Clinical trials: Foot & Ankle
Pregnancy Related, Foot Diseases
Evaluation of Morphofunctional and Baropodometric Changes in Pregnant Women
Pregnancy causes physiological and biomechanical changes in the female body, such as weight gain and hormonal changes, which can affect the structure and function of the foot and ankle.
- Trial name
- FOOTpreg (NCT06696495)
- Testing
- Measurement of the size and width of the foot
- Where
- 2 sites in Spain
- Volunteers
- 100 people
- Sponsor
- University of Seville
Lower Extremity Injuries
Effect of Custom Dynamic Orthoses on Forefoot Loading
The proposed study is designed to evaluate how foot loading changes during initial accommodation to a carbon fiber custom dynamic orthosis (CDO), after targeted training with or without visual feedback of foot loading, and after…
- Trial name
- LoadsolCP (NCT06710119)
- Testing
- Visual Feedback
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Iowa
Cerebral Palsy (CP)
Cerebral Palsy: Ankle Foot Orthoses - Footwear Combinations
Ambulatory children with cerebral palsy (CP) demonstrate altered lower limb biomechanical alignment in walking (e.g. excessive hip/knee flexion or equinus during stance) and experience walking activity limitations that negatively…
- Trial name
- CP-AFOFC (NCT03756571)
- Testing
- Ankle Foot Orthoses-Footwear Combination, Traditional Solid Ankle AFO (TSAFO)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Seattle Children's Hospital
Bunion, Metatarsophalangeal Fusion
Phase 3, Randomized, Double Blinded, Active Controlled, Multicenter Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL Admixed With Bupi vs. Bupi Only Administered as Combined Sciatic and Adductor Canal Nerve Block for Postsurgical Analgesia in Lower Extremity Surgeries
This is a Phase 3, multicenter, randomized, double blinded, active controlled study in approximately 81 subjects undergoing lower extremity surgeries with combined sciatic and adductor canal nerve block.
- Conditions
- Bunion, Metatarsophalangeal Fusion, Midfoot Fusion, Hindfoot Fusion
- Trial name
- STRIDE (NCT03954639)
- Testing
- EXPAREL 13.3Mg/mL Suspension for Injection, Bupivacaine Hydrochloride
- Sponsor
- Pacira Pharmaceuticals, Inc
Pes Planus
The Development of Flat Foot After Ankle Fractures
In this study we are trying to determine the incidence of flat foot (also called pes planus) among patients who have had an ankle fracture.
- Trial name
- NCT00507910
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Ottawa Hospital Research Institute
Fractures, Occult
Efficacy of Ultrasound in Evaluating Occult Fractures
The purpose of the study is to examine the efficacy and accuracy of Ultrasound in evaluating occult fractures. We want to examine it on children that suffer from suspected fractures of the foot and ankle and the results of the…
- Trial name
- NCT00367848
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hadassah Medical Organization
Chronic Ankle Instability
Relationship of Dynamic Knee Valgus With Foot Posture, Pain, and Balance in Chronic Ankle Instability.
The purpose of the study is to identify if there is a relationship between the frontal plane projection angle as a measure of dynamic knee valgus with foot posture, pain, and dynamic balance in chronic ankle instability patients.
- Trial name
- DKV/CAI (NCT07121725)
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Cairo University
Diabetic Peripheral Neuropathy, Limited Joint Mobility Syndrome
Foot and Ankle Mobilisation in Diabetic Peripheral Neuropathy
Diabetes can affect the blood supply to the nerves in the legs. When this occurs a peripheral neuropathy can occur when the nerves carrying sensory information are affected.
- Conditions
- Diabetic Peripheral Neuropathy, Limited Joint Mobility Syndrome, Ankle Joint Range of Motion, Forefoot Peak Plantar Pressure
- Trial name
- NCT03195855
- Testing
- Manual therapy / joint mobilisations
- Where
- United Kingdom
- Volunteers
- 61 people
- Sponsor
- University of Plymouth
Stroke
The Effect of Ankle Foot Orthesis on Task-oriented Treatment in Stroke
A stroke is a neurological condition and a major cause of disability in adults. It occurs suddenly and causes specific brain function problems, leading to noticeable symptoms that last for more than 24 hours.Stroke commonly…
- Trial name
- NCT06840132
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Ankara Medipol University
Diabetic Foot, Diabetes Mellitus, Type 2
Foot-Ankle Exercise and Walking Exercise on Diabetes Mellitus Patients
The primary purpose of this study is to determine the effectiveness of foot-ankle exercise and walking exercise on foot neuropathy, stress, and quality of life (QoL) among people with diabetes mellitus (PWDM).
