Clinical trials: Galectin 3
Vascular Surgical Procedure
Measurement Of NT-proBNP to Predict Outcomes in Surgery
The team is investigating whether N-terminal pro B-type natriuretic peptide (NT-proBNP) and other cardiac markers are useful for predicting outcomes for patients undergoing vascular surgery.
- Trial name
- MOBOS (NCT04014647)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Metastatic Melanoma
Galectin Inhibitor (GR-MD-02) and Ipilimumab in Patients With Metastatic Melanoma
The goal of this study is to determine a safe dose of GR-MD-02 used in combination with the FDA-approved dose of ipilimumab (3 mg/kg) in patients who have advanced melanoma. GR-MD-02 is a galectin.
- Trial name
- NCT02117362
- Testing
- 1 mg/kg GR-MD-02, 2 mg/kg GR-MD-02, 4 mg/kg GR-MD-02
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Providence Health & Services
Biomarkers, ST Segment Elevation Myocardial Infarction
Biomarkers for Risk Stratification After STEMI
Despite modern reperfusion strategies, myocardial infarction leads to deleterious processes resulting in left ventricular remodelling (LVR) and heart failure (HF). Several biomarkers i.e.
- Conditions
- Biomarkers, ST Segment Elevation Myocardial Infarction, Primary Percutaneous Coronary Intervention, Heart Diseases
- Trial name
- NCT03735719
- Where
- Poland
- Volunteers
- 136 people
- Sponsor
- Medical University of Warsaw
Atrial Fibrillation
ALDOsterone for Prediction of Post-Operative Atrial Fibrillation
Post-operative atrial fibrillation (POAF) is a major and frequent complication occurring after cardiac surgery, contributing to prolonged intensive care and hospital stays and is associated with several cardiovascular…
- Trial name
- ALDO-POAF (NCT02814903)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Caen
Chagas Disease
Galectin-3 as a Biomarker in Patients With Chagas Disease
The purpose of this study is to analyze the efficacy of Galectin-3 as a biomarker on the Chagas Disease prognosis. This analysis will be done through the correlation between the plasmatic levels of this molecule with functional…
- Trial name
- NCT01842854
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital Sao Rafael
Endometriosis
Galectin-3 in Patients With Endometriosis
The exact cause of endometriosis is unknown ,so our study is to investigate the relationship between Galectin-3 and endometriosis by comparing between its level in healthy and endometriosis women.
- Trial name
- NCT03212612
- Testing
- samples obtained by laparoscopy or punch biopsy for analysis by ELISA
- Where
- 3 sites in Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Periodontal Diseases
Influence of Periodontitis and Coronary Heart Disease on Galectin-3
The aim of this study was to analyze the association between serum and salivary Galectin-3 levels in patients with periodontitis.
- Trial name
- NCT04564950
- Testing
- Observation of serum and salivary Galectin-3 levels
- Where
- Italy
- Volunteers
- 155 people
- Sponsor
- University of Messina
Placenta Accreta
Galectin-3 and Placenta Accreta
Galectins are a family of carbohydrate-binding proteins that have a high affinity to galactosides, its protein portion is located in the nucleus and the cytoplasm with its carbohydrate recognition domain which has high ability to…
- Trial name
- NCT04573452
- Testing
- Galectin-3, Placental Galactin-3
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Assiut University
HIV Infections, Frailty
Sleep Quality and Frailty Among People Living With HIV
With effective antiretroviral therapy (ART), people living with HIV (PLWH) are living longer and are increasingly experiencing aging-related conditions such as frailty and sleep problems.
- Conditions
- HIV Infections, Frailty, Sleep Quality, Oral Frailty
- Trial name
- NCT07880054
- Testing
- No intervention (observational assessments)
- Where
- Taiwan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- National Sun Yat-sen University
Goiter, Nodular
Galectin 3 Dosage in Diagnosis of Nodular and Multinodular Goiter
The investigators will dose galectin 3 in plasma and water rinse of the needle aspiration biopsy in patients with thyroid nodules.
- Trial name
- Galectins (NCT01588288)
- Testing
- Galectin 3 dosage
- Where
- 2 sites in France
- Volunteers
- 193 people
- Sponsor
- University Hospital, Rouen
Galectin-3 During Respiratory Weaning
Galectin and Respiratory Weaning
Galectin-3 is a biomarker for fibrotic activity. In the course of invasive ventilation, fibrotic changes in the lungs may occur.
