Clinical trials: For Oncologic Patients
Low-grade Glioma, Plexiform Neurofibroma
Trametinib for Pediatric Neuro-oncology Patients With Refractory Tumor and Activation of the MAPK/ERK Pathway.
This is a phase 2, open-label, interventional clinical trial that will study the response rate of pediatric glioma and plexiform neurofibroma (PN) to oral administration of trametinib.
- Conditions
- Low-grade Glioma, Plexiform Neurofibroma, Central Nervous System Glioma
- Trial name
- NCT03363217
- Testing
- Trametinib
- Where
- 7 sites in Canada
- Volunteers
- 114 people
- Sponsor
- St. Justine's Hospital
Febrile Neutropenia, Hematological Malignancy
Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO
A multicenter open-label non-inferiority randomized clinical trial comparing the safety (non-inferiority) of short antibiotic treatment (72 hours) with an anti-pseudomonal carbapenem with regard to treatment failure in comparison…
- Trial name
- SHORT (NCT02149329)
- Testing
- Discontinuation of imipenem-cilastatin or meropenem
- Where
- 2 sites in Netherlands
- Volunteers
- 276 people
- Sponsor
- Amsterdam UMC, location VUmc
Bladder Cancer, Urothelial Carcinoma Bladder
Evaluating Bladder CARE™, a New Non-Invasive Urine Test, for Bladder Cancer Detection in Inconclusive Cases
The goal of this observational study is to learn about the performance of the Bladder CARE™ Assay in patients suspected of having bladder cancer with atypical cytology or equivocal cystoscopy results.
- Trial name
- NCT06870253
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Pangea Laboratory LLC
Rectal Cancer, Adenocarcinoma, Rectal Cancer Stage II
"Oncologic Results and Risk Factors for Recurrence in Patients With Locally Advanced Rectal Cancer and Pathologic Complete Response After Neoadjuvant Treatment. Results From an Observational Retrospective Multicenter Long-term Follow-up Study".
Pathologic complete response (pCR) after multimodal treatment for locally advanced rectal cancer (LARC) patients is considered as the gold-standard of treatment success as it is associated to privileged oncologic outcome.
- Conditions
- Rectal Cancer, Adenocarcinoma, Rectal Cancer Stage II, Rectal Cancer Stage III, Distant Metastasis
- Trial name
- NCT05495308
- Testing
- neoadjuvant treatment
- Where
- Spain
- Volunteers
- 4 people
- Sponsor
- Hospital San Carlos, Madrid
Malignant Brain Tumors
PRESENCE Project: An Early Palliative Care Intervention in Brain Tumors
The purpose of this pilot study is to investigate the feasibility of an early palliative care intervention (PRESENCE: Providing Resources Education, Support, and Enabling New brain tumor patients to Cope Effectively) and the…
- Trial name
- NCT01652768
- Testing
- Research Questionnaires, Palliative Care Team, Educational Information Session for Patients and Caregivers
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Stress, Health Knowledge, Attitudes, Practice
The PIFBO-study: Person-centred Information to Parents in Paediatric Oncology
The aim of this project is to evaluate a person-centred informational intervention aimed at parents of children with cancer. The following hypotheses will be tested: an informational intervention emanating from the parents'…
- Trial name
- PIFBO (NCT02332226)
- Testing
- Representational approach
- Where
- 2 sites in Sweden
- Volunteers
- 32 people
- Sponsor
- Umeå University
Breast Cancer
AKY15-HK-301_NEPA Study
Nausea and vomiting (feeling sick to your stomach and throwing up) are two of the most common unpleasant side effects of chemotherapy agents (drugs specifically used to treat cancer) that will be used for cancer treatment.
- Trial name
- NCT03386617
- Testing
- NEPA
- Where
- Hong Kong
- Volunteers
- 55 people
- Sponsor
- Chinese University of Hong Kong
Bone Metastases in Subjects With Advanced Cancer, Radiotherapy
Timely Integration of Palliative Care in Oncology Care for Patients Referred for Palliative Radiotherapy on Bone Metastases: A Randomized Trial
Rationale: With improvements in systemic tumour-directed treatments for primary tumours, survival rates for patients with bone metastases are improving.
- Trial name
- TIPZO-RT (NCT06805396)
- Testing
- Palliative Care Consult
- Where
- 5 sites in Netherlands
- Volunteers
- 246 people
- Sponsor
- Roxanne Gal
Cancer
Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Osimertinib (TAGRISSO) (ROSY-T)
The rationale of the ROSY-T study is to continue to provide study treatment for patients who have participated in a parent study with osimertinib and who are continuing to derive clinical benefit from treatment at the end of such…
- Trial name
- ROSY-T (NCT05629234)
- Testing
- Osimertinib
- Where
- 27 sites in China, France and 6 more
- Volunteers
- 37 people
- Sponsor
- AstraZeneca
Breast Cancer
Individualized Exercise Oncology Program for Newly Diagnosed Breast Cancer Patients
To test the effect of an individualized exercise oncology program on healthcare utilization, 30-day hospital readmission, pain, and cancer treatment tolerance.
- Trial name
- NCT04106609
- Testing
- Supervised, individualized exercise oncology program, Current standard of care
- Where
- United States
- Volunteers
- 251 people
- Sponsor
- Karen Wonders
Snoezelen, Pediatric Cancer
Proof-of-Concept Study of the SNOEZELEN Device on Anxiety Symptoms in Patients Hospitalized for Chemotherapy in a Pediatric Oncology Department
The goal of this clinical trial is to evaluate whether the Snoezelen multisensory relaxation approach can reduce anxiety symptoms in children and adolescents aged 8 to 17 years hospitalized for chemotherapy in a pediatric…
- Conditions
- Snoezelen, Pediatric Cancer, Symptomatologie Anxieuse, Chimiothérapie
- Trial name
- SNOOZE (NCT07202507)
- Testing
- self-report questionnaires, research interviews
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Oscar Lambret
Frailty, Oncology Problem
PATH Program for for Severely Frail or Cognitively Impaired Patients Scheduled for Cancer Surgery.
This is a single center, non-blinded randomized control trial taking place at the Queen Elizabeth II hospital (QEII) in Nova Scotia.
- Conditions
- Frailty, Oncology Problem, Cognitive Impairment
- Trial name
- NCT06022666
- Testing
- Geriatric assessment
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Nova Scotia Health Authority
Glioma, Recurrent Glioma
A Digital Treatment Platform for the Delivery of Home-Based Sequential Therapy in Patients With Glioma, GHoST Trial
This clinical trial tests how well a digital treatment platform using a mobile application works for the delivery of home-based sequential therapy in patients with glioma.
- Conditions
- Glioma, Recurrent Glioma, Recurrent Glioblastoma
- Trial name
- NCT07074756
- Testing
- Chemotherapy, Computed Tomography, Internet-Based Intervention
- Where
- 2 sites in United States
- Volunteers
- 202 people
- Sponsor
- Mayo Clinic
Advanced Malignant Solid Tumor
Cannabis extrAct in Oncology Patients for the Treatment of TUmor Related Symptom Burden
CAPTURE is a prospective, interventional, randomized, phase 2, double-blind, placebo-controlled study assessing the therapeutic add-on effect of the balanced THC/CBD extract (Cannabis extract Avextra 10/10 oral solution) on…
- Trial name
- CAPTURE (NCT07459920)
- Testing
- Cannabis Extract Oil
- Where
- Italy
- Volunteers
- 156 people
- Sponsor
- National Cancer Institute, Naples
Covid19, Oncology
An Integrated Digital PROM-platform for Cancer Patients During the COVID-19 Pandemic
During the COVID-19 pandemic, patients with cancer are subject to multiple risks (e.g. frequent hospital visits, increased infection risk, more severe clinical course, discontinued cancer treatment etc.).
- Conditions
- Covid19, Oncology, PROMs, Chemotherapeutic Toxicity
- Trial name
- COVID-ONCO (NCT04816656)
- Testing
- ePROMs assessment
- Where
- 2 sites in Belgium
- Volunteers
- 43 people
- Sponsor
- Jessa Hospital
Breast Cancer, Lung Cancer
Developing a Virtual Stress Management Intervention for Spousal/Partnered Caregivers of Solid Tumor Cancer Patients.
This randomized control trial will investigate the ability of an effective stress management psychoeducation program for employed caregivers to mitigate psychological distress and pathophysiology in spousal or partnered…
- Conditions
- Breast Cancer, Lung Cancer, Colon Cancer, Solid Tumor, Adult
- Trial name
- eCare (NCT04739696)
- Testing
- PEPRR, Pep-Pal
- Where
- United States
- Volunteers
- 538 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
GI Cancer, Lymphoma
Geriatric Communication Skills Training Program for Oncology Clinicians
The purpose of this study is to learn more about the effects of a training program designed to help doctors communicate better with older patients and their caregivers.
- Conditions
- GI Cancer, Lymphoma, GU Cancer, Bone Marrow Transplant
- Trial name
- NCT03530969
- Testing
- Self-Efficacy Assessment, UCLA Geriatrics Attitudes Scale, Course Evaluations
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Oncology
Phase I Prognostic Online (PIPO) Tool
Clinical trials are studies that test new treatments to see if they work and are safe for people with certain illnesses. Phase I clinical trials are the earliest stage of testing, where researchers give a new treatment to a small…
- Trial name
- PIPO (NCT07593053)
- Testing
- Immune checkpoint inhibitor, targeted agents
- Where
- Spain
- Volunteers
- 586 people
- Sponsor
- Vall d'Hebron Institute of Oncology
Malignant Female Reproductive System Neoplasm
Efficacy and Safety of the LovenoxTM (Enoxaparin) Versus HeparinTM Gynecologic Oncology Patients
Prophylactic treatment will start from surgery until the patients are discharged from the hospital(18). Then each patient will have 2 follow up visit in gyne- oncology clinic.
- Trial name
- Lovenox (NCT01356329)
- Testing
- Enoxaparin, Heparin
- Where
- Saudi Arabia
- Volunteers
- 150 people
- Sponsor
- National Guard Health Affairs
Hematologic Diseases, Oncology Problem
Clinical Validation of a Dried Blood Spot Method for Analysis of Immunosuppressives and Antifungals in Pediatrics
This is a clincial validation study of a dried blood spot (DBS) method for the analysis of immunosuppressive and antifungal agents currently subject of therapeutic drug monitoring (TDM) in a pediatric population.
- Conditions
- Hematologic Diseases, Oncology Problem, Kidney Diseases, Transplantation Infection
- Trial name
- PROTECT (NCT02329808)
- Testing
- blood drawing
- Where
- Netherlands
- Volunteers
- 93 people
- Sponsor
- Radboud University Medical Center