Clinical trials: GI Tract Disorders
Metabolic Syndrome, Impaired Glucose Tolerance
The Health Effect of Diet Rich in Nordic Berries
Dietary polyphenols might have beneficial effects on glucose and lipid metabolism based on the studies made in animals or cell cultures.
- Conditions
- Metabolic Syndrome, Impaired Glucose Tolerance, Low-grade Inflammation, Dyslipidemia
- Trial name
- Berry (NCT01414647)
- Testing
- 300 g of strawberry, raspberry and cloudberry, 400 g of bilberry, Control diet
- Where
- Finland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Marjukka Kolehmainen
Head and Neck Cancer
Study of Blood and Tissue Samples From Patients With Larynx Cancer, Pharynx Cancer, or Oral Cavity Cancer
RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- CARIO (NCT00963326)
- Testing
- laboratory biomarker analysis
- Where
- 9 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Oscar Lambret
Urinary Tract Infections, UTI
Cranberry and Quillaja on Symptoms of Uncomplicated UTI
This study will investigate the effects of cranberry and quillaja capsules on symptoms of uncomplicated urinary tract infections.
- Conditions
- Urinary Tract Infections, UTI, UTI - Lower Urinary Tract Infection
- Trial name
- NCT04496726
- Testing
- Pacran and Sapnov P quillaja
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Type2 Diabetes
Rifaximin Improves Gut Dysbiosis in Insulin Resistance and Type 2 Diabetes
Gut Dysbiosis had been involved in some way in the pathogenesis of some extra-intestinal disorders including metabolic syndrome, cardiovascular disease, and obesity.
- Trial name
- NCT03758144
- Testing
- Rifaximin 200 MG
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Zagazig University
Lynch Syndrome, Hereditary Colonic Polyposis Syndromes
Metagenomic Evaluation of the Gut Microbiome in Patients With Lynch Syndrome and Other Hereditary Colonic Polyposis Syndromes
The purpose of this study is to understand the role bacteria that normally live in the colon may play in colorectal cancer risk, in addition to the hereditary risk to colorectal cancer.
- Trial name
- NCT02371135
- Testing
- colonic biopsies, questionnaires
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Hypertension
Effect of Gut Microbiome Restoration on Primary Hypertension Via Dietary Intervention
Mounting preclinical and clinical evidences have proved the optimal role of diets (i.e. DASH (Dietary Approaches to Stop Hypertension) diet, Mediterranean diet) on BP control and a causal role of gut microbiota on the…
- Trial name
- NCT04403347
- Testing
- Innovative Dietary Formulation (Patent ID: CN110250417A), Regular Diet
- Where
- 8 sites in China
- Volunteers
- 130 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Overweight
Carbohydrates and Gut Hormones After Gastric Bypass Surgery
To investigate the secretion of gut hormones, in particular glucagon-like peptide 1 (GLP-1), after ingestion of glucose and fructose as separate monosaccharides or combined in the disaccharides sucrose and isomaltulose and the…
- Trial name
- NCT02879955
- Testing
- Glucose + Fructose, Sucrose, Isomaltulose
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Metastatic Sarcoma, Esophageal Cancer
64Cu-LNTH-1363S in Patients With Sarcoma or Gastrointestinal Tract Cancer
This is a multicenter, open-label, prospective Phase 1/2a study to assess safety and tolerability, establish dosimetry and to identify an optimal imaging dose (radioactivity) and imaging time window of 64Cu-LNTH-1363S, and to…
- Conditions
- Metastatic Sarcoma, Esophageal Cancer, Gastric Cancer, Pancreatic Cancer
- Trial name
- PHANTOM (NCT06298916)
- Testing
- 64Cu-LNTH-1363S
- Where
- 5 sites in United States
- Volunteers
- 26 people
- Sponsor
- Lantheus Medical Imaging
Childhood Obesity
Effect of Docosahexaenoic Acid Supplementation on Microbiome in Obese ChiLdrEn.
Evaluation of the possible effect of DHA supplementation, combined with interventions aimed at improving diet and lifestyle, on gut microbiota composition and metabolite production.
- Trial name
- DAMOCLE (NCT04151758)
- Testing
- Docosahexaenoic Acid Supplementation, Promotion of physical activity, Promotion of healthy food habits
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Milan
Upper Gastrointestinal Bleeding, Proton Pump Inhibitors
The Effect of Using Preendoscopic Proton Pump Inhibitors in Upper Gastrointestinal System Bleeding on Patient Prognosis
In this study, we aimed to investigate the effectiveness of ppi use in upper gastrointestinal bleeding in patients over the age of 18 who underwent endoscopy on mortality, length of hospital stay, rebleeding, and cost.
- Trial name
- NCT05467358
- Where
- Turkey (Türkiye)
- Volunteers
- 1,100 people
- Sponsor
- Ankara City Hospital Bilkent
Hypoglycemia
Hypoglycemia and the Gut Microbiome
This study is designed to evaluate individuals who are currently experiencing symptoms of hypoglycemia, in order to discern correlations between microbiome composition and patterns of postprandial glycemia.
- Trial name
- NCT03385707
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Joslin Diabetes Center
Sclerosis, Multiple
Gut Microbiota Composition, Cognitive Function, and Physical Fitness in Multiple Sclerosis Patients
The evidence suggests that multiple sclerosis (MS) induces a decline in motor and cognitive function and provokes a shift in gut microbiome composition in patients.
- Trial name
- MSDANCE (NCT06220409)
- Testing
- Dance classes
- Where
- Slovakia
- Volunteers
- 29 people
- Sponsor
- Comenius University
Autism Spectrum Disorder, Gastrointestinal Dysfunction
ASC - Autism Study
The ASC - Autism Pilot Study is a single center randomized open dose titrating phase I clinical intervention pilot trial with the aim of investigating safety and treatment effect of an allogeneic adipose tissue derived…
- Conditions
- Autism Spectrum Disorder, Gastrointestinal Dysfunction, Leaky Gut Syndrome, Mesenchymal Stromal Cells
- Trial name
- NCT05602116
- Testing
- Adipose tissue derived mesenchymal stromal/stem cells (Cell2Cure®)
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Cell to Cure ApS
Irritable Bowel Syndrome
Fecal Microbiota Transplantation to Relieve Symptoms of Irritable Bowel Syndrome With Constipation
Irritable bowel syndrome (IBS) is a complex multifactorial functional disorder, whose pathophysiology is largely associated to an impairment of the intestinal microbiota composition, namely dysbiosis.
- Trial name
- TRAMIR-S (NCT05803993)
- Testing
- Fecal microbiota transplantation (FMT) Single FMT infusion
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Muscle Loss
Galactooligosaccharide and Aging
Sarcopenia is a progressive muscle disease, most commonly affecting older individuals, that is categorised by 1) low muscle strength, 2) low muscle quantity or quality, and 3) low physical performance.
- Trial name
- NCT06411964
- Testing
- Prebiotic
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Bath
Schizophrenia, Schizoaffective Disorder
Schizophrenia and the Gut Microbiome
In a sample of 20 inpatients with a DSM-IV-TR/DSM 5 diagnosis of schizophrenia or schizoaffective disorder, investigators propose to conduct a prospective, 2 week observational trial to collect gastrointestinal stool samples in…
- Trial name
- NCT02921243
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Maryland, Baltimore
Autism Spectrum Disorder
WMT for Autism Spectrum Disorder (ASD)
Autism Spectrum Disorder (ASD) is a group of serious neurodevelopmental disorders. A significant comorbidity exists between ADHD and ASD: 30%-50% of individuals with ASD exhibit ADHD symptoms, and two-thirds with ADHD show ASD…
- Trial name
- NCT06030752
- Testing
- Washed Microbiota Transplantation
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Spondyloarthritis, Inflammatory Bowel Diseases
Validation of a Preclinical Model Based on Patient-derived Organoids for the Study of the Gut-joint Axis in Spondyloarthritis
This project aims to develop and validate a model of human organoids derived from patients with Spondyloarthritis, focusing on synovial and intestinal tissues as targets of the gut-joint axis.
- Trial name
- ORGANOSPA (NCT06421116)
- Testing
- Synovial ultrasound-guided biopsy Intestinal biopsy
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Allergic Rhinitis
Traditional Chinese Medicine for the Treatment of Perennial Allergic Rhinitis on Gut Microbiota and Immune-modulation
40 allergic rhinitis patients in the acute phase will be enrolled in the study. All the allergic patients should be confirmed those who are over 20 years old and hypersensitive to house dust mite allergens confirmed by MAST test…
- Trial name
- NCT04388358
- Testing
- Shin-yi-san + Xiao-qing-long-tang + Xiang-sha-liu-jun-zi-tang by the weight of 9g+3g+3g/day
- Where
- Taiwan
- Volunteers
- 33 people
- Sponsor
- Chang Gung Memorial Hospital
Cardiovascular Disease
Bioavailability of Carotenoids Added Into Processed Foods
Carotenoids are a family of pigments found abundantly in fruits and vegetables. They are responsible for the colour of many fruits and vegetables such as tomatoes, melon, peppers and orange coloured fruits and vegetables.
- Trial name
- CAROTFoods (NCT02246985)
- Testing
- Control, Vegetable bread only, Plain bread with vegetable mayonnaise
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen