Clinical trials: GI Cancer, open to volunteers
Upper GI Cancer
Immunonutrition for Surgical Prehabilitation of Patients With Upper GI Cancer
Perioperative immunonutrition has been proposed as a strategy to modulate the inflammatory response and improve outcomes after upper GI surgery.
- Trial name
- IMNUTPREH-UGIC (NCT07884214)
- Testing
- Oral nutritional supplements with immunonutrition (enriched with arginine, nucleotides, vitamin D and omega-3-fatty acid), Standart of care
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Non-GI Cancers, Cancer of Gastrointestinal Tract
Acquisition of Blood and Tumor Tissue Samples From Patients With Gastrointestinal Cancer
Background: Gastrointestinal cancers can occur in the throat, stomach, gallbladder, liver, pancreas, and colon. Researchers are interested in evaluating how active the immune system is in trying to fight the cancer by studying…
- Conditions
- Non-GI Cancers, Cancer of Gastrointestinal Tract, Gastrointestinal Cancer
- Trial name
- NCT01313442
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- National Cancer Institute (NCI)
Multiple Myeloma, GI Cancer
Gustabor Phase 1 - AI-based Creation of a Nutritional Plan to Compensate for Chemotherapy-induced Taste Disorders
The study investigates taste disorders that commonly occur during or after cancer treatment, often leading to issues such as malnutrition and treatment discontinuation.
- Conditions
- Multiple Myeloma, GI Cancer, Taste Disorders
- Trial name
- GustaborPilot (NCT07040189)
- Testing
- Gustabor server
- Where
- 3 sites in Germany
- Volunteers
- 51 people
- Sponsor
- Wuerzburg University Hospital
GI Cancers
First-in-human Study of 7MW4911 in GI Cancer
This is the first-in-human study of 7MW4911 in US patients, to investigate its prelimary safety and efficacy in patients with gastrointestinal cancers.
- Trial name
- NCT07216560
- Testing
- 7MW4911
- Where
- 6 sites in United States
- Volunteers
- 200 people
- Sponsor
- Mabwell (Shanghai) Bioscience Co., Ltd.
Multiple Myeloma (MM), GI Cancer
Gustabor Phase 2 - Treating Taste Changes During Cancer Therapy: A Randomized Study Evaluating an AI- Based Nutrition Intervention
The study investigates taste disorders that commonly occur during or after cancer treatment, often leading to issues such as malnutrition and treatment discontinuation.
- Conditions
- Multiple Myeloma (MM), GI Cancer, Taste Disorder, Melanoma (Skin Cancer)
- Trial name
- GustaborRCT (NCT07649681)
- Testing
- Gustabor server, Standard Recommendations
- Where
- 6 sites in Germany
- Volunteers
- 198 people
- Sponsor
- Wuerzburg University Hospital
Cancer, Breast Cancer
Mainstreaming Genetics: Evaluation of a Digital Application to Scale and Spread Oncologist-initiated Genetic Testing
Genetic testing can alter therapy and surgical management for cancer patients and is therefore indicated as a first-line test for many newly diagnosed patients, including breast, ovarian, pancreatic, prostate and colon/GI…
- Conditions
- Cancer, Breast Cancer, Prostate Cancer, Colon Cancer
- Trial name
- NCT07387263
- Testing
- Genetics Adviser for Mainstream Care (GA-Mainstream), Mainstreaming Standard of Care
- Where
- 2 sites in Canada
- Volunteers
- 180 people
- Sponsor
- Unity Health Toronto
Gastrointestinal, Mobile Health
GutCheck: Optimization of a Personalized Mobile Health App for Survivors of Gastrointestinal Cancer
There are two components to the study: a patient and a clinician study. The clinician study will include one-hour semi-structured interviews with oncology specialists to identify facilitators and barriers to integrating digital…
- Conditions
- Gastrointestinal, Mobile Health, Gastrointestinal Symptoms, Gut Health
- Trial name
- NCT07661017
- Testing
- Stool Sample, App Activity
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Surgery, Colorectal Cancer
Postoperative Electrical Muscle Stimulation Two
Undesirable loss of skeletal muscle mass (atrophy) is a common feature of many diseases as well as ageing, bed rest and physical inactivity.
- Conditions
- Surgery, Colorectal Cancer, Muscle Atrophy, Cancer Gi
- Trial name
- POEMS2 (NCT06964438)
- Testing
- Neuromuscular Electrical Stimulation, Protein supplement drink
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Nottingham
Neuroendocrine (NE) Tumors, Advanced NET of GI Origin
AUR103 Calcium in Advanced Neuroendocrine Tumours (BHARAT-3 Study)
A phase 2 Study Evaluating the Efficacy and Safety of Single Agent AUR103 Calcium in Patients with Advanced, Well or Moderately differentiated Neuroendocrine Tumours.
- Trial name
- BHARAT-3 (NCT07640737)
- Testing
- AUR103 Calcium
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- Aurigene Discovery Technologies Limited
Gastrointestinal Neoplasms, Pancreatic Cancer
The Canopy Cancer Collective Clinical Registry Protocol
The Canopy Cancer Collective Clinical Registry Protocol Non-Interventional Data and Sample Collection Registry Protocol Number of study sites 15 Study Design - Observational, registry Primary Objective To systematically collect…
- Conditions
- Gastrointestinal Neoplasms, Pancreatic Cancer, Colorectal Cancer, GI Cancers
- Trial name
- NCT07605702
- Where
- 10 sites in United States
- Volunteers
- 100,000 people
- Sponsor
- Canopy Cancer Collective, LLC
Bleeding After GI Endoscopy
Endoscopic Application of Tranexamic Acid and Sucralfate in Gastrointestinal Tumor Bleeding: A Randomized Controlled Trial
Background Gastrointestinal bleeding is a common disease among the population in Taiwan, with gastrointestinal tumor bleeding accounting for 3-5% of cases.
- Trial name
- NCT07540026
- Testing
- 3g of sucralfate powder and 1.5g of tranexamic acid powder, Standard Treatment
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Cheng-Kung University Hospital
CNS Cancer, Head and Neck Cancer
Prospective Evaluation of Pencil Beam Scanning Proton Therapy for Previously Irradiated Tumors
The goal of this clinical research trial is to study the use of differing investigational doses and scheduling for Proton Therapy for tumors previously treated with radiation therapy.
- Conditions
- CNS Cancer, Head and Neck Cancer, GI Cancer, Gynecologic Cancer
- Trial name
- ReRT (NCT05313191)
- Testing
- Pencil Beam Scanning Proton Therapy
- Where
- United States
- Volunteers
- 1,800 people
- Sponsor
- The New York Proton Center
Cancer, Cancer Diagnosis
Avera Cancer Sequencing and Analytics Protocol (ASAP)
The purpose of this study is to characterize the breadth of molecular features present in participants receiving care within a large, integrated, community-based healthcare system.
- Conditions
- Cancer, Cancer Diagnosis, Early Detection of Cancer, Breast Cancer
- Trial name
- ASAP (NCT05142033)
- Where
- 6 sites in United States
- Volunteers
- 25,000 people
- Sponsor
- Avera McKennan Hospital & University Health Center
Cancer Pain, Visceral Pain
Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes
Patients with digestive tract malignancy often experience severe and unremitting abdominal pain that negatively affects physical, emotional, and social function, as well as health related quality of life (HRQOL).
- Conditions
- Cancer Pain, Visceral Pain, Gastrointestinal Neoplasms, Cancer of Gastrointestinal Tract
- Trial name
- NCT04907643
- Testing
- PICO G2 4k
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Cedars-Sinai Medical Center
GI Cancers
Modified Capecitabine and Oxaliplatin (mCAPOX) for Patients With GI Malignancies
This study is a single arm, non-randomized feasibility study with tolerability and toxicity evaluation as primary endpoints which seeks to determine if a modified administration schedule of capecitabine with oxaliplatin will…
- Trial name
- NCT06648785
- Testing
- oxaliplatin, Fluoropyrimidine
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Vermont Medical Center
GI Cancer
Improving Diagnosis and Treatment for Patients With Rectal Cancer
The cancer stage information from scans guides pre-operative treatment and the type of surgery offered. The investigators are studying whether a new Magnetic Resonance Imaging (MRI) staging method can improve the accuracy of…
- Trial name
- MERCURY 3 (NCT07054047)
- Testing
- mrTDV
- Where
- 3 sites in United Kingdom
- Volunteers
- 438 people
- Sponsor
- Imperial College London
GI Cancer
Prevalence of Types and Patterns of Gastrointestinal Polyps in Assiut University Hospitals ( Cross Sectional Study
Gastrointestinal polyps (GIPs) are unusual growths of epithelial tissue projecting from the mucosa of gastrointestinal tract (GIT) and one of the most common pathologies affecting GIT .
- Trial name
- Polyp (NCT06929117)
- Volunteers
- 130 people
- Sponsor
- Assiut University
Cancer of Stomach, Oesophageal Cancer
The Australia and New Zealand Multicentre Upper Gastrointestinal Endoscopic Tissue Resection Study
To determine the long term outcomes of Endoscopic Submucosal Dissection (ESD), Endoscopic Full Thickness Resection (EFTR) and Submucosal-Tunnelling Endoscopic Resection (STER) for upper gastrointestinal neoplastic lesions
- Conditions
- Cancer of Stomach, Oesophageal Cancer, Gastric Cancer, Gastric Adenocarcinoma
- Trial name
- ANZ UGI (NCT05804331)
- Where
- Australia
- Volunteers
- 500 people
- Sponsor
- Western Sydney Local Health District
GI Cancer
Effect of Geriatric Intervention in Frail Patients with Gastric, Biliary, and Pancreatic Cancer Receiving Palliative Chemotherapy
Gastric, biliary and pancreatic cancer are commonly malignancies from gastro- intestinal tract in Taiwan. Because lack of specific symptoms at presentation and effective screening methodology, majority of these patients are…
- Trial name
- NCT06040801
- Testing
- Frailty intervention measures
- Where
- Taiwan
- Volunteers
- 138 people
- Sponsor
- Chang Gung Memorial Hospital
Cancer Gi
Prophylactic EUS-guided Gastroenterostomy in Advanced Periampullary Cancers
The goal of this randomized controlled trial is to investigate the effectiveness and safety of Prophylactic EUS-gastroenterostomy (ProEUS-GE) as a preventative approach for malignant gastric outlet obstruction (MGOO) in men and…
- Trial name
- INTERCEPT (NCT05994521)
- Testing
- ERCP alone, ERCP +ProEUS-GE
- Where
- 5 sites in Canada, France and 1 more
- Volunteers
- 110 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre