Clinical trials: GI Tract Disorders
Necrotizing Enterocolitis
Early Predictors of Necrotizing Enterocolitis in Neonates
The goal of this project is to identify neonates who are predisposed to Necrotizing Enterocolitis (NEC). the investigators will determine the effectiveness of non-invasive measures as well as biochemical markers to identify…
- Trial name
- NCT03210831
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Atherosclerosis
Investigating the Gut Microbiota Modulation Effects of Allicin for Cardiovascular Disease Protection and Establishing Microbiota Directed Personalized Nutrition Guidance With Novel Humanized Gnotobiotic Mice Model, Microbial Culturomics and Metabolomic Technique
Investigators recruited 10 trimethylamine N-oxide (TMAO) producers to test the effect of garlic juice containing allicin on gut microbiota modulation and TMAO production.
- Trial name
- NCT04545879
- Testing
- Raw garlic juice containing allicin
- Where
- Taiwan
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Hypovitaminosis D, Hypovitaminosis
Evaluating Response to Vitamin D3 and K2 Supplementation in Healthcare Personnel
The main purpose of this research study is to learn about the effects of supplemental vitamin D3 and vitamin K2 on blood levels and the gut microbial community, called the gut microbiome.
- Trial name
- NCT07199829
- Testing
- Vitamin Arm 1, Vitamin Arm 2, Vitamin Arm 3
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Madigan Army Medical Center
Obesity
Effects of Prebiotic-based Snacks on the Gut Microbiota and Perceived 'Satisfaction'
To determine the effects of prebiotic 'snacks' on gut health and satisfaction between meals
- Trial name
- NutriSAT (NCT02041975)
- Testing
- Nutriose FB06
- Where
- United Kingdom
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Reading
Ultrasonography, Gastrointestinal Disease
Role of Intraoperative Ultrasound in Gastrointestinal (GI) Malignancies
Currently available investigating modalities like CT scans, MRI etc although have a high accuracy in staging of gastrointestinal(GI) tract malignancies, are not correct in all cases .
- Conditions
- Ultrasonography, Gastrointestinal Disease, Malignancy
- Trial name
- NCT01143922
- Where
- India
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences
Sleep Disturbance, Mood Disturbance
Enhancement of Sleep Quality and Mood Following Supplementation With Lemon Balm in an Adult Population (Lemslp)
This study aims to investigate the effect of a 4-week dietary intervention of 300mg encapsulated aqueous lemon balm extract on measures of sleep quality, mood and well-being, alongside relevant biomarkers of circadian rhythms in…
- Trial name
- NCT05422599
- Testing
- Lemon balm
- Where
- United Kingdom
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Reading
Psoriasis Vulgaris With Metabolic Disorders
Metformin for Treatment of Psoriasis Combined With Disorders of Glucose and Lipid Metabolism
Psoriasis and metabolic disorders are well-known mutual comorbidities. The investigators hypothesized metformin can ameliorate both psoriasis and metabolic disorders mainly via gut microbiota modulation.
- Trial name
- MPGLM (NCT03629639)
- Testing
- Metformin
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Central South University
Obesity, Childhood
Pediatric Obesity Related Metabolite Profile and Gut Microbiota
In this study, the investigators aimed to observe changes in the gut microbial composition before and after the weight-loss intervention, including dietary control and exercise, in obese children.
- Trial name
- NCT03812497
- Testing
- Individualized Education Program
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Malnutrition, Stunting
Child Health, Nutrition and Microbiome Development
Childhood malnutrition is a global public health issue with devastating consequences on the health, well-being, and psychosocial development of children.
- Conditions
- Malnutrition, Stunting, Wasting, Underweight
- Trial name
- CHAMP (NCT05793294)
- Where
- 2 sites in Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Inflammatory Bowel Disease
Gut Microbiota in the Healthy Population, Inflammatory Bowel Disease Patients, and Their Relatives
The aim of this study is to compare the gut microbiota in Chinese patients with Inflammatory Bowel Disease (IBD) in Hong Kong with that of healthy controls, compare the gut microbiota in IBD patients in a developing country (low…
- Trial name
- NCT01140802
- Where
- Hong Kong
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Circadian Rhythm Disorders, Intestinal Flora
An Observational Clinical Study on the Intestinal Flora in Circadian Rhythm Disorder and Healthy Controls
An observational clinical study on the changes of intestinal flora between people with circadian rhythm disorders and healthy controls was conducted to explore the relationship between circadian rhythm disorders and human…
- Trial name
- NCT05694481
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Third Military Medical University
Colo-rectal Cancer
Motility of the Check-cap's MD1 Colon Capsule in Subjects Following Colon Rectal Cancer Screening by Colonoscopy
To monitor the Whole Gut Transit Time and repeatability of the motility of MD1 capsules in the colon of subjects with known polyps and in healthy subjects. Multi-Center, Open, Home Monitoring, Prospective Study.
- Trial name
- NCT03785665
- Testing
- MDI
- Where
- Israel
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Check-Cap Ltd.
Chronic Renal Insufficiency
Renal Effects of Meditarranean Diet and Low-protein Diet With Ketoacids on Physiological Intestinal Mibrobiota in CKD
Food intake has a deep influence on gut microbiota composition and function, both in health and in disease status. In chronic kidney disease (CKD), a microbiota dysbiosis status is observed.
- Trial name
- MEDIKA (NCT02302287)
- Testing
- Ketoacids diet, Mediterranean diet, Free diet
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Azienda Sanitaria ASL Avellino 2
Age Related Macular Degeneration
The Role of the Gut Metagenome on the Development of Age Related Macular Degeneration (AMD)
The primary objective of this study is to assess whether compositional and functional alterations of the gut metagenome may be related to AMD.
- Trial name
- NCT02438111
- Testing
- metagenome
- Where
- Switzerland
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Crohn's Disease
Reduced Appetite in Crohn's Disease: The Role of the Brain in the Control of Food Intake
Crohn's disease (CD) is becoming more common, specifically in the western world. One of the main features of this disease is weight loss and malnutrition. Although clinically common, these problems are not well understood.
- Trial name
- NCT02772458
- Testing
- Dodecanoate acid and saline
- Where
- 2 sites in United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Crohn's Disease (CD), Ulcerative Colitis (UC)
Accurately Profiling the Changes and Functions of Key Microflora in the Whole Intestinal Microenvironment Based on the Visual Sampling Capsule Endoscopy in Patients With Inflammatory Bowel Disease
This is a prospective, single-center, observational cohort study that will enroll 250 participants: 50 with active Crohn's disease, 50 with Crohn's disease in remission, 50 with active ulcerative colitis, 50 with ulcerative…
- Trial name
- NCT07799506
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Discrimination, Racial, Social Isolation
Discrimination and the Brain-Gut-Microbiome (BGM) Axis
Obesity is a major public health problem related to a variety of illnesses such as heart disease and diabetes. Prior research indicates that social stressors contribute to risk for obesity, possibly through alterations in diet…
- Conditions
- Discrimination, Racial, Social Isolation, Stress
- Trial name
- NCT05120908
- Where
- United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
HIV, Lipodystrophy
Factors Mediating Gut Microbiota Dysbiosis and Metabolic Disease in HIV Patients.
This study plans to learn more about immune responses in intestinal (gut) tissue in people with human immunodeficiency virus (HIV) infection.
- Trial name
- NCT02258685
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Healthy Young Adults
Exploring Wellbeing Outcomes in Adolescents Using Bifidobacterium Longum, 1714™
The purpose of this study is to evaluate changes in self-reported wellbeing outcomes in adolescents. Bifidobacterium longum, 1714™ has previously been associated with beneficial effects on stress-related outcomes, sleep quality…
- Trial name
- NCT07752342
- Testing
- Bifidobacterium longum, 1714™
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Novonesis
Obesity, Obesity & Overweight
Interaction of Sleep, Diurnal Eating Pattern, Gut Microbiota, and Obesity
The goals of the proposed study are 1) to provide scientific basis for the relationship between subjective sleep quality, diurnal eating pattern, gut microbiome, and obesity, 2) to develop and test a pragmatic, cost-effective new…
- Trial name
- ObeApp (NCT04850391)
- Testing
- Mobile app
- Where
- Finland
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
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