Clinical trials: Food Anaphylaxis
Eczema, Egg Allergy
Promoting Tolerance to Peanut in High-Risk Children
This study will evaluate whether early exposure to peanuts promotes tolerance and provides protection from developing peanut allergy in children who are allergic to eggs or who have severe eczema.
- Conditions
- Eczema, Egg Allergy, Food Allergy
- Trial name
- LEAP (NCT00329784)
- Testing
- Peanut Consumption Group
- Where
- United Kingdom
- Volunteers
- 640 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Food Allergy
Protection From Food Induced Anaphylaxis by Reducing the Serum Level of Specific IgE (Protana).
Anaphylaxis elicited by accidental intake of the offending food constitutes a major health risk to the food allergic patient. Current advice for the food allergic patient is to avoid the offending food allergen and to carry an…
- Trial name
- NCT03964051
- Testing
- Omalizumab Injection
- Where
- Denmark
- Volunteers
- 7 people
- Sponsor
- Carsten Bindslev-Jensen
Food Allergy
Registry of Food Allergy Oral Immunotherapy Treatment
The purpose of this patient registry is to demonstrate safety and efficacy of food oral immunotherapy in food allergic patients. Factors that lead to adverse reactions will be identified.
- Trial name
- NCT03059589
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Food Allergy Support Team
Food Hypersensitivity, Anaphylaxis
A Registry for the Food Allergy Community
The FARE Patient Registry will serve as a prospective, observational food allergy reporting system that stores detailed health and other basic information about patients' real-world experiences with food allergies, to encourage…
- Conditions
- Food Hypersensitivity, Anaphylaxis, Eosinophilic Esophagitis, Food Sensitivity
- Trial name
- FPR (NCT04653324)
- Where
- United States
- Volunteers
- 23,000 people
- Sponsor
- Food Allergy Research & Education
Egg Allergy
Safe Administration of Flu Vaccine to Egg Allergic Children
Historically, providing influenza vaccination of egg allergic children and young adults (EAC) with a history of anaphylaxis to egg, or other severe symptoms of an allergic reaction to egg (e.g., severe hives, swelling, or…
- Trial name
- SAFE (NCT01264601)
- Testing
- Trivalent Influenza Vaccine
- Where
- 5 sites in United States
- Volunteers
- 31 people
- Sponsor
- University of Michigan
Peanut-Induced Anaphylaxis, Peanut Allergy
UKK-0018 as an Immunotherapeutic for Treatment of Peanut Allergies
This study will test a new investigational treatment called UKK-0018. UKK-0018 as an immunotherapeutic for the treatment of peanut allergies.
- Trial name
- UKK-0018 (NCT07349212)
- Testing
- UKK-0018
- Where
- 6 sites in Australia, New Zealand
- Volunteers
- 40 people
- Sponsor
- Ukko Inc
Food Allergy, Anaphylaxis
PK/PD Study of IN-001 Sublingual Spray in Healthy Adults
This is an open-label, three-part study to assess the pharmacokinetics (PK) and pharmacodynamics (PD) of epinephrine administered as a single dose of L-dipivefrin (IN-001) sublingual spray or drop in healthy adults.
- Conditions
- Food Allergy, Anaphylaxis, Food Hypersensitivity, Food Allergy Peanut
- Trial name
- NCT07210320
- Testing
- Epinephrine Auto-Injector 0.3 mg/0.3 mL, Epinephrine 0.3 mg intramuscular manual injection via a syringe and needle, IN-001 9.06 mg Sublingual Spray
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Insignis Therapeutics, Inc.
Food Hypersensitivity, Peanut Hypersensitivity
Mechanisms Underlying Peanut Allergic Reactions in TRACE Peanut Study Participants: Extension Study
Food allergy affects up to 10% of the population. The mainstay of management involves dietary avoidance and provision of rescue medication in the event of an accidental reaction.
- Trial name
- TRACEextension (NCT02665793)
- Testing
- DBPCFC to peanut cookie, Single-dose DBPCFC to peanut flour, Single-dose DBPCFC to peanut butter
- Volunteers
- 17 people
- Sponsor
- Imperial College London
Peanut Hypersensitivity
The Effect of Extrinsic Factors on Food Allergy
Food allergy is a common problem, affecting 5-8% of the population. Peanut allergy causes reduced quality of life due to the perceived high risk of severe reactions.
- Trial name
- Ex-Factor (NCT01429896)
- Testing
- Food challenge
- Where
- 2 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Anaphylactic Reaction, Anaphylaxis
Steroid Use in Treatment of Allergic Reactions to Food
In this study, the investigators want to find out whether a specific medication commonly used for severe allergic reactions is really necessary.
- Conditions
- Anaphylactic Reaction, Anaphylaxis, Allergy in Children, IgE Mediated Food Allergy
- Trial name
- SAFARI (NCT07341776)
- Testing
- Antihistamines, Systemic corticosteroids, Adrenaline (rescue medication)
- Where
- 2 sites in Switzerland
- Volunteers
- 160 people
- Sponsor
- Johannes Trueck
Peanut Hypersensitivity, Anaphylaxis
PEAnut Anaphylaxis Predictors
Peanut allergy can be life-threatening. Current diagnostic techniques for peanut allergy have high sensitivity, but not high specificity.
- Trial name
- PEAAP (NCT02424136)
- Testing
- Questionnaire, Peanut Skin prick test, Fraction of exhaled nitric oxide
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- John Hunter Children's Hospital
Immune Deficiency, Immune Dysregulation Disorder
Allergy and Immunology Natural History Study
This protocol is a natural history study designed to evaluate subjects (and some family members) with suspected or identified genetic diseases of allergic inflammation or Immune Dysregulation.
- Conditions
- Immune Deficiency, Immune Dysregulation Disorder, Allergic Inflammation
- Trial name
- NCT05584488
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Tree Nut Allergy
Re-Introducing Nuts in Allergic Patients
This study aims to compare the safety and the compliance to different procedures (A: at home or B: at the hospital) for introducing tree nuts into the diet of patients with Immunoglobulin E (IgE)-mediated allergy to the…
- Trial name
- ReINA (NCT04151069)
- Testing
- Procedure A, Procedure B, Control group
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- National and Kapodistrian University of Athens
Food Hypersensitivity, Immune System Diseases
Oral Immunotherapy in Food Allergy in Finland
The outcomes of oral immunotherapy (OIT) in food allergy study will provide more knowledge of oral immunotherapy. So far the OIT has showed in clinical experiments to be a interesting way to increase the unresponsiveness in…
- Conditions
- Food Hypersensitivity, Immune System Diseases, Anaphylaxis
- Trial name
- NCT02640014
- Testing
- Milk
- Where
- Finland
- Volunteers
- 250 people
- Sponsor
- Helsinki University Central Hospital
Anaphylaxis
Pharmacokinetics of Intramuscular Adrenaline in Food--Allergic Teenagers
Food allergy affects up to 2% of adults and 8% of children in the United Kingdom (UK), and is a major public health issue. It is the commonest cause of life-threatening allergic reactions (anaphylaxis), which can be fatal.
- Trial name
- PIMAT (NCT03366298)
- Testing
- Epipen 0.3mg, Emerade 300mcg, Emerade 500mcg
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Imperial College London
Peanut Allergy
Pinpoint Trial: Prebiotics IN Peanut Oral ImmunoTherapy
The purpose of this research is to gather information on the safety and efficacy of using a prebiotic as an adjunctive therapy to peanut oral immunotherapy.
- Trial name
- NCT05138757
- Testing
- Prebiotic
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Egg Hypersensitivity
Safety of Nasal Influenza Immunisation in Egg Allergic Children
Egg allergy is common in early childhood, affecting at least one in 50 preschool children. Influenza ("'flu") vaccines contain egg protein, as the vaccine is cultured in hen's eggs.
- Trial name
- SNIFFLE (NCT01859039)
- Testing
- Administration of Live attenuated influenza vaccine
- Where
- 12 sites in United Kingdom
- Volunteers
- 282 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Anaphylaxis Food
FMXIN002 in Patients at Risk of Anaphylaxis
Study Objective To evaluate the efficacy of FMXIN002, a powder-based intranasal epinephrine spray, for treating anaphylaxis. Study Design Hypothesis: FMXIN002 will terminate anaphylactic reactions as effectively-or more…
- Trial name
- NCT07045701
- Testing
- Epinephrine 4mg nasal powder spray, Adrenalin 0.5mg Injectable Product
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Nasus Pharma
Food Allergy in Children, Milk Allergy
Comparison Between a Rush and a Conventional Oral Immunotherapy Protocol to Treat Cow's Milk and Hen´s Egg Allergy. CompITO Study
This study investigates the efficacy and safety of two different OIT schemes to treat milk and egg allergic children
- Conditions
- Food Allergy in Children, Milk Allergy, Egg Allergy
- Trial name
- compITO (NCT06976775)
- Testing
- "Rush" regimen, "Conventional" regimen
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Pablo Rodríguez del Rio
Food; Allergy, Anaphylactic Shock, Asthma in Children
Omalizumab in Severe Asthmatics With Food Allergy
A prospective assessment of the impact of Omalizumab in terms of efficacy, safety, and quality of life (FA-QoL) in patients with moderate/severe asthma and history of anaphylaxis to peanut, tree nuts, fish, egg, milk, and/or…
- Trial name
- OSAFA (NCT06316414)
- Testing
- Omalizumab
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- Bambino Gesù Hospital and Research Institute