Clinical trials: Fluid Management
Gall Bladder Cancer, Intrahepatic Cholangiocarcinoma (Icc)
A Cell-free DNA Methylation Blood-Based Test for Biliary Tract Cancers Screening
Biliary tract carcinoma (BTC), including gallbladder cancer, intrahepatic cholangiocarcinoma, and extrahepatic cholangiocarcinoma, ranks sixth in incidence among gastrointestinal malignancies and tenth in cancer-related mortality…
- Conditions
- Gall Bladder Cancer, Intrahepatic Cholangiocarcinoma (Icc), Extrahepatic Cholangiocarcinoma, Hilar Cholangiocarcinoma
- Trial name
- NCT07176962
- Where
- China
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Yingbin Liu, MD, PhD, FACS
Pregnancy
Effects of Preanesthetic Forced Air Warming and Administration of Warmed Intravascular Fluid
The majority of women (> 60%) developed hypothermia and shivering during cesarean delivery. Core hypothermia may be associated with a number of adverse outcomes in patients, including shivering, wound infection, coagulopathy…
- Trial name
- NCT03256786
- Testing
- Prewarming using forced air warmer, warmed intravenous fluid
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Mammaplasty, Microsurgery
Perioperative Management of DIEP Flaps
By comparison of two different protocols with diverse fluid/ catecholamine administration limits (fluid restriction vs. catecholamine restriction with target systolic blood pressure > 100 mmHg) the investigators would like to…
- Conditions
- Mammaplasty, Microsurgery, Free Tissue Flaps
- Trial name
- NCT03118024
- Testing
- Crystalloid Solutions, Catecholamines
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Regensburg
Transtibial Amputee
Bioimpedance as a Diagnostic Tool for Assessing the Need for Socket Modification in Transtibial Amputees
The purpose of the proposed study is to conduct research on individuals with lower limb amputation, evaluating if residual limb fluid volume data collected using a novel non-invasive device is beneficial towards prosthetic…
- Trial name
- NCT03164356
- Testing
- Bioimpedance monitor
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Washington
Healthy Volunteer
A Study Investigating the Bioavailability of a High Concentration Liquid Formulation Versus a Reference Lyophilized Formulation of Gantenerumab in Healthy Volunteers
This single-center, randomized open-label, single-dose, parallel group study will investigate the relative bioavailability of a high concentration liquid formulation (HCLF) versus the reference lyophilized formulation (LyoF) of…
- Trial name
- NCT02133937
- Testing
- gantenerumab
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Pregnancy Related, Hemorrhage
The Effect of Fluids on Aortic VTI During C-section
Pregnancy is associated with a myriad of physiologic changes, including expansion of blood volume, decrease in oncotic pressure, and increased cardiac output. The obstetric population is associated with intrapartum hemorrhage.
- Conditions
- Pregnancy Related, Hemorrhage, Fluid Overload, Labor Complication
- Trial name
- NCT04330742
- Testing
- lactated ringers
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Healthy, Psoriasis
Distribution of Secukinumab (AIN457) Into Dermal Interstitial Fluid After a Single Subcutaneous Administration of 300 mg
The proposed exploratory study aims to understand the in vivo skin distribution properties of subcutaneously (s.c.) administered AIN457 in psoriatic and healthy skin using open flow microperfusion (OFM).
- Trial name
- OFM ISF (NCT01539213)
- Testing
- secukinumab (AIN457)
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Thoracic Surgery With One-lung Ventilation, VExUS
Effect of VExUS Ultrasound Protocol (Venous Excess Ultrasound) on Perioperative Fluid Management, on the Incidence of Postoperative Pulmonary Complications and Postoperative Acute Kidney Injury in Patients Undergoing Thoracic Surgery
This study aims to investigate the effect of a VExUS ultrasound guided protocol of perioperative fluid management within a goal-directed therapy framework, on postoperative respiratory complications, and the occurrence of acute…
- Conditions
- Thoracic Surgery With One-lung Ventilation, VExUS, Fluid Management, Acute Kidney Injury
- Trial name
- VEXUS (NCT07258875)
- Testing
- Venous Excess Ultrasound, Standard of Care (SOC)
- Where
- Greece
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- University of Crete
Device Related Sepsis
Novel Device for Rapid Fluid Administration
The aim of the study is to determine if a new device is more effective in fluid administration than devices currently used when resuscitating pediatric patients in septic shock.
- Trial name
- NCT03074682
- Testing
- Lifeflow, Push/Pull, Pressure Bag
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Yale University
Colonoscopy, Bowel Preparation
Acid-base Balance in Patients Undergoing Colonoscopy
The purpose of this study is to determine whether fluid administration in patients undergoing colonoscopy should affect acid-base disorder in term of the strong ion differences.
- Trial name
- NCT01250886
- Testing
- Lactated Ringer's solution, Normal saline solution, Acetate Ringer's solution
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Anesthesia, General, Fluid Therapy
Management of Intraoperative Fluids in Ambulatory Surgery
This is a single-center prospective randomized control trial (RCT) to determine whether the continuous monitoring of the plethysmographic variability index (PVI) during low-risk surgeries, can be used to optimize the…
- Conditions
- Anesthesia, General, Fluid Therapy, Ambulatory Surgical Procedures
- Trial name
- MIFAS (NCT03193320)
- Testing
- Fluid therapy protocol
- Where
- Venezuela
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- Policlinica Metropolitana
Dehydration (Physiology), Thirst; Due to Deprivation of Water
Patient Controlled Fluid Administration
The purpose of the study is to determine whether participants who are dictating their own administration of IV fluid boluses in response to thirst, receive better protection from hypovolaemia and volume overload than those who…
- Conditions
- Dehydration (Physiology), Thirst; Due to Deprivation of Water, Plasma Osmolality Increased, Hypovolemia
- Trial name
- NCT03176043
- Testing
- IV Fluid Administration
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University College, London
Healthy Volunteers
Study to Assess the Intrapulmonary Pharmacokinetics of SPR859 by Comparing the Plasma, Epithelial Lining Fluid (ELF), and Alveolar Macrophages (AM) Concentrations Following the Oral Administration of Five Doses of SPR994 in Healthy, Nonsmoking Volunteers
To evaluate the intrapulmonary pharmacokinetics (PK), including ELF and AM concentrations, of SPR859 (tebipenem) compared to plasma concentrations of SPR859 (tebipenem) (the active moiety in plasma of the prodrug SPR994) in…
- Trial name
- NCT04710407
- Testing
- TBPM-PI-HBr
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Spero Therapeutics
Pregnancy, Labor Pain
The Association Between Fluid Administration, Oxytocin Administration, and Fetal Heart Rate Changes
Fetal heart rate patterns are an important parameter in the diagnosis of non-reassuring fetal status. Combined-spinal epidural analgesia is a method of initiating labor analgesia used by approximately 90% of the parturients at…
- Trial name
- NCT00787176
- Testing
- Group A Intravenous bolus of 1000 ml lactated ringers solution, Group B Intravenous bolus bolus 1000 ml lactated ringers solution oxytocin decrease to 1/2 current rate, Group C 125 mL/hr of lactated ringers
- Where
- 2 sites in United States
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Diabetes Mellitus, Type 2
Avandamet Bioequivalence Study Brazil - Fed Administration
The study is prospective, open-label, randomized, crossover, with 02 treatments, 02 sequences, and 02 periods. The volunteers received, in each period, the reference or the test formulation after standardized meals.
- Trial name
- NCT01332071
- Testing
- Rosiglitazone Maleate + Metformin 2 miligrams (mg) + 500 mg, Rosiglitazone Maleate + Metformin 4 miligrams (mg) + 1000 mg
- Where
- Brazil
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Bowel Resection
The Effect of Fluid Management by SVV of FloTrac/ Vigileo™ Monitoring on Postoperative Recovery in Bowel Resection
During an enterectomy, especially in an open surgery, large amounts of fluid are administered in consideration of the patient's fasted state, maintaining blood pressure during surgery and potential third space loss.
- Trial name
- NCT02288767
- Testing
- Conventional arterial blood pressure monitoring, Stroke volume variation monitoring with arterial blood pressure monitoring
- Where
- South Korea
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Healthy
Study of Different Forms of Danicopan (Tablet, Softgel Capsule, Liquid-filled Capsule) in Healthy Participants
This was a randomized, crossover, open-label study to assess the relative bioavailability, pharmacokinetics (PK), and safety of three different formulations of danicopan (tablet, softgel capsule, liquid-filled capsule [LFC]) in…
- Trial name
- NCT04940559
- Testing
- Danicopan - Tablet, Danicopan - Softgel, Danicopan - LFC
- Where
- New Zealand
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Alexion Pharmaceuticals, Inc.
Diphtheria, Tetanus
Safety and Immunogenicity of Hexavalent Vaccine(DTwP-HepB-IPV-Hib) in Healthy Infants
The purpose of the study is to evaluate immunogenicity and safety of three different doses of candidate hexvalent vaccine in comparison to co-administration of EupentaTM Inj.
- Conditions
- Diphtheria, Tetanus, Pertussis, Hepatitis B
- Trial name
- NCT04073459
- Testing
- DTwP-HepB-Sabin IPV-Hib, Pentavalent vaccine and Salk IPV
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- LG Chem
Encephalitis
Pharmacokinetic Study of a Single Dose of AVI-4065 in Cerebral Spinal Fluid
AVI-4020 Injection, a phosphorodiamidate Morpholino oligomer (PMO), was found to cross the blood-brain barrier during a study of patients with presumptive West Nile virus disease.
- Trial name
- NCT00381433
- Testing
- AVI-4065 Injection
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Sarepta Therapeutics, Inc.
Alzheimer's Disease, Dementia
Effect of Aricept on Biomarkers (Acetylcholine, sAPP Alpha) In Cerebrospinal Fluid
It is hypothesized that the acetylcholinesterase inhibitor, donepezil, will increase acute cerebrospinal fluid (CSF) actylcholine levels in healthy volunteers following a 5mg single dose oral administration.
- Trial name
- NCT00987220
- Testing
- donepezil (Aricept)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer