Clinical trials: Freezing of Gait
Parkinson Disease
Neural and Kinematic Features of Freezing of Gait for Adaptive Neurostimulation
Continuous deep brain stimulation (cDBS) is an established therapy for the major motor signs in Parkinson's disease, however some patients find that it does not adequately treat their freezing of gait (FOG).
- Trial name
- NCT03180515
- Testing
- Activa PC+S Neurostimulator
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stanford University
Parkinson Disease
Laser Shoes for Freezing in People With Parkinson's Disease
The purpose of this study is to assess the effectiveness of the visual cues of a wearable device in preventing freezing of gait (FOG) in those with PD.The aim is to investigate the impact of laser shoe attachments on gait in…
- Trial name
- NCT05131906
- Testing
- gait task and activity of daily living task
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Northern Arizona University
Parkinson Disease
Can tDCS Enhance Efficacy of Rehabilitative Intervention for Freezing of Gait in Parkinson's Disease?
Freezing of gait in Parkinson's disease (PD) is a major cause of disability and falls and responds often incompletely to conventional therapy. The pathogenesis remains largely unknown and therapeutic alternatives are needed.
- Trial name
- NCT02205216
- Testing
- Active tDCS, Rehabilitation Therapy
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Parkinson's Disease, Multiple System Atrophy
Exploit the Neural Source and the Feasibility of Transcranial Direct Current Stimulation for Freezing of Gait in Parkinson's Disease and Multiple System Atrophy
In this project, the investigators will deliver a 5-day session of transcranial direct current stimulation (tDCS) to the leg motor cortex of the FOG patients to examine whether the intervention will benefit the patients in a…
- Trial name
- NCT03721887
- Testing
- Transcranial direct current stimulation
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Parkinson Disease
Effect of Simultaneous Dual Stimulation on Freezing of Gait in Parkinson's Disease
The purpose of this study is to investigate the effect of dual-mode non-invasive brain stimulation (NIBS) with high-frequency repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex of the lower leg and…
- Trial name
- NCT02850159
- Testing
- rTMS and tDCS, rTMS
- Volunteers
- 32 people
- Sponsor
- Samsung Medical Center
Parkinson Disease
Comparison of Sensory Cuing Modalities for Freezing of Gait
The investigators intend to compare the effects on the resolution of visual and auditory sensory cues on the resolution of freezing of gait in patients with idiopathic Parkinson's disease.
- Trial name
- NCT05080413
- Testing
- Laser shoes, Metronome
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Veterans Health Service Medical Center, Seoul, Korea
PD - Parkinson's Disease
Freezing of Gait - Clinical Outcomes Assessment
To develop a reliable and accurate clinician-reported outcome (ClinRO) measure (against a new and precise definition) and patient reported outcome (PRO) for use by clinicians and researchers to quantify the severity of Freezing…
- Trial name
- FOG-COA (NCT06519279)
- Testing
- Opals, Axivity
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Parkinson's Disease, Gait Disorders, Neurologic
Study of Methylphenidate to Treat Gait Disorders And Attention Deficit In Parkinson's Disease (PARKGAIT-II)
Therapeutic management of gait disorders in very advanced Parkinson's disease (PD) patients can sometimes be disappointing, since dopaminergic drug treatments and subthalamic nucleus (STN) stimulation are more effective for…
- Conditions
- Parkinson's Disease, Gait Disorders, Neurologic, Dementia
- Trial name
- PARKGAIT-II (NCT00914095)
- Testing
- methylphenidate
- Where
- France
- Volunteers
- 69 people
- Sponsor
- University Hospital, Lille
Freezing of Gait, Parkinson Disease
Selectively Modulating Pathophysiological Biomaker to Improve Freezing of Gait in Parkinson' s Disease by Adaptive Subthalamic Stimulation
Freezing of gait (FoG) is defined as a brief, episodic absence or reduction of forward progression of the feet despite the intention to walk.
- Trial name
- NCT04197947
- Testing
- Neuro Omega
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Chang Gung Memorial Hospital
Parkinson's Disease
Amyloidopathy, Cholinopathy, Dopamine Responsiveness and Freezing of Gait in PD
Early stage Parkinson disease (PD) is characterized by a 'honeymoon' phase in terms of responsiveness of motor symptoms, including gait, to dopaminergic pharmacotherapy.
- Trial name
- FOG (NCT03647137)
- Testing
- Detailed motor testing, including FoG, in PD subjects
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- VA Office of Research and Development
Parkinson Disease, Motor Disorder
The Türkish Version of the Freezing of Gait Questionnaire
The freezing of gait (FOG) is one of the disabling symptoms in Parkinson's disease. The diagnosis and assessment of the FOG may be diffucult, but it is absolutely necessary.
- Conditions
- Parkinson Disease, Motor Disorder, Gait Disorders, Neurologic
- Trial name
- NCT03413787
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ordu University
Parkinson Disease
Deep Brain Stimulation of the Cuneiform Nucleus for Levodopa-resistant Freezing of Gait in Parkinson's Disease
The purpose of this research study is to determine if DBS is a safe and effective therapy for severe freezing of gait in patients with Parkinson's Disease.
- Trial name
- DBS + FOG (NCT04218526)
- Testing
- Vercise DBS System
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Jonathan Jagid
Parkinsons Disease
A Responsive Closed-Loop Approach to Treat Freezing of Gait in Parkinson's Disease
The study objective is to explore Deep Brain Stimulation (DBS) in two specific brain regions (Globus Pallidum, or GPI, plus the pedunculopontine nucleus, or PPN) for on medication freezing of gait (FoG) in Parkinsons Disease…
- Trial name
- NCT02318927
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Florida
Parkinson Disease
Effects of Bilateral GPI DBS on Freezing of Gait in PD
This study aims to evaluate the effect of deep brain stimulation in the the globus pallidus (Gpi) on freezing of gait in patients with Parkinson's disease.
- Trial name
- PD GPI DBS (NCT03227250)
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Haiyan Zhou
Gait Disorders, Neurologic
Study to Assess Droxidopa in the Treatment of Freezing Of Gait Symptoms in Patients With Parkinson's Disease
Freezing of Gait (FoG) is a class of symptoms that occur in Parkinson's patients. Also called motor blocks, FoG is characterized by a sudden inability to move the lower extremities which usually lasts less than 10 seconds.
- Trial name
- NCT01331122
- Testing
- droxidopa
- Where
- 2 sites in United States, Canada
- Sponsor
- Chelsea Therapeutics
Parkinson Disease(PD)
Gait Initiation Difficulty and Anticipatory Postural Adjustment (APA) Impairment in People With PD - Evaluation and Training
Gait initiation (GI) difficulty is common in people with Parkinson's disease (PD). Studies showed that the GI difficulty was related to impaired anticipatory postural adjustments (APA).
- Trial name
- NCT02656355
- Testing
- Weight shift training and APA feedback, Weight shift training without APA feedback
- Where
- Taiwan
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Transcranial Magnetic Stimulation, Freezing of Gait
Dual-target, High-dose TMS for PD Patients With FOG
The aim of the current study was to verify whether high-dose TMS treatment of the motor and cognitive cortices is more effective in alleviating FOG than conventional-dose TMS of the motor cortex only.
- Trial name
- NCT05625386
- Testing
- transcranial magnetic stimulation
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Anhui Medical University
Parkinson Disease
The Effect of Multi-target Magnetic Stimulation on Freezing Gait in PD
This study is a double-blinded randomized study examining the effectiveness of the multi-target magnetic stimulation treatment on Freezing of Gait (FOG) phenomenon in patients with Parkinson's disease.
- Trial name
- NCT05174299
- Testing
- magnetic stimulation
- Where
- China
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Parkinson's Disease, Gait Disorders, Neurologic
Study of Memantine for Gait Disorders And Attention Deficit In Parkinson's Disease
Along with cognitive and psychobehavioural disorders, gait disorders represent a major problem in the treatment of advanced Parkinson's disease (PD).
- Trial name
- FOGG-I (NCT01108029)
- Testing
- memantine
- Where
- France
- Volunteers
- 28 people
- Sponsor
- University Hospital, Lille
Parkinson's Disease, Freezing of Gait
The Electrophysiological Investigation of Higher Level Neural Manifestations of Freezing of Gait in Parkinson's Disease Patient
We aim to investigate the higher level mechanism of gait disorders in PD patients by ambulatory recording of electroencephalographic (EEG) and leg electromyographic (EMG) signals during unconstrained walking.
- Trial name
- NCT02214251
- Testing
- PK-16CH EXG system
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital