Clinical trials: Frozen Thawed Embryo Transfer
Infertility, Polycystic Ovarian Syndrome
HRT Versus MOS for Endometrial Preparation Prior to FET in PCOS Patients
Evaluation of endometrial preparation using either hormonal therapy or ovarian stimulation prior to frozen-thawed embryo transfer (FET) in patients with polycystic ovarian syndrome (PCOS)
- Trial name
- NCT02273791
- Testing
- Estradiol valerate, Sequential Clomiphene citrate and Gonadotropin
- Where
- 2 sites in Egypt
- Volunteers
- 126 people
- Sponsor
- Mansoura University
Infertility
Frozen-thawed Embryo Transfer in a Natural Cycle: hCG Triggering Versus LH Home Test
The primary aim of this study is to find out if ovulation triggered with hCG provides any additional benefit in comparison to spontaneous LH surge measured with the LH surge home test when transferring frozen-thawed embryo in a…
- Trial name
- NCT03115320
- Testing
- Human chorionic gonadotropin, Home ovulation test
- Where
- Finland
- Volunteers
- 62 people
- Sponsor
- Tampere University Hospital
Infertility
Sildenafil Citrate in Frozen Embryo Transfer
Comparison between usage of Sildenafil citrate with estradiol valerate or estradiol valerate alone in endometrial preparation and outcome of frozen-thawed embryo transfer cycles.
- Trial name
- NCT02845388
- Testing
- Sildenafil citrate, estradiol valerate
- Volunteers
- 90 people
- Sponsor
- Omar Ahmed El Sayed Saad
Infertility, Female
Progesterone-modified Natural Cycle for FET
Hormone replacement therapy (HRT) cycles, despite the ease of synchronizing embryo thawing and embryo transfer timing, increase the risk of pregnancies and obstetric complications compared to natural cycles (NC).
- Trial name
- COMPROSET (NCT06644794)
- Testing
- Progesterone-modified natural cycle preparation for frozen embryo transfer, Hormone replacement therapy cycle preparation for frozen embryo transfer
- Where
- China
- Volunteers
- 336 people
- Sponsor
- Shandong University of Traditional Chinese Medicine
Infertility, Female
Early Preparation With Gonadotropin- Releasing Hormon (GnRh) Agonists Injection With Frozen-Thawed Embryo Transfer?
The study intended to include >200 infertile women with impaired ovulation who will be subjected to HRT at D-21 of previous menstrual cycle (Group A) or D-1 of menses of replacement cycle (Group B).
- Trial name
- NCT03353883
- Testing
- Triptorelin SR
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Benha University
Subfertility
Clinical Effectiveness of Frozen Thawed Embryo Transfer Compared to Fresh Embryo Transfer
The objective of the present randomized controlled study is to compare clinical effectiveness and safety of freezing all embryos followed by frozen-thawed embryo transfer (FET) compared to fresh embryo transfer, in women…
- Trial name
- NCT02570386
- Testing
- Fresh embryo transfer, Frozen embryo transfer
- Where
- China
- Volunteers
- 138 people
- Sponsor
- The University of Hong Kong
Pregnancy Rate
Luteal-Phase GnRH Agonist Administration in Frozen-Thawed IVF Embryo Transfer Cycles
Supraphysiological hormonal stimulation enables collecting many oocytes in an In-Vitro Fertilization treatment, but may have a negative effect on uterine function and contribute the fact that the majority of preembryos placed in…
- Trial name
- NCT00542126
- Testing
- Decapeptyl 0.1 mg after embryo transfer
- Where
- Israel
- Sponsor
- Shaare Zedek Medical Center
Infertility Assisted Reproductive Technology
Association Between Serum Progesterone Levels on Embryo Transfer Day and Clinical Pregnancy in Frozen-thawed Embryo Transfer Cycles Using Hormone Replacement Therapy
A retrospective evaluation of routinely collected clinical, embryological, laboratory, and pregnancy outcome data provides an efficient approach to examine the association between serum progesterone on the day of FET and clinical…
- Trial name
- NCT07858227
- Testing
- data collection
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Frozen Thawed Embryo Transfer
Artificial Endometrial Preparation for Frozen Thawed Embryo Transfer Applying Either Endometrin or Utrogestan
The transfer of frozen-thawed embryos can be performed in a natural ovulatory cycle or in a hormonally manipulated cycle with a comparable pregnancy rate of 15%-20% per ET.
- Trial name
- NCT00345306
- Testing
- Comparison between two different progesterone administration
- Where
- 2 sites in Israel
- Volunteers
- 120 people
- Sponsor
- Hadassah Medical Organization
Endometrium
The Effect of Tamoxifen on Clinical Outcome in Women With Thin Endometrium Undergoing Frozen Thawed Cycle.
