Clinical trials: Fracture Tibia
Fractures, Bone, Nonunion of Fracture
Safety, Efficacy, & Use of ViviGen Cellular Bone Matrix Allograft in Orthopaedic Fracture Care
Prospective registry and retrospective data collection study to assess the efficacy and safety of Vivigen Cellular Bone Matrix (Vivigen) in orthopaedic trauma patients who require bone grafting in the acute, delayed, non-union…
- Conditions
- Fractures, Bone, Nonunion of Fracture, Fractures, Open, Fractures, Ununited
- Trial name
- NCT04299022
- Testing
- Vivigen Cellular Bone Matrix
- Where
- 4 sites in United States
- Volunteers
- 250 people
- Sponsor
- LifeNet Health
Stress Fracture of Tibia or Fibula
Fracture Recovery for Returning to Duty (Teriparatide STRONG)
The project goals are to improve combat readiness of U.S. Soldiers and sustain the availability of the military to deploy by, 1) decreasing the number of days not physically ready for duty after diagnosis of a diaphyseal tibial…
- Trial name
- NCT04589819
- Testing
- Teriparatide
- Where
- United States
- Volunteers
- 183 people
- Sponsor
- University of South Carolina
Pseudarthrosis
rhBMP-2 vs Autologous Bone Grafting for the Treatment of Non-union of the Docking Site in Tibial Bone Transport
When there is a bone defect, bone transport is used to bridge the defect. Frequently, the bone in the docking site (where the transported bone comes together) doesn't heal.
- Trial name
- NCT01756144
- Testing
- rhBMP-2
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cystic Echinococcus
Periprosthetic Fracture Following Tibial Echinococcosis
Cystic Echinococcus in the bone is rare, comprising 0.5% to 2.5% of all human hydatidosis Association of Hydatid disease to pathologic fractures involving knee prosthesis have not yet been described A combined surgical and…
- Trial name
- NCT03622346
- Testing
- Semi-constrained total knee arthroplasty
- Volunteers
- 1 people
- Sponsor
- Centro Hospitalar do Medio Tejo
Tibial Plateau Fracture
Continuous Femoral Nerve Block With a Tibial Plateau Fracture
The primary purpose of the proposed study is to compare postoperative pain scores and total opioid consumption between two groups randomized to either receive or not receive a femoral nerve block for pain control following…
- Trial name
- NCT02168959
- Testing
- bupivacaine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Utah
Tibial Plateau Fracture
3D Virtual Planning for Tibial Plateau Fractures
Tibial plateau fractures are often complex fractures and need a good preoperative planning. The investigators think that a 3D virtual planning software will help the surgeons to get a better understanding of the fracture and…
- Trial name
- NCT05397327
- Testing
- 3D virtual planning software
- Where
- 3 sites in United States, Australia and 1 more
- Volunteers
- 70 people
- Sponsor
- Radboud University Medical Center
Reconstructive Surgical Procedure
Treatment of Compound Tibia Fracture With a Microvascular Latissimus Dorsi Flap and the Ilizarov Technique
This study assesses the long-term results of compound tibial reconstruction treated with a microvascular latissimus dorsi flap and bone transport technique during the last 25 year in Helsinki University central Hospital.
- Trial name
- NCT02369991
- Testing
- Reconstructive surgery
- Where
- Finland
- Volunteers
- 9 people
- Sponsor
- Helsinki University Central Hospital
Distal Tibial Fracture, Tibial Fracture
Elastic Nailing With Kirschner Wires Versus Plate Fixation for Distal Tibial Fractures in Adolescents
This prospective randomized controlled trial will compare two surgical methods for treating distal tibial metaphyseal-diaphyseal junction fractures in adolescents aged 10 to 16 years.
- Conditions
- Distal Tibial Fracture, Tibial Fracture, Fracture Fixation, Intramedullary, Fracture Fixation, Internal
- Trial name
- NCT07783529
- Testing
- Elastic Stable Intramedullary Nailing Supplemented by Kirschner Wires, Plate fixation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Femoral Fractures, Tibial Fractures
Depuy Synthes Lower Extremity Shaft Nail Registry
The purpose of this post-market registry is to monitor the clinical safety and performance (union rates and time to union) of two DePuy Synthes lower extremity shaft nails: RFN-Advanced Retrograde Femoral Nailing System (RFNA)…
- Trial name
- NCT05272631
- Testing
- Retrograde Femoral Nail Advanced, Tibial Nail Advanced
- Where
- 8 sites in United States
- Volunteers
- 241 people
- Sponsor
- DePuy Synthes Products, Inc.
Calcaneus Fracture
Posterior Tibial Nerve PRF for Painful Calcaneal Fracture
Patients who underwent pulsed radiofrequency (PRF) treatment of the posterior tibial nerve under ultrasound guidance, which is routinely performed in our clinic for severe heel pain following a calcaneal fracture, were evaluated…
- Trial name
- NCT06888804
- Testing
- ultrasound-guided posterior tibial nerve pulsed radiofrequency, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Diskapi Teaching and Research Hospital
Implant Infection
Long-term Coated and Non-coated Tibia Nails
For this retrospective cohort study, medical records of patients treated between 2005 to 2019 with the UTN PROtect and/or ETN PROtect for tibia fractures or tibia revision cases will be examined.
- Trial name
- NCT04576052
- Where
- Germany
- Volunteers
- 397 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Tibial Fractures
Comparison of Healing Measures Tibial Fractures Following Standard Intramedullary Nailing or Micromotion Tibial Intramedullary Nailing
The primary purpose of this study is to perform a high-quality randomized control trial comparing intramedullary tibial nail fixation with standard design nails to a micromotion tibial nail device, to evaluate the rates of union…
- Trial name
- NCT06679049
- Testing
- micromotion intramedullary nail cohort, standard intramedullary nail cohort
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Tibial Fractures
ACTiF- Assessment of Closed Tibial Fractures
The purpose of this study is to find out the good and bad effects of an investigational drug called CP-533,536 in patients with closed fracture of the tibial shaft undergoing internal fixation using reamed inter-locked IM nailing…
- Trial name
- NCT00533377
- Testing
- CP-533, 536, Standard of Care, CP-533,536
- Where
- 56 sites in United States, Australia and 9 more
- Volunteers
- 276 people
- Sponsor
- Pfizer
Proximal or Diaphyseal Humerus Fracture, Diaphyseal or Distal Femur Fracture
Observational Patient Registry of the Dynamic Locking Screws
The purpose of this multi-center patient registry is to obtain first clinical results and to assess short and mid-term clinical outcome data of patients treated with DLS.
- Conditions
- Proximal or Diaphyseal Humerus Fracture, Diaphyseal or Distal Femur Fracture, Diaphyseal, Distal or Proximal Tibia Fracture
- Trial name
- DLS (NCT02656628)
- Testing
- Dynamic Locking Screw 3.7mm and 5.0mm
- Where
- Australia
- Sponsor
- Synthes GmbH
Tibial Delayed Healing
Tibial Delayed Healing Pivotal Clinical Trial
Evaluate the INFUSE/MASTERGRAFT™ Delayed Healing Device as an alternative/replacement to autograft in the treatment of tibial delayed healing.
- Trial name
- NCT01016067
- Testing
- INFUSE/MASTERGRAFT, Autograft bone
- Where
- 16 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Medtronic Spinal and Biologics
Fracture of Tibia, Wound Heal
Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures
This is a multi-center, pragmatic, parallel arm randomized controlled trial (RCT) of 352 patients with high-risk open or closed tibial plateau fracture, high-risk open or closed tibial pilon fracture, or open tibial shaft…
- Conditions
- Fracture of Tibia, Wound Heal, Infected Wound, Wound Complication
- Trial name
- iVAC (NCT06337292)
- Testing
- Incisional Negative Pressure Wound Therapy (NPWT)
- Where
- 6 sites in United States
- Volunteers
- 352 people
- Sponsor
- Major Extremity Trauma Research Consortium
Tibial Fracture, Fracture of the Tibia Type AO/OTA 42
Fracture-Related Outcome Study for Operatively Treated Tibia Shaft Fractures
Approximately 1000 patients presenting with tibial shaft fractures (AO type 42) will be enrolled prospectively in this registry.
- Trial name
- FROST (NCT03598530)
- Testing
- Surgery
- Where
- 15 sites in United States, Belgium and 7 more
- Volunteers
- 1,000 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Tibia Fracture
Is the Expert Nail With Poller Screws Superior to the Distal Tibial Locked Plate in the Management of Short Oblique Distal Tibial Fractures?
Distal tibial fracture management is difficult because of poor blood supply resulted from subcutaneous location. Therefore, the study aims to compare expert intramedullary nail (IMN) with poller screws to the distal tibial locked…
- Trial name
- NCT06436365
- Testing
- Locking expert intramedullary nail fixation, Distal locked plate
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Kasr El Aini Hospital
Postoperative Pain, Postoperative Cognitive Dysfunction
S-ketamine Prevents Postoperative Pain and Cognitive Dysfunction After Tibial Fracture
Purpose: To explore effects of S-ketamine on postoperative pain and cognitive dysfunction after tibial fracture and orthopedic surgery.
- Trial name
- NCT04643132
- Testing
- Normal saline, S-ketamine (low-dose), S-ketamine (high-dose)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tianjin Medical University General Hospital
PCL - Posterior Cruciate Ligament Deficiency, Posterior Cruciate Ligament Tear
Multicenter Clinical Study on Robotic-Assisted Surgical Management of Posterior Cruciate Ligament Tibial Avulsion Fractures
The primary objective of this clinical trial is to evaluate the efficacy of robotic-assisted surgery in the management of posterior cruciate ligament (PCL) avulsion fractures involving the tibial insertion site of the cruciate…
- Conditions
- PCL - Posterior Cruciate Ligament Deficiency, Posterior Cruciate Ligament Tear, PCL - Posterior Cruciate Ligament Rupture
- Trial name
- NCT07575256
- Testing
- Surgical robot-assisted arthroscopic surgery, Open reduction and internal fixation surgery
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital