Clinical trials: Fluid Responsiveness, open to volunteers
Fluid Responsiveness, Acute Circulatory Failure
Prediction of Fluid Responsiveness Using the Femoral Vein-to-Artery Diameter Ratio
This prospective single-center observational study aims to evaluate whether the ultrasound-measured femoral vein-to-femoral artery diameter ratio can predict fluid responsiveness in mechanically ventilated adult intensive care…
- Conditions
- Fluid Responsiveness, Acute Circulatory Failure, Shock
- Trial name
- NCT07546656
- Testing
- Ultrasound Measurement of Femoral Vein-to-Femoral Artery Diameter Ratio
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul University - Cerrahpasa
Critically Ill Patients, Circulatory Shock
Capillary Refill Time Variation to Predict Oxygen Comsumption Variation After FLuid Challenge (CARTOFL)
Circulatory shock is characterized by tissue hypoxia. Although fluid resuscitation is an essential treatment in many forms of circulatory shock, its benefits are variable, and its administration carries a risk of potentially…
- Conditions
- Critically Ill Patients, Circulatory Shock, Ventilated Patients
- Trial name
- CARTOFL (NCT07837843)
- Testing
- Indirect calorimetry measurement
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
Pulse Pressure Variation, Stroke Volume Variation
Peripheral Venous Pressure Variation, Pulse Pressure Variation and Pleth Variability Index for Fluid Responsiveness
Pulse pressure variation (PPV) and pleth variability index (PVI) are widely used in clinical practice as indicators of the responsiveness to fluid therapy in patients receiving mechanical ventilation.
- Conditions
- Pulse Pressure Variation, Stroke Volume Variation, Pleth Variability Index
- Trial name
- NCT06733389
- Testing
- peripheral waveform collection
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Seoul National University Bundang Hospital
Circulatory Failure (Shock)
Fluid-responsiveness in Children Ventilated With LOW Tidal Volume - The FLOW Study.
In this study of diagnostic accuracy, the investigators aim to validate a fluid-responsiveness test in critically ill children mechanically ventilated with low tidal volume.
- Trial name
- FLOW (NCT07494643)
- Testing
- Echocardiographic
- Where
- 6 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Bordeaux
Ultrasound-guided Fluid Management, Volume Responsiveness
Perceptions and Ultrasound Literacy for Sound Volume Management
The aim of this study is to assess the knowledge, attitudes, and practices of ICU physicians in Switzerland regarding the use of ultrasound for fluid management and evaluation of venous congestion.
- Conditions
- Ultrasound-guided Fluid Management, Volume Responsiveness, Venous Congestion Assessment, ICU Physician Practices
- Trial name
- PULSE (NCT07237347)
- Testing
- Quastionnaire
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Venous Congestion
Changes in Portal Vein Pulsatility Variability During a Tidal Volume Challenge Can Predict Fluid Tolerance
In critically ill patients, appropriate fluid administration is one of the cornerstones of hemodynamic management, as both hypovolemia and fluid overload can negatively impact clinical outcomes.
- Trial name
- SERLU (NCT07131228)
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Fluid Responsiveness, Laparoscopic Surgery
Fluid Responsiveness in Laparoscopic Surgery: End-Expiratory Occlusion Test Versus Mini-Fluid Challenge
Background Fluid management is central to perioperative care, but only about half of surgical patients increase their stroke volume after a fluid challenge.
- Conditions
- Fluid Responsiveness, Laparoscopic Surgery, Hemodynamic Monitoring
- Trial name
- FLUID-LAP (NCT07911059)
- Volunteers
- 104 people
- Sponsor
- University Of Perugia
To Assess the Ability of PI to Detect Preload Responsiveness
Changes in Pulse-Oximetry Perfusion Index Induced by Tidal Volume Challenge Versus Fluid Volume Challenge to Detect Preload Responsiveness in Mechanically Ventilated Patients With Low Tidal Volume
The primary goal of this study was to assess the ability of PI changes induced by a Vt challenge or fluid challenge test to detect preload responsiveness in critically ill adult patients on mechanical ventilation with low-tidal…
- Trial name
- NCT06673862
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Benha University
Central Venous Pressure and Inferior Vena Cava Distensibility Index in Assessing Fluid Responsiveness in Septic Shocked Patients
Central Venous Pressure Versus Inferior Vena Cava Distensibility Index in Assessing Fluid Responsiveness in Septic Shocked Patients
This study aims to compare ultrasound-guided inferior vena cava distensibility index(IVC_DI) assessment with central venous pressure (CVP) monitoring for the detection of hypovolemia in septic shocked patients in the emergency…
- Trial name
- NCT07279064
- Testing
- Ultrasound guided inferior vena cava distensibility index
- Volunteers
- 70 people
- Sponsor
- Assiut University
Shock
Tissue Perfusion Pressure for Predicting Fluid Responsiveness in Patients With Shock
This prospective observational study aims to evaluate the ability of tissue perfusion pressure (TPP) to predict fluid responsiveness in critically ill patients with shock and tissue hypoperfusion.