Cryopreservation of embryos created during fresh IVF cycles provides a less expensive and time-intensive opportunity for pregnancy. Ideal endometrium thickness is the key point to optimization FET cycle.
- Trial name
- NCT03060304
- Testing
- Tamoxifen, estradiol valerate
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Infertility, Female
Effect of Oxytocin Antagonists on Implantation Success Rates of Frozen-thawed Embryo Transfer
Uterine contraction has a negative impact on implantation and pregnancy rates. Inhibition of oxytocin receptors decreases uterine contraction frequency both on pregnant and non-pregnant women.
- Trial name
- NCT03904745
- Testing
- Atosiban
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Infertility
The Effects of Estrogen on Artificial Endometrium
In this prospective randomized trial, the parameters of the frozen-thawed embryo transfer (FET) cycles were analyzed. This study was undertaken in the Department of Assisted Reproductive Technologies and Reproductive Genetics…
- Trial name
- NCT03155048
- Testing
- oral estrogen replacement therapy, Estradiol transdermal patch
- Where
- Turkey (Türkiye)
- Volunteers
- 317 people
- Sponsor
- Memorial Sisli Hospital, Istanbul
Infertility
Evaluation of Blastocyst Morphology and Quality in Patients With Embryo Transfer at the Blastocyst Stage
In this prospective study, the investigators aim to investigate the role of trophectoderm cells and inner cell mass cells on pregnancy outcomes in blastocyst transferred in-vitro fertilization pregnancy.
- Trial name
- NCT05510557
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Infertility
Frozen Embryo Transfer (FET) in Natural Cycles or in Natural Cycles Controlled by Human Chorionic Gonadotropin (hCG) Administration
The rational of the study is to assess the implantation, pregnancy and live birth rates after the transfer of frozen- thawed embryos in natural cycles with spontaneous Luteinizing Hormone (LH)/Progesterone rise or in natural…
- Trial name
- FRET (NCT00809107)
- Testing
- HCG
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Progesterone Supplementation
Optimal Length of Progesterone Supplementation Before the Transfer of Cryopreserved (Frozen)-Thawed Day 3 Embryos in an Artificial Cycle With Exogenous Estrogen and Progesterone
Cryopreserved-thawed embryos are often replaced in an artificial cycle, in which the endometrium is prepared by exogenous estrogen and progesterone with or without the use of GnRH agonist downregulation.
- Trial name
- PROFETA-3 (NCT01940653)
- Testing
- Progesterone
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
IVF
Natural Cycle Versus Hormone Replaced Cycle
Recent sutdies indicate that the existence of corpus lutein in the ovary is a key point to prevent preeclampsia, and patients undergoing FET with hormone replaced cycle have no corpus lutein and the absence of corpus lutein…
- Trial name
- NCT04310683
- Testing
- natural cycle for endometrium preparation, hormone replaced cycle for endometrium preparation
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Embryo Transfer
Natural Cycles With Spontaneous Versus Induced Ovulation in FET
In recent years, frozen-thawed embryo transfer procedure (FET) has been widely used to increase the cumulative pregnancy rate per IVF-cycle: which is the best preparation protocol remains a matter of debate.
- Trial name
- NCT03581422
- Testing
- hCG administration before embryo transfer
- Volunteers
- 2,866 people
- Sponsor
- Istituto Clinico Humanitas
Infertility
Pregnancy Outcome of Women Using Low Molecular Weight Heparin Before Frozen-thawed Embryo Transfer
Embryo freezing is a technique used commonly to optimize the pregnancy rate in assisted reproduction techniques (ART). Hormone replacement therapy (HRT) regimen is applied to prepare endometrium for frozen embryo transfer (FET)…
- Trial name
- NCT03120715
- Testing
- estrogen, Low Molecular Weight Heparin, hCG
- Where
- China
- Volunteers
- 342 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Infertility
The Effects of Two Endometrium Preparation Protocols in Frozen-thawed Embryo Transfer in Women With Irregular Cycles
There are two main cycle regimens used for endometrial preparation for frozen embryo transfer （FET) in women with irregular cycles: hormone replacement therapy cycles (HRT) in which the endometrium is artificially prepared by…
- Trial name
- NCT01780610
- Testing
- Letrozole and human chorionic gonadotrophin, estradiol and progesterone
- Where
- China
- Volunteers
- 670 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Subfertility
Oral Dydrogesterone as Luteal Phase Support in Natural Cycle FET
This randomised double-blinded controlled trial aims to compare the live birth rate in natural FET cycles with and without oral dydrogesterone as luteal phase support.
- Trial name
- NCT03859921
- Testing
- Dydrogesterone
- Where
- China
- Volunteers
- 716 people
- Sponsor
- The University of Hong Kong