Clinical trials: Free Tissue Flaps
Pain, Postoperative
Regional Anesthesia for Head and Neck Reconstruction
By utilizing regional anesthesia blocks at the surgery tissue donor sites, it can potentially reduce post-operative pain while also reducing the use of opioids.
- Trial name
- NCT04304716
- Testing
- Regional Anesthesia
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Free Tissue Flaps
Detection of Flap Ischemia Using Interstitial Glucose Monitor
A simple device that objectively assesses flap perfusion - either as a stand-alone tool or an adjunct to the current monitoring method - would be a tremendous improvement in detection of early postoperative flap ischemia and, in…
- Trial name
- NCT02604069
- Testing
- Continuous Glucose Monitor
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Peri-Implant Health, Peri-Implant Tissues
Comparison Between Free Gingival Graft and Palatal Pedicle Flap
Patients requiring KMW gain(mm) during uncovering surgery were included. Two surgical methods were compared: apically position flap with free gingival graft (FGG group) and the palatal pedicle flap with collagen matrix (PPF…
- Conditions
- Peri-Implant Health, Peri-Implant Tissues, Peri-implant Bone Level
- Trial name
- Pedicle (NCT06816680)
- Testing
- APF + FGG, PPF group
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Complication,Postoperative
Heparin Alone vs. Heparin-Aspirin Combo in Free Flap Survival
This randomized clinical trial aims to compare the effectiveness of heparin alone versus combination therapy of Heparin- Aspirin in improving free flap survival in patients undergoing reconstructive surgery.
- Trial name
- NCT06512233
- Testing
- LMW Heparin 5000 U/ML-Aspirin 75 MG, LMW Heparin 5000 U/ML
- Where
- Pakistan
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Head and Neck Disorder, Free Flap
Platelet-Rich Fibrin in the Healing of Regional and Free Flaps
Determine if the use of platelet-rich fibrin (PRF) versus historical treatment methods improves the post-operative management of healing complications from flap donor sites.
- Trial name
- NCT04023474
- Testing
- Platelet Rich Fibrin (PRF) Application
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Florida
Oncology
Pretreatment Quality of Life as a Predictor of Distant Metastasis-Free Survival and Overall Survival in Patients With Head and Neck Cancer
This study shed light on an under-researched area by examining the prognostic associations of pre-treatment QoL with overall survival and distant metastasis free survival among patients with head and neck cancer who underwent…
- Trial name
- NCT03290352
- Testing
- Questionnaire
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Reconstructive Surgery After Carcinological Excision
Evaluation of the Interest of the Neurorrhaphy in Resensitizing Free Flaps
The surgical procedure consists in removing a tumor of the oral cavity and then repairing the oral defect by the use of a free flap.
- Trial name
- NCT03677349
- Testing
- neurorrhaphy
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Head and Neck Cancer, Healthy
Non-invasive Preoperative Tissue Evaluation in Head and Neck Tumor Patients Using Multispectral Optoacoustic Tomography (MSOT)
Multispectral Optoacoustic Tomography (MSOT) is a promising imaging technology that utilizes pulsed laser light. One of the key capabilities of this technology is measuring oxygenation within human tissue.
- Trial name
- msotcmfflap (NCT06716892)
- Testing
- Multispectral Optoacoustic Tomography (MSOT)
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Surgery, Fluorescence
ICG Indocyanine Green in Reconstructive Surgery
The success or failure of a reconstruction is largely related to the vascularization of the operated area. Near infrared fluorescence (also near infrared fluorescence angiography, NIR FA) with ICG administration is an innovative…
- Trial name
- ICG-R (NCT06129669)
- Testing
- Indocyanine green
- Where
- Netherlands
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Keratinized Mucosa, Dental Implants
Procedures for Improving the Mucosa Around Implants
This research study is looking at three different procedures for improving the oral mucosa (membrane) around dental implants. The three procedures will be the standard procedure, the standard procedure with the use of tissue…
- Trial name
- NCT01944267
- Testing
- Apically positioned flap, Free Gingival Graft, apically positioned flap with Mucograft
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tufts University
Anesthesia, Local, Surgery
Regional Anesthesia Block in Fibula Free Flap Reconstruction
Despite many recent advances in pain management, post-operative pain is widely considered to be poorly managed. Furthermore, the mainstay of current pain management is opioids, for which there is strong evidence of ill effects…
- Conditions
- Anesthesia, Local, Surgery, Opioid Use, Pain, Postoperative
- Trial name
- NCT03906838
- Testing
- Ropivacaine injection
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Breast/Surgery
Nipple-sparing Mastectomy in Combined With Buried Flap Monitoring
1. Learning curve of ms-Tram and DIEP breast reconstructions surgery are important to guide the training of new surgeon. 2. Buried flap post operative monitoring without implantable doppler was seldom studied, a validated…
- Trial name
- NCT05560633
- Testing
- No intervention
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Gingival Recession
Single Stage Root Coverage for Gingival Recession With or Without Free Gingival Graft
Background and Objective: Gingival recession accounts for apical migration of the gingival margin resulting in exposure of the cementoenamel junction (CEJ) and root surface.
- Trial name
- NCT03370042
- Testing
- semilunar coronally positioned flap with free gingival graft, semilunar coronally positioned flap alone
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kamineni Institute of Dental Sciences
Modified Free Gingival Graft , Connective Tissue Graft
Efficacy of the Modified Free Gingival Graft Technique
Gingival recessions can be defined as the exposure of the root surface after an apical migration of the gingival margin in relation to the cemento-enamel junction. Gingival recessions affect both younger and older populations.
- Trial name
- FGG (NCT06580821)
- Testing
- mucogingigval surgery
- Where
- Ecuador
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad de Especialidades Espiritu Santo
Negative-Pressure Wound Therapy, Edema
Impact of Negative Pressure Wound Therapy on Free Muscle Flaps
Aim of the study is to prove the utility and safety of the negative pressure wound therapy (NPWT) in the postoperative management of free flaps.
- Conditions
- Negative-Pressure Wound Therapy, Edema, Free Flap, Microcirculation
- Trial name
- NCT02526342
- Testing
- V.A.C. UltraTM (KCI®,San Antonio, Texas, USA)
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Ulf Dornseifer, MD
Microcirculation, Thermoregulation
Impact of Active Thermoregulation on the Microcirculation of Free Flaps
This study evaluates the impact of active thermoregulation on free flap microcirculation following free flap transfer. Thermoregulation is performed by passive warming, active warming (water circulation based device) and active…
- Conditions
- Microcirculation, Thermoregulation, Free Flap
- Trial name
- NCT02466594
- Testing
- Hilotherm Clinic®
- Where
- Germany
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Ulf Dornseifer, MD
Ischemic Preconditioning
Cutaneous Remote Ischemic Preconditioning in Plastic Surgery
Background: In plastic and reconstructive surgery, free flaps are routinely used for treatment of soft tissue defects. Treatment strategies aim at reducing or preventing flap necrosis by conditioning tissue tolerance against…
- Trial name
- RIPC (NCT01235286)
- Testing
- remote ischemic preconditioning
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Flap Monitoring
Free Flap Microcirculatory Monitoring Correlates to Free Flap Temperature Assessment
In case of free flap failure, time is of utmost importance as salvage rates have been reported to be inversely related to the time interval between the onset of ischemia and its clinical recognition.
- Trial name
- NCT01235299
- Where
- Germany
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Oral Cancer
Analysis Of Sensory Recovery Of Donor Size And Quality Life In Oral Cancer Patients
The aim of the study is to investigate post-surgery sensory impairment and life quality changes in oral cancer patients who underwent free flap (Free Flap) on post-operative 6 months, 12 months, and 24 months, respectively
- Trial name
- NCT02048631
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Mammaplasty, Microsurgery
Perioperative Management of DIEP Flaps
By comparison of two different protocols with diverse fluid/ catecholamine administration limits (fluid restriction vs. catecholamine restriction with target systolic blood pressure > 100 mmHg) the investigators would like to…
- Conditions
- Mammaplasty, Microsurgery, Free Tissue Flaps
- Trial name
- NCT03118024
- Testing
- Crystalloid Solutions, Catecholamines
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Regensburg