Clinical trials: GI Disorders
Colo-rectal Cancer
Personalised and Gamification-based Decision Aid (DA): a Randomized Controlled Pilot Study About Colorectal Cancer (CRC) Screening
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide, accounting for approximately 903,000 deaths annually.
- Trial name
- DA-CRC (NCT07269028)
- Testing
- Gamified Mobile App
- Where
- Italy
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Cancer
Oligogenic Determinism of Colorectal Cancer
The majority of the clinical situations suggestive of an increased genetic risk for colorectal cancer (CRC) are not explained by a simple monogenic model.
- Trial name
- DOCC (NCT01057953)
- Testing
- Blood drawn
- Where
- 16 sites in France
- Volunteers
- 1,550 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Inflammatory Bowel Diseases, Osteoporosis
Analysis of Bone Quality in Adult Patients With Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is considered a risk factor for the development of osteoporosis, which leads to an increased risk of fractures.
- Trial name
- NCT05171153
- Testing
- Densitometry with Trabecular Bone Score, Quantitative Ultrasound of Calcaneus, Laboratory test
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Quironsalud
Esophageal Cancer
Non-endoscopic EC Screening Program in Northern Iran
The aim of this study is to assess the effects of implementation of a non-endoscopic esophageal cancer-screening program on outcomes of interest in an asymptomatic high-risk population in Golestan Province, Iran.
- Trial name
- NESP (NCT02311712)
- Testing
- Capsule sponge
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Fecal Incontinence, Urinary Incontinence
First Time Mothers and Anal Incontinence Six Years Postpartum
Previous studies show that incontinence is relatively common during pregnancy and after delivery. Experiencing incontinence during pregnancy or in the first year after delivery increases the risk of long term incontinence.
- Conditions
- Fecal Incontinence, Urinary Incontinence, Quality of Life
- Trial name
- FiTMAI6 (NCT02792244)
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Ostfold Hospital Trust
Dysphagia, Healthy Aging
Swallowing Impairments in ICU Survivors and Community-Dwelling Adults
Post-intensive care syndrome (PICS), which consists of physical, cognitive, and psychosocial problems, is a pervasive complication for older intensive care unit (ICU) survivors and contributes to detrimental health outcomes and…
- Conditions
- Dysphagia, Healthy Aging, Post Intensive Care Syndrome, Caregiver Burden
- Trial name
- NCT07005037
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Gastric Cancer
Multi-Omics Noninvasive Inspection of TumOr Risk for Gastric Cancer
This is a prospective, case-control study intended to develop and validate a blood-based multi-omics assay and computational model for early detection of gastric cancer.
- Trial name
- MONITOR- GAC (NCT04947995)
- Testing
- ctDNA multi-omics test
- Where
- China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- GeneCast Biotechnology Co., Ltd.
Helicobacter Pylori, Eradication
The Preventive Effect of Helicobacter Pylori Eradication on the Development of Gastric Cancer
Recently, the preventive effect of Helicobacter pylori (Hp) eradication treatment on the incidence of gastric cancer has been reported.
- Conditions
- Helicobacter Pylori, Eradication, Gastric Cancer, Medical Care Cost
- Trial name
- NCT00596401
- Where
- Japan
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Showa Inan General Hospital
Post Operative Sore Throat, Dysphagia
Post-operative Sore Throat as Determined by Endotracheal Tube Inflation Technique
The purpose of this study is to test whether the incidence of sore throat and other tracheal co-morbidities such as dysphagia and hoarseness can be lessened by use of a cuff manometer at the beginning of surgery to inflate to the…
- Conditions
- Post Operative Sore Throat, Dysphagia, Hoarseness
- Trial name
- NCT01305265
- Testing
- cuff manometer
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Swallowing
Longitudinal Ultrasound Kinematic Evaluation of Digastric Muscles
Ultrasound applied to the upper aerodigestive tract for the assessment of swallowing disorders has been the subject of numerous publications in recent years.
- Trial name
- LUKE (NCT07670429)
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hopital Forcilles
Crohn Disease
Diet Intervention for Crohn's Disease Patient
The purpose of this study is to determine the effectiveness of a low-fat, high fiber diet (LFD) containing a minimal proportion of fat to improve gastrointestinal symptoms, quality of life and signs of inflammation in blood and…
- Trial name
- NCT04213729
- Testing
- Diet Counseling, CD LFD, Dyadic Psychological Support (DPS)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Miami
Ulcerative Colitis
Fecal Microbiota Transplantation as a Treatment for Ulcerative Colitis
Ulcerative colitis (UC) is characterized by a disrupted homeostasis of the commensal bacterial population (dysbiosis). A promising therapy for restoration of the altered balance of the enteric microbiota is fecal microbial…
- Trial name
- NCT04434872
- Testing
- Colonoscopy, Gastroscopy, Fecal Microbiota
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Colorectal Cancer
RCT of Air Insufflation Versus Water Infusion Colonoscopy by Supervised Trainees
Our aim is to perform a randomized-controlled trial comparing air insufflation sedated colonoscopy (conventional method) vs. water infusion sedated colonoscopy (study method) by supervised trainees.
- Trial name
- NCT00841282
- Testing
- Colonoscopy for colorectal cancer screening, Water Infusion Colonoscopy, Air insufflation colonoscopy
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- East Bay Institute for Research and Education
Colorectal Cancer, Gastric Cancer
Familial Colorectal Cancer Registry in Hispanics
Colorectal cancer (CRC) is the second leading cause of cancer in Puerto Rico (PR) accounting for approximately 1,500 individuals annually, which represent 12% of all cancer cases in the island.
- Conditions
- Colorectal Cancer, Gastric Cancer, Colorectal Neoplasms, Colorectal Adenoma
- Trial name
- PURIFICAR (NCT00927680)
- Where
- 2 sites in Puerto Rico
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- University of Puerto Rico
Colorectal Neoplasms
Improving Colonoscopy Quality for Colorectal Cancer Screening in the National VA Healthcare System
High quality screening colonoscopy is critical for colorectal cancer (CRC) prevention in Veterans. There is significant variability in colonoscopy quality in VA that is directly linked to differences in CRC incidence and death.
- Trial name
- NCT04389957
- Testing
- Veterans Affairs Endoscopy Quality Improvement Program (VA-EQuIP)
- Where
- 6 sites in United States
- Volunteers
- 445 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Enteritis; Escherichia Coli, Enterotoxigenic
Challenge Study of an ETEC Vaccine
The purpose of the study is to determine the efficacy of a vaccine against enterotoxigenic E. coli (ETEC)-caused diarrhea.
- Trial name
- NCT01922856
- Testing
- LTR192G with dscCfaE, No Intervention
- Where
- 2 sites in United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Non Small Cell Lung Cancer, Esophageal Cancer
Tumor Cell and DNA Detection in the Blood, Urine, and Bone Marrow
Patients with resectable solid primary cancers and even limited number of metastases are potentially curable. However, most patients develop recurrences despite surgery.
- Conditions
- Non Small Cell Lung Cancer, Esophageal Cancer, Gastric Cancer, Pancreatic Cancer
- Trial name
- NCT03551951
- Testing
- Test for circulating tumor cells, DNA alterations
- Where
- United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Colonic Adenoma, Colonic Cancer
R vs L Lateral Decubitus Positioning in Colonoscopy
Colonoscopy continues to be the gold standard in detecting precancerous lesions in the colon. It relies on adequate visualization of the bowel wall to see and remove such lesions.
- Trial name
- NCT03355495
- Testing
- Colonoscopy - Position Change
- Where
- Canada
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Memorial University of Newfoundland
Colon Polyps and Adenomas, Colon Cancer
Polyp Detection With The Peerscope System™
The PeerScope System consists of Peer Medical camera heads, endoscopes, video system, light source and other ancillary equipment.
- Trial name
- NCT01549535
- Testing
- Colonoscopy done with:PeerMedical System and Olympus/Pentax/Fuji colonoscopy system
- Where
- 6 sites in United States, Israel and 1 more
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- PeerMedical Ltd.
Colon Cancer, Colon Polyp
Comparison of Two Preparations for the Study of the Colon Through Colonoscopy
Compare the quality of bowel preparation between two groups of patients, who will undergo two different preparations: 1. Moviprep + diet; 2. Plenvu + diet
- Conditions
- Colon Cancer, Colon Polyp, Colon Adenoma, Colon Rectal Cancer
- Trial name
- NCT04497935
- Testing
- PLENVU, MoviPrep
- Where
- Portugal
- Volunteers
- 613 people, healthy volunteers welcome
- Sponsor
- Unidade Local de Saúde do Alto Ave, EPE
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