Clinical trials: Frostbite
Frostbite
Comparison of ICG Microangiography and Conventional Angiography in Severe Frostbite
Severe frostbite injury is a significant cause of morbidity in northern climates. Minnesota has some of the highest numbers of severe frostbite injuries in North America.
- Trial name
- NCT05777590
- Testing
- Indocyanine Green Angiogram
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- HealthPartners Institute
Cold Hypersensitivity, Vascular System Injuries
Treatment of Frostbite Sequelae With Botulinum Toxin A
Background Digital vasospasm as part of frostbite sequelae is comparable to the vasospastic disorders found in Raynaud's phenomenon which has been successfully treated with Botulinum toxin type A injections in the palm of the…
- Conditions
- Cold Hypersensitivity, Vascular System Injuries, Vibration; Disorder, Sensory Disorders
- Trial name
- NCT06460194
- Testing
- Botuinum toxin
- Where
- Norway
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
Cutaneous Manifestations, Skin Manifestations
Cutaneous Manifestations of Coronavirus Disease 2019(COVID-19).
An outbreak of Corona virus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-coV-2) occurred in Wuhan city, Hubei province, China in December 2019.
- Conditions
- Cutaneous Manifestations, Skin Manifestations, COVID-19, COVID-19 Pneumonia
- Trial name
- NCT05094687
- Where
- Pakistan
- Volunteers
- 1,206 people, healthy volunteers welcome
- Sponsor
- Jinnah Postgraduate Medical Centre
Lung Diseases
Safety of a Sheath Cryoprobe Bronchoscopic Transbronchial Biopsy Technique
The purpose of this study is to evaluate the safety and collect data on the initial effectiveness of a 1.1mm flexible single-use cryoprobe with oversheath used for transbronchial lung biopsy via a bronchoscopic approach.
- Trial name
- FROSTBITE (NCT04486560)
- Testing
- ERBECRYO® 2 Cryosurgical Unit and Accessories - K190651
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Johns Hopkins University
Frostbite, Frostbite of Hand
Multicenter Sous Vide Frostbite
The purpose of this study is to determine the efficacy of using sous vide devices for heating and maintaining the circulating warm water bath used in the rewarming of acute frostbite.
- Conditions
- Frostbite, Frostbite of Hand, Frostbite of Foot
- Trial name
- NCT05280301
- Testing
- Sous Vide Device (SVD)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Chilblains, Perniosis
Assessment of Vasomotion of People With Idiopathic Chilblains
Chilblains, also known as perniosis, is a non-freezing cold injury causing painful inflammatory skin lesions. Chilblains typically affect the dorsal feet or hands, causing inflammatory skin lesions that are often painful, and…
- Conditions
- Chilblains, Perniosis, Thermoregulation
- Trial name
- NCT06237517
- Testing
- Assessment of Vasomotion of People With Idiopathic Chilblains
- Where
- Greece
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Skin Manifestations, COVID
Assessment of Chilbains Occuring During Covid-19 Infection
Some patients infected by covid-19 develop skin manifestations. These manifestations are still not well known and there pathophysiology remain unclear.
- Conditions
- Skin Manifestations, COVID, Chilblains
- Trial name
- ChilblainCOVID (NCT04344119)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Chilblains, COVID-19
COVID-19 and Chilblains
Chilblains (inflammatory lesion of the feet or hands) have been reported with an unusual frequency during the confinement period, most commonly in children, teenagers and young adults.
- Trial name
- ECCES (NCT04455308)
- Testing
- Biological sample collection
- Where
- 5 sites in France
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Alpine Accident, Frostbite
10-years Nationwide Alpine Accidents in Austria
This observational study intends to analyze the characteristic of specific accidents happened in Austrian's mountainous regions.
- Conditions
- Alpine Accident, Frostbite, Cardiopulmonary Arrest With Successful Resuscitation, Lightning Injuries
- Trial name
- NCT03405467
- Testing
- general and specific data
- Where
- Austria
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Frostbite
Epoprostenol Plus Conventional Therapy in COld and Frostbite Injury (ECCO)
Severe frostbite injury can result in significant lifelong disability and amputation. Various medicines, including intravenous vasodilators (prostaglandins/iloprost, pentoxifylline, buflomedil) along with thrombolytics…
- Trial name
- ECCO (NCT07424378)
- Testing
- Standard of care plus Epoprostenol infusion for 8 hours (hrs) per day up to 5 days maximum
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- University of Colorado, Denver
Frostbite
Prevention and Treatment of Frostbite Infection With Antimicrobial Pharmacokinetic Analysis
This study will compare the effectiveness of two different treatments for preventing infection from frostbite injuries. These two treatments are A) aloe vera and B) long-acting silver wound dressings.
- Trial name
- Frostbite (NCT06266494)
- Testing
- Long-Acting silver dressings, Aloe Vera, Dalbavancin
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
COVID 19
Acral Cutaneous Thrombotic Vasculopathy and Covid-19 Infection
Spectrum of skin lesions may arise during Covid-19 virus infection. It includes non-specific urticaria, aphtoids lesions, but also acrosyndromes, in particular suggestive of chilblains.
- Trial name
- NCT04361786
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Montpellier
Frostbite, Frostbite of Hand
Sous Vide Rewarming for Frostbitten Extremities
The purpose of this study is to determine the efficacy of using sous vide devices for heating and maintaining the circulating warm water bath used in the rewarming of acute frostbite.
- Conditions
- Frostbite, Frostbite of Hand, Frostbite of Foot
- Trial name
- NCT04633174
- Testing
- Sous Vide Device (SVD)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
COVID-19, Chilblains
Analysis of Chilblains pROfile During coVID-19 Epidemic (ACROVID)
Cases of chilblains have been reported with an unusual frequency in France in the context of the COronaVirus Infectious Disease 2019 (COVID-19) epidemic.
- Trial name
- ACROVID (NCT04387955)
- Testing
- Biological Sample Collection
- Where
- France
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Frostbite, Altitude
Field Study on Intravenous Iloprost for Treatment of Severe Frostbite at High Altitude
The goal of this observational study is to learn whether intravenous iloprost treatment for severe frostbite (grades 3-4) is feasible and safe when delivered in pre-hospital, remote high-altitude settings.
- Conditions
- Frostbite, Altitude, Field Physician Care
- Trial name
- HAI-Frost (NCT07450469)
- Testing
- Iloprost (Ilomedin, BAYQ6256)
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Institute of Mountain Emergency Medicine
Hypothermia.
CAERvest® - A Novel Endothermic Hypothermic Device for Core Body Cooling. Safety and Efficacy Testing.
Cooling the whole body to 32-34 degrees Centigrade from the normal of around 37 degrees Centigrade for 24 hours has been shown to be an effective way of reducing damage to brain function after return of spontaneous circulation…
- Trial name
- NCT02030236
- Testing
- Cooling
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bodychillz Ltd
Chilblains
Characteristics and the Future of the City Chilblains
Chilblains are cutaneous lesions affecting extremities (foot and fingers) with erythemic papules, evolving by painful relapse due to cold and sudden reheating. This pathology is currently poorly understood while it's frequent.
- Trial name
- NCT03101761
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Fondation Hôpital Saint-Joseph