Clinical trials: GI Symptoms
Gastrointestinal Irritation, Nutrition, Healthy
Effects of Wheat Flour Milling Method on Glycemic Response and Gastrointestinal Symptoms
The goal of this clinical trial is to learn if the way wheat flour is ground - by stone milling (an older method) or roller milling (used for most flour today) - changes blood sugar levels after eating bread, in healthy adults…
- Trial name
- STONEMILL (NCT07858110)
- Testing
- Stone-milled wheat flour bread, Roller-milled wheat flour bread (sourdough)
- Where
- Norway
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Pain
Efficacy of Yogurt Containing BB12 in Subjects With GI Symptoms
The purpose of this study is to determine if probiotics bacteria, specifically bifidobacterium lactis (BB12) improve gastrointestinal symptoms in subjects with functional gastrointestinal symptoms (i.e., non-patients…
- Trial name
- NCT00618488
- Testing
- Probiotic BB12 - Bifidobacterium lactis
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of North Carolina
Pancreatic Cancer, Pancreatic Diseases
PAN-CLO-BU (PANcreas-CLOstridium-BUtyricum)
This is a prospective, randomized, double-blind, single-center clinical trial designed to evaluate the effects of Clostridium butyricum CBM588 supplementation on postoperative diarrhea, gastrointestinal symptoms, and quality of…
- Conditions
- Pancreatic Cancer, Pancreatic Diseases, Gastrointestinal Symptoms, Clostridium Butyricum Miyairi
- Trial name
- PAN-CLO-BU (NCT07422103)
- Testing
- Clostridium butyricum CBM588 Strain
- Where
- Italy
- Volunteers
- 158 people
- Sponsor
- Casa di Cura Dott. Pederzoli
Gastroesophageal Reflux Disease
A Cross-sectional Study on the Prevalence and Extraesophageal Symptoms of Gastroesophageal Reflux Disease(GERD) in Patients With Upper GI Symptoms, Visiting the Outpatient Departments of Peripheral Hospitals in Greece
The present study has been designed to provide current data on GERD prevalence in several regional areas of Greece outside the two major urban centres (Athens and Thessaloniki), to measure the treatment response in GERD patients…
- Trial name
- GERDQ-XS (NCT01215305)
- Where
- 19 sites in Greece
- Volunteers
- 600 people
- Sponsor
- AstraZeneca
Gastrointestinal Symptoms, Digestive Health
An 8-Week Study Evaluating Gut and Digestive Health After Use of a Dietary Supplement System
This clinical research study is being conducted to evaluate gut and digestive health before and after the use of a dietary supplement system over an eight-week period.
- Conditions
- Gastrointestinal Symptoms, Digestive Health, Gut Health
- Trial name
- NCT07421596
- Testing
- PhytoPower 1 and PhytoPower 2
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- SF Research Institute, Inc.
Gastrointestinal Diseases
Trans GERD: Efficacy and Tolerability of Esomeprazol in Patients Under Ordinary Medical Care Conditions
Under daily routine conditions and without any intervention by the sponsor regarding the selection of subjects, diagnostic procedures, therapeutic decisions (medicinal and non- medicinal therapy, dose, duration, etc.), routine…
- Trial name
- NCT00612027
- Volunteers
- 29,586 people
- Sponsor
- AstraZeneca
Healthy
Evaluation of Bacillus Subtilis R0179 in Healthy Young Adults
The purpose of this study is to evaluate the effect of three doses of the probiotic B. subtilis (Bacillus subtilis R0179) delivered in capsules on gastrointestinal and general wellness in healthy young adults, survival through…
- Trial name
- NCT01802151
- Testing
- B. subtilis R0179
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Florida
Motility Disorder, Gastroparesis
Body Surface Gastric Mapping to Evaluate Patients With Upper Gastrointestinal Symptoms and Controls
This is an analytical validation observational cohort study is designed to provide evidence of: safety and reliability of Body Surface Gastric Mapping using the Gastric Alimetry System (GAS), normal reference values, and…
- Conditions
- Motility Disorder, Gastroparesis, Functional Dyspepsia, Cyclical Vomiting
- Trial name
- NCT05812339
- Testing
- Gastric Alimetry System
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Autism Spectrum Disorder
Randomized Double-blind Clinical Trial With L.Reuteri Supplementation in Children With Autism Spectrum Disorder
The aim of this study is to assess the effects of a 6-months probiotic supplementation on behavioral profiles, microbiota and metabolic profiles, inflammatory biomarkers, gastrointestinal disturbances, in children with Autism…
- Trial name
- NCT04293783
- Testing
- L.Reuteri
- Where
- 2 sites in Italy
- Volunteers
- 43 people
- Sponsor
- University of Rome Tor Vergata
Gastric Symptoms, Indicated for Upper GI Endoscopy
Comparative Study of the Magnetic-controlled Capsule Endoscopy Versus Standard Gastroscopy
Passive video capsule endoscopy is the criterion standard for small-bowel diseases but cannot be used for the large gastric cavity.This blinded prospective study investigates the accuracy of the magnetic-controlled capsule…
- Trial name
- NCT01903629
- Testing
- MCE, Standard gastroscopy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Changhai Hospital
Gastrointestinal Hemorrhage
Early Colonoscopy for Lower Gastrointestinal (GI) Bleeding
Study hypothesis is that performing early colonoscopy in patients who present to the hospital with lower GI bleeding improves their outcome.
- Trial name
- NCT01031342
- Testing
- Early colonoscopy, Elective colonoscopy
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Southern California
Autism Spectrum Disorder (ASD)
Butyrate Supplementation in Children With Autism Spectrum Disorder (ASD) and Functional Gastrointestinal Disorders
Autism spectrum disorder (ASD) is a neurodevelopmental condition occurring in 1:77 Italian children. Several comorbidities are reported, including functional gastrointestinal disorders (FGIDs) present in up to 70% of patients.
- Trial name
- b(AUT)yrate (NCT06514573)
- Testing
- Sodium Butyrate
- Where
- 3 sites in Italy
- Volunteers
- 128 people
- Sponsor
- Istituto Superiore di Sanità
Critically Ill
Pilot Study on Gastro-intestinal (GI) Enteral Nutrition (EN) Tolerance in Intensive Care Unit Patients
Specifically designed enteral formulations may improve the gastrointestinal tolerance during early enteral nutrition in the critically ill patient.
- Trial name
- SPIRIT (NCT01581957)
- Testing
- Specific Enteral Nutrition, Standard Enteral Nutrition
- Where
- Switzerland
- Volunteers
- 90 people
- Sponsor
- Société des Produits Nestlé (SPN)
Oncologic Disease, Urgent Surgery
Dynamic Postoperative Trends for Early Detection of Complications After Gastrointestinal Surgery
Postoperative complications after gastrointestinal (GI) surgery remain a major source of morbidity, mortality, prolonged hospitalisation, and healthcare costs.
- Trial name
- DYNAMIC-GI (NCT07509710)
- Testing
- blood sampling
- Volunteers
- 1,500 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Autism Spectrum Disorder, Autism
Autism Spectrum Disorder (ASD) Neurodevelopmental Disorder With Issues Social Behavior, Communication Issues, GI Dysfunction. Study is Multimodal Interventions Targeting These Pathways With cSVF, Stored MSCs, FMT and Diet Modification. Role of Autoimmunity, Gut-brain Issues, & Issues Examined.
Autism spectrum disorder (ASD) is a neurodevelopmental condition with core deficits in social communication and behavior, often accompanied by gastrointestinal (GI) and metabolic dysfunction.
- Conditions
- Autism Spectrum Disorder, Autism, Autism Spectral Disorder
- Trial name
- GARM-Autism (NCT07546942)
- Testing
- Autologous MSC isolation, concentration, and cryopreservation of adult mesenchymal stem cells, Fecal Biomicrome Transplantation (FMT), Ketogenic RESET Diet Protocol
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Black Tie Medical, Inc.
Gastrointestinal Symptoms
Effects of GlutenShield, a Prebiotic, Probiotic, and Enzyme Supplement, on the Gut Microbiome of Adults With GI Symptoms
This study evaluates the effects of combination probiotic, prebiotic, and enzyme supplementation on the colonic microbiome of individuals with GI symptoms (e.g. diarrhea, constipation, increased gas).
- Trial name
- NCT03403387
- Testing
- GlutenShield
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- East Tennessee State University
IBD (Inflammatory Bowel Disease), IBS (Irritable Bowel Syndrome)
Specimen and Data Collection for a Novel Biomarker Combination for the Differential Diagnosis of Inflammatory Bowel Disease and Irritable Bowel Syndrome.
This study will evaluate how well the a new stool test can distinguish inflammatory bowel disease (IBD) from non-IBD conditions compared with standard calprotectin testing and colonoscopy findings.
- Conditions
- IBD (Inflammatory Bowel Disease), IBS (Irritable Bowel Syndrome), Gastrointestinal Symptoms
- Trial name
- COMBI (NCT07471490)
- Where
- 2 sites in United States, Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- DiaSorin Inc.
IBS - Irritable Bowel Syndrome, Diet, Healthy
Low FODMAP Diet and Gluten Free Diet in IBS
The data of the research will be collected from patients who have applied to the Gastroenterology Polyclinic of Kayseri City Hospital or have previously been diagnosed with Irritable Bowel Syndrome (IBS).
- Conditions
- IBS - Irritable Bowel Syndrome, Diet, Healthy, Elimination Disorder With Fecal Symptoms
- Trial name
- NCT06923696
- Testing
- Diet therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Nuh Naci Yazgan University
Gastrointestinal Dysfunction, Mitochondrial Disorders
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders
Hypothesis: Many patients with underlying mitochondrial disorders have feeding problems because of poor gastrointestinal motility; feeding problems lead to growth impairment and many affected children are malnourished.
- Trial name
- NCT01137240
- Testing
- gastric emptying scan
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- The University of Texas Health Science Center, Houston
Gastrointestinal Symptoms, Gastrointestinal Transit Time
Potato Fiber and Gastrointestinal Function: Phase 3
The primary physiological impacts of fiber intake include the gastrointestinal effects of stool bulking, increased stool frequency and decreased gastrointestinal transit time (GTT).
- Conditions
- Gastrointestinal Symptoms, Gastrointestinal Transit Time, Stool Frequency
- Trial name
- NCT01964599
- Testing
- PF-RS, PF-RO1, PF-RO2
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Florida