Clinical trials: Galectin 3
Human Papillomavirus Infection
Serum Galectin-3 as a Marker of Human Papillomavirus Infection
This study aimed to assess the serum Galectin-3 levels in patients with warts both before and after cryotherapy and to investigate its potential contribution to the pathogenesis of human papillomavirus infection.
- Trial name
- NCT06005389
- Testing
- cryotherapy, serum Galectin-3 assay
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Acute Kidney Injury, Sepsis
Galectin-3 in Septic and Non-septic Acute Kidney Injury
Acute kidney injury (AKI) is a common critical condition with high morbidity and mortality. The level of circulating Galectin-3 (Gal3) largely depends on renal function, so it is elevated in patients with AKI or CKD; elevated…
- Trial name
- NCT05691621
- Testing
- Standard Reagents, Whole Blood
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Fengyun Wang
Periodontal Diseases
Evaluation of Biomarker Levels in Gingival Crevicular Fluid of Patients With Different Periodontal Diseases
Objectives: The aim of this study is; detection of peptidyl arginine deiminase4 (PAD4), galectin-3 and tumor necrosis factor alpha (TNF-α) levels in gingival crevicular fluid (GCF) samples of periodontally healthy, gingivitis and…
- Trial name
- NCT04777487
- Testing
- GCF obtaining
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Idiopathic Pulmonary Fibrosis (IPF)
A Study to Test the Efficacy and Safety of Inhaled GB0139 in Subjects With Idiopathic Pulmonary Fibrosis (IPF)
This is a randomized, double-blind, placebo-controlled phase 2b trial in subjects with IPF (idiopathic pulmonary fibrosis) investigating the efficacy and safety of GB0139.
- Trial name
- NCT03832946
- Testing
- GB0139
- Where
- 128 sites in United States, Australia and 13 more
- Volunteers
- 172 people
- Sponsor
- Galecto Biotech AB
Ulcerative Colitis (UC)
The Effects of a Modified Mediterranean Diet on Ulcerative Colitis Patients
Ulcerative colitis is a chronic disease with a significant impact on quality of life where a substantial proportion of patients fails to achieve disease remission.
- Trial name
- OLIVE-UC-1 (NCT07857447)
- Testing
- Modified Mediterranean Diet, Standard Nutritional Guidance
- Where
- Croatia
- Volunteers
- 62 people
- Sponsor
- University Hospital Sestre Milosrdnice
Thyroid Cancer
Predicting Prognosis and Recurrence of Thyroid Cancer Via New Biomarkers, Urinary Exosomal Thyroglobulin and Galectin-3
Although thyroid cancers are low-grade endocrine malignancy, most patients usually received thyroidectomy with ablative radioactive iodine therapy.
- Trial name
- NCT03488134
- Where
- Taiwan
- Volunteers
- 74 people
- Sponsor
- National Taiwan University Hospital
Vasculitis, Systemic, Kawasaki Disease
Cardiovascular Status of Children 5 Years After Kawasaki Disease
The aim of present study is to determine cardiovascular status of children who had KD in past and to identify possible biochemical markers of cardiovascular damage in those patients.
- Trial name
- CAVASAKI (NCT03750123)
- Where
- Poland
- Volunteers
- 61 people
- Sponsor
- Medical University of Warsaw
Placenta Accreta, Third Trimester
A Serum Galectin-3 Levels in Placenta Accreta Spectrum Pregnancies
Placenta Accreta Spectrum (PAS) represents a significant cause of maternal morbidity and mortality, causing complications that surpass those posed by most routine obstetric issues.
- Trial name
- NCT05945446
- Testing
- Galectin 3
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Metastatic Melanoma
Galectin Inhibitor (GR-MD-02) and Ipilimumab in Patients With Metastatic Melanoma
The goal of this study is to determine a safe dose of GR-MD-02 used in combination with the FDA-approved dose of ipilimumab (3 mg/kg) in patients who have advanced melanoma. GR-MD-02 is a galectin.
- Trial name
- NCT02117362
- Testing
- 1 mg/kg GR-MD-02, 2 mg/kg GR-MD-02, 4 mg/kg GR-MD-02
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Providence Health & Services
Stable Angina
Correlational Study on the Biomarkers Application to the Prediction and Diagnosis of Cardiovascular Diseases
Through the literature review , we pick out a series of forward-looking biological indicators as follows : 1. NGAL 2. Cystatin C: 3. Galectin-3: 4. Copeptin: 5. MR-Pro ANP: 6. sST2:
- Trial name
- NCT02179047
- Testing
- coronary angiography
- Where
- Taiwan
- Volunteers
- 214 people
- Sponsor
- Taipei City Hospital
Galactin 3-thyroid Carcinoma
Galectin-3 in Papillary Thyroid Carcinoma
Thyroid cancer is a common head and neck malignancy. It is the most common endocrine tumor in the body accounting for 1% of all cancers worldwide. The incidence of thyroid cancer varies worldwide.
- Trial name
- NCT05699590
- Volunteers
- 60 people
- Sponsor
- Sohag University
Periodontitis, Periodontal Inflammation
GCF Galectin-3 and Interleukin-1beta Levels in Periodontitis.
This study aims to evaluate gingival crevicular fluid Galectin-3 and Interleukin-1beta levels in different grades (B and C) of stage 3 periodontitis, concurrently, and also to investigate their discriminative efficiencies in…
- Trial name
- NCT05449093
- Testing
- Periodontal clinical measurements and gingival crevicular fluid sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Renal Cell Carcinoma (Kidney Cancer), Non Small Cell Lung Cancer
Association Between Galectin-3 Levels and Outcomes in Patients With Renal Cell Carcinoma, Transitional Cell Carcinoma , Non Small Cell Lung Cancer, and Hepatocellular Carcinoma, Treated With PD-1/PDL-1 Inhibitors
1. Background and Rationale:: Galectin-3 (Gal-3) is a β-galactoside-binding protein involved in various biological processes, including cell proliferation, apoptosis, adhesion, and immune regulation.
- Conditions
- Renal Cell Carcinoma (Kidney Cancer), Non Small Cell Lung Cancer, Hepatocellular Carcinoma, Transitional Cell Carcinoma
- Trial name
- NCT07485114
- Testing
- Serum Gal-3 level, blood count and chemistry included liver function
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Daniel Keizman
Sedentary Lifestyle, Cardiometabolic Risk
Effects of Aerobic and Resistance Exercise on Cardiovascular Biomarkers in Sedentary Women
This randomized controlled trial investigated the effects of aerobic and resistance exercise on cardiovascular and inflammatory biomarkers in sedentary young women.
- Trial name
- NCT07457047
- Testing
- Aerobic Exercise Training, Resistance Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Ankylosing Spondylitis
Galectin-3 Level in Ankylosing Spondylitis Patients
Forty-five AS patients and 35 healthy controls were enrolled in this study. Patients diagnosed with AS according to Modified New York criteria were included in the study.
- Trial name
- NCT04746196
- Testing
- Serum galectin-3 concentration was measured.
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital