Clinical trials: Gastric Bypass
Post Bariatric Surgery, Gastric Bypass
The Effects of Bariatric Surgeries on Glucose Metabolism
The purpose of this study is learn the effect of gastric bypass surgery and sleeve gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after eating.
- Conditions
- Post Bariatric Surgery, Gastric Bypass, Sleeve Gastrectomy, Hypoglycemia After Gastric Bypass
- Trial name
- NCT02823665
- Testing
- Exendin-(9-39), Atropine
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Gastric Bypass Surgery
Efficacy of Oversewing Versus Surgical Ligation Clips for Staple Line Reinforcement of the Gastric Pouch to Reduce Post Operative Bleeding in Laparoscopic One Anastomosis Gastric Bypass
1. To test if there is a significant differences between Oversewing versus surgical ligation clips for staple line reinforcement of the gastric pouch regarding the reduction of post operative bleeding and the need for blood…
- Trial name
- NCT07238309
- Testing
- Oversewing, Surgical Ligation Clips
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Obesity, Bariatrics
Ketamine and Propofol Combination Versus Propofol for Upper Gastrointestinal Endoscopy
Propofol is one of the most popular anesthetic drugs used for sedation during upper gastrointestinal endoscopies due to its quick onset and quick resolution of symptoms allowing patients to leave the hospital sooner.
- Conditions
- Obesity, Bariatrics, Sleep Apnea Syndromes, Gastric Bypass
- Trial name
- NCT02643979
- Testing
- Ketofol, Propofol, Saline
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Type 2 Diabetes, Obesity
Splanchnic Blood Redistribution After Incretin Hormone Infusion and Obesity Surgery
Obesity is a worldwide problem and leads to multiple metabolic and endocrinological problems. Bariatric surgeries are a growing field as a treatment choice for morbid obesity (BMI > 35 kg/m2).
- Trial name
- GIP-PET (NCT01880827)
- Testing
- Roux-en-Y, GIP-infusion, GLP-1
- Where
- Finland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Overweight and Obesity, Type 2 Diabetes
Fat Metabolites and Gut Hormones
To investigate the effects of different fat metabolites on gut hormone secretion in gastric bypass operated subjects and BMI-matched controls.
- Conditions
- Overweight and Obesity, Type 2 Diabetes, Bariatric Surgery, Gut Hormones
- Trial name
- NCT03223389
- Testing
- C-8 dietary oil, Tricaprylin, Olive oil
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Obesity, Gliosis, Weight-Loss
A Cohort Study of Weight Loss and Gliosis
Patients and clinicians need better options to prevent the weight regain that almost universally follows a weight loss intervention. In lay terms, a new, higher "set point" seems to occur after people gain weight.
- Trial name
- NCT03578887
- Testing
- Behavioral Weight Loss Program, Roux-en-Y Gastric Bypass or Sleeve Gastrectomy
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Washington
Roux-en-Y Gastric Bypass, Cholecystitis; Gallstone
Randomized Trial Comparing Gastric Bypass With and Without Cholecystectomy
The main objective of this pilot study is to show feasibility to collect peri-operative and postoperative clinical data of the study group of gastric bypass without cholecystectomy compared with the control group of gastric…
- Conditions
- Roux-en-Y Gastric Bypass, Cholecystitis; Gallstone, Gallbladder Diseases
- Trial name
- NCT04324515
- Testing
- Robotic gastric bypass with or without cholecystectomy
- Where
- Switzerland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Geneva, Switzerland
Bariatric Surgery
Fat Absorption and Metabolism After Roux-en-Y Gastric Bypass
Using intravenous and oral administration of stable isotope tracers, we will investigate the importance of altered fat absorption and altered whole body fat metabolism for the reduced postprandial systemic TAG concentrations in…
- Trial name
- FAT-BAR (NCT04859816)
- Testing
- Metabolic test, DXA-scan, MRS
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Obesity, Morbid, Bariatric Surgery
Photographic Food Recognition and Meal Size Estimation Before and After Roux-en-Y Gastric Bypass
Direct measurements of changes in food selection in humans after RYGB have been limited by the unreliability of patients, which poses significant methodological and conceptual challenges to researchers and study design.
- Conditions
- Obesity, Morbid, Bariatric Surgery, Roux-en-Y Gastric Bypass, Food Preferences
- Trial name
- NCT04600596
- Testing
- Recording of food intake.
