Clinical trials: Frozen Embryos
Infertility, Pregnancy Related
The Impact of Vaginal Intercourse on Pregnancy Rates After Frozen Embryo Transfer
This study aims to evaluate whether allowing unprotected vaginal intercourse 24 hours after frozen embryo transfer will result in higher ongoing clinical pregnancy rates in comparison to having participants abstain from…
- Conditions
- Infertility, Pregnancy Related, IVF
- Trial name
- NCT03974295
- Testing
- Vaginal unprotected intercourse
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Thin Endometrium
a-PRP Intrauterine Instillation in Women With Thin Endometrium
This study sought to compare the endometrial thickness among infertile women with a history of thin endometrium together with previous cancellation from IVF/ICSI inspection of intrauterine instillation of autologous-PRP or no…
- Trial name
- PRP(a-PRP) (NCT06234540)
- Testing
- PRP, Standard treatment
- Where
- Thailand
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Infertility
Preparing and Timing of the Endometrium in Modified Natural Cycle Frozen-thawed Embryo Transfers
The increasing use of FET emphasizes the importance of preparing and timing the endometrium in FET cycles, however there is no consensus on luteal phase progesterone supplementation in mNC-FET and the optimal day of blastocyst…
- Trial name
- NCT03795220
- Testing
- Lutinus + transfer day 6, Lutinus + transfer day 7, No Lutinus + transfer day 6
- Where
- Denmark
- Volunteers
- 679 people
- Sponsor
- Anja Bisgaard Pinborg
Frozen Embryo Transfer
Frozen-thawed Embryo Transfers and Hormone Substitution on Thrombotic Risk Markers
The study focus on the impact of estrogen/progesterone substitution during artificial cycle frozen embryo transfer (AC-FET) in women undertaking assisted reproductive technology treatment (ART).
- Trial name
- TromboFET (NCT04359576)
- Testing
- Primary and secondary hemostasis
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Horsens Hospital
Pregnancy
PGT-A Versus Blastocyst Morphology Selection
Introduction Embryo aneuploidy is likely the leading cause of implantation failure in IVF cycles. Since the inception of IVF, non-invasive morphology based scoring has been the most widely used embryo selection method, resulting…
- Trial name
- NCT03095053
- Testing
- comprehensive chromosome screening
- Where
- Turkey (Türkiye)
- Volunteers
- 302 people
- Sponsor
- Antalya IVF
Infertility
Vitrification and Slow Freezing for Cryopreservation of Blastocyst
Improvement in the treatment of infertility by Assisted Reproductive Techniques (ART) allows single embryo transfer to be applied without compromising pregnancy rates after the first in vitro fertilization (IVF) or Intra…
- Trial name
- NCT02068924
- Testing
- Slow freezing versus vitrification
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Recurrent Implantation Failure (RIF)
Management of Recurrent Implantation Failure
This is the first study to investigate, whether pregnancy and implantation rates would improve in patients with recurrent implantation failure (RIF), if all embryos were to be frozen and transferred in a consecutive natural cycle.
- Trial name
- RIF (NCT02681367)
- Testing
- Freeze all policy
- Volunteers
- 200 people
- Sponsor
- TopLab Company for ART Laboratories Consultation and Training
Polycystic Ovary Syndrome, Assisted Reproduction
Mitochondrial DNA in Fresh Versus Frozen Embryo Culture Media of PCOS Women Undergoing In Vitro Fertilization
Ninety women with PCOS candidate for ICSI were randomized to 2 groups:Group A: fresh samples of PCOS patients undergoing IVF (no= 45) and Group B: frozen samples of PCOS patients undergoing IVF (no= 45).
- Trial name
- NCT03820167
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
IVF, Frozen Embryo Transfer
Natural Cycle vs. Modified Natural Cycle vs. Artificial Cycle Protocol for Endometrial Preparation.
Fresh embryo transfer is a routine procedure in vitro fertilization (IVF) treatment. Since the first live birth after an IVF-FET (frozen embryo transfer), recent years have seen a dramatic rise in the number of FET cycles.
- Trial name
- MONART (NCT04804020)
- Testing
- NC, mNC, AC
- Where
- Vietnam
- Volunteers
- 1,428 people
- Sponsor
- Mỹ Đức Hospital
Adenomyosis
Modified Downregulation for Women With Adenomyosis of the Uterus Prior to Frozen-thawed Embryo Transfer.
1 in 7 couples experience difficulty in conceiving. Many will require in vitro fertilization (IVF). IVF involves an initial period of downregulation to suppress the ovaries and prevent premature ovulation.
- Trial name
- MODA (NCT03946722)
- Testing
- GnRH analogue downregulation, Participant questionnaire
- Where
- United Kingdom
- Volunteers
- 162 people
- Sponsor
- University College, London
Infertility Due to Nonimplantation, Infertility
Progesterone Supplementation in Frozen Embryo Transfer Cycles
Recurrent implantation failure (RIF) occurs after women undergo in vitro fertilization and have multiple embryos transferred but no resulting pregnancies.
- Trial name
- NCT03504345
- Testing
- Prometrium
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Subfertility, Pregnancy
A RCT Comparing Spontaneous Natural Cycles and Human Chorionic Gonadotrophin-induced Natural Cycles in FET
This is a randomized controlled trial on the comparison of the ongoing pregnancy rate in frozen-thawed embryo transfer cycles with spontaneous ovulation and hCG-induced natural cycles.
- Trial name
- NCT02197208
- Testing
- Daily monitoring of LH and E2, hCG induced natural cycle, ultrasound
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 300 people
- Sponsor
- The University of Hong Kong
Frozen Embryo Transfer, Infertility, Female
Estrogen (Gel)Transdermal vs Oral Estrogen for Endometrial Preparation
The goal of this randomized study trial is to comparing transdermal estradiol gel and oral estradiol for endometrial preparation in the Frozen Embryo Transfer Cycle.
- Trial name
- NCT05802303
- Testing
- 17-beta Estradiol gel 0.06% w/w(ESTOGEL.Intas pharma), Estradiol Hemihydrate(Estrabet Tablet, abbott pharma)
- Where
- India
- Volunteers
- 172 people
- Sponsor
- Indira IVF Hospital Pvt Ltd
Infertility, Female, IVF/ICSI
RCT to Assess the Clinical Benefit of the ERA Test in Infertile Women at Their First IVF/ICSI Cycle
Endometrial receptivity takes place in a self-limited period of time during the endometrial mid-secretory stage. This period, named as window of implantation (WOI), is modulated by molecular changes allowing embryo implantation…
- Trial name
- NCT04687670
- Testing
- ERA
- Where
- 3 sites in China
- Volunteers
- 714 people
- Sponsor
- Peking University Third Hospital
Female Infertility
Hormonal Monitoring and Progesterone Adjustment in Frozen Embryo Transfer Cycles
Hormonal monitoring impact on overall pregnancy rate in frozen embryo transfer (FET)cycles and hence progesterone supplement adjustments remain debatable in current literature.
- Trial name
- NCT05189145
- Testing
- estradiol valerate, Hormonal monitoring progesterone, estradiol, luteinizing hormone, transvaginal ultrasound examination
- Where
- Egypt
- Volunteers
- 600 people
- Sponsor
- Alexandria University
Female Infertility Due to Nonimplantation of Ovum
Endometrial Local Injury to Improve the Outcome of Embryo Transfer
The purpose of this study is to determine whether edometrial local injury improves the outcome of embryo transfer,and to find out more evidence about the time of trauma,the way of intervention,and the possible mechanism.
- Trial name
- NCT02306395
- Testing
- Endometrial local injury
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Navy General Hospital, Beijing
Ovarian Hyperstimulation Syndrome, Infertility Drugs
Transfer of Fresh Versus Frozen/Thawed Embryos in IVF Cycles Where GnRH Agonist is Utilized for Oocyte Maturation.
It has been suggested that in IVF cycles where GNRH agonist is utilized for final oocyte maturation in patients at risk of ovarian hyperstimulation, pregnancy rates are reduced.
- Conditions
- Ovarian Hyperstimulation Syndrome, Infertility Drugs, Female
- Trial name
- NCT00365027
- Testing
- Delayed embryo transfer
- Sponsor
- HaEmek Medical Center, Israel
Infertility
Impact of Serum Progesterone Levels on the Day of Fresh and Frozen Embryo Transfer on the Ongoing Pregnancy Rates.
Serum progesterone levels prepare the endometrium for implantation and play an important role during embryo transfer (ET). In clinical practice, luteal phase support progesterone supplementation is systematically offered to all…
- Trial name
- NCT04839627
- Testing
- serum progesterone measurement
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Hospital St. Joseph, Marseille, France
Embryo Implantation
Synchronizing Blastocyst in Frozen Embryo Transfer
The aim of the present study is to determine if implantation rate could be increased in women undergoing frozen embryo transfer cycles in case of adjusting their embryo development at hatching stage.
- Trial name
- NCT03128970
- Testing
- synchronizing blastocysts
- Where
- 2 sites in Egypt
- Volunteers
- 742 people
- Sponsor
- Al-Yasmeen Fertility and Gynecology Center
Fertility Disorders
Natural Frozen Embryo Transfer (FET) vs Substituted Frozen Embryo Transfer (FET)
In frozen embryo transfer substituted cycles, patients are treated with progesterone and estrogen in an attempt to mimic the natural cycle and a transfer is planned whenever the endometrium is ready.
- Trial name
- NCT06053827
- Testing
- Frozen embryo transfer
- Where
- Canada
- Volunteers
- 1,207 people
- Sponsor
- Clinique Ovo