Clinical trials: Fluid Imbalance
Hydration, Fluid Retention
Hydration Dynamics and Influence of Beverage Composition
The study examines interactions between fluid availability in the gut and fluid retention in the body. The relative rate of fluid uptake, the expansion of the plasma volume, and percent of fluid retained by the body will be…
- Conditions
- Hydration, Fluid Retention, Dehydration
- Trial name
- NCT05111392
- Testing
- Oral Rehydration Solution 1, Oral Rehydration Solution 2
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Dehydration, Rehydration
Clinical Trial to Evaluate the Effects of Two Novel Hydration Beverage Formulas on Rehydration in Healthy Adults
Dehydration lowers both physical and mental performance if it is severe enough. Performance declines are more pronounced in hot conditions or after prolonged strenuous activity such as exercise.
- Conditions
- Dehydration, Rehydration, Exercise Performance, Exercise Recovery
- Trial name
- NCT05428761
- Testing
- TP1, TP2
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Liquid I.V.
Hyponatremia, Hypernatremia
Hypotonic Versus Isotonic Parenteral (HIP) Fluid Trial
Children who are undergoing surgery need intravenous fluids to prevent dehydration and maintain their electrolyte balance. The current standard of care in these children is to use a fluid which is low in sodium (hypotonic fluid).
- Trial name
- NCT00734214
- Testing
- 0.9% NaCl, 0.45%NaCl
- Where
- Canada
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Gastroenteritis, Dehydration
Study Investigating the Use of Intravenous Fluids With Dextrose for Dehydrated Children
Infants and young children often become infected with gastroenteritis leading to vomiting and diarrhea. This can lead to dehydration, one of the most common complaints in the Pediatric Emergency Department.
- Trial name
- NCT01343758
- Testing
- 5% dextrose in normal saline
- Where
- United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Dehydration, Electrolyte Imbalance
Buoy Electrolyte Study on Hydration Status of Active Men and Women
Buoy is an all-natural, organic, FDA compliant dietary electrolyte supplement that can be dissolved in 8-12oz water (or other liquid) and provide electrolytes in servings of 1/3 teaspoon.
- Conditions
- Dehydration, Electrolyte Imbalance, Electrolyte Depletion, Fluid and Electrolyte Imbalance
- Trial name
- NCT05768789
- Testing
- Buoy Electrolyte, Water only, Nuun Electrolyte
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Anesthesia, Thirst; Due to Deprivation of Water
Benefits of Drinking Clear Fluids Until Called to the Operating Room in Adult Surgical Patients
The purpose of this study is to show if - compared to standard practice - allowing adults undergoing surgical procedures under anaesthesia care to drink clear fluids up to a volume of 200 ml between 2 h prior to the operation and…
- Conditions
- Anesthesia, Thirst; Due to Deprivation of Water, Aspiration
- Trial name
- HYDRATE (NCT06253052)
- Testing
- Additional pre-OP-visit, Liberal fasting regime
- Where
- Germany
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Wuerzburg University Hospital
Ketosis
A Trial of Intravenous Fluids During Labor
The purpose of this study is to determine if intrapartum use of a glucose-containing solution will improve the outcomes in pregnant women and their babies.
- Trial name
- RARHY (NCT01110005)
- Testing
- D5 Lactated Ringer's Solution (D5LR), Lactated Ringer's Solution (LR)
- Where
- 4 sites in United States
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Ketosis
Effects of Exogenous Ketone Ester Supplementation on 3-hydroxybutyrate Concentrations in Human Cerebrospinal Fluid
It is well established that the brain is capable of consuming ketone bodies, especially during low glucose availability, e.g. fasting.
- Trial name
- KetoBrain (NCT06318299)
- Testing
- Ketone Ester
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Fluid Retention, Sodium Retention
The Effect of AMP Human Sodium Bicarbonate Lotion on Dehydrated Heat Stress
The primary purpose of the proposed study is to evaluate the effects of a topical sodium bicarbonate lotion (PR Lotion, AMP Human, Park City, UT) on measures of hydration status and fluid balance in humans when exposed to the…
- Conditions
- Fluid Retention, Sodium Retention, Heat Stress, Dehydration (Physiology)
- Trial name
- AMP2 (NCT05092854)
- Testing
- PR Lotion - AMP Human Performance, AminoVital - Rapid Recovery
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Dehydration
IV Glucose for Dehydration Treatment
To determine whether the addition of dextrose to IV fluids in the treatment of gastroenteritis leads to a decrease in serum ketones.
- Trial name
- NCT01285713
- Testing
- 5% Dextrose (D5) in Normal Saline (NS), Normal Saline (NS)
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Abnormal Labor, Failed Induction of Labor
Enhanced vs. Routine Clear Liquid Intake in Labor
The goal of the study is to see if the addition of a carbohydrate- and protein-enhanced gel during labor speeds labor and reduces the rate of cesarean delivery.
- Conditions
- Abnormal Labor, Failed Induction of Labor, Ketosis
- Trial name
- NCT02524002
- Testing
- Accel Gel, Usual clear diet
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Temple University
Electrolyte Imbalance, Hyponatremia
V2 Receptor Effects on Fluid Regulation and Performance
This primary aim of this study was to critically assess whether or not sweat water content and sodium concentration were acutely regulated by dynamic changes in antidiuretic hormone (arginine vasopressin or AVP) acting on the…
- Conditions
- Electrolyte Imbalance, Hyponatremia, Hypernatremia
- Trial name
- NCT02084797
- Testing
- V2R (Vasopressin 2 receptor)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Oakland University
Hyponatremia, Hypernatremia
Comparison of Isotonic Versus Hypotonic Fluids in Neonates for Maintenance Fluid Therapy After Surgery
The goal of this clinical trial is to determine if isotonic or hypotonic fluids are more effective in maintaining serum sodium levels in neonates undergoing maintenance fluid therapy post-surgery.
- Conditions
- Hyponatremia, Hypernatremia, Postoperative Care in Neonates, Edema
- Trial name
- NCT06484608
- Testing
- Isotonic Saline with Dextrose
- Where
- Pakistan
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Medical College
Hyponatremia
Saline Infusion Test in Hyponatremia
Observational study of biochemical volume biomarker levels in response to a standardized intravenous isotonic saline infusion in patients with hyponatremia.
- Trial name
- SITH (NCT06498856)
- Testing
- Isotonic saline infusion
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Oligohydramnios, Amniotic Fluid; Disorder
Effect of Intermittent Pneumatic Compression Device of Lower Limbs in Oligohydramnios
the study will examine the effect of application of intermittent pneumatic pressure device on lower limbs on the amniotic fluid amount and fetal doppler indices in women with oligohydramnios
- Trial name
- NCT05474326
- Testing
- intermittent pneumatic pressure device (Kendall SCD™ 700 Smart Compression™ System)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Dehydration
Efficacy of Education Versus Education Plus Prescribed Fluid Intake on Hydration Status in High School Athletes
Sports science testing by investigators at Gatorade Sports Science Institute has revealed that many athletes arrive at practice with a high urine specific gravity indicating they are hypohydrated.
- Trial name
- NCT06651619
- Testing
- Water, Hydration Education
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Fluid Overload, Water Electrolyte Imbalance
The Effect of Crystalloids and Colloids on Visceral Blood Flow
Patients often require fluid replacement during and after an operation. This is usually given through veins in the arm using an intravenous cannula and doctors have traditionally used fluid containing sodium chloride (saline).
- Conditions
- Fluid Overload, Water Electrolyte Imbalance, Acid Base Imbalance
- Trial name
- NCT01087853
- Testing
- Crystalloid, Colloid
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Fluid Retention, Fluid Loss
The Effect of AMP Human Sodium Bicarbonate Lotion on Hydration
The purpose of this research study is to evaluate the effects of a topical sodium bicarbonate lotion on physiological and psychological responses associated with hydration status and fluid balance in humans during passive heat…
- Conditions
- Fluid Retention, Fluid Loss, Sodium Retention, Cognitive Change
- Trial name
- AMPlify (NCT04598386)
- Testing
- PR Lotion - AMP Human Performance
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Dehydration
IV NaCl (Sodium Chloride) 0.9% Vs (Versus) IV NaCl 0.9% + 5% Dextrose in Pediatric ER for Dehydration
Dehydration and refusal to eat and drink are common complaints in the Pediatric ED (Emergency Department). Most of these children have had an unsuccessful trial of oral rehydration in their community service, therefore are…
- Trial name
- NCT02054585
- Testing
- NaCl 0.9%, NaCl 0.9 +5% dextrose
- Where
- Israel
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Dehydration
Fluid Balance During Exercise in the Heat With Water, Flavored Placebo, or a Carbohydrate-electrolyte Beverage Intake (The APEX Study)
The purpose of the APEX study is to determine whether carbohydrate-electrolyte beverage intake promotes fluid balance during exercise in the heat compared with water or placebo intake.
- Trial name
- APEX (NCT01893853)
- Testing
- Exercise Intervention
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center