- Where
- Switzerland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Marco Bueter
Bariatric Surgery Candidate
Alcohol Related Impairment and Reinforcement: Pre to Post Roux en Y Gastric Bypass Surgery
The proposed project will help to understand the changes in reinforcement and impairment experienced by Roux en Y bariatric surgery (RYGB) patients who consume alcohol.
- Trial name
- NCT02370732
- Testing
- Alcohol
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Neuropsychiatric Research Institute, Fargo, North Dakota
Obesity, Insulin Resistance
Ghrelin and Insulin Resistance
Ghrelin, a hormone produced in the stomach that stimulates hunger and food intake, declines immediately after weight loss surgery. Some studies suggest that ghrelin may worsen an individual's ability to respond to insulin.
- Conditions
- Obesity, Insulin Resistance, Normal Weight,Healthy Controls
- Trial name
- NCT00884494
- Testing
- Ghrelin infusion to assess effects on insulin sensitivity
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Obesity
A Prospective Study Evaluating The Utility of Transnasal Endoscopy With Roux en Y Gastric Bypass
Improvements in imaging technology have allowed for the development of small endoscopes ("slim scopes") half the size of a typical endoscope.
- Trial name
- NCT01526772
- Testing
- Endoscopy
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Obesity
Endoscopic Suturing System for Tissue Apposition
The objective of this feasibility trial is to evaluate the Ethicon Endo-Surgery Endoscopic Suturing System (ESS) for tissue apposition and reduction of the size of a dilated GJ anastomosis in subjects who are regaining weight…
- Trial name
- NCT00495222
- Testing
- Tissue plication, Endoscopic Suturing System
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Ethicon Endo-Surgery
Obesity
Clinic-based Nasopharyngoesophagogastroscopy Following Bariatric Surgery
This study aims to determine that this new technology, nasopharyngoendoscopy, is just as effective in diagnosing problems as the current gold standard.
- Trial name
- EGScan (NCT01602991)
- Testing
- clinic-based nasopharyngoendoscopy, Standard Endoscopy
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Dennis Hong MD
Obesity, Morbid, Surgery
Indocyanine Green Test in Bariatric Surgery
Indocyanine green (ICG) can be injected into the human bloodstream and it allows us to show stomach vascularity in real time
- Conditions
- Obesity, Morbid, Surgery, Leak, Anastomotic
- Trial name
- NCT05476159
- Testing
- Indocyanine green solution, Gastric bypass
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Foggia
Post-bariatric Surgery
Glucagon-like Peptide 1, Glucose Metabolism and Gastric Bypass
The overall goal of this project is to understand the mechanisms by which gastric bypass surgery improves glucose metabolism. The central hypothesis guiding this project is that the reconfiguration of intestinal transit with the…
- Trial name
- GLP-1 (NCT01803451)
- Testing
- exendin-(9-39), exendin -(9-39)
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Roux en Y Gastric Bypass
A Comparison of Sustained and Extended Release Bupropion Following Bariatric Surgery
This study is being conducted to evaluate how the body absorbs and processes the sustained release (SR) and extended release (XL) medication bupropion (Wellbutrin®).
- Trial name
- NCT02173886
- Testing
- Bupropion SR and XL
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- North Dakota State University
Iron Absorption, Bariatric Surgery
Iron Absorption Trial
Introduction: There are indications that the absorption of oral iron supplementation is reduced after a Roux- en -Y gastric bypass.
- Conditions
- Iron Absorption, Bariatric Surgery, Roux- en -y Gastric Bypass
- Trial name
- NCT02228902
- Testing
- Ferrous fumarate, Ferrous gluconate
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Rijnstate Hospital
Type 2 Diabetes, Obesity
Changes in Incretins Response and Glycemic Control After Gastric Bypass Surgery in Type 2 Diabetic Patients Versus Healthy
The purpose of this study is to determine the early changes in gut hormonal, and other metabolites with known relations to the glycemic homeostasis.
- Trial name
- NCT01820273
- Where
- Sweden
- Volunteers
- healthy volunteers welcome
- Sponsor
- Lund University
Bariatric Surgery, Osteoporosis
Skeletal Health in Bariatric Surgery Patients
The investigators propose a prospective cohort trial that will help to understand the impact of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) in pre- and post-menopausal female bariatric patients.
- Conditions
- Bariatric Surgery, Osteoporosis, Fractures, Bone, Roux En-Y Gastric Bypass
- Trial name
- NCT03331536
- Testing
- Roux en Y Gastric Bypass Pre-menopausal, Roux en Y Gastric Bypass Post-menopausal, Sleeve Gastrectomy Pre-menopausal
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham