Clinical trials: Former Smokers
High-risk Lung Nodules
Immunoprevention for High-risk Lung Lesions
The main purpose of this study is to assess nadunolimab as an immunoprevention strategy for high-risk lung nodules in participants who are current or former tobacco smokers. The study may last up to 5 years for each participant.
- Trial name
- NCT07284485
- Testing
- Nadunolimab
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Robert Samstein
Smoking Cessation, Pregnancy
Preliminary Effectiveness of Enhanced Text Message + Incentives
This study is a preliminary evaluation of a smoking cessation intervention designed for pregnant women that combines text message support and financial incentives.
- Trial name
- NCT07420621
- Testing
- Text Messages, Incentives
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Kansas Medical Center
Non-small Cell Lung Cancer
Pemetrexed (ALIMTA) and Gefitinib (IRESSA®) in Never-Smoker and Adenocarcinoma Patients With Non-Small Cell Lung Cancer Previously Treated With Platinum-Based Chemotherapy
Pemetrexed was known to be effective to pulmonary adenocarcinoma and gefitinib was known to be more effective to non-small cell lung cancer (NSCLC) patients with clinical characteristics such as adenocarcinoma, never smoker and…
- Trial name
- NCT01066195
- Testing
- iressa, alimta
- Where
- South Korea
- Volunteers
- 129 people
- Sponsor
- Samsung Medical Center
Chronic Obstructive Pulmonary Disease
QVA Mechanistic Efficacy Study (Receptor Effects, Etc)
The purpose of this study was to assess global ventilated lung volume in moderate to severe COPD patients using MRI lung imaging after treatment with QVA149 compared to placebo.
- Trial name
- NCT02634983
- Testing
- QVA149
- Where
- 3 sites in United Kingdom
- Volunteers
- 31 people
- Sponsor
- Novartis Pharmaceuticals
Non-small Cell Lung Cancer, Squamous Lung Dysplasia
Inositol in Preventing Lung Cancer in Current or Former Smokers With Bronchial Dysplasia
This randomized phase II trial is studying inositol to see how well it works compared with a placebo in preventing lung cancer in current or former smokers with bronchial dysplasia.
- Trial name
- NCT00783705
- Testing
- inositol
- Where
- 4 sites in United States, Canada
- Volunteers
- 85 people
- Sponsor
- National Cancer Institute (NCI)
Lung Diseases
Effect of the Mediterranean Diet on Lung Function in Smokers Without Previous Respiratory Disease
Several studies have shown the influence of the eating pattern on lung function. However, the benefits of the Mediterranean diet (DiMet) in preventing pulmonary dysfunction are not well known.
- Trial name
- MEDISTAR (NCT03362372)
- Testing
- Mediterranean diet counseling
- Where
- Spain
- Volunteers
- 566 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Lung Carcinoma
Feasibility of Cell-Free DNA Liquid Biopsy in Screening High-Risk Patients for Lung Cancer
This clinical trial investigates how practical and doable (feasibility) cell-free deoxyribonucleic acid (DNA) liquid biopsy is in screening high-risk patients for lung cancer.
- Trial name
- NCT05384769
- Testing
- Liquid Biopsy, Low Dose Computed Tomography of the Chest, Survey Administration
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Smoking Cessation
Implementation of Smoking Cessation Within NCI Community Oncology Research Program (NCORP) Sites
Evaluate a multi-faceted training program to improve short-term smoking cessation rates (<14 days post-visit) and short (3 months) and sustained abstinence (6 months) among 1,114 enrolled smokers who present for low-dose computed…
- Trial name
- OaSiS (NCT03291587)
- Testing
- Personnel Training and Coaching Calls
- Where
- 49 sites in United States
- Volunteers
- 1,094 people
- Sponsor
- Wake Forest University Health Sciences
Head and Neck Neoplasms
Smoking Cessation in Head and Neck Cancer Patients Receiving Curative Radiation Therapy
To propose a feasibility study of introducing a smoking cessation program in head and neck cancer patients with planned radiotherapy.
- Trial name
- NCT02251730
- Testing
- Smoking cessation
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- National Taiwan University Hospital
Recurrent Non-small Cell Lung Cancer, Stage IIIB Non-small Cell Lung Cancer
Celecoxib and Erlotinib in Treating Former Smokers With Stage IIIB or Stage IV Non-Small Cell Lung Cancer
This phase I trial is studying the side effects and best dose of celecoxib when given together with erlotinib in treating former smokers with stage IIIB, stage IV, recurrent, or progressive non-small cell lung cancer.
- Conditions
- Recurrent Non-small Cell Lung Cancer, Stage IIIB Non-small Cell Lung Cancer, Stage IV Non-small Cell Lung Cancer
- Trial name
- NCT00088959
- Testing
- erlotinib hydrochloride, celecoxib, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Cancer Institute (NCI)
Smoking Cessation
Escape Smoke Project: Non-Intervention Non-Drug Multicenter Study on the Real-life Effectiveness of Smoking Cessation in General Practice in Denmark
Real life smoking cessation rates after 24 weeks non-intervention design. Approximately 40 General Practice (GP) centers with 800 smokers will participate.
- Trial name
- ESCAPE SMOKE (NCT01544621)
- Testing
- Smoking cessation
- Volunteers
- 544 people, healthy volunteers welcome
- Sponsor
- Pfizer
Smoking, Pain
Pain and Smoking Study 2.0: A Randomized Clinical Trial of Smoking Cessation Among Veterans With Chronic Pain
PASS2 aims to expand upon the recently completed study (PASS intervention), which tested the telephone delivery of a cognitive behavioral intervention (CBI).
- Conditions
- Smoking, Pain, Smoking Cessation
- Trial name
- PASS2 (NCT06442514)
- Testing
- PASS2, Treatment as Usual
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- VA Office of Research and Development
Chronic Obstructive Pulmonary Disease
Indoor Air Quality and Respiratory Symptoms in Former Smokers
The investigators will conduct a randomized, controlled, double-blind, crossover trial to determine whether the presence of a portable high-efficiency indoor air filter in the bedroom reduces respiratory symptoms in former…
- Trial name
- NCT02956213
- Testing
- HEPA portable air filter
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Intermountain Health Care, Inc.
Non Small Cell Lung Cancer
A Study of Alimta/Cisplatin/Gefitinib for Asian Non-smoking Participants With Non Small Cell Lung Cancer
The purpose of this study is to compare two different approaches to treating non-small cell lung cancer (NSCLC) in East Asian never-smoker participants.
- Trial name
- NCT01017874
- Testing
- Pemetrexed, Cisplatin, Gefitinib
- Where
- 12 sites in Hong Kong, Singapore and 3 more
- Volunteers
- 236 people
- Sponsor
- Eli Lilly and Company
Smoking Cessation, Diabetes
Efficacy And Safety Of Smoking Cessation With Varenicline Tartrate In Diabetic Smokers: (DIASMOKE)
Objectives This protocol is intended to provide information regarding the efficacy and safety of the nicotine partial agonist varenicline tartrate, at a dose of 1 mg twice daily, for smoking cessation in diabetic subjects who…
- Trial name
- DIASMOKE (NCT01387425)
- Testing
- varenicline
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- University of Catania
Smoking Cessation, Metabolic Syndrome
Short Term Effect of Smoking Cessation on Human Metabolism
Investigating the short term smoking cessation on metabolism, examining of participant of smoking cessation workshops and former participants' file survey for metabolic aspects
- Trial name
- NCT03446183
- Testing
- Smoking cessation workshops
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- Hebrew University of Jerusalem
Alcoholism, Smoking
Smoking Cessation in Alcoholism Treatment
This study is designed to increase understanding of the processes that affect the treatment outcome of individuals with both alcohol and nicotine dependence.
- Trial name
- NCT00000454
- Testing
- nicotine replacement patch
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Yale University
Current Smoker, Never Smoker
Effects of Electronic Cigarette Use on the Lungs
This randomized pilot clinical trial studies the effects of electronic cigarettes on the lungs. Studying the effects of electronic cigarettes on the lungs may provide the Food and Drug Administration (FDA) and other government…
- Conditions
- Current Smoker, Never Smoker, Tobacco Use Disorder, Former Smoker
- Trial name
- NCT02596685
- Testing
- Bronchoscopy, Electronic Cigarette, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
COPD (Chronic Obstructive Pulmonary Disease)
RETHINC: REdefining THerapy In Early COPD for the Pulmonary Trials Cooperative
The study hypothesis is that symptomatic current and former smokers with spirometric values within the normal range (post-bronchodilator FEV1/FVC≥0.70 and post-BD FVC ≥ 70% predicted will still derive symptomatic benefit from…
- Trial name
- RETHINC (NCT02867761)
- Testing
- Indacaterol/Glycopyrrolate
- Where
- 16 sites in United States
- Volunteers
- 780 people
- Sponsor
- University of Michigan
Smokers, Former Smokers
A Study of Exercise and Pharmacologic Intervention on Systemic Inflammation
This is a study assessing the feasibility of performing an anti-aging intervention which is a combination of an exercise regimen, spermidine supplementation, and either rapamycin or lamivudine.
- Trial name
- NCT07058974
- Testing
- lamivudine, rapamycin, Exercise Regimen
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Icahn School of Medicine at Mount Sinai