Clinical trials: Fournier's Gangrene
Necrotizing Soft Tissue Infection, Necrotizing Fasciitis
Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial
The purpose of this study is to estimate the effect of intravenous polyspecific immunoglobulin G (IVIG) compared with placebo (saline) on the patient-reported outcome measure Physical Component Summary Score (PCS) of the SF-36 in…
- Conditions
- Necrotizing Soft Tissue Infection, Necrotizing Fasciitis, Gas Gangrene, Fournier Gangrene
- Trial name
- INSTINCT (NCT02111161)
- Testing
- IVIG (Privigen), Saline 0.9%
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Anders Perner
Necrotizing Soft Tissue Infection, Necrotizing Fasciitis
Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen Treatment
The purpose of this study is to investigate the effects of hyperic oxygen treatment on the immune response in patients with necrotizing soft tissue infections
- Conditions
- Necrotizing Soft Tissue Infection, Necrotizing Fasciitis, Gas Gangrene, Fournier Gangrene
- Trial name
- BIONEC-II (NCT02501382)
- Where
- Denmark
- Volunteers
- 65 people
- Sponsor
- Ole Hyldegaard
Fasciitis, Necrotizing
Exploratory Study of Raised Serum Lactate as a Marker of Necrotizing Fasciitis
The investigators examined the hypothesis that serum lactate is raised in early necrotizing fasciitis to a much greater extent than in other differential diagnoses, such as severe cellulitis, and therefore provides a diagnostic…
- Trial name
- NCT01739959
- Where
- United Kingdom
- Volunteers
- 53 people
- Sponsor
- National Health Service, United Kingdom
Necrotizing Soft Tissue Infection, Necrotizing Fasciitis
Biomarkers in Patients With Flesh-eating Bacterial Infections
The purpose of this study is to investigate the immune response in patients with necrotizing soft tissue infections (NSTI). The investigation will focus on inflammatory and vasoactive biomarkers as prognostic markers of severity…
- Conditions
- Necrotizing Soft Tissue Infection, Necrotizing Fasciitis, Gas Gangrene, Fournier Gangrene
- Trial name
- BIONEC (NCT02180906)
- Where
- Denmark
- Volunteers
- 169 people
- Sponsor
- Ole Hyldegaard
Necrotizing Soft Tissue Infection, Fournier Gangrene
Necrotizing Soft Tissue Infections
SnapNSTI is an international, multicenter, time-bound prospective observational cohort study designed to characterize current epidemiology, management patterns, and outcomes of patients with necrotizing soft-tissue infections…
- Conditions
- Necrotizing Soft Tissue Infection, Fournier Gangrene, Sepsis, Surgical Infection
- Trial name
- SnapNSTI (NCT07107555)
- Where
- Spain
- Volunteers
- 480 people
- Sponsor
- European Society for Trauma and Emergency Surgery
Fournier Gangrene, Perianal Abscess
The Immunological Differences Between Fournier Gangrene and Perianal Abscess
Although it is rarely observed, necrotizing fasciitis progresses with high mortality and serious complications. Fournier's gangrene is a specific form of necrotizing fasciitis.
- Trial name
- NCT05529628
- Testing
- Cytokine levels
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Istanbul Training and Research Hospital
Necrotizing Soft Tissue Infections, Necrotizing Fasciitis
Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue Infections
The purpose of this study is to determine whether AB103 is safe and effective in the treatment of patients with necrotizing soft tissue infections (NSTI) receiving standard of care therapy.
- Conditions
- Necrotizing Soft Tissue Infections, Necrotizing Fasciitis, Fournier's Gangrene
- Trial name
- ACCUTE (NCT02469857)
- Testing
- AB103 0.5 mg/kg, NaCl 0.9%
- Where
- 71 sites in United States, France
- Volunteers
- 290 people
- Sponsor
- Atox Bio Ltd
Fournier Gangrene, Fournier's Gangrene of Penis
Fournier's Gangrene and the Origin of the Infection as a Prognostic of Morbidity and Mortality, an Analysis of 121 Patients
Background: Fournier's gangrene it's a necrotizing infection of the genital area, with high morbidity and mortality. The site of infection its the origin of the necrotizing fasciitis.
- Conditions
- Fournier Gangrene, Fournier's Gangrene of Penis, Fournier's Gangrene of Scrotum
- Trial name
- NCT03443544
- Testing
- Aggressive debridement
- Where
- Mexico
- Volunteers
- 121 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Necrotizing Fascitis, Fournier Gangrene
FATAL-NSTI Study (Factors Associated With In-hospital mortALity in NSTI).
Necrotizing soft tissue infections (NSTIs) are rare but potentially life-threatening infections involving the skin and underlying tissues such as fat, fascia, and sometimes muscle.
- Conditions
- Necrotizing Fascitis, Fournier Gangrene, Fournier's Gangrene, Soft Tissue Infections
- Trial name
- FATAL-NSTI (NCT07359651)
- Testing
- No Intervention: Observational Cohort
- Where
- 4 sites in Italy
- Volunteers
- 300 people
- Sponsor
- University of Cagliari
Tissue Repair, Soft Tissue Reconstruction
Urinary Bladder Matrix (UBM) Registry
The purpose of this registry is to collect real-world information on patients treated with Urinary Bladder Matrix (UBM) products.
- Conditions
- Tissue Repair, Soft Tissue Reconstruction, Wound Management, Pressure Ulcer (PU)
- Trial name
- NCT07805798
- Testing
- Urinary Bladder Matrix (UBM) Products
- Volunteers
- 300 people
- Sponsor
- Integra LifeSciences Corporation
Necrotizing Soft Tissue Infection, Necrotizing Fascitis
Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study
The investigators will analyze biomarkers related to the prognosis and treatment of necrotizing soft tissue infections (NSTI). The focus will be on whether certain endothelial and immune system biomarkers can function as markers…
- Conditions
- Necrotizing Soft Tissue Infection, Necrotizing Fascitis, Gas Gangrene, Fournier Gangrene
- Trial name
- ProTreat (NCT03147352)
- Testing
- Hyperbaric oxygen therapy
- Where
- Denmark
- Volunteers
- 260 people
- Sponsor
- Ole Hyldegaard
Fasciitis, Necrotizing, Severe Necrotizing Skin and Soft Tissue Infections
Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue Infections
Daptomycin is a new antimicrobial agent which has activity against resistant Gram positive cocci including MRSA. The phase 3 clinical trials for skin and soft tissue infections (SSTI) with Staphylococci and Streptococci have…
- Conditions
- Fasciitis, Necrotizing, Severe Necrotizing Skin and Soft Tissue Infections, Fournier's Gangrene
- Trial name
- NCT00261807
- Testing
- Daptomycin 6mg/kg/day
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Maryland, Baltimore
Fournier Gangrene
Management of Fournier Gangrene at Ibn Rochd University Hospital Center
Case series with retrospective data collection of patients treated for Fournier's gangrene between January 2010 and March 2017. The main etiologies, risk factors, postoperative complications outcomes and long term follow up…
- Trial name
- NCT04983056
- Testing
- Necrotesectomy associated with cleanleness stoma
- Volunteers
- 84 people
- Sponsor
- Sylvestre KABURA
Fournier Gangrene
Fournier's Gangrene in Patient With Uncontrolled Type 2 Diabetes
A 66-year-old man, with a history of uncontrolled type 2 diabetes, obesity with BMI 38, chronic kidney failure and chronic heart failure, was admitted to the Emergency Department with a large area of necrosis involving the…
- Trial name
- NCT04694053
- Testing
- surgical debridement
- Where
- Italy
- Volunteers
- 1 people
- Sponsor
- University of Catania
Necrotizing Fasciitis, Fournier Gangrene
SKin and Soft Tissue Necrotizing INfections in the Intensive Care Unit: a Prospective Multi-national Cohort Study
Necrotizing soft-tissue infections (NSTI) are rare and life-threatening bacterial infections characterized by subcutaneous tissue, fascia or muscle necrosis.
- Conditions
- Necrotizing Fasciitis, Fournier Gangrene, Necrotizing Soft Tissue Infection
- Trial name
- SKIN-ICU (NCT05116956)
- Testing
- non interventional
- Where
- France
- Volunteers
- 1,033 people
- Sponsor
- Henri Mondor University Hospital