Clinical trials: For Oncologic Patients
Cardiac Toxicity, Unspecified Childhood Solid Tumor, Protocol Specific
Enalapril in Treating Heart Damage Patients Who Received Anthracycline Chemotherapy for Childhood Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Chemoprotective drugs, such as enalapril, may protect normal cells from the toxic effects of chemotherapy.
- Trial name
- NCT00003070
- Testing
- enalapril maleate, quality-of-life assessment
- Where
- 61 sites in United States, Canada and 1 more
- Volunteers
- 13 people
- Sponsor
- Children's Oncology Group
Esophageal Squamous Cell Carcinoma (ESCC)
Phase II Study Evaluating Safety and Efficacy of Tislelizumab for Elderly Patients Unfit for Chemotherapy, With Advanced Esophageal Squamous-cell Carcinoma
The goal of this clinical trial is to assess the percentage of patients alive at 6 months in elderly patients, not eligible to an platinum-based chemotherapy, but who can received the Tislelizumab treatment alone as first-line…
- Trial name
- SAFE ESO (NCT07205731)
- Testing
- Tislelizumab is a fully humanized monoclonal antibody specific for human PD-1
- Where
- 30 sites in France
- Volunteers
- 95 people
- Sponsor
- University Hospital, Clermont-Ferrand
Oncology
Remote COVID-19 Symptom Tracking for Cancer Patients at Home During the Pandemic
This project will evaluate the benefit of an automated home symptom monitoring system, Symptom Care at Home, to track COVID-19 symptoms, provide instructions to reduce COVID-19 exposure, and reduce cancer symptom severity during…
- Trial name
- NCT04464486
- Testing
- SCH Intervention
- Where
- United States
- Volunteers
- 301 people
- Sponsor
- University of Utah
Surgical Site Infection, Gynecologic Cancer
Effectiveness of Wound Drains for the Prevention Of Surgical sITe infectION
The aim of the present randomized trial is to assess the efficacy of wound drains in terms of reducing the rates of surgical site infection in obese patients with gynecological cancer.
- Conditions
- Surgical Site Infection, Gynecologic Cancer, Wound Drain
- Trial name
- POSITION (NCT05179122)
- Testing
- Surgical drain
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Lung Cancer Non-small Cell Stage IV
Osimertinib as 1st Line Therapy for Patients With Advanced EGFR Positive Non-Small Cell Lung Cancer
The present study will evaluate the use of osimertinib as 1st line therapy for patients with advanced EGFR positive non-small cell lung cancer who are treated at Hellenic Cooperative Oncology Group (HeCOG)-affiliated departments…
- Trial name
- NCT05127382
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Hellenic Cooperative Oncology Group
Recurrent Adult Acute Lymphoblastic Leukemia, Recurrent Adult Non-Hodgkin Lymphoma
Collecting and Storing Samples of Bone Marrow and Blood From Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma
This research study is collecting and storing samples of bone marrow and blood from patients with relapsed acute lymphoblastic leukemia or relapsed non-Hodgkin lymphoma.
- Conditions
- Recurrent Adult Acute Lymphoblastic Leukemia, Recurrent Adult Non-Hodgkin Lymphoma, Recurrent Childhood Acute Lymphoblastic Leukemia, Recurrent Childhood Non-Hodgkin Lymphoma
- Trial name
- NCT00897325
- Testing
- Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis
- Where
- 183 sites in United States, Australia and 3 more
- Volunteers
- 811 people
- Sponsor
- Children's Oncology Group
Cervical Cancer, Endometrial Cancer
Fondaparinux in Preventing Blood Clots in Patients Undergoing Surgery for Gynecologic Cancer
RATIONALE: Fondaparinux may help prevent blood clots from forming in patients who are undergoing surgery for gynecologic cancer.
- Conditions
- Cervical Cancer, Endometrial Cancer, Fallopian Tube Cancer, Ovarian Cancer
- Trial name
- NCT00381888
- Testing
- fondaparinux sodium
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Cancer Debulking, Enlarged Uterus
Comparing Intrathecal Morphine and Intraoperative Lidocaine Infusion to Epidural Anesthesia With Postoperative PCA for Patients Undergoing Exploratory Laparotomy
To determine if opioid consumption postoperatively among patients undergoing non-emergent laparotomy by the gynecologic oncology service who receive intrathecal morphine with intraoperative lidocaine (IML) infusion are lower than…
- Conditions
- Cancer Debulking, Enlarged Uterus, Fibroid Uterus, Adnexal Mass
- Trial name
- NCT05017246
- Testing
- Bupivacaine, Morphine, Lidocaine
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Washington University School of Medicine
Vulvar Cancer, Ovarian Cancer
Study of a Rapid Triadic Communication Intention Elicitation Intervention to Improve Supportive Oncology Care Delivery
The purpose of this study is to help test an idea designed to foster more supportive talk between providers (doctors or nurse practitioners), patients, and caregivers during an outpatient oncology appointment.
