Clinical trials: GAD
Generalized Anxiety Disorder
Clinical Trial of Shugan Jieyu Capsule in Generalized Anxiety Disorder
This is a randomized double-blind placebo-controlled phase 3 clinical trial to further validate the effectiveness and safety of Shugan Jieyu Capsules in treating generalized anxiety disorder.
- Trial name
- NCT05772104
- Testing
- Shugan Jieyu Capsules
- Where
- China
- Volunteers
- 495 people
- Sponsor
- Sichuan Jishengtang Pharmaceutical Co., Ltd.
Generalized Anxiety Disorder
A 10-Week Study Evaluating the Efficacy And Safety of PD 0332334 for the Treatment of Generalized Anxiety Disorder
This study will evaluate the efficacy and safety of PD 0332334 for the treatment of generalized anxiety disorder.
- Trial name
- NCT00542685
- Testing
- PD 0332334
- Where
- 43 sites in United States
- Volunteers
- 551 people
- Sponsor
- Pfizer
Anxiety Disorders, Social Anxiety Disorder
The Effectiveness of Transdiagnostic CBT Protocol on Anxiety Disorders
The transdiagnostic approach argues that the common features are needed to be taken into account [e.g. distress intolerance (DI), intolerance of uncertainty (IU), worry)] underlying emotional disorders rather than evaluating them…
- Conditions
- Anxiety Disorders, Social Anxiety Disorder, Generalized Anxiety Disorder, Panic Disorder
- Trial name
- NCT06422728
- Testing
- Unified Protocol for Anxiety Disorders, Client-centered Supportive Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ibn Haldun University
Type 1 Diabetes Mellitus
Effects of Recombinant Human Glutamic Acid Decarboxylase on the Progression of Type 1 Diabetes in New Onset Subjects
The purpose of this study is to determine whether treatment with multiple injections of GAD-Alum will preserve the body's own (endogenous) insulin production in patients who have been recently diagnosed with type 1 diabetes…
- Trial name
- TN08 (NCT00529399)
- Testing
- GAD-Alum, GAD-Alum and Aluminum hydroxide, Aluminum hydroxide
- Where
- 15 sites in United States, Canada
- Volunteers
- 145 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
General Anxiety Disorder
Evaluate the Safety of GABITRIL in Adults With Generalized Anxiety Disorder
To assess the long-term safety and tolerability of tiagabine treatment in patients with generalized anxiety disorder (GAD).
- Trial name
- NCT00233675
- Testing
- GABITRIL (tiagabine hydrochloride; CEP-6671)
- Where
- 28 sites in United States
- Sponsor
- Cephalon
PostTraumatic Stress Disorder
Effectiveness and Acceptability of Stellate Ganglion Block for Posttraumatic Stress Disorder Symptoms - Effectiveness
This is a multisite, randomized, blinded, sham-procedure-controlled study to evaluate the efficacy of right-sided stellate ganglion block (SGB) on the acute symptomatology of Post traumatic Stress Disorder (PTSD), evaluated by…
- Trial name
- NCT03077919
- Testing
- Ropivacaine
- Where
- 3 sites in United States, Germany
- Volunteers
- 113 people
- Sponsor
- RTI International
Generalized Anxiety, Fear of Failure
Optimization of Late Imagery Rescripting Research Using Generative Artificial Intelligence
The aim of the study is to examine the effect of imagery rescripting (ImRs) in the context of utilizing large language models (LLMs).
- Conditions
- Generalized Anxiety, Fear of Failure, Rumination
- Trial name
- ImRs_LLM_DeanG (NCT07565714)
- Testing
- Imagery Rescripting Intervention
- Where
- 2 sites in Poland
- Volunteers
- 40 people
- Sponsor
- University of Social Sciences and Humanities, Warsaw
Anxiety Disorders, Social Anxiety Disorder
Transdiagnostic Internet-delivered REBT Intervention for Adolescents' Internalizing Problems
To investigate the efficacy and mechanisms of change of an Internet-delivered transdiagnostic REBT intervention for adolescents with internalizing problems.
- Conditions
- Anxiety Disorders, Social Anxiety Disorder, Generalized Anxiety Disorder, Panic Disorder
- Trial name
- REBTonAd (NCT04179526)
- Testing
- Transdiagnostic Internet-delivered REBT
- Where
- Romania
- Volunteers
- 106 people
- Sponsor
- Babes-Bolyai University
Anxiety, Mental Health Issue
Sound Healing for Anxiety: A Randomized Controlled Trial
The goal of this randomized controlled trial is to compare a novel sound healing approach, biofield tuning, to a waitlist control group in a healthy adult population naive to the intervention.
- Conditions
- Anxiety, Mental Health Issue, Anxiety Generalized, Anxiety State
- Trial name
- NCT06100406
- Testing
- Biofield tuning
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Consciousness and Healing Initiative
Fear, GAD
Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans
Anxiety disorders such as post-traumatic stress disorder (PTSD) and generalized anxiety disorder (GAD) affect a large number of individuals with a significant portion of patients failing to improve with current treatments.
- Conditions
- Fear, GAD, Emotional Memory, PTSD
- Trial name
- NCT05120635
- Testing
- Deep Brain Stimulation, Virtual and augmented reality tasks
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Duke University
Schizophrenia Disorders, Major Depression
Non-Coding RNAs Gene Expression in Psychiatric Disorders
This study aims to investigate whether specific non-coding RNAs, molecules involved in the regulation of gene expression, are altered in individuals with psychiatric disorders such as schizophrenia, bipolar disorder, major…
- Conditions
- Schizophrenia Disorders, Major Depression, Bipolar Affective Disorders, Obsessive Compulsive Disorder (OCD)
- Trial name
- PsiRNA26 (NCT07649993)
- Testing
- Reverse Transcription Quantitative Polymerase Chain Reaction
- Where
- 5 sites in Italy
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Carmen Concerto
Attention Deficit Hyperactivity Disorder, Anxiety, Separation
Treatment of Youth With ADHD and Anxiety
The purpose of this NIMH-sponsored pilot study is to collect information on the efficacy and safety of drug treatments for children and adolescents who suffer from both ADHD and anxiety disorders.
- Conditions
- Attention Deficit Hyperactivity Disorder, Anxiety, Separation, Social Phobia, Generalized Anxiety Disorder
- Trial name
- NCT00012584
- Testing
- methylphenidate, fluvoxamine
- Where
- 5 sites in United States
- Volunteers
- 120 people
- Sponsor
- National Institute of Mental Health (NIMH)
Social Phobia, Generalized Anxiety Disorder
Brain Markers of Anxiety Disorders and SSRI/CBT Treatment in Children and Adolescents
This study will attempt to identify gene and brain activity markers that predict whether children and adolescents with anxiety disorders will respond to selective serotonin reuptake inhibitor medications or Cognitive Behavioral…
- Conditions
- Social Phobia, Generalized Anxiety Disorder, Separation Anxiety Disorder
- Trial name
- NCT01160588
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Major Depression, Generalized Anxiety
Common Factors Group Psychotherapy for General Mental Health Concerns
The current research will investigate the impact of general psychotherapy using common factors (i.e., techniques and communication skills that are common to all major forms of psychotherapy) to investigate whether mental health…
- Conditions
- Major Depression, Generalized Anxiety, Stress Disorder, Post Traumatic, Stress
- Trial name
- NCT06614842
- Testing
- Common Factors Group Psychotherapy
- Sponsor
- University of Alabama at Birmingham
Generalized Anxiety Disorder (GAD)
EDG004 Treatment of Adult Patients With Generalized Anxiety Disorder (GAD)
To evaluate the efficacy of EDG004 compared to placebo for the treatment of adult patients with GAD, diagnosed by Diagnostic and Statistical Manual of Mental Disorders, 5th Ed.
- Trial name
- NCT02305797
- Testing
- Extended-release lorazepam
- Where
- United States
- Volunteers
- 495 people
- Sponsor
- Edgemont Pharmaceuticals, LLC
Anxiety, Anxiety Disorder (Panic Disorder or GAD)
Preoperative Pregabalin vs Gabapentin in Elderly Undergoing Surgry,Controlled Trial
Several studies have evaluated the efficacy of pregabalin in reducing preoperative anxiety, with inconsistent results. Similarly, inconclusive results have been reported regarding gabapentin and its effects in reducing…
- Trial name
- NCT07000201
- Testing
- One hour prior to admission to the operating room, patients will receive the study medication (as premedication) by mouth with a sip of water;
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Cairo University
Major Depressive Disorder, Generalized Anxiety Disorder
The Modular Protocol for Mental Health (MPMH)
Currently, our best psychological treatments for anxiety and mood disorders only focus on individual diagnoses. So, there are separate treatments for Panic Disorder, or Depressive Disorder, or Social Anxiety, etc.
- Conditions
- Major Depressive Disorder, Generalized Anxiety Disorder, Posttraumatic Stress Disorder, Social Anxiety Disorder
- Trial name
- MPMH (NCT03143634)
- Testing
- The Modular Protocol for Mental Health, Treatment-as-usual
- Where
- United Kingdom
- Volunteers
- 43 people
- Sponsor
- Medical Research Council Cognition and Brain Sciences Unit
Anxiety Disorders
Threat Interpretation Bias as Cognitive Marker and Treatment Target in Pediatric Anxiety
Anxiety is the most common mental health problem in children and adolescents. This two-phased study will test the effects of an experimental computerized intervention aimed at reducing threat-based thinking (i.e., interpretation…
- Trial name
- NCT04245501
- Testing
- Cognitive Bias Modification for Interpretations (CBM-I), Interpretation Control Condition (ICC)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Denver
Diabetes Mellitus, Type 1, Prediabetic State
Prevention Trial: Immune-tolerance With Alum-GAD (Diamyd) and Vitamin D3 to Children With Multiple Islet Autoantibodies
The purpose of this study is to evaluate if immune-tolerance with Alum-formulated GAD (Diamyd), in combination with high dose Vitamin D3, may delay or stop the autoimmune process leading to clinical type 1 diabetes in…
- Trial name
- DiAPREV-IT2 (NCT02387164)
- Testing
- Alum-GAD, Vitamin D3
- Where
- Sweden
- Volunteers
- 26 people
- Sponsor
- Lund University
Obsessive-Compulsive Disorder, Anxiety Disorders
Improving Access to Child Anxiety Treatment
There is strong evidence that cognitive behavioral therapy (CBT) with exposure is the preferred treatment for youth with anxiety disorders, but outpatient services that provide this type of treatment are limited.
- Conditions
- Obsessive-Compulsive Disorder, Anxiety Disorders, Pediatric Disorder, Anxiety
- Trial name
- IMPACT (NCT03528109)
- Testing
- Exposure Therapy
- Where
- United States
- Volunteers
- 379 people
- Sponsor
- Bradley Hospital