Clinical trials: Focal Liver Lesions
Focal Liver Lesions
Auxiliary Diagnosis of Liver Nodules Using cfDNA Whole-genome Signatures
As a prospective, multi-center study, GUIDER will recruit 400 liver nodules participants from different provinces and regions across China.
- Trial name
- GUIDER (NCT05393102)
- Testing
- No interventions
- Where
- 3 sites in China
- Volunteers
- 400 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Adult Primary Liver Cancer, Kidney Tumor
Ultrasound Elastography in Diagnosing Patients With Kidney or Liver Solid Focal Lesions
This clinical trial studies ultrasound elastography in diagnosing patients with kidney or liver solid focal lesions. New diagnostic procedures, such as ultrasound elastography, may be a less invasive way to check for kidney or…
- Trial name
- NCT01908166
- Testing
- ultrasound elasticity imaging
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Stanford University
Focal Liver Lesions, Ultrasonics
Utility of Ultrasound Imaging for Diagnosis of Focal Liver Lesions: A Radiomics Analysis
Ultrasound (US) as first-line imaging technology in detecting focal liver lesions,also plays a crucial role in evaluating image and guiding ablation which is the main treatment for liver lesions.
- Conditions
- Focal Liver Lesions, Ultrasonics, Intelligent Diagnosis, Ablation
- Trial name
- NCT03871140
- Testing
- diagnosis
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Hepatic Lesions
Comparative Diagnostic Yield of Contrast-Enhanced Versus Conventional Ultrasound Guidance for Coaxial Biopsy of Hepatic Lesions
This study compared two methods used to guide needle biopsies of suspicious lumps (lesions) in the liver. A biopsy is a procedure where a small sample of tissue is taken to make a diagnosis.
- Trial name
- NCT07249268
- Testing
- CEUS or Contrast enhanced Ultrasound, US
- Where
- China
- Volunteers
- 330 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Liver Lesions
An Efficacy and Safety Study of Sonazoid™ and SonoVue® in Participants With Focal Liver Lesions, Undergoing Pre- and Post-Contrast Ultrasound Imaging
The purpose of this study is to compare the efficacy of Sonazoid™ and SonoVue® in participants with focal liver lesions (FLLs), by comparing pre-and post-contrast ultrasound examination findings with regard to various aspects of…
- Trial name
- NCT03335566
- Testing
- Sonazoid™, SonoVue®
- Where
- 18 sites in China, South Korea and 1 more
- Volunteers
- 424 people
- Sponsor
- GE Healthcare
Liver Neoplasms
Multimodal Ultrasound and Focal Liver Lesions (FLLs)
Background and aim: FLLs are common findings in abdominal ultrasound and differential diagnosis between benign and malignant lesions is often challenging, especially in patients with chronic liver diseases.
- Trial name
- NCT05977764
- Testing
- Ultrasound
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hepatocellular Carcinoma (HCC), Intrahepatic Cholangiocarcinoma (Icc)
Pragmatic RCT of AI-Assisted Reading for Malignant Hepatic Lesions on CE-CT
The purpose of this multicenter pragmatic randomized controlled trial is to determine whether AI-assisted interpretation of multiphasic liver contrast-enhanced computed tomography (CE-CT) is non-inferior to standard radiology…
- Conditions
- Hepatocellular Carcinoma (HCC), Intrahepatic Cholangiocarcinoma (Icc), Hepatic Metastasis, Hepatic Hemangioma
- Trial name
- NCT07768085
- Testing
- AI-assisted abdominal CE-CT reporting, Standard abdominal CE-CT reporting without AI assistance
- Where
- China
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
Liver Diseases
Contrast Enhanced Ultrasound Guidance Biopsy for the Diagnosis of Liver Tumors
The main purpose of this study is to compare contrast-enhanced ultrasound guided liver biopsy (CEUS-LB) with conventional ultrasound guided liver biopsy (US-LB) in the diagnosis of liver tumors developed on a background of…
- Trial name
- ConCLUDe (NCT03811431)
- Testing
- Contrast enhanced ultrasound guided liver biopsy
- Where
- Romania
- Volunteers
- 138 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Liver Cancer
[18F]FAPI PET/CT in Suspicious Focal Liver Lesions Without FDG Avidity
Fibroblast activation protein (FAP) is a serine protease that belongs to the dipeptidyl peptidase-IV (DPP-IV) family located in fbroblast membranes.
- Trial name
- NCT05806333
- Testing
- FAPI PET
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jilin University
Known or Suspected Focal Liver Lesions, Severe Renal Impairment
Safety and Diagnostic Efficacy of Mangoral in Participants With Focal Liver Lesions and Reduced Kidney Function
The overall objective of this study is to evaluate the safety and diagnostic efficacy of Mangoral in liver MRI in participants with known or suspected focal liver lesions and severe renal impairment.