- Conditions
- Vulvar Cancer, Ovarian Cancer, Uterine Cancer, Vaginal Cancer
- Trial name
- PRECursOr (NCT05995860)
- Testing
- Intervention group triads
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- Indiana University
Pain
Effect of Lubricating Gel for Pain Relief During Speculum Examination in Gynecologic Oncology Patients
Pelvic examination, an important part of gynecologic oncology patients to help detect cancers recurrence or infections.Despite its importance, many women are reluctant and anxious about the procedure because of fear, as well as…
- Trial name
- NCT01987440
- Testing
- lubricating gel
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Erzincan Military Hospital
Sepsis
Dynamic Infection Kinetics for Early Diagnosis, Monitoring, and Prognostication of Sepsis in Adult Oncology Patients: Evaluating Serial Infection Biomarkers, Blood Culture Kinetics, Treatment Response, Disease Severity, and Clinical Outcomes
Dynamic Infection Kinetics as an Early Diagnostic and Monitoring Tool for Sepsis in Oncology Patients This study aims to evaluate whether changes over time in infection-related biomarkers and blood culture findings can help…
- Trial name
- NCT07795502
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Cancer, Solid Tumor
MNPR-101-PCTA-177Lu Expanded Access Program (EAP) for Patients With Solid Tumor Cancer
The purpose of this Expanded Access Program (EAP) is to allow use of the investigational therapeutic agent, MNPR-101-PCTA-177Lu, for treatment of urokinase plasminogen activator receptor (uPAR)-positive solid tumors identified…
- Conditions
- Cancer, Solid Tumor, Solid Tumor Cancer, Oncology
- Trial name
- NCT06980519
- Testing
- MNPR-101-PCTA-177Lu
- Where
- United States
- Sponsor
- Monopar Therapeutics
Advanced Cancer
International Study to Evaluate Two Programs of Support for Patients With Advanced Cancer and Their Families
The overall aim of this project is to evaluate the effectiveness, cost-effectiveness and mechanisms of action of two psychoeducational interventions (a face-to-face nurse-led intervention called FOCUS+ and an eHealth intervention…
- Trial name
- DIAdIC (NCT04626349)
- Testing
- FOCUS+ (face-to-face nurse-led intervention), iFOCUS (web-based intervention)
- Where
- 13 sites in Belgium, Denmark and 4 more
- Volunteers
- 431 people
- Sponsor
- Vrije Universiteit Brussel
Rehabilitation Exercise, Oncologic Diseases
Home-Based Physiotherapy in Oncology
The goal of this clinical trial is to assess the feasibility, acceptability, and safety of a supervised home-based physiotherapy programme for adult oncology patients.
- Trial name
- NCT07440433
- Testing
- Home-based cycling + resistance training with physiotherapist supervision
- Where
- Switzerland
- Volunteers
- 21 people
- Sponsor
- University Hospital, Geneva
Anthracyclines-Induced Cardiotoxicity, Cardiotoxicity
Dapagliflozin to Prevent Anthracycline-Induced Cardiotoxicity
Anthracyclines, such as doxorubicin, are effective anticancer agents but may cause dose-dependent cardiac injury, including early changes in left ventricular function and cardiac biomarkers.
- Trial name
- DAPA-AIC (NCT06888505)
- Testing
- Dapagliflozin (Forxiga)
- Where
- Iraq
- Volunteers
- 94 people
- Sponsor
- Hawler Medical University
Cancer, Quality of Life
Integrative Care Training Program for Nurses on Supportive Cancer Care
The integration of complementary medicine in supportive and palliative cancer care (i.e., Integrative Oncology) is becoming more prevalent in many of the leading oncology centers in Israel and worldwide.
- Conditions
- Cancer, Quality of Life, Nurse's Role
- Trial name
- NCT03676153
- Testing
- Nurse-provided guidance, Integrative medicine treatment program
- Where
- Israel
- Volunteers
- 363 people
- Sponsor
- Carmel Medical Center
Music Therapy, General Anesthesia
Intraoperative Music Therapy in Gynecological Oncology
Background Perioperative anxiety and postoperative pain can impact surgical morbidity. We aimed to evaluate the effect of intraoperative music therapy in the reduction of immediate postoperative pain in patients undergoing…
- Conditions
- Music Therapy, General Anesthesia, Surgery, Pain
- Trial name
- NCT04694508
- Testing
- Headphones (Disok, Alicante, España)
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Serious Adverse Events, Patient Safety
Chemokeyp: A Feasibility Study for Realtime Safety Data-Capture for Potential Serious Adverse Drug Events
Chemokeyp is a feasibility study testing a secure ED-Oncology interface for patients receiving chemotherapy who may present to unscheduled care with possible treatment-related complications.
- Conditions
- Serious Adverse Events, Patient Safety, Pharmacovigilance, Oncology
- Trial name
- NCT07592234
- Where
- Ireland
- Volunteers
- 100 people
- Sponsor
- St Vincent's University Hospital, Ireland
Cancer, Neoplasm Metastasis
ECI301 and Radiation for Advanced or Metastatic Cancer
Background: ECI301 is a drug that may help make cancer cells more visible to the immune system after radiation. The drug may also help the immune system destroy the cancer at sites that have not received radiation therapy.
- Conditions
- Cancer, Neoplasm Metastasis, Radiation Oncology, Neoplasm
- Trial name
- NCT01441115
- Testing
- Radiation Therapy, ECI301
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer
Comprehensive Patient Reported Outcomes (PRO) Management for Oncology Practice
Cancer symptoms due to disease progression or side effects caused by cancer treatment are prevalent. Most cancer patients are treated in outpatient settings.
- Trial name
- NCT01108315
- Testing
- Report symptoms via web or phone-based system
- Where
- 2 sites in United States
- Volunteers
- 138 people
- Sponsor
- BrightOutcome