Clinical trials: Gas Exchange
HSCT, Respiratory
Assessing Pulmonary Changes in HSCT
This will be an un-blinded, open-label study of children and adults, including those who are being evaluated for or who have undergone HSCT, those with existing respiratory conditions and/or diagnosed gas-exchange impairment, and…
- Conditions
- HSCT, Respiratory, Gas Exchange Impairment
- Trial name
- NCT07823036
- Testing
- Hyperpolarized 129 Xenon
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Hypertension, Pulmonary, Altitude Sickness
Efficacy Study of Riociguat and Its Effects on Exercise Performance and Pulmonary Artery Pressure at High Altitude
During ascent to high altitude there is a physiologic response to hypoxia that results in an elevated pulmonary arterial pressure associated with decreased exercise performance, altitude-induced pulmonary hypertension, and high…
- Trial name
- NCT02024386
- Testing
- Riociguat
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Richard Moon
COPD
Evaluation Inhaled Corticosteroids on Exhaled Nitric Oxide Gas Exchange
To evaluate the role of inhaled corticosteroids to suppress nitric oxide gas exchange in stable patients with moderate-to-severe COPD who are current non-smokers and not on oral corticosteroids.
- Trial name
- NCT00568347
- Testing
- fluticasone 100mcg/ salmeterol 50mcg, fluticasone 250/salmeterol 50, salmeterol
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Arthur F Gelb MD
Trauma ICU Patients, Endothelial Injury
Inflammation Severity and miRNA-126 in Trauma
Trauma triggers a complex immune response intended to eliminate danger signals and restore physiological balance. Early post-traumatic inflammation is primarily initiated by damage-associated molecular patterns (DAMPs) and…
- Trial name
- NCT07291908
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Melike Cengiz
Idiopathic Pulmonary Fibrosis
Inhaled Nitric Oxide (iNO) in Idiopathic Pulmonary Fibrosis (IPF).
Idiopathic Pulmonary Fibrosis (IPF) is a progressive lung disease marked by reduced exercise capacity and activity-related breathlessness (commonly termed dyspnea).
- Trial name
- NCT05052229
- Testing
- Nitric Oxide, Medical air
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dr. Denis O'Donnell
Cardio Respiratory Arrest, Cardiac Death
Ventilation in Cardiac Arrest
Over the last decades, research in cardiopulmonary resuscitation was primarily focused on uninterrupted chest compressions to restore sufficient circulation.
- Conditions
- Cardio Respiratory Arrest, Cardiac Death, Ventilation Therapy; Complications, Apnea
- Trial name
- VICA (NCT04657393)
- Testing
- mechanical ventilation
- Where
- Austria
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Methods of Exercise in Children
Gas Exchange Kinetics and Work Load During Exercise
The purpose of this research study is to understand how different kinds of exercise affect the human body and the health of the heart and lungs.Participants will exercise in different protocols on a bicycle ergometer or…
- Trial name
- NCT03770507
- Testing
- Exercise Training
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
COPD
Pulmonary Gas Exchange Abnormalities in Patients With Mild COPD
People with mild chronic obstructive pulmonary disease (COPD) can have significant physiological abnormalities and breathing inefficiency which become more pronounced during the stress of exercise, leading to intolerable…
- Trial name
- NCT02346604
- Where
- Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Queen's University
Prostatic Neoplasm, Urinary Bladder Neoplasm
The Effect of Prolonged Inspiratory Time on Gas Exchange During Robot-assisted Laparoscopic Surgery With Steep Trendelenburg Position : A Crossover Randomized Clinical Trial
Gas exchange disturbance frequently occurs in steep Trendelenburg position during robot-assisted laparoscopic prostatectomy or cystectomy.
- Trial name
- NCT02966535
- Testing
- Adjustment of Mechanical Ventilator Inspiratory to expiratory time ratio (1:2 to 1:1), Adjustment of Mechanical Ventilator Inspiratory to expiratory time ratio (1:1 to 1:2)
- Where
- South Korea
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Idiopathic Pulmonary Fibrosis, Hypersensitivity Pneumonitis
129Xe Gas Exchange Imaging in IPF and cHP: A Reliability Study
This research is a study to test the reliability of Hyperpolarized Xenon MRI (HXe MRI) as a biomarker in interstitial lung disease.
- Trial name
- NCT04677426
- Testing
- Hyperpolarized Xe129
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Accident Caused by Snow Avalanche
Hypercapnia and Gas Exchange Under the Avalanche Snow Model (HyperAvaSM)
The aim of the study is to investigate respiratory parameters of a person in the simulated avalanche snow and consequent use of the measured data for development of a mathematical-physical model of breathing during increasing…
- Trial name
- HyperAvaSM (NCT02521272)
- Testing
- Breathing in the simulated avalanche snow., air pocket
- Where
- Czechia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague
Long COVID, Breathlessness
Long COVID and Post-exertional Pulmonary Diffusion
Aim of investigators was to study whether abnormalities of lung diffusing capacity for nitric oxide (DLNO) and carbon monoxide (DLCO) in long COVID may have a clinical impact in relation to exercise intolerance.
- Conditions
- Long COVID, Breathlessness, Exercise Intolerance, Alveolar Lung Disease
- Trial name
- Long_COVID_Ex (NCT05430503)
- Testing
- Lung volumes, spirometry and standard single-breath DLCO were measured at rest while combined DLNO and DLCO were measured at rest and post-exercise
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Avalanche Burial
Impact of CO2 Absorption on Gas Exchange and Ventilation Patterns While Breathing Into a Snow Air Pocket
Asphyxia is by far the most common cause of death after critical avalanche burial. The presence of an air pocket increases the survival chances, but expired air rich in carbon dioxide (CO2) progressively displaces oxygen (O2) in…
- Trial name
- AVACO2R (NCT06895759)
- Testing
- Soda lime
- Where
- Italy
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Institute of Mountain Emergency Medicine
Lung Diffusion, Acute Respiratory Failure
Evaluation of Gas Exchange by the Measurement of Lung Diffusion for Carbon Monoxide During General Anaesthesia
Mechanical ventilation is a therapeutic method used in order to keep gas exchange adequate to cell metabolism in patients with acute respiratory failure.
- Trial name
- NCT01503879
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- San Gerardo Hospital
Positive Pressure Ventilation
Flow- Versus Volume-controlled Ventilation During Robot-assisted Laparoscopic Radical Prostatectomy
During robot-assisted laparoscopic radical prostatectomy (RALRP), patients are placed under general anesthesia and supported with mechanical ventilation.
- Trial name
- NCT07453810
- Testing
- Flow-Controlled Ventilation, Volume-Controlled Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Respiratory Failure
The Effects of Sound Energy on Pulmonary Gas Exchange
Study of the effects of sonic pressure oscillations on pulmonary gas exchange with added dead space.
- Trial name
- NCT02447731
- Testing
- Induction of sound waves in lungs by "sonic oscillator"
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
Accident Caused by Snow Avalanche
Snow Properties and Its Modeling for Studying Gas Exchange Under the Simulated Avalanche Snow
The aim of the study is to investigate respiratory parameters of a person in the simulated avalanche snow and consequent use of the measured data for development of a mathematical-physical model of breathing during increasing…
- Trial name
- SPAM (NCT03413878)
- Testing
- Breathing in the simulated avalanche snow
- Where
- 2 sites in Czechia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague
Healthy Volunteers
Gas Exchange and Cardiovascular Kinetics of Regulation - Effects of Short Term Changes in Gravity
The regulation of the cardiovascular respiratory system after changing environmental conditions or changes in work rates are essential for cognitive as well as physical functioning.
- Trial name
- GasEx (NCT02850354)
- Testing
- anti-g maneuvers
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Middle Ear Disease, Nasal Allergy
TransMEM Gas Exchange -- Project 1, Aim 2
This study will determine if exposure to an allergy material (ragweed) or exposure to an allergic-symptom-provoking substance (histamine) and medications typically used to decongest the nose changes the rate of blood-flow in the…
- Trial name
- NCT01925729
- Testing
- ragweed, histamine, pseudoephedrine
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Cuneyt M. Alper
Diffusion Limitation of Pulmonary Gas Exchange in Systemic Sclerosis
Mechanisms of Pulmonary Diffusion Limitation in Systemic Sclerosis
This study was designed to test the hypothesis that, irrespective of the degree of interstiaI lung disease and/or pulmonary arterial hypertension, the combined measurement of lung diffusing capacity for nitric oxide and carbon…
- Trial name
- DL-SSc (NCT03601520)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy