Clinical trials: Functional Cardiac Disorder
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Ventricular Fibrillation, Ventricular Tachycardia
Investigation of Cognitive Function Before and After Induced Ventricular Fibrillation in Electrophysiological (EP) Study
In this study, changes in electroencephalogram (EEG) and the hemodynamic state during ventricular fibrillation or induced ventricular tachycardia are investigated.
- Trial name
- NCT00176176
- Testing
- EEG
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Heidelberg University
STEMI
ReModeling in ST-elevation myocARrdial Infarction: a Comparison of Left VEntricuLar Functions in Long-term Follow-up Among STEMI Patients
Patients diagnosed with STEMI who underwent pPCI were included in this study. The investigators collected comprehensive data on each patient's status, including laboratory findings such as NT-proBNP, troponin levels, and…
- Trial name
- MARVEL (NCT07041840)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University of Pisa
Acute Coronary Syndrome, Acute Myocardial Infarction
VerifyNow to Optimise Platelet Inhibition in Coronary Acute Syndrome
The objective of the study is to establish a de-scaling strategy of P2Y12 inhibitors (P2Y12 i) with a decrease in hemorrhagic events without increasing ischemic complications based on a Platelet Function Test (PFT).
- Conditions
- Acute Coronary Syndrome, Acute Myocardial Infarction, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- VERONICA (NCT04654052)
- Testing
- Clopidogrel, Previous treatment
- Where
- 19 sites in Spain
- Volunteers
- 637 people
- Sponsor
- Fundación EPIC
Drug Effect
The Effects of Sacubitril/Valsartan on the Heart Functions
Background: Sacubitril/valsartan, has been found to be more beneficial than enalapril for reducing the incidences of sudden cardiac death, death from worsening heart failure (HF), and hospitalization.
- Trial name
- NCT03830814
- Testing
- Echocardiography
- Volunteers
- 100 people
- Sponsor
- The Young Investigator Group of Cardiovascular Research
Chronic Obstructive Pulmonary Disease (COPD)
Physical Training and Heart Rate Variability in COPD
To contrast the potential effects of physical exercise training program (PTP) of a 6 versus 12 weeks on cardiac autonomic modulation by linear and non-linear heart rate variability (HRV) indices and functional capacity in…
- Trial name
- NCT01889563
- Testing
- Physical Exercise Training Program Exercise
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Universidade Federal de Sao Carlos
Insulin Resistance, Diabetes Mellitus Type 2
Insulin Sensitivity, Irisin and Adipokines as Outcome Parameters in Patients Undergoing Cardiac Surgery
BACKGROUND: Surgical injury and inflammation provoke a stereotypical stress response. Insulin resistance plays an intriguing role in these metabolic alterations and depends on the intensity of injury.
- Conditions
- Insulin Resistance, Diabetes Mellitus Type 2, Other Functional Disturbances Following Cardiac Surgery
- Trial name
- NCT02258698
- Testing
- Cardiac surgery
- Where
- Switzerland
- Volunteers
- 348 people
- Sponsor
- University Hospital, Basel, Switzerland
Anterior MI, Colchicine
Effect of Colchicine On Left Ventricle Function After Anterior Myocardial Infarction Assessed By Speckle Tracking
Effect of colchicine use on Left ventricles systolic function in patients with anterior S-T elevation myocardial infarction undergoing primary Percutaneous coronary intervention by using speckle tracking Echocardiography…
- Trial name
- NCT05200052
- Testing
- Colchicine 0.5 mg Oral Tablet
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Atrial Fibrillation, Renal Insufficiency
Renal Function Post Cardioversion for Atrial Fibrillation
Atrial fibrillation is a common arrhythmia which requires electrical cardioversion in many patients in order to regain sinus rhythm.
- Conditions
- Atrial Fibrillation, Renal Insufficiency, Cardioversion
- Trial name
- AFCARD-II (NCT02742207)
- Testing
- Electrical atrial fibrillation Cardioversion, Cardioversion
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Hadassah Medical Organization
Coronary Heart Disease, Image
Research on the Relationship Between Cognitive Function Changes and Cerebrovascular Health in Patients With Coronary Heart Disease
The purpose of this study is to elucidate the imaging mechanisms of cognitive function changes in patients with coronary heart disease before and after surgery or conservative treatment, and to evaluate and predict the…
- Trial name
- NCT05848934
- Testing
- magnetic resonance image, Neuropsychological scale
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nanjing University of Traditional Chinese Medicine
Cardiomyopathy, Dilated
Vitamin D Supplementation Can Improve Heart Function in Idiopathic Cardiomyopathy
Vitamin D deficiency could be a high risk for cardiovascular diseases. It has been recently reported that vitamin D deficiency is another cause of heart failure and cardiomyopathies.
- Trial name
- NCT02517814
- Testing
- Vitamin D
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hillel Yaffe Medical Center
Coronary Artery Disease, Oxidative Stress
Effects of Curcumin on Markers of Cardiovascular Risk in Patients With CAD
General Objective To evaluate the effects of curcumin supplementation on cardiovascular risk markers, inflammation, oxidative stress and functional capacity in participants with coronary artery disease.
- Conditions
- Coronary Artery Disease, Oxidative Stress, Inflammation
- Trial name
- NCT04458116
- Testing
- Curcumin
- Where
- Brazil
- Sponsor
- Universidade Federal Fluminense
Pulmonary Function, Coronary Artery Disease
Additional Effects of Ujjayi Pranayama
Studying the impact of Ujjayi pranayama on post-Coronary Artery Bypass Grafting (CABG) patients has the potential to positively influence healthcare.
- Trial name
- NCT06663800
- Testing
- Ujjayi Paranayama, Standard Protocol
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Myocardial Infarct, Hyperglycemia
Impact of Tight Glycaemic Control in Acute Myocardial Infarction
To determine whether tight glycaemic control with insulin improves myocardial function and myocardial perfusion (measured by myocardial contrast echocardiography) and novel vascular risk factors in patients with acute myocardial…
- Trial name
- NCT00237471
- Testing
- Insulin (tight blood glucose control)
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Melbourne Health
Schizophrenia, Insight Impaired
The Effects of Bimodal tDCS on Illness Severity, Insight, Functional Outcomes, Neurocognition and HRV in Schizophrenia
The study aimed to investigate the effects of bimodal anodal transcranial direct current stimulation (tDCS) over bilateral dorsolateral prefrontal cortex (DLPFC) on psychopathological symptoms, insight, psychosocial functioning…
- Conditions
- Schizophrenia, Insight Impaired, Psychotic Symptoms, Schizoaffective Disorder
- Trial name
- NCT03701100
- Testing
- tDCS
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Obesity, Metabolic Dysfunction-associated Steatotic Liver Disease
ELEVATE-LIVER: A Study to Test Whether Survodutide Helps Improve Heart Structure and Function in People With Overweight or Obesity and Fatty Liver Disease
This study is for adults aged 18 years and older who have a type of fatty liver disease called metabolic dysfunction-associated steatotic liver disease (MASLD).
- Trial name
- NCT07850063
- Testing
- Survodutide
- Where
- 34 sites in United States, China and 3 more
- Volunteers
- 600 people
- Sponsor
- Boehringer Ingelheim
Heart Failure, Diabetes Mellitus
Metabolic Determinants of Cardiac Function
Assessment of cardiac energy metabolism in patients with impaired glucose tolerance
- Trial name
- NCT03386864
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- German Diabetes Center
Atrial Fibrillation, Left Ventricular Failure
Non-invasive Blood Pressure and Cardiac Output Measurement by Using Applanation Tonometry
To evaluate and to validate accuracy, precision and trending ability of blood pressure and cardiac output measurement by applanation tonometry in cardiological patients having: atrial fibrillation severe impaired leftventricular…
- Conditions
- Atrial Fibrillation, Left Ventricular Failure, Left Ventricular Impaired Function, Aortic Valve Stenosis
- Trial name
- NCT02444104
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Kidney Failure, Chronic
Saving Residual Renal Function Among Haemodialysis Patients Receiving Irbesartan
Angiotensin II receptor blockers (ARB) are known to preserve kidney function among patients with kidney diseases and reduced renal function, but not among haemodialysis patients.
- Trial name
- SAFIR (NCT00791830)
- Testing
- Irbesartan
- Where
- 6 sites in Denmark
- Volunteers
- 82 people
- Sponsor
- University of Aarhus
Coronary Artery Disease
A Pharmacodynamic Study Comparing Prasugrel Versus Ticagrelor in Patients Undergoing PCI With CYP2C19 Loss-of-function:
Numerous studies have shown that pharmacodynamics (PD) response profiles vary among clopidogrel treated patients and that individuals with reduced response have an increased risk of recurrent ischemic events.
- Trial name
- NCT02065479
- Testing
- Prasugrel, Ticagrelor
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Florida
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