Clinical trials: GI Tract Disorders
Type 2 Diabetes
SAFEGUARD: Pleiotropic Effects of Incretin Based Therapies
The aim of this study is to detail the (mechanisms underlying the) actions of the GLP-1 receptor agonists and DPP-4 inhibitors on the cardiovascular, renal and gastrointestinal systems in patients with Type 2 Diabetes Mellitus.
- Trial name
- NCT01744236
- Testing
- Liraglutide, Sitagliptin, Exenatide
- Where
- Netherlands
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Irritable Bowel Syndrome, Functional Dyspepsia
The Multi-disciplinary Treatment of Functional Gut Disorders Study
Randomised controlled trial comparing standard outpatient clinic treatment with multi-disciplinary clinic treatment for functional gastrointestinal disorders.
- Conditions
- Irritable Bowel Syndrome, Functional Dyspepsia, Constipation - Functional, Faecal Incontinence
- Trial name
- MANTRA (NCT03078634)
- Testing
- Multi-disciplinary clinic model, Standard outpatient care
- Where
- Australia
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- St Vincent's Hospital Melbourne
Obesity & Overweight, Circadian Rhythm Disorders
Effects of Akkermansia Muciniphila and Berberine Supplementation on Insulin Sensitivity in Night-shift Workers
Night shift work is associated with an increased risk of obesity, insulin resistance, and cardiometabolic disorders, largely due to circadian misalignment, disrupted sleep, and altered eating patterns.
- Conditions
- Obesity & Overweight, Circadian Rhythm Disorders, Gut Microbiota Modulation, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
- Trial name
- Shift2Health (NCT07440147)
- Testing
- Verum (A)
- Where
- Austria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- FH Joanneum Gesellschaft mbH
Leaky Gut Syndrome
Effect of Colostrum on Gut Permeability and Endotoxin Level in Chronic Alcoholic Disease
Chronic alcohol ingestion is related with leaky gut syndrome. Colostrum is well-studied that it has a effect of decreasing the degree of leaky gut syndrome.
- Trial name
- NCT01088087
- Testing
- colostrum
- Where
- South Korea
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Bronchiectasis
Identification of Microbiome and Metabolome of Bronchiectasis in Chinese Population.
This study aims to investigate the characteristics of gut microbiome and metabolome in non-CF bronchiectasis patients, hoping to explore the underlying mechanisms as well as the influence of gut microbiota composition on…
- Trial name
- NCT04490447
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Psoriasis
INulin-type Fructans-induced Gut Microbiota Modulation Impact on GUT-SKIN Axis Parameters in Psoriasis
There is increasing evidence of a strong, bidirectional correlation between the gut and the skin, that associates gastrointestinal health with skin homeostasis and allostasis.
- Trial name
- INGUTSKIN (NCT05971992)
- Testing
- Chicory-derived inulin-type β-fructans, Maltodextrin
- Where
- 2 sites in Poland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Polish Academy of Sciences
Complex Regional Pain Syndromes
Role of the Gut Microbiome in Complex Regional Pain Syndrome
The objective of this prospective, observational study is to determine the association between the composition of the gut microbiota and the severity and persistence of Complex Regional Pain Syndrome symptoms (Study A).
- Trial name
- NCT03612193
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Obesity, Healthy
Gastrointestinal Tolerability to Agavins and Impact on Host-gut Microbiota-metabolism Interactions Modulation
Agavins are branched neo-fructans and prebiotic fiber found in Agave plants. In preclinical studies, agavins have demonstrated an effect in reversing metabolic disorders associated to overweight and obesity through the modulation…
- Trial name
- NCT04555447
- Testing
- Agavins (prebiotic fiber)
- Where
- 2 sites in Mexico
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Centro De Investigación Y De Estudios Avanzados Del Instituto Politécnico Nacional-Unidad Irapuato
Pregnancy, Food Hypersensitivity
Traditional Asian Diet and Gut Microbiome and Metabolome in Healthy Volunteers and Pregnancy on Infant's Allergy Development
The research aims to elucidate a specially-designed personalized diet based on Traditional Asian Diet and its efficacy in increasing the gut colonization of Prevotella sp.
- Conditions
- Pregnancy, Food Hypersensitivity, Healthy
- Trial name
- NCT04885959
- Testing
- Traditional Asian Diet
- Where
- Malaysia
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Obesity, Chronic Inflammation
Impact of Gut Hormones and Inflammatory Adipokines in Obese Patients Underwent Bariatric Surgery
Obesity and type 2 diabetes, dyslipidemia and related metabolic disease has become a threat to our national life and health which is showing a trend.
- Conditions
- Obesity, Chronic Inflammation, Type 2 Diabetes
- Trial name
- NCT02963662
- Testing
- laparoscopic Roux-en-Y gastric bypass, laparoscopic sleeve gastrectomy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Gao Zhiguang
Essential Hypertension, Liver Cancer
A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China
The human gut microbiome has been associated with many health factors but variability between studies limits the exploration of effects between them.
- Conditions
- Essential Hypertension, Liver Cancer, Nasopharyngeal Cancer, Pancreatic Cancer
- Trial name
- NCT05638269
- Testing
- no intervention
- Where
- 50 sites in China
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Menopause
The BALANCE Study - Improving Glucose Control Through Prebiotic Gut Health Drink in Postmenopausal Women
The menopausal transition is associated with a decline in oestrogen levels, contributing to adverse metabolic changes including increased central adiposity, systemic inflammation, and insulin resistance.
- Trial name
- BALANCE (NCT07565675)
- Testing
- ió everyday (a prebiotic- enriched gut health drink containing inulin)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Roehampton
Metabolic Disease
Protein, Calcium and Gut Hormone Secretion
Hormones that are produced by our stomach and intestines play a role in regulating our appetite and health, and are therefore of high interest for managing conditions such as obesity and Type 2 Diabetes (T2D).
- Trial name
- PROCAL2 (NCT04659902)
- Testing
- Protein form
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Bath
Diabetes Mellitus
Effect of Smoking on Postprandial Gastric Emptying, Glucose Tolerance and Secretion of Gut and Pancreatic Hormones
The study aims to evaluate the effect of smoking on postprandial responses such as plasma glucose, secretion of gut - and pancreatic hormones and gastric emptying in healthy, heavy smoking men.
- Trial name
- SmokinGLP-1 (NCT02497651)
- Testing
- Liquid mixed meal, Skin Biopsy
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis)
Study on the Use of Traditional Chinese Medicine Diagnostic Tools to Assist in Identifying the Clinical Characteristics of Inflammatory Bowel Disease and Research on Metabolic Plastids of Tongue Coating
This study will be conducted at the outpatient clinic of China Medical University hospital. It is expected to enroll two groups of 30 subjects, including the experimental group must meet the clinical diagnosis of IBD, and the…
- Trial name
- NCT07314151
- Testing
- No intervention (observational study with diagnostic assessments only)
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Appendicitis, Appendicitis Acute
Clinical Study of PEG Bowel Preparation in Appendectomy Patients
Colonoscopy is a necessary item of physical examination for colorectal cancer. For high-risk groups, annual physical examination is the most effective way of early prevention; At present, a large amount of polyethylene glycol…
- Trial name
- NCT07478029
- Testing
- Bowel Preparation with Polyethylene Glycol (PEG) Laxatives
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Huaping Xie
Malaria
Gut and Azithromycin Mechanisms in Infants and Children II
Childhood mortality is decreasing worldwide. However, many sub-Saharan countries still have high children under 5 mortality rates.
- Trial name
- GAMINII (NCT04315272)
- Testing
- Azithromycin
- Where
- Burkina Faso
- Volunteers
- 449 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Obesity, Body Weight
Metabolic and Bio-behavioral Effects of Following Recommendations in the Dietary Guidelines for Americans
This study, at the Western Human Nutrition Research Center (WHNRC), will focus on whether or not achieving and maintaining a healthy body weight is the most important health promoting recommendation of the Dietary Guidelines for…
- Trial name
- DGA4ME (NCT04293224)
- Testing
- DGA Mediterranean diet pattern, energy balance, DGA Mediterranean diet pattern, negative energy balance, TAD diet pattern, negative energy balance
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Type 2 Diabetes
Exercise, Gut Microbiota and Type 2 Diabetes
This randomized, parallel, controlled study, will investigate the effect of regular exercise on GM composition, inflammatory status, and insulin sensitivity, in the progression from normal glucose tolerance (NGT), to prediabetes…
- Trial name
- Ex-GM-T2D (NCT06562842)
- Testing
- Regular exercise, Control comparator
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Severe Malnutrition, Malnutrition
Characterizing the Gut Microbiota Alteration Associated With Severe Acute Malnutrition
The investigators performed two case-control studies in Niger and Senegal analysing fecal microbiota to characterize the specificity of the gut microbiota alteration associated with severe acute malnutrition (SAM).
- Conditions
- Severe Malnutrition, Malnutrition, Infant Nutrition Disorders, Child Nutrition Disorders
- Trial name
- NCT02413905
- Testing
- Stool samples
- Where
- 2 sites in Niger, Senegal
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut Hospitalo-Universitaire Méditerranée Infection
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