- Conditions
- Diabetic Foot, Diabetes Mellitus, Type 2, Diabetic Neuropathies, Diabetes Type 2
- Trial name
- NCT06518486
- Testing
- Foot-ankle exercise, Walking exercise, Usual care and health education
- Where
- 5 sites in Indonesia
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Osteoarthritis, Osteo Arthritis Knee
Adipose-Derived Biocellular Regenerative Therapy for Osteoarthritis
Use of Biocellular and cellular approaches to treatment of Osteoarthritis (OA), musculoskeletal aging processes, pain, and degenerative changes are to be studied with minimally invasive protocols, and non-pharmaceutical means to…
- Conditions
- Osteoarthritis, Osteo Arthritis Knee, Osteo Arthritis Shoulders, Osteoarthritis of Multiple Joints
- Trial name
- GARM-MSK-ALD (NCT04238143)
- Testing
- Tissue Stromal Vascular Fraction (tSVF) Arm 1, PRP Concentrate Arm 1, Tissue Stromal Vascular Fraction (tSVF) Arm 2
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Healeon Medical Inc
Amputation
Comparative Effectiveness of Microprocessor Controlled and Carbon Fiber Prosthetic Feet in Transtibial Amputees
The purpose of this research is to evaluate benefits of a microprocessor controlled prosthetic ankle-foot device compared to a non-microprocessor controlled or passive carbon fiber prosthetic ankle-foot device.
- Trial name
- NCT02864693
- Testing
- Kinnex, Pacifica LP
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Ability Prosthetics and Orthotics, Inc.
Cerebral Palsy
Comparison of Two Ankle Foot Orthosis on Mobility, Participation and Adhesion in Childrend With Cerebral Palsy
Children with cerebral palsy (CP) present a variety of motor impairments and activity limitations. Plastic ankle-foot orthoses (pl-AFO) are frequently prescribed to improve their gait.
- Trial name
- DynamicPC (NCT07301593)
- Testing
- orthosis use
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Foot Ankle Injuries
Compare Continuous Gastrocnemius Plane Block With Intravenous Analgesia After Foot and Ankle Surgery
This study aims to evaluate the efficacy and safety of a continuous gastrocnemius plane block for perioperative analgesia in patients undergoing foot and ankle surgery under elective general anesthesia.
- Trial name
- NCT05463809
- Testing
- Continuous Gastrocnemius plane block with ropivacaine, oxycodone
- Volunteers
- 60 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Cerebral Palsy
Muscle Activity With the Use of Ankle Foot Orthoses in Cerebral Palsy
The purpose of this study is to investigate the change in muscle activity during gait with the use of ankle foot orthoses in children diagnosed with hemiplegic cerebral palsy.
- Trial name
- NCT00462085
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital Basel
Elective Foot and Ankle Surgery.
Use of Platelet-Rich Plasma (PRP) and Platelet-Poor Plasma (PPP) to Prevent Infection and Delayed Wound Healing
The purpose of this study is to see if applying PRP and PPP to surgical sites and the closing incision helps prevent infection and slow wound healing.
- Trial name
- PRP (NCT01639144)
- Testing
- PRP and PPP
- Where
- United States
- Volunteers
- 515 people
- Sponsor
- Gary M. Kiebzak, Ph.D.
Knee Osteoarthritis (OA)
Effects of Core Stabilization Exercises Versus Foot-Ankle Strengthening Program in Patients With Knee Osteoarthritis.
Knee osteoarthritis (OA) is also known as degenerative joint disease, is typically the result of wear and tear and progressive loss of articular cartilage. It is most common in the elder population.
- Trial name
- NCT06658249
- Testing
- Core Stabilization Exercises with Foot-Ankle Strengthening Program, Foot-Ankle Strengthening Program
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Riphah International University
Ankle Surgery, Foot Surgery
Evaluation of a New Tool for Measuring Hindfoot Alignment Under Load and in 3D.
The automated TALAS measurement tool, working with the Cone Beam 3D scanner under load, provides a reproducible measurement of the Foot Ankle Offset (FAO).
- Conditions
- Ankle Surgery, Foot Surgery, 3D Imaging
- Trial name
- 3D-HAM (NCT04134962)
- Testing
- 3D Imaging FAO measurement and Clinical evaluation of the hindfoot alignment
- Where
- France
- Volunteers
- 125 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Diabetic Peripheral Neuropathy (DPN)
Plantar Intrinsic Muscles Exercises and Three-dimensional Ankle Foot Exercises Comparative Effect in DPN
The aim of this study is to determine the comparative effects of plantar intrinsic muscles exercises and three-dimensional ankle foot exercises on balance, gait and fall risk in patients with diabetic peripheral neuropathy.
- Trial name
- NCT07576179
- Testing
- Plantar intrinsic foot exercises, Three-Dimensional ankle foot exercises
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Gait Analysis
An Ankle-foot Orthosis Improves Gait Performance and Satisfaction in Stroke Patients
All participants were at least 6-month post-stroke and had unilateral limb involvement (8 right/4 left). The main inclusion criteria in selection of the participants in this study were as follows :(1) First stroke (2) At least 6…
- Trial name
- NCT03965715
- Testing
- 3D printing AFO, anterior AFO, off-the-shelf AFO
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Cheng-Kung University Hospital