Clinical trials: Functional Brain Mapping
Glioma (Any Grade) in the Brain, Gliomas, Malignant
Brain Connectivity Changes in Glioma Patients During Treatment
The goal of this observational study is to better understand how the brain changes during the treatment of glioma. In particular, the study looks at changes in important brain areas that are responsible for functions such as…
- Conditions
- Glioma (Any Grade) in the Brain, Gliomas, Malignant, fMRI Research, Neurocognitive Function
- Trial name
- GliRecon (NCT07612917)
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Johannes Kepler University of Linz
Healthy
Magnetic Resonance Imaging of Calculus Problem Solving
This study will use magnetic resonance imaging (MRI) to identify brain regions involved in solving algebraic math problems. It will examine brain activation according to the level of difficulty and the number of steps required to…
- Trial name
- NCT00060658
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Spinal Cord Diseases
Reorganization of Brain Functions in Patients With Cervical Myelopathy Using fMRI and MRS
Decompressive surgery to relieve symptoms of spinal cord compression due to dysfunction, such as arthritis, has proved variable in success.
- Trial name
- NCT00447343
- Testing
- Decompressive cervical spine surgery, fMRI and MRS scan
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Functional Neuroimaging
Sensorimotor Imaging for Brain-Computer Interfaces
The investigators will use fMRI to map movement activity in motor and somatosensory cortex using enriched imagery in people with chronic tetraplegia.
- Trial name
- NCT04723823
- Testing
- Motor or sensory imagery with fMRI
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pittsburgh
Stroke
The Application of Thermal Stimulation on Functional Recovery of Stroke Patients
In literature review, thermal stimulation (TS) intervention is effective in facilitating upper extremity functional recovery in stroke patients.
- Trial name
- NCT01418404
- Testing
- Noxious TS, Innocuous TS, High Frequency of Noxious TS
- Where
- Taiwan
- Volunteers
- 220 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Brain Mapping, Deafness
Areas of Brain Responsible for Understanding American Sign Language
The human brain is made up of two halves called hemispheres. Each half of the brain is responsible for processing different kinds of information.
- Conditions
- Brain Mapping, Deafness, Healthy
- Trial name
- NCT00001782
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy Control Subjects, Schizophrenia Diagnosis
Understanding Lifespan Trajectories of Social Cognition, Brain Microstructure and Iron Dysregulation in Schizophrenia
This study aims to better understand how schizophrenia may affect social thinking, emotion regulation, brain function, and biological processes over time. Two groups will take part in the study: 1.
- Trial name
- NCT07856381
- Where
- Austria
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Ischemic Stroke
A Phase 2b Trial of Lesion Network Mapping-Guided cTBS for Motor Recovery After Acute Ischemic Stroke
This Phase 2b study will evaluate whether lesion network mapping-guided continuous theta burst stimulation (cTBS) can improve recovery after acute ischemic stroke.
- Trial name
- MASTRE-2 (NCT07645560)
- Testing
- LNM-navigated cTBS
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Brain Neoplasm, Metastatic Malignant Neoplasm in the Brain
Electrocorticography in Mapping Functional Brain Areas During Surgery in Patients With Brain Tumors
This pilot clinical trial studies how well electrocorticography works in mapping functional brain areas during surgery in patients with brain tumors.
- Conditions
- Brain Neoplasm, Metastatic Malignant Neoplasm in the Brain, Recurrent Brain Neoplasm
- Trial name
- NCT02754544
- Testing
- Direct Electrocortical Stimulation, Electrocorticography
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- M.D. Anderson Cancer Center
Premature Ejaculation, Sexual Dysfunction
Brain Networks Implicated in Lifelong Premature Ejaculation Patients
Using Brain Mapping and Cognitive ERPs, the investigatos have searched for a Brain Networks involved during Inhibitory Control in Lifelong Premature Ejaculation (LPE) participants.
- Trial name
- LPE (NCT04850703)
- Testing
- Transcranial Radom Noise Stimulation, Take Dapoxetine, Compare LPE EEG endophenotype between participants and healthy controls
- Where
- Spain
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Moises Domingo
Fragile X Associated Tremor-ataxia Syndrome, FXTAS
Brain Network Activation and Gait and Posture in FXTAS
In this study the investigators aim to identify and characterize a potential neurophysiological biomarker by mapping functional networks of brain activity (Brain Network Activation, BNA) based on analysis of evoked response…
- Trial name
- FXTAS-BNA (NCT02936531)
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Sheba Medical Center
Ideomotor Apraxia
Using fMRI to Understand the Roles of Brain Areas for Fine Hand Movements
Ideomotor apraxia, a disorder that affects patients with stroke and a variety of other brain lesions, features disturbed timing, sequence, and spatial organization of skilled movements.
- Trial name
- NCT00063115
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Functional Brain Mapping
Tapfinger Psychomotor Target
The study aims at mapping the magnetoencephalographic (MEG) activities induced in normal volunteers by tapping the finger .
- Trial name
- TAPFINGER (NCT02574026)
- Testing
- Psychomotor tasks
- Where
- France
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Psilocybin
Precision Functional Brain Mapping in Psilocybin
This project will employ functional brain imaging to study the mechanism and immediate and long-term effects of psilocybin, a serotonin receptor 2A agonist, on cortical and cortico-subcortical brain networks in healthy adults.
- Trial name
- Psilocybin PFM (NCT04501653)
- Testing
- Psilocybin, Methylphenidate
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Epilepsy
Intrinsic Optical Imaging Study to Map Neocortical Seizure in Human Epilepsy Patients
The purpose of this study is to develop a technique for the intraoperative identification of human functional and epileptiform cortex using intrinsic signal imaging.
- Trial name
- NCT00195052
- Testing
- Intrinsic signal imaging of human cortex
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Weill Medical College of Cornell University
Glioblastoma, IDH-wildtype, Glioblastoma
The RECMAP-study: Resection With or Without Intraoperative Mapping for Recurrent Glioblastoma
Resection of glioblastoma in or near functional brain tissue is challenging because of the proximity of important structures to the tumor site.
- Conditions
- Glioblastoma, IDH-wildtype, Glioblastoma, Glioblastoma Multiforme of Brain, Astrocytoma, Malignant
- Trial name
- RECMAP (NCT06273176)
- Testing
- Awake mapping under local anesthesia, Asleep mapping under general anesthesia, Resection under general anesthesia without mapping
- Where
- 8 sites in United States, Belgium and 3 more
- Volunteers
- 225 people
- Sponsor
- Erasmus Medical Center
Parkinson Disease
Mapping Functional Networks of Brain Activity (Brain Network Activation, BNA) Based on Analysis of Evoked Response Potential (ERP) Signals for Healthy Controls Evoked Response Potential (ERP) Signals for Healthy Controls and Patients With Parkinson Disease
A cornerstone in PD research is the investigation of neurophysiological changes as potential biomarkers that could help in tracking disease progression and response to therapies.
- Trial name
- NCT02149498
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dr. Oren Cohen
Epilepsy, Temporal Lobe, Cognitive Decline
Pre-operative Mapping of the Anterior Temporal Lobe Using Functional MRI Innovative Techniques in in Drug-resistant Epileptic Patients
Anterior temporal epilepsy is the most frequent form of focal epilepsy (more than 50% of focal epilepsies). The epilepsy is drug-resistant when epileptic seizures persist despite antiepileptic treatment (25% of cases).
- Trial name
- CARTA (NCT05339438)
- Testing
- functional MRI
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Stroke
Multisite Transcranial Direct Current Stimulation to Promote Hand Function Recovery After Stroke
A novel multisite high definition tDCS (HD-tDCS) in healthy people showed that such network-targeted stimulation could enhance motor excitability beyond traditional stimulation which targeting only one region.
- Trial name
- NCT05638464
- Testing
- multisite HD-tDCS EMG-driven robot hand
- Where
- Hong Kong
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Parkinson Disease
Mapping Levodopa Effects on Cortico-basal Ganglia Circuit Function in Parkinson's Disease
Levodopa-induced dyskinesia (LID) in Parkinson's disease (PD) are involuntary movements caused by long-term treatment with dopaminergic replacement therapy (levodopa). During the cause of PD, most patients develop LID.
- Trial name
- Dyn-fMRI-PD (NCT06240624)
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Danish Research Centre for Magnetic Resonance