- Trial name
- Gal-3 (NCT05054556)
- Testing
- Labaratory tests
- Where
- 2 sites in Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Asklepios Neurological Clinic Bad Salzhausen
Renal Cell Carcinoma (Kidney Cancer), Non Small Cell Lung Cancer
Association Between Galectin-3 Levels and Outcomes in Patients With Renal Cell Carcinoma, Transitional Cell Carcinoma , Non Small Cell Lung Cancer, and Hepatocellular Carcinoma, Treated With PD-1/PDL-1 Inhibitors
1. Background and Rationale:: Galectin-3 (Gal-3) is a β-galactoside-binding protein involved in various biological processes, including cell proliferation, apoptosis, adhesion, and immune regulation.
- Conditions
- Renal Cell Carcinoma (Kidney Cancer), Non Small Cell Lung Cancer, Hepatocellular Carcinoma, Transitional Cell Carcinoma
- Trial name
- NCT07485114
- Testing
- Serum Gal-3 level, blood count and chemistry included liver function
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Daniel Keizman
Non-Small Cell Lung Cancer
A Study to Investigate the Safety and Efficacy of GB1211 (a Galectin-3 Inhibitor) in Combination With Atezolizumab in Patients With Non-Small Cell Lung Cancer (NSCLC).
This study is an open label study followed by a randomised, double-blind, placebo-controlled, parallel group and an extension study to investigate the safety and efficacy of GB1211 (a galectin-3 inhibitor) in combination with…
- Trial name
- NCT05240131
- Testing
- GB1211, Atezolizumab
- Where
- 5 sites in France, Poland and 1 more
- Volunteers
- 88 people
- Sponsor
- Galecto Biotech AB
Galectin-3 and Pemphigus
Evaluation of Galectin-3 in Serum and Saliva of Pemphigus Patients
Assessment of the expression of galectin-3 in serum and saliva of pemphigus patients and compare it with age and sex matched controls.
- Trial name
- NCT05992727
- Testing
- Galectin 3 measurement in serum and saliva by ELIZA
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Human Papillomavirus Infection
Serum Galectin-3 as a Marker of Human Papillomavirus Infection
This study aimed to assess the serum Galectin-3 levels in patients with warts both before and after cryotherapy and to investigate its potential contribution to the pathogenesis of human papillomavirus infection.
- Trial name
- NCT06005389
- Testing
- cryotherapy, serum Galectin-3 assay
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Metastatic Melanoma, Head and Neck Squamous Cell Carcinoma
GB1211 and Pembrolizumab Versus Pembrolizumab and Placebo in Patients With Metastatic Melanoma and Head and Neck Squamous Cell Carcinoma
The purpose of this study is to determine the objective response of GB1211 and pembrolizumab versus pembrolizumab and placebo in patients with advance metastatic melanoma or head and neck squamous cell carcinoma.
- Trial name
- NCT05913388
- Testing
- GB1211, Pembrolizumab
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Providence Health & Services
Non-alcoholic Steatohepatitis (NASH)
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Orally Administered GB1211 in Participants With Suspected or Confirmed Non-alcoholic Steatohepatitis (NASH) and Liver Fibrosis
This study is a randomised, double-blind, placebo controlled, phase Ib trial in subjects with suspected or confirmed non-alcoholic steatohepatitis (NASH) and liver fibrosis
- Trial name
- NCT04607655
- Testing
- GB1211
- Sponsor
- Galecto Biotech AB
Heart Failure
Sacubitril-valsartan in Patients With Heart Failure.
The aim of this study is to evaluate the safety and efficacy of Sacubitril -Valsartan in patients with heart failure.
- Trial name
- NCT07341893
- Testing
- Sacubitril-valsartan, standard treatment of heart failure
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Damanhour University
Sedentary Lifestyle, Cardiometabolic Risk
Effects of Aerobic and Resistance Exercise on Cardiovascular Biomarkers in Sedentary Women
This randomized controlled trial investigated the effects of aerobic and resistance exercise on cardiovascular and inflammatory biomarkers in sedentary young women.
- Trial name
- NCT07457047
- Testing
- Aerobic Exercise Training, Resistance Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Hypertension
Galectin-3 Blockade in Patients With High Blood Pressure
This study will investigate if Modified Citrus Pectin (MCP) can help people with high blood pressure. MCP is a dietary supplement that is derived from plants, and therefore is not subject to approval by the U.S.
- Trial name
- NCT01960946
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Massachusetts General Hospital