Clinical trials: Fundoplication
Hiatal Hernia, Paraesophageal Hernia
Nissen Versus Dor Hiatal Hernia Repair
Hiatal hernia can present with a wide range of symptoms. An usual surgical repair technique usually includes Nissen fundoplication, while other procedures are less frequently employed.
- Conditions
- Hiatal Hernia, Paraesophageal Hernia, Recurrence
- Trial name
- NiDor (NCT06725433)
- Testing
- Nissen fundoplication, Dor fundoplication
- Where
- Finland
- Volunteers
- 150 people
- Sponsor
- Kuopio University Hospital
GERD
Conventional Nissen Fundoplication Versus Laparoscopic Nissen Fundoplication
This is a long-term follow-up of a prospective randomized trial comparing open and laparoscopic Nissen fundoplication.
- Trial name
- NCT01230944
- Testing
- Laparoscopic Nissen fundoplication, Open Nissen fundoplication
- Where
- Finland
- Volunteers
- 110 people
- Sponsor
- Turku University Hospital
Gastro -Oesophagal Reflux, Laryngo-pharyngeal Reflux
European TIF2.0 Registry
This is a European, multi-centre, prospective registry that aims to determine the safety and efficacy of transoral incisionless fundoplication, with or without concomitant hiatal hernia repair, for the treatment of patients with…
- Trial name
- EURO-TIF (NCT07395219)
- Testing
- Transoral incisionless fundoplication with or without concomitant hiatal hernia repair with the EsophyX device
- Where
- 7 sites in Austria, Italy and 5 more
- Volunteers
- 500 people
- Sponsor
- Cleveland Clinic London
Gastro Esophageal Reflux
GERD Treatment With Transoral Incisionless Fundoplication (TIF) Following Hiatal Hernia Surgery
The investigators prospectively studied ninety nine GERD patients following laparoscopic hiatal surgery combined with transoral incisionless fundoplication at two community hospitals.
- Trial name
- GERD (NCT03143608)
- Testing
- Esophyx
- Where
- 2 sites in United States
- Volunteers
- 99 people
- Sponsor
- Peter G Mavrelis
Gastro-oesophageal Reflux Disease
LINX vs Fundoplication
Reflux disease can severely impact upon quality-of-life and lead to complications, including ulceration of the oesophagus. It is often controlled with self-help measures and medication. However, sometimes surgery is recommended.
- Trial name
- GOLF (NCT07093359)
- Testing
- Laparoscopic or robotic LINX procedure, Laparoscopic or robotic fundoplication
- Where
- 5 sites in United Kingdom
- Volunteers
- 460 people
- Sponsor
- University of Oxford
GERD, Gastroesophageal Reflux
Observational Study of Anti-Reflux Surgery
The Anti-Reflux Surgical Study has been established to: Collect data about anti-reflux surgical treatment options (magnetic sphincter augmentation and Fundoplication) in everyday clinical practice Track the clinical course of…
- Conditions
- GERD, Gastroesophageal Reflux, Gastro Esophageal Reflux
- Trial name
- NCT01624506
- Where
- 21 sites in Austria, Germany and 2 more
- Volunteers
- 760 people
- Sponsor
- Torax Medical Incorporated
Fundoplication
Hernia Reduction Prior to Scheduled TIF Completion
Hernia Reduction Prior to Scheduled TIF Completion using EsophyX ZR transoral device
- Trial name
- HEURISTIC (NCT03280121)
- Testing
- EsophyX ZR transoral device
- Where
- 3 sites in United States
- Volunteers
- 14 people
- Sponsor
- EndoGastric Solutions
Congenital Disorders
Feeding After Neonate Surgery Review
The purpose is to determine what factors, if any, lead to delayed feeding, discharge with a NG tube, G-tube placement or Nissen fundoplication.
- Trial name
- NCT00229866
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Children's Healthcare of Atlanta
Laparoscopic Toupet Fundoplication, Radiological Negative
Laparoscopic Toupet's Fundoplication: Is it Proper Solution of Radiological Negative, Endoscopically Positive Hiatal Hernia Patients
This study aims to assess the feasibility and effectiveness of laparoscopic toupet fundoplication (LTF) for treating gastroesophageal reflux disease (GERD) symptoms and disease-specific Quality of Life (QoL).
- Conditions
- Laparoscopic Toupet Fundoplication, Radiological Negative, Endoscope, Hiatal Hernia
- Trial name
- NCT06884800
- Testing
- Laparoscopic toupet fundoplication
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Minia University
Hiatal Hernia, Paraesophageal, Hiatal Hernia Large
Laparoscopic Nissen Versus Toupet Fundoplication for Hiatal Hernia.
This randomized controlled trial compares laparoscopic Nissen fundoplication and laparoscopic Toupet fundoplication in patients undergoing surgical treatment for hiatal hernia associated with gastroesophageal reflux disease.
- Conditions
- Hiatal Hernia, Paraesophageal, Hiatal Hernia Large, Hiatal Hernia With Gastroesophageal Reflux Disease
- Trial name
- NCT07718828
- Testing
- Laparoscopic Nissen Fundoplication, Laparoscopic Toupet Fundoplication
- Where
- Bulgaria
- Volunteers
- 200 people
- Sponsor
- Sofia Med Hospital
Gastroesophageal Reflux
Laparoscopic Nissen Fundoplication Comparing Division Versus Non-Division of Short Gastric Vessels
Recently, total fundoplication followed by laparoscopic esophageal hiatoplasty has been the most common surgical treatment for gastro-esophageal reflux.
- Trial name
- NCT00852098
- Testing
- Lap Nissen fundoplication with division of short gastric vessels, Laparoscopic Nissen fundoplication without division of short gastric vessels
- Where
- 2 sites in Brazil
- Volunteers
- 2 people
- Sponsor
- Federal University of São Paulo
Quality of Life
Quality of Life Results After Laparoscopic Fundoplication.
The present study focuses on determining aspects of satisfaction and quality of life of patients that underwent laparoscopic Nissen fundoplication with or without short gastric vessel division (SGVD) and long-term differences.
- Trial name
- NCT04237038
- Testing
- laparoscopic Nissen fundoplication short gastric vessel division
- Volunteers
- 87 people
- Sponsor
- Instituto Mexicano del Seguro Social
Achalasia
POEM + F for Achalasia - a Pilot Study
This is a pilot study to investigate the feasibility of performing per-oral endoscopic Myotomy (POEM) with endoscopic fundoplication for patient with achalasia.
- Trial name
- NCT05214443
- Testing
- POEM + F
- Where
- Hong Kong
- Volunteers
- 10 people
- Sponsor
- Chinese University of Hong Kong
Airway Responsiveness
The Effect of Esomeprazole and Fundoplication on Airways
Evaluate the prevalence of bronchial responsiveness (BHR) among patients with gastroesophageal reflux disease (GERD). Investigate correlation between bronchial reactivity and the severity of GERD, and similarly investigate the…
- Trial name
- NCT00994708
- Testing
- esomeprazole
- Where
- Finland
- Sponsor
- Tampere University Hospital
Hiatal Hernia Large, Gastro Esophageal Reflux
LINX Reflux Management System or Fundoplication Clinical Study in Patients With Hiatal Hernia >3 cm
The cohort registry is both retrospective and prospective, multicenter surveillance of subjects who underwent a prior hiatal hernia repair and Magnetic Sphincter Augmentation or fundoplication construction more than 2 years prior…
- Conditions
- Hiatal Hernia Large, Gastro Esophageal Reflux, Hiatal Hernia, Hiatal Hernia, Paraesophageal
- Trial name
- NCT04695171
- Testing
- LINX Reflux Management System, Fundoplication
- Where
- 6 sites in United States
- Volunteers
- 336 people
- Sponsor
- Foregut Research Foundation
Hiatal Hernia Large, Reflux, Gastroesophageal
Platelet Rich Plasma in Hiatal Hernia Repair
Rationale: Gastroesophageal reflux disease (GERD) is a common disease caused by a dysfunctional lower esophageal sphincter and an abnormal esophageal hiatus or hiatal hernia.
- Trial name
- PPR-HHR (NCT05023174)
- Testing
- Hiatal Hernia Repair with Platelet Rich Plasma, Hiatal Hernia Repair without Platelet Rich Plasma
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Southern California
Bypass, Gastric
Evaluation of the Fundoplicature of the Excluded Stomach Post Omega Bypass
The purpose of this study is to evaluate the efficacy of fundoplication with stomach excluded in the suppression of disabling gastroesophageal reflux requiring surgery in patients who have undergone one anastomosis gastric…
- Trial name
- FEE-RGOIC (NCT06621979)
- Testing
- Bypass surgery type one anastomosis gastric bypass
- Where
- France
- Volunteers
- 17 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Patients Who Were Scheduled for General and Gynecological Laparoscopic Procedures
Evaluation of the Follow Me Mode of the AutoLap System - A Feasibility Study
The main objectives of this study are to evaluate the performance and ease of use of the Follow me mode of the AutoLap system during general and gynecological laparoscopic procedures.
- Trial name
- NCT02326870
- Testing
- AutoLap
- Where
- 4 sites in Israel, Netherlands
- Volunteers
- 33 people
- Sponsor
- M.S.T. Medical Surgery Technology LTD.
Barrett Esophagus, Transoral Incisionless Fundoplication
Outcomes After Transoral Incisionless Fundoplication (TIF) Following Successful Endoscopic Ablation for Barrett's Esophagus
Barrett's esophagus (BE) is a precancerous lesion characterized by the replacement of the normal stratified squamous epithelium of the distal esophagus by intestinal metaplasia (IM).
- Trial name
- NCT04457193
- Testing
- TIF
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Johns Hopkins University
Laparoscopic Nissen Fundoplication
Intraoperative Use of Dexketoprofen Trometamol, Pethidine Hcl, Tramadol Hcl and Their Combinations for Postoperative Pain Management in Laparoscopic Nissen Fundoplication
The purpose of this study is to evaluate the analgesic effects of dexketoprofen trometamol, tramadol hydrochloride, pethidine hydrochloride and their combinations in laparoscopic Nissen fundoplication.
- Trial name
- NCT01558622
- Testing
- dexketoprofen trometamol, tramadol hydrochloride, pethidine hydrochloride
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Kavaklıdere Umut Hospital