- Trial name
- SPARKLE (NCT04119843)
- Testing
- Mangoral
- Where
- 60 sites in United States, Argentina and 8 more
- Volunteers
- 87 people
- Sponsor
- Ascelia Pharma AB
Liver Cirrhoses
Non-Invasive Characterization of Focal Liver Lesions in Liver Cirrhosis
This study aims to analyze non-invasive characterization focal liver lesions in patients with liver cirrhosis. The diagnostic accuracy and predictive value of non-invasive methods is studied.
- Trial name
- NICETIES (NCT03746210)
- Testing
- Standard diagnostic procedures
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital, Bonn
Liver Disease
A Phase II Study of DMP 115 to Assess Focal Liver Lesions
To determine the optimal dose of DMP 115 to image liver lesions and to assess whether contrast can improve the detection of focal liver lesions.
- Trial name
- NCT00162058
- Testing
- Peflutren Lipid Microsphere Injectable Suspension
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- Lantheus Medical Imaging
Liver Neoplasms
SonoVue®-Enhanced Ultrasound Versus Unenhanced US for Focal Liver Lesion Characterization
The purpose of this study is to demonstrate the superiority of SonoVue®-enhanced ultrasound versus unenhanced ultrasound for characterization of Focal Liver Lesions using final diagnosis based on histology or combined…
- Trial name
- NCT00788697
- Testing
- SonoVue-enhanced ultrasound, Unenhanced ultrasound
- Where
- United States
- Volunteers
- 349 people
- Sponsor
- Bracco Diagnostics, Inc
Posterior Fossa Hemorrhage, Lung Cancer
Pilot Study of Model Based Iterative Reconstruction Using 64-Slice
This study is being performed to confirm that the new technique, Model-Based Iterative Reconstruction (MBIR) with reduced radiation dose can deliver equivalent image quality for CT scans compared to current techniques (Filtered…
- Conditions
- Posterior Fossa Hemorrhage, Lung Cancer, Flank Pain, Urolithiasis
- Trial name
- MBIR (NCT01431378)
- Where
- 3 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Focal Liver Lesions
Phase 4 Paediatric Study to Evaluate Sonazoid Safety and Efficacy for Contrast-Enhanced Ultrasound Liver Imaging
Liver tumours, 40% of which are benign, account for 1% to 4% of all solid tumours in children. The benign tumours are mainly haemangiomas, liver hamartomas, and liver cell adenomas.
- Trial name
- NCT06639828
- Testing
- Contrast-Enhanced Ultrasound
- Where
- 6 sites in Germany, Italy and 1 more
- Volunteers
- 50 people
- Sponsor
- GE Healthcare
Focal Liver Lesions, Contrast-enhanced Ultrasound
Radiomics Analysis of Focal Liver Lesions Based on Contrast-Enhanced Ultrasound Imaging
Contrast-enhanced ultrasound (CEUS) substantially improves the potential of ultrasound (US) for the identification and characterization of focal liver lesions (FLLs).
- Trial name
- NCT04682886
- Testing
- diagnosis
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Ping Liang
Postoperative Bile Leak, Focal Liver Lesions
Prevention of Bile Leakage After Liver Resection in Children
Bile leakage is a clinically important complication after liver resection in children and may require prolonged drainage, additional radiological or endoscopic procedures, or repeat surgery.
- Trial name
- NCT07867522
- Testing
- prophylactic extrahepatic biliary drainage during liver resection
- Where
- Russia
- Volunteers
- 12 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Hepatocellular Cancer
Effect of Pregabalin on the Postoperative Analgesia in RFA of Focal Lesions in the Liver
The study aimed to investigate the preemptive analgesia efficacy of of preemptive pregabalin for the postoperative pain management after radiofrequency ablation (RFA) of liver cancer.
- Trial name
- pregabalin (NCT03151213)
- Testing
- Pregabalin 150mg
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Sherief Abd-Elsalam
Focal Liver Lesions, Focal Lesions in the Abdomen
Interventional Sonography Guided by Image Fusion
The purpose of this study is to register the precision of image fusion between live sonography and CT, MRI or PET/CT of liver lesions and other focal lesions in the abdomen.
- Trial name
- NCT00781924
- Testing
- biopsy
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Liver Biopsy
Use of 50% Nitrous Oxide / 50% Oxygen Premix During Liver Biopsy of Focal Lesion
A 50% nitrous oxide / 50% oxygen premix is administrated to the patient during the realization of liver biopsy in order to relax him and to reduce his pain during this painful medical treatment.
- Trial name
- NCT00643656
- Testing
- Kalinox 170 bar, Mix of 50% oxygen and 50% nitrogen
- Where
- France
- Volunteers
- 94 people
- Sponsor
- Air Liquide Santé International