Clinical trials: Frozen Embryos
Infertility Assisted Reproductive Technology
Association Between Serum Progesterone Levels on Embryo Transfer Day and Clinical Pregnancy in Frozen-thawed Embryo Transfer Cycles Using Hormone Replacement Therapy
A retrospective evaluation of routinely collected clinical, embryological, laboratory, and pregnancy outcome data provides an efficient approach to examine the association between serum progesterone on the day of FET and clinical…
- Trial name
- NCT07858227
- Testing
- data collection
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Embryo Transfer, Infertility
Comparison of Vaginal and Transdermal Oestrogen Before Frozen Thawed Embryo Transfer
The purpose of this study is to compare pregnancy outcomes of frozen-thawed embryo transfer after endometrial preparation with vaginal estradiol or transdermal estradiol and to evaluate women's satisfaction
- Trial name
- NCT03518528
- Testing
- Estradiol 2 MG, Estradiol 100 µg
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Angers
IVF, Frozen Embryo Transfer
Lipiodol Prior to FET (LIFE)
Lipiodol® flushing is an effective fertility treatment for women with unexplained infertility. It is speculated that the treatment effect could work through a direct effect of Lipiodol® on the endometrium.
- Conditions
- IVF, Frozen Embryo Transfer, Hysterosalpingography
- Trial name
- LIFE (NCT06563908)
- Testing
- Lipiodol® uterine treatment prior to IVF/ICSI
- Volunteers
- 784 people
- Sponsor
- Mỹ Đức Hospital
Infertility, Infertility, Female
Serum Progesterone Levels on the Day of Frozen Embryo Transfer (FET) and Pregnancy Outcomes
Frozen embryo transfer (FET) cycles have become more common in recent years due to a push towards elective single embryo transfer (SET).
- Conditions
- Infertility, Infertility, Female, IVF
- Trial name
- ProFET (NCT04170517)
- Testing
- Measurement of serum progesterone on the day of FET
- Where
- United Kingdom
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- CARE Fertility UK
IVF Outcomes
Comparison of Two Protocols in Frozen Embryo Transfer
This randomized clinical trial evaluates two different endometrial preparation protocols-hormone replacement therapy (HRT) and natural cycle-for frozen embryo transfer (FET) in infertile women undergoing assisted reproductive…
- Trial name
- NCT07003373
- Testing
- hormone replacement therapy (HRT) group
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Malihe Mahmoudinia
Infertility
Uterine Contractions and Mode of Progesterone in Frozen Embryo Transfer (FET) Cycles: Randomized Clinical Trial
When patients undergo in vitro fertilization (IVF), they often make more embryos than it is safe to transfer back in the womb all at once. These excess embryos are frozen and stored for future use.
- Trial name
- NCT02078869
- Testing
- Progesterone in oil, vaginal progesterone suppositories
- Volunteers
- 34 people
- Sponsor
- Toronto Centre for Advanced Reproductive Technology
Embryo Transfer, Luteal Support
Modified Luteal Support for Frozen-Thawed Embryo Transfer - A Prospective Study
This study evaluates the outcomes of frozen-thawed embryo transfer (FET) success rate with modified luteal support - addition of a single injection of HCG and GnRH-agonist, on day of ET and 4 days later, respectively vs.
- Trial name
- NCT02825290
- Testing
- Choriogonadotropin alfa, Triptorelin acetate
- Where
- Israel
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Cryopreservation, Embryo Implantation
Optimal Length of Progesterone Supplementation Before the Transfer of Cryopreserved(Frozen)-Thawed Embryos in an Artificial Cycle With Exogenous Estrogen and Progesterone.
The aim of the study is to determine whether 5 or 7 days of progesterone supplementation before transfer of a day 5 cryopreserved thawed embryos in an artificial cycle results in a significant higher pregnancy rate.
- Conditions
- Cryopreservation, Embryo Implantation, Progesteron
- Trial name
- PROFETA-5 (NCT02032797)
- Testing
- Progesterone
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- Universitair Ziekenhuis Brussel
Fertility Issues, Embryo Implantation
Rescue Progesterone Supplementation During Frozen Embryo Transfer
Endometrin is a progesterone supplement prescribed during in vitro fertilization (IVF) for preparation for embryo transfer. The usual dose of Endometrin is 100 mg two to three times per day in the form of an effervescent tablet…
- Conditions
- Fertility Issues, Embryo Implantation, Frozen Embryo Transfer
- Trial name
- P4R (NCT05555121)
- Testing
- Progesterone Effervescent Vaginal Tablet
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Clinique Ovo
Infertility, IVF
Immediate Versus Postponed Single Blastocyst Transfer in mNC-FET
The purpose of this randomized controlled trial is to investigate if immediate single blastocyst transfer (in the first menstrual cycle following oocyte retrieval) is non-inferior to standard postponed single blastocyst transfer…
- Trial name
- NCT04748874
- Testing
- Immediate mNC-FET
- Where
- Denmark
- Volunteers
- 464 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Fertility Disorders
Timing Frozen Embryo Transfer by Following Two Different Methods
This proof of concept study is designed to determine the practicality of using home ovulation tests to enable optimum timing for transfer of frozen embryos in a natural menstrual cycle in comparison to the standard ultrasound and…
- Trial name
- NCT03156374
- Testing
- Test use
- Where
- Australia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- SPD Development Company Limited
Hormonal Replacement Frozen Embryo Transfer Cycle
The Rescue of Hormonal Replacement Frozen Embryo Transfer Cycle With Low Serum Progesterone.
Frozen embryo transfer (FET) is increasingly adopted strategy in modern IVF. Among the many factors that have contributed to such change, the pursuit of an ovarian hyperstimulation syndrome free clinic has been strongly required.
- Trial name
- NCT05758064
- Testing
- Duphaston, prolutex
- Where
- 2 sites in Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- El Shatby University Hospital for Obstetrics and Gynecology
Infertility
Sildenafil Citrate in Frozen Embryo Transfer
Comparison between usage of Sildenafil citrate with estradiol valerate or estradiol valerate alone in endometrial preparation and outcome of frozen-thawed embryo transfer cycles.
- Trial name
- NCT02845388
- Testing
- Sildenafil citrate, estradiol valerate
- Volunteers
- 90 people
- Sponsor
- Omar Ahmed El Sayed Saad
Infertility
MIcronized PROgesterone in Frozen Embryo Transfer Cycles
This randomized trial was designed as non-inferiority trial aiming to compare ongoing pregnancy rates following LPS with 600 mg/day vs 800 mg/day vaginal VMP.
- Trial name
- MI-PROF (NCT05899010)
- Testing
- Vaginal progesterone 600mg daily, Vaginal progesterone 800mg daily
- Where
- Spain
- Volunteers
- 1,020 people
- Sponsor
- Fundación Santiago Dexeus Font
Asherman Syndrome
Effects of Platelet Rich Plasma on Endometrium
Intrauterine platelet rich plasma will be injected in the endometrial region via the vaginal route after the cessation of menstrual period.
- Trial name
- NCT04424160
- Testing
- PRP injection in the endometrium
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Acibadem University
Infertility (IVF Patients), Infertility Assisted Reproductive Technology
Estradiol 8 vs 12 mg for Endometrial Preparation in HRT-FET
The goal of this clinical trial is to learn whether 12 mg or 8 mg of oral estradiol valerate is better for preparing the endometrium in women undergoing hormone replacement frozen embryo transfer (HRT-FET) cycles.
- Conditions
- Infertility (IVF Patients), Infertility Assisted Reproductive Technology, Frozen Embryo Transfer (FET), Endometrial Preparation
- Trial name
- NCT07526207
- Testing
- Progynova®
- Where
- 2 sites in Egypt
- Volunteers
- 850 people
- Sponsor
- Cairo University
Infertility
Effect of Vaginal Sildenafil Citrate on Endometrial Preparation and Outcome in Frozen Thawed Embryo Transfer Cycles
A total of 80 Patients who meet these conditions will enter the study and be divided into two groups based on randomized tables.
- Trial name
- NCT03854175
- Testing
- sildenafil citrate, Estradiol Valerate 2 MG
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Infertility, IVF
The Importance of Embryo Transfer Day Progesterone Value in Natural Cycle Frozen Embryo Transfers and the Evaluation of the Effect of Rescue Therapy on Pregnancy Outcomes in Patients With Low Progesterone Levels
Thanks to recent advances in clinical practice and laboratory, embryo cryopreservation has become the first-line procedure in assisted reproductive technology.
- Conditions
- Infertility, IVF, Progesterone
- Trial name
- NCT05481684
- Testing
- Normal Progesterone group, Low Progesterone group
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Infertility
Natural Cycle/Progesterone Fortified Protocol for Endometrial Preparation for Frozen/Thawed Embryo Transfer
This is a pilot study of a novel protocol for preparation of the endometrium for frozen/thawed embryo transfer whereby estrogen is not administered during the proliferative phase and progesterone is administered through vaginal…
- Trial name
- NCT02749344
- Testing
- FET after endometrial preparation
- Where
- Israel
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Infertility
The Effects of Estrogen on Artificial Endometrium
In this prospective randomized trial, the parameters of the frozen-thawed embryo transfer (FET) cycles were analyzed. This study was undertaken in the Department of Assisted Reproductive Technologies and Reproductive Genetics…
- Trial name
- NCT03155048
- Testing
- oral estrogen replacement therapy, Estradiol transdermal patch
- Where
- Turkey (Türkiye)
- Volunteers
- 317 people
- Sponsor
- Memorial Sisli Hospital, Istanbul