Clinical trials: Fracture Non Union
Long Bone Non-Union
Study on Autologous Osteoblastic Cells Implantation in Hypotrophic Non-Union Fractures
Fracture healing is a complex physiological process caused by interaction of cellular elements, cytokines and signaling proteins, which results in the formation of new bone (Gerstenfeld et al., 2003).
- Trial name
- NCT01756326
- Testing
- PREOB® Implantation, Bone Autograft
- Where
- 16 sites in Belgium, France and 1 more
- Volunteers
- 5 people
- Sponsor
- Bone Therapeutics S.A
Osteoarthritis, Knee, Fractures, Ununited
Modern Methods of Treatment and Diagnosis of Patients With Injuries and Diseases of the Musculoskeletal System
Brief Summary This clinical study investigates the safety and effectiveness of combining advanced regenerative therapies with personalized surgical technology for patients with delayed fracture healing (non-unions), knee…
- Conditions
- Osteoarthritis, Knee, Fractures, Ununited, Arthroplasty, Replacement, Knee
- Trial name
- MTDMS (NCT07628010)
- Testing
- Autologous Mesenchymal Stromal Cells Combined with Platelet-Rich Plasma, Patient-Specific 3D-Printed Surgical Instruments
- Where
- Ukraine
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zaporizhzhiya State Medical University
Tibial Fractures, Nonunion of Fracture
Intramedullary Bone Grafting for Open Tibial Shaft Fractures
This study will examine if there is a difference between the time to full union between the control group and the study group. Each group will be composed of patients who have an open fracture in the mid tibia.
- Conditions
- Tibial Fractures, Nonunion of Fracture, Delayed Union of Fracture
- Trial name
- NCT03891888
- Testing
- Intramedullary Bone Graft
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of Louisville
Nonunion of Fracture
Evaluation the Treatment of Nonunion of Long Bone Fracture of Lower Extremities (Femur and Tibia) Using Mononuclear Stem Cells From the Iliac Wing Within a 3-D Tissue Engineered Scaffold
Because the rate of non union of long bone in lower extremities specially in tibia in this two last decade due to malnutrition and smoking and other risk factors was increased, so many patient in our country suffer from non…
- Trial name
- NCT01958502
- Testing
- surgical treatment of non union with mesenchymal stem cells with BMP2 within a 3-D tissue engineered scaffold
- Where
- Iran
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Emdadi Kamyab Hospital
Fracture, Fracture Nonunion
Relationships Between Vitamin D and Orthopedic Trauma
Vitamin D is an essential hormone involved in bone metabolism, bone mineral density maintenance, and bone health. Vitamin D deficiency is putatively linked to poor pediatric orthopedic outcomes [1].
- Conditions
- Fracture, Fracture Nonunion, Fractures, Bone, Vitamin D
- Trial name
- NCT04564625
- Testing
- Vitamin D Assessment, Fracture
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Methodist Health System
Nonunion of Fracture [Pseudarthrosis], Site Unspecified
Validation of Laboratory Test for Predicting Bone Tissue Regeneration
The aim of the study is to determine whether the evaluation of pro-osteogenic activity of autologous serum may predict the effectiveness of platelet gel in regenerating bone tissue in patients with nonunions of long bones.
- Trial name
- Rebone-test (NCT01362413)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteomyelitis, Bone Infection
Clinical Effectiveness of S53P4 Bioactive Glass in Treatment of Long-bone Chronic Osteomyelitis
This clinical trial studies the clinical effectiveness of S53P4 bioactive glass (BAG) as a bacterial growth inhibiting bone graft substitute in a one-stage or two-stage surgical procedure for treatment of chronic long bone…
- Conditions
- Osteomyelitis, Bone Infection, Non-Union Fracture, Bone Infection of Lower Leg
- Trial name
- NCT04945434
- Testing
- S53P4 bioactive glass (BonAlive)
- Volunteers
- 78 people
- Sponsor
- Academisch Ziekenhuis Maastricht
Pseudarthrosis, Clavicle Fracture
Descriptive Single-center Retrospective Study of a Series of Cases of Clavicle Pseudarthrosis: Epidemiology, Surgical Management, and Functional Outcomes
1. Study identification Study title: PSEUDO-CLAV - Single-center retrospective descriptive study of clavicle nonunion (pseudarthrosis): epidemiology, surgical management, and functional outcomes PSEUDO-clav_Notice non oppositi……
- Conditions
- Pseudarthrosis, Clavicle Fracture, Clavicle Fracture, Non Union/Malunion
- Trial name
- PSEUDO-CLAV (NCT07414654)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Brest
Pseudoarthrosis of Bone, Implant Breakage
Corticalisation After Femoral Nail Dynamization in Hypertrophic Non-unions
In 12 patients with corticalization and hypertrophic pseudarthrosis were present after dynamization, the old nail was removed and nail exchange was performed with a longer and larger diameter nail to pass the region formed in the…
- Trial name
- NCT05423561
- Testing
- exchange nailing with larger, thicker nail crossing corticalization
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Vertebral Fracture, Vertebral Trauma
CT Guided Percutaneous Vertebroplasty for Vertebral Non-union Following Posterior Fixation
Traumatic thoracolumbar vertebral fractures are frequently treated with posterior fixation (PF) and vertebral augmentation, but sometimes vertebral augmentation is not performed, being judged too risky under fluoroscopic guidance…
- Trial name
- NCT05071625
- Testing
- percutaneous vertebroplasty
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Femur Distal Fracture, Nonunion of Fracture
Distal Femur Fracture Nonunion - Statistical Analysis Plan
Here the investigators describe the statistical analysis plan for the study assessing the prediction of fracture nonunion leading to secondary surgery in patients with distal femur fractures.
- Trial name
- NCT05163795
- Testing
- Lateral locking plate
- Where
- Finland
- Volunteers
- 299 people
- Sponsor
- Töölö Hospital
Pseudarthrosis, Fractures, Ununited
Treatment of Atrophic Nonunion by Preosteoblast Cells
Treatment of nonunion, delayed union and malunion fractures of long bones remains problematic. The definition of nonunion is a failure of the fracture to heal in six months in a patient in whom progressive repair had not been…
- Trial name
- NCT00916981
- Testing
- percutaneous autologous preosteoblast cells implantation
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Jean-Philippe Hauzeur
Bone Fracture
Autologous BM-MSC Transplantation in Combination With Platelet Lysate (PL) for Nonunion Treatment
Nonunion of long bones would occur in almost 10% of fractures and because of its long term and complicated treatment, is known as a therapeutic challenge for both of the surgeons and patients.
- Trial name
- NCT02448849
- Testing
- Percutaneous injection
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Royan Institute
Nonunion Fracture
Treatment of Nonunion of Limb Fracture With Human Amniotic Epithelial Cells（hAECs）
The purpose of this study is to evaluate the efficacy and safety of human amniotic epithelial cells transplant in nonunion of limb fracture patients.
- Trial name
- NCT03031509
- Testing
- Human Amniotic Epithelial Cells, debridement
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Shanghai East Hospital
Osteoarthritis, Traumatic Arthritis
Actis Total Hip System 2 Year Follow-up
Two-year (2 year) information regarding the performance of the commercially available Actis™ Total Hip System in order to obtain and evaluate the clinical outcomes on a series of cementless primary total hip arthroplasty (THA)…
- Conditions
- Osteoarthritis, Traumatic Arthritis, Rheumatoid Arthritis, Congenital Hip Dysplasia
- Trial name
- Actis14014 (NCT02783274)
- Testing
- Actis Total Hip System
- Where
- 9 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- DePuy Orthopaedics
Nonunion of Bone Graft, Fractures Non Union
Reamer Irrigator Aspirator (RIA) vs Autogenous Iliac Crest Bone Graft (AICBG) for the Treatment of Non-unions
The specific question the investigators will seek to answer is: can the Reamer Irrigator Aspirator (RIA) provide a bone graft source for the treatment of nonunions that is equally effective to Autogenous Iliac Crest Bone Graft…
- Trial name
- NCT01382485
- Testing
- RIA harvesting group, AICBG harvesting group
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- Unity Health Toronto
Hypovitaminosis D
The Effect of Hypovitaminosis D and Vitamin D Supplementation on Fracture Nonunion Rates
The purpose of the study is to determine whether vitamin D supplementation in patients with hypovitaminosis D can decrease nonunion (failure to heal) incidence in patients with fractures of the humerus, femur, or tibia.
- Trial name
- VitD (NCT01691833)
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- Wake Forest University Health Sciences
Nonunion Fracture
The Efficacy of Mesenchymal Stem Cells for Stimulate the Union in Treatment of Non-united Tibial and Femoral Fractures in Shahid Kamyab Hospital
Because the rate of non union of long bone in lower extremities specially in tibia in this two last decade due to malnutrition and smoking and other risk factors was increased, so many patient in our country suffer from non union…
- Trial name
- NCT01788059
- Testing
- injection the mesenchymal stem cell in non union site
- Where
- Iran
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Emdadi Kamyab Hospital
Sternum Wound Infection, Nonunion of Fracture of Sternum
Sternal Closure With STERNUMFIX in Patients With High Risk
The primary objective is to establish if the SternumFix System improves sternal closure. The study should test the hypothesis that in a high risk patient population with increased risk for the development of sternal wound…
- Trial name
- STEPHIX (NCT01408745)
- Testing
- Sternumfix, steel wire
- Where
- 4 sites in Germany, Switzerland
- Volunteers
- 166 people
- Sponsor
- Aesculap AG
Fracture, Healed, Fibrous Union
Mid-term Outcome Following Revision Surgery of Clavicular Non- and Malunion
Background Treatment of clavicular non- and malunion is still challenging. Current surgical procedures often result in partially frustrating functional outcome along with high-grade subjective impairment and increased rates of…
- Trial name
- Nonunion (NCT02951468)
- Testing
- LCP plus iliac crest autograft
- Volunteers
- 14 people
- Sponsor
- Technical University of Munich