Clinical trials: Functional Aging
Frailty, Quality of Life
Indonesia Frailty, Aging, and Longitudinal Study
Frailty is a dynamic process from fit (robust) and pre-frail elderly. There is no previous study that determine the risk factors from fit to pre-frailty and pre-frailty to frailty in Indonesian elderly.
- Trial name
- INA-FRAGILE (NCT02345083)
- Where
- Indonesia
- Volunteers
- 300 people
- Sponsor
- Universitas Indonesia
Arterial Stiffness, Oral Health
Predication of Arterial Stiffness in Healthy Adults by Oral Health and Chewing Assessments
INN.oral.HEALTH is an sub-study embedded in the Innsbruck Health Promotion Program (INN.HEALTH). The study investigates whether oral health, oral structure, and oral function provide additional information for understanding…
- Conditions
- Arterial Stiffness, Oral Health, Mastication, Deglutition
- Trial name
- INNoralHEALTH (NCT07736222)
- Testing
- Dentition and Occlusal Status Assessment, Oral Health Assessment Tool, Maximum Bite Force Measurement
- Where
- Austria
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- VASCage GmbH
Sarcopenia, Aging
Supplemental Egg Protein Intervention in Older Adults
Older adults are at risk for developing sarcopenia, or age-related muscle loss, which increased the risk of disabilities, falls, and loss of independence.
- Trial name
- SPRI (NCT03530774)
- Testing
- powdered egg white protein supplement, maltodextrin supplement
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- The University of Texas at San Antonio
Perimenopause, Aging
Impact of Funcional Exercise and Supplementation in Perimenopausal Women's Health
The goal of this clinical trial is to learn whether a natural-origin nutritional supplement, combined with a functional exercise program, can improve psycho-emotional, cognitive, functional, and neuroendocrine health in…
- Trial name
- NCT07251296
- Testing
- Exercise + nutritional supplement
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- University of Valencia
Aging, Cognitive Function
Efficacy of Computer-Based Cognitive Game Training for Healthy Elderly
The declination on cognitive and motor functions in older adults increases the difficulty to achieve successful aging. Previous studies had reported that contrast to the traditional cognitive training methods, computer cognitive…
- Trial name
- NCT03940079
- Testing
- computer-based cognitive game (including 3 training tasks)
- Where
- Taiwan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Motoric Cognitive Risk Syndrome, Mild Cognitive Impairment
Pre-demential Motoric Cognitive Risk Syndrome in Ageing Subjects
The main aim of the study is to characterize and understand the pathological mechanisms underlying the motoric cognitive risk syndrome, which is a predictor of Alzheimer disease.
- Conditions
- Motoric Cognitive Risk Syndrome, Mild Cognitive Impairment, Alzheimer Disease, Dementia
- Trial name
- PRESAGE (NCT05640141)
- Testing
- MRI evaluation, Actimetry & IMU, Gait evaluation
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Aging, Inspiratory Muscle Weakness
Effect of Inspiratory Muscle Training on Diaphragm Muscle Thickness, Fatty Liver Density and Aerobic Capacity in Elderly Men: A Randomized Controlled Trial
This randomized controlled trial aims to investigate the effects of a 4-week inspiratory muscle training (IMT) program on diaphragm muscle thickness, fatty liver density, functional capacity, and quality of life in elderly men…
- Conditions
- Aging, Inspiratory Muscle Weakness, Fatty Liver, Reduced Functional Capacity
- Trial name
- IMT AND ELDERL (NCT07193082)
- Testing
- Experimental Inspiratory Muscle Training (IMT Group), Control Group: No inspiratory muscle training.
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gümüşhane Universıty
Sleep, Cognitive Impairment
Observational Study About Sleep Quality and Its Impact on Daily Life of Nursing-home Residents
Introduction: Poor sleep quality is common in most older adults. Because of the progressive aging of the population in Spain, there are more and more nursing-home and day centers, which give care to older adults.
- Conditions
- Sleep, Cognitive Impairment, Quality of Life, Age Problem
- Trial name
- NCT04592796
- Testing
- Xiaomi MiBand2, Socio-demographic questionnaire, EuroQol-5D-5L
- Where
- Spain
- Volunteers
- 21 people
- Sponsor
- Universidade da Coruña
Older Adults (65 Years and Older), Balance
Gait Reeducation Program in Older Adults
The sequential square mat (SSM) Fisior® program is a novel functional gait training tool designed to enhance motor control, coordination, and strength through guided step sequences on a visual-tactile platform.
- Conditions
- Older Adults (65 Years and Older), Balance, Gait Disorders, Physical Performance
- Trial name
- NCT07006584
- Testing
- Experimental, Active Comparator #1
- Where
- Peru
- Volunteers
- 47 people
- Sponsor
- Universidad Europea de Madrid
Depressive Symptoms, Aging
Digital Gaming Intervention for Older People in Long-term Care
Older people in long-term care (LTC) are often less physically active than their community-dwelling peers. Low physical activity level is associated with more symptoms of anxiety and depression as well as with lower physical…
- Conditions
- Depressive Symptoms, Aging, Loneliness, Sedentary Behavior
- Trial name
- NCT06018974
- Testing
- Yetitablet gaming
- Where
- Finland
- Volunteers
- 49 people
- Sponsor
- University of Oulu
Anxiety Disorders, Depression
Mindfulness-based Stress Reduction and Cognitive Function in Stress and Aging
The investigators are developing and then testing whether Mindfulness-Based Stress Reduction, a group-based instruction for increasing mindfulness, reduces anxiety and depressive symptoms and improves cognitive functioning in…
- Trial name
- NCT01693874
- Testing
- MBSR, control (health education)
- Where
- 2 sites in United States
- Volunteers
- 103 people
- Sponsor
- Washington University School of Medicine
Aging, Older Adults
Effects of Resistance Training in Untrained Older Adults
The latest randomized controlled trials and systematic reviews of resistance training performed by older adults reported that the systematic use of exercise in machines improves muscle strength and power, functional abilities…
- Trial name
- NCT02253615
- Testing
- Machines exercises, Elastic exercises
- Where
- Brazil
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Brasilia
Aging, Endothelial Dysfunction
COMP-4 Supplementation and Brachial Artery FMD
In a young and healthy person, the production of nitric oxide (NO) by the endothelium, the inner lining of the blood vessel, is responsible for a) the ability of the blood vessel to dilate so it can increase its blood flow and b)…
- Conditions
- Aging, Endothelial Dysfunction, Senescence
- Trial name
- NCT05595915
- Testing
- COMP-4
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Alzheimer Disease, Dementia
Brain Safe: Consumer Intervention to Reduce Exposure to Drugs Linked to Alzheimer's Disease
This study is an RCT to evaluate the effectiveness of Brain Safe on reducing anticholinergic exposure. Over 42 months, the trial will enroll 700 community-dwelling older adults who were prescribed one or more strong…
- Trial name
- NCT04121858
- Testing
- Brain Safe App, Attention Control App
- Where
- 2 sites in United States
- Volunteers
- 706 people
- Sponsor
- Indiana University
Aging, Functional Disturbance
Home Support for Elderly: Evaluation of Intra- Extrinsic Determinants Which Maximize This Possibility
The French National Institute of Statistics and Economic Studies (INSEE) projects that the number of people aged 75 and over will increase in France from 5.2 million in 2007 to 11.6 million in 2060 (i.e., a 123% increase) and…
- Conditions
- Aging, Functional Disturbance, Home
- Trial name
- MADMAX (NCT06121778)
- Testing
- Home
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Erectile Dysfunction, Cardiac Disease
Stem Cells for the Improvement of Erectile and Cardiac Function in Aging Men
Men who present with erectile dysfunction as defined as an IIEF (International Index of Erectile Function) score less than 21 will be evaluated for risk factors for cardiovascular disease (CVD). This is a single-blind study.
- Trial name
- NCT02107118
- Testing
- ARM 1: AdMSC: adipose stem cells
- Where
- United States
- Sponsor
- Baylor College of Medicine
Persistent COVID-19, Quality of Life
Vascular Structure, Vascular Function and Vascular Aging in Adults Diagnosed With Persistent COVID
The ICOPER study aims to analyze the structure, vascular function, vascular aging and determining factors in 300 adults diagnosed with Persistent Covid in the field of Primary Health Care.
- Conditions
- Persistent COVID-19, Quality of Life, Lifestyles, Arterial Stiffness
- Trial name
- ICOPER (NCT05819840)
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Aging
Effect of Two Years of Resistance Training on Health Status in Postmenopausal Women: Longitudinal Study Active Aging.
Aging is a natural process of the life cycle that can result in morphological, neuromuscular, metabolic, physiological, cognitive and behavioral changes that can compromise quality of life, autonomy, self-esteem, health and life…
- Trial name
- NCT06621368
- Testing
- Exercise, Control-no treatment
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Londrina
Stroke
Power Exercise for Stroke Recovery: The POWER Pilot Trial (POWER-P)
Weakness is one of the most common consequences of stroke. For the over 750,000 Canadians living with stroke, many daily activities like standing from a chair, walking and balance not only require strength but often efforts in…
- Trial name
- POWER-P (NCT06780995)
- Testing
- Power Exercise for Stroke Recovery (POWER), Strength Training Engaging Guidelines to Enhance Total Health (STRENGTH)
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- McMaster University
Ventricular Function
The Effect of Exercise and Alagebrium on the Diastolic Function of the Heart
The purpose of this study is to determine whether an investigational drug (Alagebrium (generic: ALT-711), a type of medication referred to as an advanced glycaton end-product clever) can be combined with exercise training to…
- Trial name
- AGE (NCT01014572)
- Testing
- Aerobic Exercise Training, Alagebrium (generic: ALT-711), Tai Chi and/or Yoga Training
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center