Clinical trials: Functional Aging
Age-Related Lung Function Decline
Ongoing Lung Decline With Age Intensified Response
This Phase II, randomized, double-blind, placebo-controlled pilot study will evaluate the effects of fisetin, a senolytic flavonoid compound, on lung function and biomarkers of cellular senescence in older adults aged 60 years…
- Trial name
- OLD AIR (NCT07676435)
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Aging
Anticipatory Care Planning Intervention for Older Adults at Risk of Functional Decline: A Primary Care Feasibility Study
The purpose of this study is to explore the feasibility of delivering anticipatory care planning provided by nurses through a series of home visits.
- Trial name
- NCT03902743
- Testing
- Anticipatory Care Plan group
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Chronic Stroke, Healthy Aging
Alternative Therapies for Improving Motor Impairment, Fall-risk and Overall Physical Function
Neurological impairment such as stroke and aging is a leading cause of adult disability. Traditional rehabilitative therapies can help regain motor function and ameliorate disability.
- Trial name
- NCT03758846
- Testing
- Cognitive-motor exergaming, Conventional balance Training, Dance Therapy for Stroke
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
HIV
Feasibility of an Exercise Intervention
The overall purpose of this research is to evaluate the effect of a home-based exercise program on physical function and to improve the health and quality of life for the HIV-infected older adult community.
- Trial name
- MESH (NCT01984060)
- Testing
- HOME-EX
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Rochester
Sedentary Lifestyle, Blood Pressure
Blueberry Enhances Activity and Cognition Through Increased Vascular Efficiency
Recent evidence suggests that increased berry intake results in a variety of health benefits, across multiple health domains. This 3-month randomized, double-blind, placebo-controlled trial assess the effects of combining daily…
- Conditions
- Sedentary Lifestyle, Blood Pressure, Arterial Stiffness, Overweight and Obesity
- Trial name
- BEACTIVE (NCT04049162)
- Testing
- Blueberry Plus Exercise (BB-EX)
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Duke University
Endothelial Dysfunction, Aging
Effects of Aronia Berries on Vascular Endothelial Function and the Gut Microbiota in Middle-Aged/Older Adults
Aging is the primary risk factor for cardiovascular disease (CVD) largely due to vascular endothelial dysfunction, a major initial step in the development of atherosclerosis.
- Trial name
- NCT03824041
- Testing
- Aronia full spectrum - half dose, Aronia full spectrum - full dose
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Aging, Physical Activity
Effects of Regular Exercise on Cerebrovascular Reserve in Older Adults
While it is well established that physical inactivity is a modifiable risk factor for vascular disease and cognitive decline, the mechanism by which exercise exerts its protective effect on the cerebral circulation and cognition…
- Conditions
- Aging, Physical Activity, Cognitive Function
- Trial name
- BIM (NCT03158337)
- Testing
- Aerobic exercise
- Where
- Canada
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Healthy
The Effect of Probiotic Supplementation on Cognitive and Emotional Functions in Healthy Elderly Subjects
This study evaluates the cognitive and emotional effects of probiotics in healthy elderly patients.
- Trial name
- NCT04828421
- Testing
- Lactobacillus rhamnosus and Bifidobacterium lactis
- Where
- 3 sites in Spain
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universidad de Almeria
Central Nervous System Disease, Cerebrovascular Accident
Brain Processing of Language Meanings
This research trial will study discourse processing-that is, how the brain processes the meaning of language. It will examine, for example, how words and sentences are interpreted in cases where more than one meaning is possible.
- Conditions
- Central Nervous System Disease, Cerebrovascular Accident, Craniocerebral Trauma, Head Injury
- Trial name
- NCT00005004
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Preventing Age-Related Muscle Loss: the Role of Exercise in Improving Strength, Function, and Well-being
Muscle Aging Evaluation
This study aims to assess the effects of physical activity in counteracting muscle aging. The increasing life expectancy worldwide has led to a rise in age-related muscle decline, which negatively impacts strength, function, and…
- Trial name
- NCT06845748
- Testing
- Physical activity Group
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Milan
Aging, Healthy
Healthy Aging Through Dietary Intervention
To test the impact of flavanol supplementation of cardiac and vascular function and subsequently on exercise capacity in elderly individuals
- Trial name
- NCT05782309
- Testing
- Flavanol
- Where
- Germany
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Aging, Cognitive Decline
Impact of a Novel Brain Longevity Supplement Containing the Postbiotic Urolithin A (Mitopure) on Cognitive Function and Related Health Outcomes
This is a parallel group, randomized, double-blind, placebo-controlled clinical study assessing the safety and effects of a novel nutritional product on self-reported cognitive function and health in adults that reside in the…
- Conditions
- Aging, Cognitive Decline, Brain Fog, Cognitive Function
- Trial name
- CLARITY (NCT07060898)
- Testing
- Active Product
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Healthy Ageing
Neuroplasticity: The Effects of Exercise Training on Cognitive and Affective Functioning of Older People
This study investigates the effects of exercise on older people's cognitive and affective functions, and the possible underlying neurobiological pathways.
- Trial name
- NCT04641429
- Testing
- Qigong exercise, Stretching exercise
- Where
- Hong Kong
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Obesity (Disorder), Obesity
Effect of Vitamin D on Body Composition and Functionality of Older Adults
Older adults with obesity often experience a gradual loss of muscle mass and muscle strength, a condition sometimes described as sarcopenic obesity.
- Conditions
- Obesity (Disorder), Obesity, Sarcopenia, Sarcopenia in Elderly
- Trial name
- NCT07275177
- Testing
- Vitamin D
- Where
- Mexico
- Volunteers
- 29 people
- Sponsor
- Universidad Autónoma Benito Juárez de Oaxaca
Functional Ability, Cognitive Decline
Caregiver Training: Evidence of Its Effectiveness for Cognitive and Functional Improvement in Older Adults
Due to demographic changes that have resulted in an aging population, the role of caregiver of an older adult has become very important in recent years.
- Conditions
- Functional Ability, Cognitive Decline, Older Adults, Healthy Aging
- Trial name
- NCT04490070
- Testing
- Cognitive Stimulation
- Where
- 10 sites in Spain
- Volunteers
- 160 people
- Sponsor
- Universidad de Granada
Aging, Balance Control in Elderly
Effects of Telerehabilitation-Based Dual-Task Exercises on Balance, Fall Risk, Cognitive Function, and Sleep Quality in Geriatric Individuals
The purpose of this study is to investigate the effects of dual-task exercises-which simultaneously target cognitive and motor functions-delivered via telerehabilitation on fall risk, balance, cognitive functions, and sleep…
- Conditions
- Aging, Balance Control in Elderly, Sleep Disorder (Disorder)
- Trial name
- NCT07472101
- Testing
- Telerehabilitation Based Dual-Task Exercises, Educational Brochure and Phone Follow-Up
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bulent Ecevit University
COPD, Particulate Matter Induced Inflammation of the Lung
Efficacy and Feasibility of Ectoin® Inhalation Solution in Inflammatory Obstruction and Ageing of the Lung
To investigate the physical inflammation inhibition effects of EIL (Ectoin-Hydro-Complex) in subjects of the established SALIA-cohort and the preventive effects on lung function decline.
- Trial name
- EFECT (NCT01225965)
- Testing
- Ectoin Inhalation Solution
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- Bitop AG
Aging
Using TMS to Increase Executive Function in Older Adults
Cognitive decline and dementia have become important public health issues in our time as medical science has increased lifespan and our society becomes progressively older.
- Trial name
- WMTMS (NCT02767323)
- Testing
- rTMS
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Duke University
Obesity
Vibegron for ENergy Thinking and Resilience in Aging
This 12-week randomized, double-blind, placebo-controlled trial will test the hypothesis that Vibegron (brand name GEMTESA) can improve energy metabolism, cardiometabolic risk factors, and physical and cognitive function in…
- Trial name
- VENTURA (NCT06987383)
- Testing
- Vibegron
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University Health Sciences
Fall Prevention in Healthy Aging, Fall
Effect of LiFE-SePBT on Postural Stability in Community-dwelling Older Adults: an Assessor-blinded Randomised Controlled Trial
This study is an assessor-blinded randomised controlled trial investigating the effects of combined Lifestyle-integrated Functional Exercise and Self-initiated Perturbation-based Balance Training (LiFE-SePBT) on postural…
- Conditions
- Fall Prevention in Healthy Aging, Fall, Fall Prevention Training, Postural Control
- Trial name
- LiFE-SePBT (NCT07842094)
- Testing
- Lifestyle-integrated Functional Exercise, Upper limb mobilisation and flexibility training
- Where
- Hong Kong
- Volunteers
- 44 people
- Sponsor
- The Hong Kong Polytechnic University