Clinical trials: Functional Endoscopic Sinus Surgery
Paranasal Sinus Disease
Effectiveness of Antibiotic Delivery Via Bio-absorbable Sponge
This study will evaluate the efficacy of a nasopore sponge dressing soaked in Bacitracin VS a sponge soaked in Saline / and the administration of oral antibiotics.
- Trial name
- NCT01222832
- Testing
- Bacitracin
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Agitated; State, Acute Reaction to Stress
Preemptive Chlorepheniramine Maleate Reducing Postoperative Agitation
The aim of the study is to identify the role of preoperative chlorepheniramine maleate on alleviating or reducing the severity of postoperative agitation following FESS procedures.
- Trial name
- NCT04293081
- Testing
- Preemptive chlorepheniramine maleate intravenous injection, normal saline
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Chronic Rhinosinusitis With Polyposis, Chronic Hyperplastic Sinusitis
Intravenous Tranexamic Acid and Intraoperative Visualization During Functional Endoscopic Sinus Surgery
Functional endoscopic sinus surgery (FESS) is an effective treatment of sinus disease. FESS is carried out using cameras to view the surgical field. Bleeding during the surgery can lead to poor surgical field visualization.
- Trial name
- NCT01111669
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Sinusitis, Chronic Sinusitis
Pilot Study To Evaluate A Pharmacologically Active Nasal Sponge Following Endoscopic Sinus Surgery
This study will compare the incidence of post-op infection after sinus surgery using conventional post-op oral antibiotics to the incidence of infection after sinus surgery when a bio-resorbable antibiotic soaked nasal sponge is…
- Trial name
- NCT00705354
- Testing
- Bacitracin, Nasopore sponge soaked with saline
- Where
- United States
- Sponsor
- Lahey Clinic
Endoscopic Sinus Surgery
SPI-guided vs PRD-guided Analgesia During FESS for Intraoperative Blood Loss
The aim of this randomized trial is to assess the efficacy of analgesia , compare the utility of Pupillary Dilatation Reflex (PRD), Surgical Pleth Index (SPI) for monitoring pain perception intraoperatively and their influence on…
- Trial name
- NCT03389763
- Testing
- Remifentanil
- Where
- Poland
- Volunteers
- 105 people
- Sponsor
- Medical University of Silesia
Bleeding
Nasal Desmopressin Versus Oral Bisoprolol for Controlling Bleeding During Endoscopic Sinus Surgery
Functional endoscopic sinus surgery (FESS) is well established for treatment of chronic rhinosinusitis and nasal polyps. Masking of the surgical field can lead to severe complication as tissue injury, increase post-operative…
- Trial name
- NCT05430048
- Testing
- nasal Desmopressin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Zagazig University
Functional Endoscopic Sinus Surgery
Comparison Between Pregabalin and Magnesium Sulfate in Hypotensive Anaesthesia
Comparison between pregabalin and magnesium sulfate in hypotensive anaethesia
- Trial name
- NCT05442931
- Testing
- Pregabalin 150mg, Magnesium Sulfate, Nitroglycerin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Minia University
Chronic Sinusitis
Clinical Evaluation of the Steroid-Eluting Sinexus Intranasal Splint When Used Following Functional Endoscopic Sinus Surgery (FESS) in Patients With Chronic Sinusitis
This study allows continued access to the Sinexus Intranasal Splint while a marketing application is being prepared. This study will generate additional performance, reimbursement and safety data for the steroid-eluting Sinexus…
- Trial name
- NCT00912405
- Testing
- Steroid-Eluting Sinexus Intranasal Splint
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Intersect ENT
Sinus Infection Chronic
Propofol Versus Sevoflurane During FESS
Good surgical conditions are crucial for an optimal surgery result and safe procedure. Minimal blood loss in the surgical field is one of the most important conditions to maintain a good visualization, especially in surgeries…
- Trial name
- NCT04619160
- Testing
- Propofol, Sevoflurane
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Sinus Endoscopic Surgery, Turbinate
Safety and Effectiveness of TurbAlign™ for Middle Turbinate Medialization After Functional Endoscopic Sinus Surgery
A study of a bioabsorbable implant to separate the middle turbinate from the lateral nasal wall associated with nasal/sinus surgery
- Trial name
- Gaia (NCT07027267)
- Testing
- Implantation of Spirair device into the middle turbinates, TurbAlign
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- Spirair, Inc
Chronic Sinusitis
A Clinical Evaluation of a Steroid-Coated Sinus Stent When Used Following Functional Endoscopic Sinus Surgery in Patients With Chronic Sinusitis
The purpose of this study is to assess the safety and efficacy of the Propel mometasone furoate implant when used following Functional Endoscopic Sinus Surgery (FESS) in patients with Chronic Sinusitis (CS).
- Trial name
- ADVANCE II (NCT01253577)
- Testing
- Sinus Stent with drug coating, Non Coated Sinus Stent
- Where
- 11 sites in United States
- Volunteers
- 105 people
- Sponsor
- Intersect ENT
Enhanced Recovery, Functional Endoscopic Sinus Surgery
Lidocaine Infusion Versus Magnesium Infusion in Decreasing Fentanyl Requirements in Endoscopic Sinus Surgeries
Enhanced recovery after ear, nose and throat surgery is based on multimodal and multidisciplinary perioperative interventions to decrease postoperative pain.
- Conditions
- Enhanced Recovery, Functional Endoscopic Sinus Surgery, Lidocaine, Magnesium Sulphate
- Trial name
- NCT06966102
- Testing
- Lidocaine group, Magnesium group, Control group
- Where
- Egypt
- Volunteers
- 156 people
- Sponsor
- Cairo University
Hypotension
Ivabradine Versus Propranolol for Induced Hypotension in Endoscopic Sinus Surgery
the study is designed to compare the effect of addition of oral Ivabradine, propranolol to general anesthesia aimed reduction in blood loss during functional endoscopic sinus surgery.
- Trial name
- NCT04580342
- Testing
- oral Ivabradine, oral Propranolol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ahmed talaat ahmed aly
Nasal Polyps
Infrazygomatic Versus Intranasal Injection Sphinopalatine Ganglion Blockade Effect on Surgical Field in FESS
This study aimed to show the effect of sphinopalatine ganglion blockade on surgical field, hemodynamics and postoperative pain in FEES operation.
- Trial name
- NCT04996576
- Testing
- infrazygomatic approach sphinopalatine ganglion block, intranasal injection approach of sphinopalatine ganglion block
- Where
- 2 sites in Egypt
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Blood Loss, Surgical
Assessment of Nebulized Tranexamic Acid in Functional Endoscopic Sinus Surgery Using Modena Bleeding Score
The aim of this study is to investigate the effect of preoperative administration of intravenous or nebulized tranexamic acid on surgical field, blood loss, anesthetic consumption and hemodynamics of patients undergoing FESS.
- Trial name
- NCT06725732
- Testing
- Tranexamic Acid (TXA), Tranexamic Acid
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Monitoring During Deliberate Hypotensive Anesthesia
Peripheral Perfusion Index (PPI) as Monitor During Deliberate Hypotensive Anesthesia
Hypotensive anesthesia is effective in reducing the intraoperative blood loss. The risk of hypoperfusion of vital organs continues to be a concern. An adequate monitoring of tissue perfusion and oxygenation is crucial issue.
- Trial name
- PPI (NCT03007355)
- Testing
- peripheral perfusion index measurement
- Volunteers
- 50 people
- Sponsor
- Cairo University
Chronic Rhinosinusitis, Enhanced Recovery After Surgery
Effects of Esketamine Versus Magnesium Sulfate on Emotional State and Postoperative Pain in Patients Undergoing Nasal Endoscopic Surgery
Functional endoscopic sinus surgery (FESS) is one of the effective modalities for the treatment of Functional endoscopic sinus surgery (FESS) is one of the effective ways to treat chronic sinusitis, which has the advantages of…
- Trial name
- NCT06920576
- Testing
- Esketamine, Magnesium sulfate, Saline
- Where
- China
- Volunteers
- 144 people
- Sponsor
- The Second People's Hospital of Huai'an
Nasal Polyps
Mometasone Furoate Nasal Spray for Treatment of Nasal Polyposis After Surgery (Study P03218)
This study was conducted to evaluate the effectiveness of mometasone nasal spray in preventing polyp relapse/symptom worsening in patients after surgical treatment of nasal polyps.
- Trial name
- NCT00731185
- Testing
- Mometasone Furoate Nasal Spray
- Volunteers
- 162 people
- Sponsor
- Organon and Co
Pain Management
Regional Anesthesia to Reduce Opioid Use Following Functional Endoscopic Sinus Surgery
Opioids are prescribed for moderate to severe pain disorders; however, there are contraindications and side effects that are common to all opioids.
- Trial name
- NCT03757715
- Testing
- Bupivacaine, Dexamethasone
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Alabama at Birmingham
Acetaminophen
Acetaminophen Given Per Os and Intravenous in Sinus Surgery
The primary objective of this study is to investigate the Visual Analog Score (VAS) for pain within the post-operative setting and determine if there is a statistically significant difference between the VAS for PO or IV…
- Trial name
- NCT03295214
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Massachusetts Eye and Ear Infirmary