Clinical trials: GAD
Latent Autoimmune Diabetes in Adults
Injections of Glutamic Acid Decarboxylase (GAD) for LADA Type of Diabetes
This study will evaluate the effects of 3 intra-nodal injections of GAD-alum (Diamyd), together with oral vitamin D supplementation.
- Trial name
- GADinLADA (NCT04262479)
- Testing
- recombinant human glutamic acid dehydrogenase (rhGAD65), formulated in aluminium hydrogel, Vitamin D
- Where
- 2 sites in Norway, Sweden
- Volunteers
- 14 people
- Sponsor
- Norwegian University of Science and Technology
Generalized Anxiety Disorder (GAD), Chronic Insomnia
Transcranial Alternating Current Stimulation for Generalized Anxiety Disorder and Insomnia: An Open-Label Pilot Study
This is an open-label pilot clinical trial to evaluate the effects of transcranial alternating current stimulation (tACS) in adults diagnosed with generalized anxiety disorder (GAD) and chronic primary insomnia.
- Trial name
- NewWaves (NCT07429578)
- Testing
- Transcranial Alternating Current Stimulation (tACS)
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Stiff Person Syndrome
Rituximab to Treat Stiff Person Syndrome
This study will test whether rituximab (RITUXAN (Trademark)) can relieve symptoms of stiff person syndrome (SPS), a progressive disease that causes stiffness of the muscles and muscle spasms induced by unexpected noises, touches…
- Trial name
- NCT00091897
- Testing
- Rituximab
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Generalized Anxiety Disorder
Transcutaneous Vagus Nerve Stimulation for Generalized Anxiety Disorder
This is a randomized, double-blind, parallel-controlled study of patients with generalized anxiety disorder, who will be randomly assigned to either drug-combined transcutaneous vagus nerve stimulation (tVNS) group or…
- Trial name
- NCT06134323
- Testing
- medication-combined transcutaneous vagus nerve stimulation
- Where
- 2 sites in China
- Volunteers
- 82 people
- Sponsor
- Xijing Hospital
Generalized Anxiety Disorder
Evaluating The Effects Of Cimetidine On The Elimination Of PD 0332334 From The Body
The purpose of this study is to estimate the effects of multiple doses of cimetidine on the pharmacokinetics of a single dose of PD 0332334 and to evaluate the safety and tolerability of PD 0332334 when co-administered with…
- Trial name
- NCT00800280
- Testing
- PD 0332334, cimetidine
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Lumbar Spine Spondylosis, Anxiety Generalized
The Effect of Midazolam Sedation on Diagnostic Medial Branch Blocks
This prospective observational study aims to investigate the effect of midazolam sedation on the diagnostic validity of diagnostic lumbar medial branch block in patients diagnosed with lumbar spondylosis without myelopathy.
- Trial name
- MBB (NCT04453449)
- Testing
- Midazolam
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Henry Ford Health System
Generalized Anxiety Disorder, Major Depressive Disorder
Improving Access to the Treatment of Anxiety and Depression Among Young Adults
Anxiety and depression represent the most common mental health problems. Unfortunately, only a minority of people in need will seek or access traditional mental health services.
- Conditions
- Generalized Anxiety Disorder, Major Depressive Disorder, Social Anxiety Disorder, Panic Disorder
- Trial name
- NCT03156556
- Testing
- Mood Mechanic Course
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Universite de Moncton
Depression, Anxiety Disorders
Effectiveness & Cost-effectiveness of Internet-delivered Interventions for Depression and Anxiety Disorders in IAPT
Depression and anxiety are common mental health problems. There are effective treatments for depression and anxiety and one of these is talking therapies using cognitive behaviour therapy (CBT).
- Conditions
- Depression, Anxiety Disorders, Depressive Disorder, Generalized Anxiety Disorder
- Trial name
- D-IAPT (NCT03188575)
- Testing
- SilverCloud Internet-delivered Cognitive Behavioural Therapy, Waiting List
- Where
- United Kingdom
- Volunteers
- 384 people
- Sponsor
- Silver Cloud Health
Generalized Anxiety Disorder
Efficacy of an Acceptance-based Group Behavioral Therapy for Generalized Anxiety Disorder.
Generalized anxiety disorder (GAD) shows the weakest treatment response among anxiety disorders. The present study aimed at examining whether an acceptance-based behavioral treatment, combining mindfulness and exposure…
- Trial name
- ABBT-GAD (NCT03930095)
- Testing
- Acceptance-based Behavior Therapy, Non-directive Supportive Therapy
- Where
- Brazil
- Volunteers
- 92 people
- Sponsor
- University of Sao Paulo General Hospital
Major Depressive Disorder, Anxiety Disorder
Ketamine Infusion for Adolescent Depression and Anxiety
The purpose of this study is to determine the tolerability and short-term efficacy of a single ketamine infusion for the treatment of adolescents with 1) medication-refractory major depressive disorder (MDD) and/or 2)…
- Trial name
- NCT02579928
- Testing
- Ketamine, Midazolam
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Yale University
Generalized Anxiety Disorder
Cognitive-behavioral Therapy for Generalized Anxiety Disorder in Primary Care
The feasibilty and preliminary comparative effectiveness of two methods of cognitive-behavioral therapy - metacognitive therapy and intolerance of uncertainty therapy - for primary care patients with generalized anxiety disorder…
- Trial name
- NCT03621371
- Testing
- Metacognitive therapy, Intolerance of uncertainty therapy
- Where
- Sweden
- Volunteers
- 64 people
- Sponsor
- Karolinska Institutet
Generalized Anxiety Disorder
A 52-Week Open-Label Safety Study of PD 0332334 in Subjects With Generalized Anxiety Disorder (GAD)
This study will assess the long-term safety and tolerability of 350 to 600 mg/day of PD 0332334 administered in split dose (twice daily) in subjects with Generalized Anxiety Disorder.
- Trial name
- NCT00735267
- Testing
- PD 0332334
- Where
- 93 sites in United States
- Volunteers
- 468 people
- Sponsor
- Pfizer
Anxiety Disorder, Generalized Anxiety Disorder
Electroclinical Correlation of Anxiety
Anxiety disorders have the highest prevalence among mental disorders and cause considerable individual and financial costs. Current treatments do not relieve mental suffering of many patients.
- Conditions
- Anxiety Disorder, Generalized Anxiety Disorder, Drug Resistant Epilepsy
- Trial name
- IRAnxNet (NCT05393518)
- Testing
- Anxiety-induced task, Neuropsychiatric assessment
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bordeaux
Anxiety Disorder
A Comparison of Duloxetine Hydrochloride, Marketed Comparator, and Placebo in the Treatment of Generalized Anxiety Disorder
This is a clinical trial assessing duloxetine and comparator to placebo in patients who have generalized anxiety disorder.
- Trial name
- NCT00122837
- Testing
- Duloxetine, venlafaxine
- Where
- 22 sites in Argentina, Australia and 6 more
- Volunteers
- 560 people
- Sponsor
- Eli Lilly and Company
Generalized Anxiety Disorder (GAD)
Temporal Interference Transcranial Alternating Current Stimulation Targeting the BNST or Amygdala for Generalized Anxiety Disorder
This randomized controlled trial will use a three-arm, parallel-group design to evaluate the efficacy and safety of 5-Hz Temporal Interference transcranial Alternating Current Stimulation (TI-tACS) in adults with generalized…
- Trial name
- TIs-GAD (NCT07909200)
- Testing
- Temporal Interference transcranial Alternating Current Stimulation (TI-tACS)
- Where
- 4 sites in China
- Volunteers
- 75 people
- Sponsor
- Central South University
Adverse Drug Reaction, Anxiety Disorders and Symptoms
Antidepressant Monotherapy on Depressive and Anxiety Symptom in Chinese Patients
The primary objective is to evaluate the improvement of antidepressant monotherapy on depressive and anxiety symptom in Chinese patients who meet Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)…
- Trial name
- NCT02012504
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Zhongshan Hospital
Generalized Anxiety Disorder
Comparing Cognitive Behaviour Therapy (CBT) With Metacognitive Therapy (MCT) in the Treatment of GAD
Meta Cognitive Therapy (MCT) has been introduced as a new specific treatment for generalised anxiety disorder. So far, no studies have examined CBT and MCT in comparison with each other in a randomised controlled trial.
- Trial name
- NCT00426426
- Testing
- Cognitive-Behavioural Therapy, Meta-Cognitive Therapy, Waiting list
- Where
- Norway
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Generalized Anxiety Disorder
Safety, Efficacy and Tolerability of Vilazodone in (GAD) Generalized Anxiety Disorder
The purpose of this study is to evaluate the efficacy, safety, and tolerability of vilazodone relative to placebo in the treatment of generalized anxiety disorder (GAD).
- Trial name
- NCT01844115
- Testing
- Vilazodone
- Where
- 36 sites in United States
- Volunteers
- 415 people
- Sponsor
- Forest Laboratories
Generalized Anxiety Disorder
The Effect of Psychoeducation Based on Acceptance and Commitment Therapy Applied to Patients Diagnosed With Generalized Anxiety Disorder on Cognitive Avoidance Levels and Coping Attitudes
This study will be conducted to determine the effects of acceptance and commitment therapy-based psychoeducation on cognitive avoidance levels and coping attitudes in patients diagnosed with generalized anxiety disorder.
- Trial name
- NCT06972563
- Testing
- Psychoeducation Based on Acceptance and Commitment Therapy Applied to Patients Diagnosed with Generalized Anxiety Disorder, The initiative was not implemented.
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Arzu Çalışkan
Generalized Anxiety Disorder
Navigated cTBS for the Treatment of Generalized Anxiety Disorder
The purpose of this study is to investigate the effectiveness of a non-invasive brain stimulation technique called continuous Theta Burst Stimulation (cTBS) for treating Generalized Anxiety Disorder (GAD).
- Trial name
- NAVI-GAD (NCT07121712)
- Testing
- Mapsd Continuous Theta Burst Stimulation
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- WANG KAI