Clinical trials: Folate
Blood Pressure
Blood Pressure and Central Haemodynamics in Healthy Adults Stratified by MTHFR Genotype
Approximately 12% of the world's population have a have a common C677T polymorphism in the gene encoding the folate metabolising enzyme, methylenetetrahydrofolate reductase (MTHFR).
- Trial name
- RAFA Obs (NCT04948086)
- Where
- United Kingdom
- Volunteers
- 498 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Physiological Effects of Vitamin D
Vitamin D3, Folic Acid and Fexofenadine in Healthy Volunteers
The study is conducted to assess the effect of a vitamin D3 supplementation on the activities of two intestinal transporters and on the pharmacokinetics of the transporter substrates folic acid and fexofenadine.
- Trial name
- NCT01856348
- Testing
- Vitamin D
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Neural Tube Defects - Spina Bifida and Anencephaly
Blood Folate and Homocysteine Levels Following Administration of Folic Acid According to Different Daily Dosing Schedules:a Simulation of Food Fortification
The aim of this study is to examine whether the same total daily dosage of folic acid, when taken as a single daily dose or as multiple divided doses throughout the day, results in different blood folate and homocysteine levels…
- Trial name
- NCT00207558
- Testing
- folic acid
- Where
- China
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Iron Deficiency Anemia, Infectious Diseases
Efficacy Trial to Examine Efficacy of Multimicronutrient Home Supplementation in Infants
The objective of the program is to examine the efficacy of 6 month home micronutrient supplementation in Bedouin and Jewish children on improvements in nutritional status including measures of iron, ferritin, zinc and folic acid…
- Conditions
- Iron Deficiency Anemia, Infectious Diseases, Undernutrition
- Trial name
- NCT00276198
- Testing
- Sprinkles, Ferripel-3, Vitamins A&D drops
- Where
- Israel
- Volunteers
- 771 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Atherosclerosis
The Effect of Coffee Consumption on the Serum Levels of Leptin, Folic Acid, and Vitamin B12
The effect of coffee and body weight during the last 3 months on the level of leptin, folic acid, and vitamin B12
- Trial name
- NCT04488731
- Testing
- Normal BMI and moderate coffee consumption, Normal BMI and heavy coffee consumption, overweight and moderate coffee consumption
- Where
- Jordan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Applied Science Private University
Healthy, Cardiovascular Diseases
Effect of Betaine, Serine and Folic Acid on Vascular Function in Healthy Volunteers
The purpose of this study is to determine whether reducing the increase in plasma homocysteine concentrations following an oral methionine load affects vascular function in healthy volunteers, irrespective of the…
- Trial name
- NCT00126347
- Testing
- supplementation with betaine, serine, and folic acid
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wageningen Centre for Food Sciences
Autism Spectrum Disorder, Asthma
Folic Acid Clinical Trial: Follow up of Children (FACT 4 Child)
FACT 4 Child is a follow up study of mothers who participated in the Folic Acid Clinical Trial (NCT01355159) and their children at 4-6 years of age to determine the effect of high dose folic acid supplementation on social…
- Conditions
- Autism Spectrum Disorder, Asthma, Executive Dysfunction, Emotional Problem
- Trial name
- NCT03269110
- Testing
- SRS 2, CBCL, BRIEF-P
- Where
- 58 sites in Australia, Canada and 2 more
- Volunteers
- 664 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Cleft Lip, Cleft Palate
Oral Cleft Prevention Trial in Brazil
Cleft lip and palate are a significant component of morbid human birth defects in the developing world. By supplementing a high-risk group of women with folic acid (4.0 mg versus 0.4 mg) from preconception and continuing…
- Trial name
- NCT00098319
- Testing
- Folic acid (0.4mg vs. 4.0mg)
- Where
- 3 sites in Brazil
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Folate Deficiency, Neural Tube Defects
Folic Acid Salt Study (FISFA Zambia)
Question: How effective is fortified iodized salt with folic acid (FISFA) in increasing serum and red blood cell folate in non-lactating, non-pregnant women of reproductive age in the country of Zambia who do not have active food…
- Trial name
- NCT06734611
- Testing
- Fortified Iodized Salt with Folic Acid (FISFA)
- Where
- 2 sites in United States, Zambia
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Obesity
Folic Acid Supplementation in Women of Child Bearing Age
The objective of this study is to identify genes whose expression is potentially modifiable due to changes in folate intake and help delineate mechanisms accounting for the variability in individual response to folic acid…
- Trial name
- FASUPP (NCT01841658)
- Testing
- Folic acid
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Healthy
Bioavailability Study of Folate in Healthy Subjects
The aim of this prospective interventional study is to compare the bioavailability of the 6S-5-methyltetrahydrofolate (5-MTHF) glucosamine salt versus two other forms of 5- MTHF calcium salts by measuring serum 5-MTHF responses…
- Trial name
- NCT05699473
- Testing
- 5-MTHF glucosamine salt, 5-MTHF calcium salt 1, 5-MTHF calcium salt 2
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Lesaffre International
Pregnancy
The Effect of Folic Acid Supplementation and Pregnancy on the Folate Forms in Red Blood Cells
The purpose of this cross-sectional study was to examine whether or not physical changes or adaptations occur in response pregnancy or to the higher intakes of folic acid from supplementation typically consumed during the…
- Trial name
- NCT01741077
- Testing
- folic acid
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Diarrhea, Pneumonia
Folic Acid and Vitamin B12 in Young Indian Children
Hypothesis: Supplementation of two recommended daily allowances (RDA) of folic acid with or without simultaneous administration of vitamin B12 reduces the rates of acute lower respiratory tract infections (ALRI), clinical…
- Trial name
- NCT00717730
- Testing
- Folic Acid, Vitamin B12, Folic acid and vitamin B12
- Where
- India
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Tor A. Strand
Pregnancy; Spina Bifida, Fetal, Environmental Exposure
Understanding Effects of Folic Acid on the Methylosome and Transcriptome of Women With Spina Bifida Affected Pregnancies
Folic acid is currently considered to be the standard of care for primary and secondary prevention of spina bifida, but the mechanisms underlying folic acid's benefits are unknown.
- Trial name
- NCT05500690
- Testing
- Folic Acid Tablet
- Where
- Bangladesh
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Spina Bifida and Anencephaly
Dosage Effects of Folic Acid on Blood Folates of Honduran Women
CDC staff at the National Center on Birth Defects and Developmental Disabilities have been working closely with a Honduras-based organization, Project Healthy Children (PNS) and the Ministry of Health, on a folic acid…
- Trial name
- NCT00207532
- Testing
- folic acid
- Where
- Honduras
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Pregnancy
Natural Folate vs. Synthetic Folic Acid in Pregnancy
In this two-arm, double-blind randomized pilot study, the investigators will recruit 60 generally healthy, low-risk pregnant women aged 19-42 years living in Vancouver, Canada.
- Trial name
- NCT04022135
- Testing
- Folic acid, (6S)-5-methyltetrahydrofolic acid
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Single Nucleotide Polymorphism
Folate Gene Polymorphisms and Cellular Folate Speciation Pilot Study
This pilot study is designed to investigate differences in folate-related genes (single nucleotide polymorphisms) and their relationship to the species of folate present on red blood cells.
- Trial name
- FolGene (NCT00975364)
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Quadram Institute Bioscience
Diabetic Peripheral Neuropathy
Metanx® P.L.U.S. Program (Progress Through Learning, Understanding & Support)
This study will be an observational study in which patients who have been prescribed Metanx® are invited to participate in surveys regarding their experiences with Metanx®.
- Trial name
- NCT01368549
- Testing
- Metanx® (a medical food)
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Pamlab, L.L.C.
Primary Malnurtrition
Folic Acid Supplementation as an Appetizer in Primary Malnourished Egyptian Infants and Children
Folic acid as a appetizer in primary malnutrition
- Trial name
- NCT03040219
- Testing
- Folic Acid
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Dyslipidemias
Effect of Adding Folic Acid on Lipid Parameters in Population With Dyslipidemias
Background: Homocysteinemia is associated with increased risk of stroke, dyslipidemias, dementia, peripheral vascular disease and coronary artery disease. folic acid is involved in the metabolism of homocysteine.
- Trial name
- NCT03674333
- Testing
- Folic Acid
- Where
- Pakistan
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University