Clinical trials: Focus of Study
Prostate Cancer
Metabolomic Study for Localized Prostate Cancer
Prostate cancer is a common disease in men treated using surgery, radiation therapy and/or hormonal therapy. Clinical prognosis relates to stage and grade of disease.
- Trial name
- NCT01968538
- Testing
- Radiation Therapy
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Respiratory Tract Diseases
Safety and Accuracy of Alveoscopy in Interstitial Lung Diseases
Fibered confocal fluorescence microscopy (FCFM), also referred to as Cell-Vizio® (MaunaKea Technologies, France) is a new technique that produces microscopic imaging in a living tissue, through a 1 mm fiberoptic miniprobe that…
- Trial name
- ALVEOLE (NCT00377338)
- Where
- France
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
This Study Focus on the Effect of Low-Level Light Therapy on the Amount of Upper Molar Distalization
Assessment of Low Level Laser Therapy Effect on Treatment Outcomes of Bony Supported Distal Jet for Correction of Angle Class II Malocclusion (Randomized Clinical Trial)
The goal of this randomized clinical trial is to compare the effect of LLLT in adolescent patient with class II malocclusion. The main question it aims to answer is: is there a difference in the amount of distalization between…
- Trial name
- LLLT (NCT06170099)
- Testing
- low level laser therapy, bonny supported distal jet
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Hypophosphatasia
The PORTRAIT Study
Clinical Consequences of Adults Presenting with Hypophosphatasia with Special Focus on Gait, Bone Microstructure and Cognition: The PORTRAIT study Hypophosphatasia (HPP) is an inherited condition that leads to weak bones.
- Trial name
- PORTRAIT (NCT04222452)
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Self-Harm, Self-harm Behavior
Self-harm and the Prison Environment Mixed Methods Study
Self-harming behaviour is a major problem in UK prisons: the number of self-harm incidents has more than doubled over the past decade. People who self-harm in prison are at greater risk of subsequent death by suicide.
- Conditions
- Self-Harm, Self-harm Behavior, Self-Harm, Deliberate
- Trial name
- SHAPE (NCT06895668)
- Testing
- None (cohort study)
- Volunteers
- 458 people, healthy volunteers welcome
- Sponsor
- King's College London
Healthy Subjects
Study to Evaluate the Pharmacokinetics of Oral Sparsentan Suspension
This single-center, open-label, randomized, single and multiple-dose, 3-way sequential study at 3 dose levels will be performed in healthy subjects. Subjects will be randomized to 1 of the 3 dose levels.
- Trial name
- NCT05562362
- Testing
- RE-021, sparsentan
- Where
- United Kingdom
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Travere Therapeutics, Inc.
Prostate Cancer
Anxiety in Patients Under Active Surveillance for Localized Prostate Cancer and Their Partners.
Prostate cancer (PCa) is the most common cancer and the third leading cause of cancer-related death among men in France. Active surveillance is one of the management options for low-risk prostate cancer.
- Trial name
- ANCAPRO (NCT07351461)
- Testing
- Patient on active surveillance
- Where
- France
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Uterine Fibroids
Efficacy Study of Magnetic Resonance (MR) Guided Focused Ultrasound in the Treatment of Large Fibroids
The purpose of this study is to determine whether ablation of uterine fibroids with MR guided focused ultrasound following 3 months pre-treatment with Gonadotrophin releasing analogues will allow the effective use of this therapy…
- Trial name
- NCT00159328
- Testing
- Magnetic Resonance Guided Focused Ultrasound
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Autoimmune Diseases, Sickle Cell Disease
Microvascular and Fibrosis Imaging Study
In this study, Laser Doppler Flowmetry (LDF), Laser Doppler Imaging (LDI), Orthogonal Polarization Spectral Imaging (OPSI), Nail fold video capillaroscopy (NVC) and Optical Coherence Tomography (OCT) will be used to assess…
- Conditions
- Autoimmune Diseases, Sickle Cell Disease, Chronic Graft Versus Host Disease
- Trial name
- NCT01758250
- Testing
- Acoustic Radiation Force Impulse (ARFI), Laser Doppler Flowmetry (LDF), Laser Doppler Perfusion Imaging (LDI)
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Duke University
Myopia
SEED-LVPEI Myopia Study
This randomized clinical trial study aims to investigate the efficacy of novel SEED's EDOF based mid-lens design in controlling the myopia progression in Indian children with these specific objectives: 1.
- Trial name
- SLIMS (NCT04618510)
- Testing
- SEED 1-dayPure EDOF soft contact lens, Single Vision Spectacles
- Where
- India
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- L.V. Prasad Eye Institute
Gingival Recession
Platelet Rich Fibrin in the Treatment of Localized Gingival Recessions
The present study deals with treatment of localized gingival recessions. The hypothesis of this study is that platelet rich fibrin can be used an alternative to subepithelial connective tissue graft in the coverage of denuded…
- Trial name
- NCT01793389
- Testing
- Subepithelial connective tissue graft, Platelet Rich Fibrin
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ege University
Dystonic Disorders, Healthy
Surround Inhibition in Patients With Dystonia
This study will use transcranial magnetic stimulation (TMS) to examine how the brain controls muscle movement in dystonia. Dystonia is a movement disorder in which involuntary muscle contractions cause uncontrolled twisting and…
- Trial name
- NCT00029601
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
The Focus of This Study is to Identify How Different Approaches to Mammography Communication Affect Skepticism Toward Mammography Evidence
Evaluating Mammography Communication Approaches
This is a randomized online experiment testing different methods for communicating about the benefits and harms of breast cancer screening.
- Trial name
- NCT07228234
- Testing
- Harm/benefit language vs. outcomes that can happen, Breast cancer survivability information, No intervention
- Where
- United States
- Volunteers
- 1,900 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Focus of the Study is MRI Sequence Development
MRI Development for Radiotherapy Planning and Delivery in Non-Patient Volunteers
Non-patient volunteers will be scanned on the MR-Linac and MRSIM to facilitate the development, optimisation and validation of MRI protocols at The Christie NHS Foundation Trust.
- Trial name
- MINION (NCT04749134)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The Christie NHS Foundation Trust
Urinary Incontinence
In-person Focus Groups in the Management of Urinary Incontinence in Women
The purpose of this study is to investigate how a support group with other individuals who share the condition urinary incontinence (UI) impacts patients experience with management of urinary incontinence.
- Trial name
- NCT05395793
- Testing
- Support Group
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Malaria
Human Mass Balance Study of Pyronaridine
The combination of pyronaridine and artesunate is an antimalarial therapy in development. This mass balance study is intended to determine the rate and extent of excretion of total radioactivity in urine and feces following…
- Trial name
- NCT01383109
- Testing
- 14C-labeled Pyronaridine
- Where
- Switzerland
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
FSGS
A Prospective Controlled Study of Serum suPAR in the CsA-treated FSGS Patients
The purpose of this study is to determine whether the improved responsiveness to treatment achieved by CsA in patients with steroid-resistant or steroid-dependent FSGS could be explained by CsA's inhibitory action on the…
- Trial name
- SuparSDRF (NCT01468493)
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Provoked Localized Vulvodynia
Subtypes of Provoked Vestibulodynia
The proposed study will evaluate a clinical algorithm for the diagnosis and treatment of provoked vestibulodynia (PVD). The algorithm, distinguishes between four subtypes of PVD: hormonally mediated PVD, hypertonic pelvic floor…
- Trial name
- NCT02712814
- Testing
- Topical hormonal cream (estrogen), Pelvic floor physical therapy, Low Level Laser therapy
- Where
- Israel
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
The Focus of the Study is Romantic Relationship Quality
Mindfulness and Romantic Relationship Quality
The overarching aim of this proposal is to experimentally test whether a mindfulness intervention improves relationship quality. Romantic couples from the community will be randomly assigned to one of two arms: mindfulness vs.
- Trial name
- MINDv2 (NCT04177836)
- Testing
- Mindfulness intervention
- Where
- United States
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Type 2 Diabetes, Healthy (Controls)
Specimen and Data Collection in South Carolina Medicaid-Enrolled Patients With Type 2 Diabetes (T2D) and Metabolically Healthy Controls
The primary purpose of this study is to use multiomic data in combination with clinical assessments, electronic health records, cognitive and mood assessments, wearable technologies and lifestyle/behavioral data to identify data…
- Trial name
- BRISK 2 (NCT07731399)
- Testing
- Not applicable- observational study
- Where
- 2 sites in United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Guardian Research Network, Inc.