- Trial name
- NCT07670390
- Testing
- When the attending physician determines that fluid resuscitation is clinically indicated: Patients will remain in the supine position. Crystalloid solution will be administered intravenously via centr
- Volunteers
- 34 people
- Sponsor
- Jingyuan,Xu
Velocity-time Integral Measurement, Critically Ill Patients
Reliability of Minimally Trained Operator's Velocity-Time Integral Measurement Guided by Artificial Intelligence VTI
Stroke volume is a major determinant of tissue perfusion and therefore a key parameter to monitor in patients with hemodynamic instability and hypoperfusion.
- Conditions
- Velocity-time Integral Measurement, Critically Ill Patients, Tissue Hypoperfusion
- Trial name
- MiniTrainedVTI (NCT06486467)
- Testing
- Fluid challenge (cristalloids) OR passive leg raising
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Circulatory Failure / Shock State, Fluid Therapy
Metabolic Fluid Responsiveness in Children
The investigators aim to validate markers of metabolic fluid-responsiveness in children with acute circulatory failure following cardiac surgery.
- Trial name
- METAFRIC (NCT07255469)
- Where
- 8 sites in France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Bordeaux
Sepsis
Infraclavicular Axillary Vein Collapsibility Index as a Predictor of Fluid Responsiveness
Fluid responsiveness refers to the ability of the left ventricle to significantly increase stroke volume following fluid administration, and its assessment is critical in managing acute circulatory failure while avoiding fluid…
- Trial name
- NCT07507877
- Testing
- Infraclavicular axillary vein collapsibility index
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Hypotension Drug-Induced, General Anesthesia Using Endotracheal Intubation
Alveolar Recruitment Maneuver-Induced Hypotension: A Dynamic Consequence and Intraoperative Indicator of Fluid Responsiveness
This study investigates whether two simple bedside tests - the Passive Leg Raising (PLR) test and the Pleth Variability Index (PVI) - can predict a drop in blood pressure that sometimes occurs during a lung-opening procedure…
- Conditions
- Hypotension Drug-Induced, General Anesthesia Using Endotracheal Intubation, Atelectasis, Fluid Responsiveness
- Trial name
- NCT07766967
- Testing
- Alveolar Recruitment Maneuver (ARM), Passive Leg Raising (PLR) Test
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- University of Health Sciences Balikesir Hospital Eduation and Research
Hypotension, Anesthesia, General
Internal Jugular Vein Collapsibility Index for Predicting Post-Induction Hypotension
This study aims to investigate whether the Internal Jugular Vein Collapsibility Index (IJV-CI), measured via ultrasonography, can predict hypotension (low blood pressure) that occurs after the induction of general anesthesia.
- Conditions
- Hypotension, Anesthesia, General, Cholecystectomy, Laparoscopic
- Trial name
- IJV-CI (NCT07565025)
- Testing
- IJV-CI Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- University of Gaziantep
Septic Shock, Fluid Reponsiveness
This Study Compares Two Noninvasive Dynamic Tools: Lung Ultrasound and Transthoracic Echocardiography Using LVOT VTI. It Aims to Measure the Sensitivity and Specificity of LUS in Guiding Fluid Resuscitation and Early Detection of Fluid Responsiveness and to Prevent Volume Overload
Reliability of the LVOT-VTI versus lung ultrasonography for early detection of fluid intolerance during fluid resuscitation of septic patients.
- Trial name
- lvotvti (NCT07797751)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Sepsis, Circulatory Instability
Ultrasound-Calibrated Pulse Contour Cardiac Output Monitoring: Value and Accuracy in Hemodynamic Care
This is a single-center prospective clinical study in the intensive care unit (ICU). Thirty adult patients with sepsis requiring hemodynamic monitoring and fluid resuscitation will be enrolled.
- Conditions
- Sepsis, Circulatory Instability, Hemodynamic Monitoring
- Trial name
- NCT07920237
- Volunteers
- 30 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Circulatory Failure, Critical Illness
Role of End-Tidal CO2 During Passive Leg Raising to Predict Fluid Responsiveness in ICU
This prospective observational study evaluates whether monitoring changes in exhaled carbon dioxide (End-Tidal CO2 or EtCO2) during a "Passive Leg Raising" (PLR) test can reliably predict fluid responsiveness in critically ill…
- Conditions
- Circulatory Failure, Critical Illness, Hypovolemia
- Trial name
- NCT07304648
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Izmir Katip Celebi University
Cardiac Surgical Procedures, Hemodynamics
Structured Hemodynamic Assessment to Guide Care After Cardiac Surgery
This multicenter pilot randomized controlled trial will evaluate whether providing treating physicians with a structured hemodynamic assessment influences care after cardiac surgery.
- Conditions
- Cardiac Surgical Procedures, Hemodynamics, Fluid Therapy, Acute Kidney Injury
- Trial name
- UTF-in-CVICU (NCT07792707)
- Testing
- Expert Report of a Structured Hemodynamic Assessment, Standard Care (in control arm)
- Where
- 2 sites in Canada
- Volunteers
- 75 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Brain Edema
Haemodynamical Optimization During Brain Surgery
The decision to give fluids perioperatively could be based on methods used to identify preload responsiveness, either invasive or noninvasive estimates of stroke volume variation during mechanical ventilation.
- Trial name
- NCT04114799
- Testing
- Hemodynamic management based on invasive fluid responsiveness parameters, Hemodynamic management based on noninvasive cardiac output and SVV measurement
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- University Hospital Hradec Kralove