Clinical trials: Fluid Response
Chronic Hepatitis b, Viremia
Adaptability of an Undetectable = Untransmissible Model for HBV
Persons with chronic hepatitis B (HBV) infection and active viremia are infectious and may transmit virus to others through blood/body fluid exposure.
- Trial name
- NCT07449091
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Sepsis, Severe Sepsis
Unsupervised Machine Learning for Clustering of Septic Patients to Determine Optimal Treatment
The focus of this study will be to conduct a prospective, randomized controlled trial (RCT) at Cape Regional Medical Center (CRMC), Oroville Hospital (OH), and UCSF Medical Center (UCSF) in which a fluid treatment-specific…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT03752489
- Testing
- Treatment-specific InSight, InSight
- Volunteers
- 51,645 people, healthy volunteers welcome
- Sponsor
- Dascena
Volume Overload, Tissue Perfusion
Non-Invasive Cardiometry and Ultrasound Guided Inferior Vena Cava Collapsibility Index in Assessing Fluid Responsiveness
43 patients between 18-60 years presenting with criteria of sepsis (life-threatening organ dysfunction caused by a dysregulated host response to infection, suspected or documented infection and an acute increase ≥2 SOFA…
- Trial name
- NCT05104528
- Testing
- OSYPKA Medical ICONTM Noninvasive CardiometerTM Model C3, Fujifilm Sonosite M-Turbo C Ultrasound system
- Where
- Egypt
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute, Egypt
Healthy
Determining the Dose Response Profile of the Headward Fluid Shift During Varying Gravity Levels
Parabolic flight provides a unique opportunity to evaluate the acute changes associated with varying levels of gravity and to describe how key venous parameters change at levels less than normal Earth gravity.
- Trial name
- AG2 (NCT06500338)
- Testing
- free-fall
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- National Aeronautics and Space Administration (NASA)
Allergic Rhinitis, Asthma
Development of Human Nasal Challenge Models With Microbial Constituents and Grass Pollen
The investigators propose the development of a range of nasal spray challenge models to study the way the nose can respond to different types of nasal challenge that elicit different forms of inflammation.
- Conditions
- Allergic Rhinitis, Asthma, Latent Tuberculosis
- Trial name
- NCT02090374
- Testing
- Poly ICLC, Poly I:C, R848
- Where
- United Kingdom
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Critical Illness
ICU Fluid Utilization Survey in Southeast Asia
The objective of this study is to examine the use of different types of fluids for resuscitation in different phases of fluid management in 3 types of critically ill patients including (1) not bleeding, not septic but need volume…
- Trial name
- Fluid-SEA (NCT06034990)
- Testing
- 10-min online survey
- Where
- Thailand
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Sepsis, Fluid Overload
Investigation of Novel and Established Therapies in a Human Intravenous Lipopolysaccharide Model of Sepsis
Sepsis is a common and life-threatening condition caused by a dysregulated host immune response to infection. Given the prominent role of endothelial breakdown and dysfunction in sepsis, therefore, there is an urgent need to…
- Conditions
- Sepsis, Fluid Overload, Endothelial Dysfunction, Microcirculation
- Trial name
- INITIALISE (NCT06626984)
- Testing
- Imatinib, Compound sodium lactate solution
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Belfast Health and Social Care Trust
Hemodynamics
The Effect of Age on the Hemodynamic Response During Rest and Exercise in Healthy Humans
Primary: To observe how hemodynamic parameters are affected by age during rest and exercise in healthy humans. Furthermore, how an acute fluid challenge changes hemodynamic parameters.
- Trial name
- HemReX (NCT01974557)
- Testing
- Exercise
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Finn Gustafsson
Influenza
Trial to Investigate Immune Responses Elicited by a Liquid Formulation of Influenza Virus Vaccine, Trivalent, Types A & B, Live Cold Adapted (CAIV-T) in Healthy Adults
To perform a variety of assays on blood, serum, nasal wash samples and cells obtained from healthy adult subjects for the purposes of developing assays for application in the further investigation of immune responses generated by…
- Trial name
- NCT00192192
- Testing
- CAIV-T
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- MedImmune LLC
Transverse Maxillary Deficiency, Oxidative Stress
Oxidative Stress and Antioxidant Responses During Rapid Maxillary Expansion: A Controlled Clinical Study
Rapid maxillary expansion is an orthopedic treatment used to correct transverse maxillary deficiency in growing patients. Mechanical forces generated during expansion may induce local biological responses, including changes in…
- Trial name
- NCT07695584
- Testing
- Expansion group
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- IRCCS Ospedale San Raffaele
Periodontitis, Peri-implant Mucositis
Biological Responses Affecting Early-stage Dental Implant Placement in Patients With History of Periodontitis
This prospective parallel, double-blind, four-arm randomised controlled clinical study is planned to assess the difference in the level of the inflammatory biomarkers expressed following the placement of the first dental implant…
- Conditions
- Periodontitis, Peri-implant Mucositis, Peri-Implantitis
- Trial name
- NCT05834946
- Testing
- Megagen implant placement, Biomate-Swiss implant
- Where
- Malaysia
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Periodontitis, Acute-Phase Response
Relationship Between LRG and Periodontal Disease
This study aimed to investigate gingival crevicular fluid (GCF) and serum levels of LRG, interleukin (IL)-6 and tumor necrosis factor (TNF)-α in patients with periodontitis before and after non-surgical periodontal treatment.
- Conditions
- Periodontitis, Acute-Phase Response, Inflammation
- Trial name
- NCT04383561
- Testing
- Non-surgical periodontal treatment, Oral hygiene instructions
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Stress, Psychological, Autonomic Nervous System
Feldenkrais Method and Stress-Related Responses in Adult Women
This pilot study aimed to explore whether the Feldenkrais Method, a gentle movement and awareness practice, could help reduce stress and improve well-being in sedentary adult women.
- Conditions
- Stress, Psychological, Autonomic Nervous System, Hydration, Healthy Volunteers
- Trial name
- NCT07175974
- Testing
- Feldenkrais Method - Awareness Through Movement (ATM)
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Satiety, Appetite
Effect of Liquid Volume and the Amount of Incorporated Gas Into a Carbohydrate/Protein Beverage on Satiety
Liquid foams can be formed by trapping pockets of gas in a beverage. The primary objective of this study is to test the individual contribution, and possible interaction, of the liquid volume and gas to liquid volume ratio (i.e.
- Trial name
- NCT02405494
- Testing
- Beverage 1, Beverage 2, Beverage 3
- Where
- United Kingdom
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Anesthesia
Can Peripheral NIRS Predict the Response to a Fluid Challenge in Pediatric Patients: An Interventional Study
This study will be conducted on pediatric patients up to 14 years of age. The effect of two fluid challenge regimes on cerebral and peripheral NIRS will be assessed, in a randomized double blinded controlled trial.
- Trial name
- NCT05111132
- Testing
- Fluid challenge (cristalloïd, NaCl 0,9%)
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Poor Ovarian Response
SIRT3 Expression in Granulosa Cells and the Levels of Follicular Fluid Metabolites Among POR Subgroups
The goal of this prospective, observational study is to learn about the pathogenesis and biological target of the subtypes of poor ovarian response (POR) during In vitro fertilization and embryo transfer (IVF-ET).
- Trial name
- POR SIRT3 (NCT06617988)
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shandong University of Traditional Chinese Medicine
Vegetable Signature Documentation With Metabolomic Technique
Vegetable Signature From Human Metabolomics Responses
The purpose of this study is to perform dietary intervention studies on a variety of vegetables.
- Trial name
- NCT03483558
- Testing
- Control, Spinach, Celery
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Orthodontic Tooth Movement
GCF Volume Changes in Aligners and Fixed Appliances
Orthodontic tooth movement induces biological responses in periodontal tissues that can be reflected by changes in gingival crevicular fluid (GCF).
- Trial name
- GCF-OTM (NCT07480538)
- Testing
- Clear Aligner Therapy, Fixed Appliance
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Nervous System Diseases
Cerebrospinal Fluid Collection and Repository Storage
Background: Cerebrospinal fluid (CSF) is the liquid around the brain and spinal cord. Many diseases can only be diagnosed by examining the CSF. A lumbar puncture is used to collect and test CSF.
- Trial name
- NCT01862107
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Peri-Implantitis, Peri-implant Mucositis
Proteomic Analysis of Newly Restored Single Implants
In 10 systemically healthy non-smokers, free of periodontitis, one newly restored implant (baseline-T0) and one corresponding tooth were followed over 12 months (T1). All implants were screw-retained, and platform-switched.
- Conditions
- Peri-Implantitis, Peri-implant Mucositis, Periodontal Diseases
- Trial name
- NCT06379022
- Testing
- Plaque control
- Where
- Greece
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki