Clinical trials: Gait Dysfunction
Parkinson Disease, Parkinson Disease Dementia
Cholinergic Neurotransmission in Mobility and Cognition in Parkinson Disease
This is a single-site non-randomized open label pilot study. The investigators will use accelerometer-based instrumented gait analysis and computerized cognitive testing to study the interaction of motor and cognitive dysfunction…
- Trial name
- NCT03840837
- Testing
- Rivastigmine transdermal patch
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Maryland, Baltimore
Chronic Stroke Patients
Cognitive Impairment and Gait Balance in Chronic Stroke Survivors
This study aims to investigate the relationship between cognitive impairment and gait balance in individuals with chronic stroke.
- Trial name
- NCT07078903
- Volunteers
- 26 people
- Sponsor
- Islam Hassan Fayed
Stroke, Ischemic, Cognitive Impairment
Effects of Cognitive Versus Task Oriented Training on Balance, Gait and Daily Activity in Chronic Stroke Patients
To determine effects of cognitive sensorimotor exercises versus task oriented training on balance, gait and activities of daily living in chronic stroke patients.
- Conditions
- Stroke, Ischemic, Cognitive Impairment, Balance; Distorted, ADL
- Trial name
- NCT06663657
- Testing
- Cognitive Sensorimotor Exercises, Task Oriented Training group
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Mild Cognitive Impairment
SYNchronizing Exercises, Remedies in GaIt and Cognition
The proposed SYNERGIC trial is uniquely designed to evaluate the effect of aerobic and progressive resistance training exercises, combined with cognitive training and Vitamin D3 supplementation, in cognition and mobility in older…
- Trial name
- SYNERGIC (NCT02808676)
- Testing
- Vitamin D3, Exercises (E), Cognitive Training (CT)
- Where
- 6 sites in Canada
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Parkinson Disease, Dementia
Using Gait Robotics to Improve Symptoms of Parkinson's Disease
This study evaluates the benefits of exoskeleton-based exercise for improving mood and cognition in people with Parkinson's disease (PD).
- Conditions
- Parkinson Disease, Dementia, Mild Cognitive Impairment
- Trial name
- NCT03583879
- Testing
- Exoskeleton exercise, Standard exercise, No treatment
- Where
- 2 sites in Canada
- Volunteers
- 41 people
- Sponsor
- University of New Brunswick
Frailty, Cognition
Promoting Independent Living in Frail Older Adults by Improving Cognition and Gait Ability and Using Assistive Products
A strategy involving 6 partners was planned, targeting the components of education, innovation, and practice-based research with knowledge transfer into clinical practice.The project MIND\&GAIT aims to promote independent living…
- Conditions
- Frailty, Cognition, Mild Cognitive Impairment
- Trial name
- MIND&GAIT (NCT03390478)
- Testing
- Combined Intervention Group
- Where
- Portugal
- Volunteers
- 62 people
- Sponsor
- Escola Superior de Enfermagem de Coimbra
Multiple Sclerosis, Gait Disorders, Neurologic
Investigating the Effects of Wearable Robotic Exoskeleton for Improving Mobility and Cognition in Persons With MS
The purpose of this research study is to evaluate the usefulness of a wearable robotic exoskeleton device (Ekso-GT), to improve learning and memory, and gait therapy in persons with walking disability due to Multiple Sclerosis.
- Conditions
- Multiple Sclerosis, Gait Disorders, Neurologic, Motility Disorder, Cognitive Impairment
- Trial name
- NCT04855825
- Testing
- Robotic Exoskeleton Rehabilitation, Conventional Gait Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Kessler Foundation
Repetitive Transcranial Magnetic Stimulation, Transcranial Direct Current Stimulation
Efficacy of rTMS and tDCS as Adjunctive Rehabilitation for Cerebrovascular Disease-related Gait Dysfunction
This study was a prospective, randomized, single-blind, parallel-controlled, multicenter clinical study to evaluate the efficacy and safety of repetitive transcranial magnetic stimulation and transcranial direct current…
- Conditions
- Repetitive Transcranial Magnetic Stimulation, Transcranial Direct Current Stimulation, Cerebrovascular Disease, Gait Dysfunction, Neurologic
- Trial name
- NCT04282538
- Testing
- Active rTMS, Active tDCS, Walking training
- Where
- 6 sites in China
- Volunteers
- 100 people
- Sponsor
- zsneurology
Multiple Sclerosis, Gait Disorders, Neurologic
Gait Pattern and Its Relation to Cognition and VEP in Multiple Sclerosis
This cross-sectional study aims to assess the pattern of gait in patients with multiple sclerosis and to evaluate its relation to cognitive function, visual evoked potentials, and radiological findings.
- Trial name
- NCT07847086
- Volunteers
- 70 people
- Sponsor
- Assiut University
Alzheimer Disease (AD), Mild Cognitive Impairment (MCI)
Use of a Mobile Brain-Body Imaging Approach to Evaluate the Effects of Rhythmic Auditory Stimulation on Gait and Brain Function in Alzheimer's Disease
Alzheimer's Disease (AD) is associated with impairments in both gait and cognition, significantly increasing fall risk. Falls are a leading cause of injury-related disability in older adults, and individuals with AD experience a…
- Trial name
- NCT07659964
- Testing
- Metronome
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Spinal Cord Injuries (SCI), Spinal Cord Injury, Chronic
BCI-Assisted SCS-EXS for Gait Optimization
The goal of this clinical trial is to evaluate the safety and technical feasibility of a novel brain-machine interface (BCI)-assisted spinal cord stimulation (SCS) and exoskeleton (EXS) system in patients with spinal cord injury…
- Conditions
- Spinal Cord Injuries (SCI), Spinal Cord Injury, Chronic, Spinal Cord Injury, Spinal Cord Injury Cervical
- Trial name
- BASEGO (NCT06939660)
- Testing
- BCI-SCS-EXS
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Xuanwu Hospital, Beijing
Motoric Cognitive Risk Syndrome, Mild Cognitive Impairment
Pre-demential Motoric Cognitive Risk Syndrome in Ageing Subjects
The main aim of the study is to characterize and understand the pathological mechanisms underlying the motoric cognitive risk syndrome, which is a predictor of Alzheimer disease.
- Conditions
- Motoric Cognitive Risk Syndrome, Mild Cognitive Impairment, Alzheimer Disease, Dementia
- Trial name
- PRESAGE (NCT05640141)
- Testing
- MRI evaluation, Actimetry & IMU, Gait evaluation
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Mild Cognitive Impairment
Cognitive Integrated Motor Training (CM) to Improve Gait and Balance and Reduce Falls in Older Adults With Mild Cognitive Impairment
Problems with walking and balance are common in older adults with mild cognitive impairment. Walking and balance problems limit independence and increase risk for injuries due to falls.
- Trial name
- CM (NCT06719297)
- Testing
- Personalized cognitive-sensorimotor VR/MR training, Standard of Care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Kessler Foundation
Fallers, Mild Cognitive Impairment
Temporal Relations and Exercise Interventions of Various Gait and Cognitive Domains in Older Adults
The effectiveness of conventional exercise, tai chi chuan and health education/usual physical activity over a 6-month intervention period in improving primary outcomes and secondary outcomes in older mild cognitive impairment…
- Trial name
- NCT03839563
- Testing
- Exercise
- Where
- Taiwan
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Tibialis Posterior Dysfunction, Emg
Pilot Study to Develop Protocols for Recording Tibialis Posterior EMG
This is an observational pilot study to allow us to create a normal database of muscle function of one of the muscles in the back of the leg (tibialis posterior).
- Trial name
- NCT06131359
- Testing
- Fine wire EMG and Force Frame muscle strength testing
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Mild Cognitive Impairment
Arch Support Effects on Balance and Gait in Older Adults With Mild Cognitive Impairment
This study aims to explore the effects of arch support insoles on balance and gait performance in older adults with mild cognitive impairment (MCI). We will recruit 40 female older adults with MCI.
- Trial name
- NCT05470062
- Testing
- arch support insoles (FootDisc)
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Mild Cognitive Impairment
Gaze and Gait Training With rTMS
The purpose of this study is to evaluate the feasibility of combining repetitive transcranial magnetic stimulation (rTMS), gaze and gait training to improve walking and balance in people with or without mild cognitive impairment.
- Trial name
- NCT05864313
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), Gait training, Gaze training
- Volunteers
- 30 people
- Sponsor
- University of Florida
Stroke
Home-Based Functional Electrical Stimulation for Lower Limb Rehabilitation in Stroke Patients.
This assessor-blinded, randomized, parallel-group feasibility trial will evaluate the feasibility and preliminary effectiveness of a home-based Functional Electrical Stimulation (FES) system for lower-limb rehabilitation in…
- Trial name
- FES (NCT07785700)
- Testing
- Functional Electrical Stimulation (FES), Standard Rehabilitation
- Where
- 3 sites in India
- Volunteers
- 70 people
- Sponsor
- Christian Medical College and Hospital, Ludhiana, India
Sacroiliac Dysfunction
Sacroiliac Joint Dysfunction Consequences and Its Reversal by Manipulation
Sacroiliac joint dysfunction (ASI) is an alteration in the normal biomechanics of the joint, which leads to hypomobility or hypermobility of that joint.
- Trial name
- LOUIS (NCT06710535)
- Testing
- Manual Manipulation
- Where
- Portugal
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Aveiro University
Falls, Gait
Donepezil and the Risk of Falls in Seniors With Cognitive Impairment
Compared with cognitively normal older adults, those with mild cognitive problems (MCI) have a two-fold higher rate of falls, sustain more fractures, and have a higher rate of mortality due to falls.
- Conditions
- Falls, Gait, Balance, Mild Cognitive Impairment (MCI)
- Trial name
- NCT00934531
- Testing
- Donepezil
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's