Clinical trials: Fragility
Muscle Mass, Muscle Strength
Multicomponent vs Pilates on Mass, Strength, and Physical Performance in Older Adults
Introduction: The aging process can result in several physiological changes, such as the loss of muscle mass, muscle strength, and physical performance, collectively defined as sarcopenia.
- Conditions
- Muscle Mass, Muscle Strength, Physical Performance
- Trial name
- versus (NCT06719505)
- Testing
- ME, PE
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual do Norte do Parana
Fragility
Testing the Effectiveness of an Occupation-based Cultural Intervention in Long-term Care
The goals of the proposed research were to: 1. describe the person and environment characteristics and activity patterns of residents in long-term care (LTC) facilities; 2.
- Trial name
- OBCHI (NCT03009851)
- Testing
- OBCHI
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Texas Woman's University
Multimodal Intervention, Fragility
Effectiveness of a Multi-component Physical Training in Hyper-fragile Elders: A Randomized Clinical Trial
Objective: To compare short-term and medium-term effectiveness of a multimodal program that integrates a program of therapeutic exercise, medication review, adequacy of diet and health education, compared with standard medical…
- Conditions
- Multimodal Intervention, Fragility, Other Metabolic Diseases, Physical Activity
- Trial name
- PowerA-01 (NCT02772952)
- Testing
- Control Intervention, Multimodal Intervention
- Where
- Spain
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Malaga
Fragility
Mobility Assessment & Follow-up in Frail Elderly: Clinic-technical Validation of a Smart Insole in Real Life
The investigators aim is to evaluate an instrument for supporting physical activity and monitors multiple parameters of frailty (a pre-disability condition) in frail elderly persons.
- Trial name
- RESPECT (NCT02316600)
- Testing
- smart insole
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Fragility
Investigation of a Link Between Heart Rate Variability and Frailty in Geriatric Patients
The aim of this study is the evaluation of differences in heart rate variability (both time- and frequency-domain) [a]: between frail and non-frail patients and [b] at the beginning and end of a geriatric therapy which included…
- Trial name
- NCT03585985
- Testing
- Standard patient monitor, Photoplethysmographie-Imaging (PPGI) + Infrared thermography (IRT)
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Aging
Effect of Topical Sulforaphane on Skin Fragility Seen in Skin Aging and With Ultraviolet Exposure
This study aims to compare the expression of keratins before and after application of sulforaphane (SF) to determine whether this agent alters skin fragility seen in both intrinsic and extrinsic skin aging and UV light exposure.
- Trial name
- NCT03126539
- Testing
- Sulforaphane, Narrow-band Ultraviolet B exposure, 4 mm skin punch biopsy
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Frailty, Frailty Syndrome
Prevalence, Determinants and Natural History of Frailty and Pre-frailty in Elderly People
Frailty syndrome (i.e. frailty) is a geriatric syndrome which relies on the reduction of multisystem reserve capacity. Frail people have a lower potential to respond to external stressors and various life incidents as well as…
- Conditions
- Frailty, Frailty Syndrome, Frail Elderly Syndrome, Fragility
- Trial name
- FRAILPOL (NCT04518423)
- Where
- Poland
- Volunteers
- 1,093 people, healthy volunteers welcome
- Sponsor
- The Opole University of Technology
Fragility
Biological Markers of Functional Effects of Physical Activity in an Elderly Population
Circulating biomarkers are promising tools for the early diagnosis of aging-associated pathologies. Inflammation and immunity are associated with the risk of sarcopenia and frailty in elderly patients.
- Trial name
- BIO-APAS (NCT04080063)
- Testing
- adapted physical activity
- Where
- France
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Fragility, Intensive Care Unit Syndrome
Fragility and Programmed Cardiovascular Surgery (EcoSarco)
Objectives: To characterize textural ultrasonographic biomarkers of the brachial biceps musculature, wrist flexors, quadriceps and anterior tibial muscle that allow the recognition of the muscular and functional status of…
- Trial name
- EcoSarco (NCT04110509)
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad Antonio de Nebrija
Sarcopenia
Sarcopenia Screening in Elderly Individuals
In this study, it is aimed to evaluate parameters such as sarcopenia screening, muscle mass measurement, loss of strength that may develop due to sarcopenia, loss of balance and related fall, decrease in functionality, fragility…
- Trial name
- NCT06012422
- Testing
- evaluation group
- Volunteers
- 843 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Age Related Osteoporosis, Fall
Effects of FRAX+SARC-F Pre-screening on Preventing Fragility Fracture and Fall in Community-dwelling Older Adults
Hip fragility fractures are a major threat to functional independence in older adults locally and globally. In Hong Kong, the prevalence of osteoporosis and osteopenia in people aged >50 years were reported to be as high as 37%…
- Trial name
- NCT04709393
- Testing
- FRAX+SARC-F questionnaire pre-screening
- Where
- Hong Kong
- Volunteers
- 2,956 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Hip Fractures
Fragility Fracture Integrated Rehabilitation Management (FIRM)
A number of studies for clinical pathway (CP) after hip fracture have been suggested to improve post-fracture outcome. However, CP is not carried out properly in most countries due to inadequate system and awareness, and lack of…
- Trial name
- FIRM (NCT03430193)
- Testing
- FIRM, Conventional rehabilitation
- Where
- South Korea
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Schizophrenia; Psychosis
The Fragility of Metaphors (FraMe): Learning, Loosing, and How to Train Them
Tracking down the difficulties in metaphor comprehension experienced by individuals with schizophrenia across different metaphor types and exploring the neurological correlates via EEG recording technique
- Trial name
- FRAME (NCT06375902)
- Testing
- PragmaCom
- Where
- Italy
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
COVID-19, Testosterone Deficiency
SARS-CoV-2, TESTOSTERONE AND MALE FRAGILITY
The hormonal environment (steroid, primarily) could have a very relevant pathophysiological role in association with SARS-CoV-2.
- Conditions
- COVID-19, Testosterone Deficiency, Infertility, Male
- Trial name
- PROTEGGIMI (NCT06177002)
- Testing
- Collection of biological data
- Where
- Italy
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Fragility Fracture
Hip Fracture Prevention Follow-up of Elderly Women in Primary Health Care
Researchers plan a 2022 follow-up of medical records data to investigate fracture incidence and survival for 1248 women, born 1902-1931, in a comparative fracture prevention study with 435 participants from an intervention area…
- Trial name
- HIP22 (NCT05269979)
- Testing
- Prevention of hip fractures
- Volunteers
- 1,248 people, healthy volunteers welcome
- Sponsor
- Kronoberg County Council
Bone Loss, Age-Related
Bone Fragility Study in Pediatric Population With Risk Factors
Low bone mass and osteoporosis are underdiagnosed in childhood in our environment and its prevalence is unknown. In most cases they are secondary to chronic diseases that conduct to a poor bone health condition and thereby a risk…
- Trial name
- NCT02751008
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Cholestasis, Red Cell Membrane and Enzyme Abnormalities
Osmotic Fragility in Red Blood Cells of Pediatric Patients With Cholestatic Liver Disease
Objective: The investigators propose to perform ektacytometry on 20 pediatric patients over age one with cholestatic liver diseases and a direct bilirubin level of greater than 2 gm/dl.
- Trial name
- NCT05582447
- Testing
- ektacytometry of red blood cells
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Fractures, Bone, Fragility
Factors Associated With Future Fractures in Middle-aged Men and Women
From prospectively collected health and life-style data and anthropometric data in the Malmo Diet and Cancer (MDC) cohort identify factors that predicts or are associated with forthcoming fracture in middle-aged men and women.
- Conditions
- Fractures, Bone, Fragility, Life Style
- Trial name
- MDCFract (NCT04151732)
- Testing
- Physical activity, alcohol, tobacco, Hormonal factors, Cardiovascular disease
- Where
- Sweden
- Volunteers
- 30,351 people, healthy volunteers welcome
- Sponsor
- Lund University
Skin Condition, Hair Fragility
Assessment of Anti-aging Efficacy of Marine Collagen Peptides
To assess the anti-aging efficacy of Marine Collagen Peptides on skin, hair and finger nails for human
- Conditions
- Skin Condition, Hair Fragility, Nails, Ingrown
- Trial name
- NCT06306105
- Testing
- Marine Collagen Peptides
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Aging
Acceptability Study of Sensor in Elderly People's House Living Alone (Fragility Box)
The Fragility box is a project lead by Mines de Saint-Etienne, Gérontopôle Auvergne-Rhône-Alpes (AURA) and Eovi Mcd Mutually to prevent autonomy loss in the elderly dwelling population.
- Trial name
- NCT04763811
- Testing
- Focus groups, Individual interviews
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne