Clinical trials: Free Radicals
Obesity, Adolescent, Oxidative Stress
Effects of Vitamin E Supplementation on Free Radicals and Fat Level of Obese Adolescence in Jakarta, Indonesia
This study evaluate supplementation of vitamin E (alpha-tocopherol) in obese adolescent. Half of the patient will receive vitamin E and the other half received placebo
- Trial name
- NCT03358524
- Testing
- Vitamin E 400 UNT
- Where
- Indonesia
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
High-Risk Cancer, Urothelial Carcinoma Bladder
Adjuvant Radiotherapy Versus Observation After Radical Cystectomy in High Risk Urothelial Bladder Cancer
This is a prospective randomized clinical trial in high risk urothelial bladder cancer to compare adjuvant radiotherapy versus observation after radical cyctectomy.
- Trial name
- NCT04740866
- Testing
- Adjuvant Radiotherapy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Modified Radical Mastectomy, Post Operative Pain, Acute
Comparıson of Analgesıc Effıcacy of Dıfferent Volumes of Serratus Posterior Superıor Intercostal Plane Block After Modıfıed Radıcal Mastectomy Surgery
The aim of researchers is to compare the effects of three different local anesthetic concentrations and volumes on opioid consumption, postoperative analgesic efficacy, and pain scores during ultrasound-guided SPSIP blocks in…
- Conditions
- Modified Radical Mastectomy, Post Operative Pain, Acute, Facial Plane Blocks
- Trial name
- NCT07670078
- Testing
- Serratus Posterior Superior Intercostal Plane (SPSIP) block 40 ml of 0.1875% bupivacaine, Serratus Posterior Superior Intercostal Plane (SPSIP) 50 ml of 0.15% bupivacaine, Serratus Posterior Superior Intercostal Plane (SPSIP) 30 ml of 0.25% bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Cumhuriyet University
Squamous Cell Carcinoma
Free Radical Level in SCC of Tongue Patients Tumor, Serum and Saliva
Study comparing level of free radicals in tumor tissue, blood serum and saliva in patients with Squamous Cell Carcinoma of tongue and mouth floor.
- Trial name
- NCT00426062
- Where
- Israel
- Sponsor
- Sheba Medical Center
Infertility, Male, Oxidative Stress
Menevit Study: Menevit Anti-Oxidant Therapy for the Treatment of Male Infertility
Oxidative stress related damage to sperm is believed to be a major cause of male infertility. The object of the Menevit study is to investigate the role of a novel anti-oxidant preparation (Menevit) on sperm function, embryo…
- Trial name
- NCT00100269
- Testing
- Menevit anti-oxidant
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Repromed
Breast Neoplasms
DFS and QOL After Modified Radical Mastectomy vs. Expanded Mckissock Surgery for EIC of the Breast
Extensive intraductal carcinoma of the breast refers to a type of breast cancer in which ≥ 25% of ductal carcinoma in situ is present in invasive tumors and there is a scattered distribution of ductal carcinoma in situ (DCIS) in…
- Trial name
- NCT04052893
- Testing
- Expanded Mckissock surgery, Modified radical mastectomy
- Where
- 3 sites in China
- Volunteers
- 200 people
- Sponsor
- Shengjing Hospital
Metastasis, Castration-resistant Prostate Cancer
Prognostic Role of Free Psa Ratio at Biochemical Recurrence After Radical Treatments for Prostate Cancer
Measurement of Free PSA ratio in patients after definitive radical treatment for prostate cancer, and assessment of whether post-treatment free PSA ratio can function as a biomarker for advanced disease in prostate cancer…
- Conditions
- Metastasis, Castration-resistant Prostate Cancer, Death
- Trial name
- FPSAR (NCT03927287)
- Testing
- Free PSA ratio test in patients after definitive treatment for localized prostate cancer
- Where
- Canada
- Volunteers
- 822 people
- Sponsor
- Rabin Medical Center
Cervical Cancer, Hysterectomy
Minimally Invasive Surgery Versus Open Radical Hysterectomy in Presumably Early Stage Cervical Cancer: a Retrospective Multicenter Non-inferiority Study Comparing Overall and Progression-free Survival.
The goal of this retrospective observational study with prospective follow-up is to compare the safety and treatment outcomes of radical laparoscopic hysterectomy (removal of the uterus with cervix) versus abdominal (open)…
- Trial name
- MOOSE (NCT07120529)
- Testing
- CT scan, Ultrasound scan (Transvaginal or Transabdominal), Gynecological examination
- Where
- 5 sites in Poland
- Volunteers
- 300 people
- Sponsor
- Medical University of Silesia
Amyotrophic Lateral Sclerosis (ALS)
Efficacy and Safety Study of MCI-186 for Treatment of Amyotrophic Lateral Sclerosis (ALS) Who Met Severity Classification III
The primary objective of this study is to evaluate the efficacy of 60mg of MCI-186 via intravenous drip once a day in patients with ALS whose severity is classified as grade III, based on the changes in the revised ALS functional…
- Trial name
- NCT00415519
- Testing
- MCI-186
- Volunteers
- 25 people
- Sponsor
- Shionogi
Bladder Cancer Requiring Cystectomy, Ureteral Stents
STENT X: a Randomized Trial to Assess Stent-free Radical Cystectomy
Radical Cystectomy (RC) remains the gold standard for localized muscle-invasive bladder cancer (MIBC); however, use of ureteral stents at time of surgery remains controversial without level 1 evidence to comment on risks or…
- Trial name
- NCT07655284
- Testing
- ureteral stents, no ureteral stent
- Where
- 2 sites in United States, Brazil
- Sponsor
- Brigham and Women's Hospital
Congestive Heart Failure
The Effect of Left Ventricular Filling Pressure on Pulmonary Clearance of Free Radical Loaded White Blood Cells and Platelets in Congestive Heart Failure Patients Before and After Biventricular Pacing
1. To assess whether a correlation exist between the degree of pulmonary clearance of free radical positive white bloodcells and platelets and the degree of pulmonary congestion in congestive heart failure (CHF) patients 2.
- Trial name
- OXIS-PACING (NCT00716885)
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Amsterdam UMC, location VUmc
Overweight and Obesity, Exertion; Excess
Effects of Ketogenic Diet in Divers Breathing Enriched Air Nitrox
Overweight divers face a challenging activity such as immersions, starting from a higher levels of circulating cytokines and oxidative stress.
- Conditions
- Overweight and Obesity, Exertion; Excess, Oxygen Toxicity
- Trial name
- NCT03114176
- Testing
- Ketogenic Diet
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Padova
Amyotrophic Lateral Sclerosis (ALS)
Efficacy and Safety Study of MCI-186 for Treatment of Amyotrophic Lateral Sclerosis (ALS)
The primary objective of this study is to confirm the efficacy of 60 mg of MCI-186 via intravenous drip once a day in patients with ALS based on the changes in the revised ALS functional rating scale (ALSFRS-R) scores after 24…
- Trial name
- NCT00330681
- Testing
- MCI-186
- Volunteers
- 206 people
- Sponsor
- Shionogi
Department of Anorectal Surgery, Changhai Hospital Affiliated to Naval Medical University
A Randomized, Controlled, Multicenter, Noninferiority Clinical Study of Perioperative and Oncological Safety in Patients With Rectal Cancer
Laparoscopic natural orifice specimen extraction surgery (NOSES) for low rectal cancer has a good minimally invasive effect. However, the NOSES prognosis studies are all small sample retrospective studies.
- Trial name
- NCT05503381
- Testing
- Laparoscopic radical resection of low rectal cancer with transanal specimens
- Volunteers
- 500 people
- Sponsor
- Changhai Hospital
Infertility, Male, Infertility
Measuring Free Radicals in Human Sperm Cells Related to Microbiota and Lifestyle Factors
The cause of infertility can be due to a female factor or a male factor. In case of a male factor, it is often due to poor semen quality. However, the cause of poor quality is often unknown.
- Trial name
- SIRIUS (NCT05514223)
- Testing
- Biomaterial collection for observational purpose
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- University Medical Center Groningen
Hepatocellular Carcinoma, Recurrence
Clinical Study of Antiviral and Aspirin Treatment in Liver Cancer After Radical Surgery
Evaluation the Treatment Outcome of Antiviral and Aspirin Treatment in Liver Cancer After Radical Surgery.
- Trial name
- NCT01936233
- Testing
- Aspirin, Lamivudine
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Fudan University
Stroke, Cerebral Infarction
Efficacy and Safety Study of Neu2000KWL for Acute Ischemic Stroke Patients Within 6 Hours of Onset
The purpose of the study is to explore safety and efficacy of Salfaprodil administration for patients with acute ischemic stroke within 6 hours of onset.
- Trial name
- Salfaprodil (NCT04486430)
- Testing
- Neu2000KWL
- Where
- China
- Volunteers
- 236 people
- Sponsor
- Beijing Tiantan Hospital
Urinary Incontinence, Stress
Tension-free Vaginal Tape (TVT) Versus Bulking Agent for the Treatment of Post Vulvectomy Urinary Incontinence
The surgical treatment of vulvar cancer is characterized by a radical approach as standard, often associated to an important rate of functional complications.
- Trial name
- NCT01148290
- Testing
- Tension free vaginal tape, Bulking agent injection
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University Magna Graecia
Skin Pigmentation, Free Radicals
EPR (Electron Paramagnetic Resonance) as Method of Non-invasive Characterization of Melanin Content in Skins With Different Phototypes
The aim of this study is to assess the signal of melanin using Electron Paramagnetic resonance (EPR). Melanin is a paramagnetic pigment detectable by EPR.
- Conditions
- Skin Pigmentation, Free Radicals, Phototype, Magnetic Resonance
- Trial name
- NCT04270903
- Testing
- EPR measurement
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Dyspepsia, Chronic Gastritis
Anti Free Radical & Anti Inflammatory Effect & Safety of Rebamipide in Chronic Gastritis
To study the anti free radical \& inflammatory effect and safety of Rebamipide in patients suffering of dyspepsia due to chronic gastritis.
- Trial name
- NCT00996788
- Testing
- Rebamipide
- Where
- Indonesia
- Volunteers
- 55 people
- Sponsor
- PT Otsuka Indonesia