loss, Hemodynamic Instability
- Trial name
- Volu-Flow (NCT05705115)
- Testing
- Ringer acetate, Lower body negative pressure
- Where
- Norway
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Anesthesia, Perioperative/Postoperative Complications
Use of Heart-lung Interaction to Predict Haemodynamic Tolerance to the Open Lung Approach With Individualised PEEP
This is an observational, prospective, single-centre study that will focus on patients undergoing major non-cardiac surgery requiring invasive mechanical ventilation and invasive blood pressure monitoring Hypotheses: A positive…
- Conditions
- Anesthesia, Perioperative/Postoperative Complications, Hypovolemia, Haemodynamic Instability
- Trial name
- HiPEEP (NCT06123039)
- Testing
- Tidal Volume Challenge, Recruitment maneuver obtaining individualised PEEP
- Where
- Spain
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario La Fe